Structural Classification of Proteins
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Superfamily: Sigma3 and sigma4 domains of RNA polymerase sigma factors

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: DNA/RNA-binding 3-helical bundle [46688]
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. Superfamily: Sigma3 and sigma4 domains of RNA polymerase sigma factors [88659]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Sigma3 domain [88660] (3)
    1. Sigma70 [88661]
      1. Thermus thermophilus [TaxId: 274] [88662] (16)
        SQ Q9WX78
        1. 1smy picpicxrefxrefxrefxrefxrefxrefxref
          complexed with g4p, mg, zn
          1. region f:258-318 [105781] picpiclink
          2. region p:258-318 [105791] picpiclink
        2. 2a6h picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, std, zn
          1. region f:258-318 [126267] picpiclink
        3. 2a6h picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, std, zn
          1. region p:258-318 [126277] picpiclink
        4. 2a69 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, rpt, zn
          1. region f:258-318 [126218] picpiclink
        5. 2a69 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, rpt, zn
          1. region p:258-318 [126228] picpiclink
        6. 2a68 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, rbt, zn
          1. region f:258-318 [126198] picpiclink
        7. 2a68 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, rbt, zn
          1. region p:258-318 [126208] picpiclink
        8. 2be5 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, tgt, zn
          1. region f:258-318 [128358] picpiclink
        9. 2be5 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, tgt, zn
          1. region p:258-318 [128368] picpiclink
        10. 1iw7 picpicxrefxrefxrefxrefxrefxrefxref
          complexed with mg, pb
          1. region f:258-318 [83086] picpiclink
          2. region p:258-318 [83089] picpiclink
        11. 2a6e picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, zn
          1. region f:258-318 [126247] picpiclink
        12. 2a6e picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, zn
          1. region p:258-318 [126257] picpiclink
        13. 1zyr picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, std, zn
          1. region f:258-318 [125856] picpiclink
        14. 1zyr picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, std, zn
          1. region p:258-318 [125866] picpiclink
        15. 2cw0 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, zn
          1. region f:258-318 [130905] picpiclink
        16. 2cw0 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f1
          complexed with mg, zn
          1. region p:258-318 [130915] picpiclink
    2. Sigma factor SigA [88663]
      1. Thermus aquaticus [TaxId: 271] [88664] (1)
        1. 1ku2 picpicxref
          complexed with so4
          1. region a:273-332 [83096] picpiclink
          2. region b:273-332 [83098] picpiclink
    3. Sigma factor sigma-28 (FliA) [101055]
      1. Aquifex aeolicus [TaxId: 63363] [101056] (2)
        1. 1rp3 picpicxrefxrefxref
          1. region a:87-163 [97678] picpiclink
          2. region c:87-163 [97682] picpiclink
          3. region e:87-163 [97686] picpiclink
          4. region g:87-156 [97690] picpiclink
        2. 1sc5 picpicxrefxrefxref
          1. region a:87-163 [98798] picpiclink
  2. Sigma4 domain [88665] (7)
    1. Sigma70 (SigA, RpoD) [88666]
      1. Thermus thermophilus [TaxId: 274] [88667] (16)
        SQ Q9WX78
        1. 1smy picpicxrefxrefxrefxrefxrefxrefxref
          complexed with g4p, mg, zn
          1. region f:319-423 [105782] picpiclink
          2. region p:319-423 [105792] picpiclink
        2. 2a6h picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, std, zn
          1. region f:319-423 [126268] picpiclink
        3. 2a6h picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, std, zn
          1. region p:319-423 [126278] picpiclink
        4. 2a69 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, rpt, zn
          1. region f:319-423 [126219] picpiclink
        5. 2a69 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, rpt, zn
          1. region p:319-423 [126229] picpiclink
        6. 2a68 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, rbt, zn
          1. region f:319-423 [126199] picpiclink
        7. 2a68 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, rbt, zn
          1. region p:319-423 [126209] picpiclink
        8. 2be5 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, tgt, zn
          1. region f:319-423 [128359] picpiclink
        9. 2be5 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, tgt, zn
          1. region p:319-423 [128369] picpiclink
        10. 1iw7 picpicxrefxrefxrefxrefxrefxrefxref
          complexed with mg, pb
          1. region f:319-423 [83087] picpiclink
          2. region p:319-423 [83090] picpiclink
        11. 2a6e picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, zn
          1. region f:319-423 [126248] picpiclink
        12. 2a6e picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, zn
          1. region p:319-423 [126258] picpiclink
        13. 1zyr picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, std, zn
          1. region f:319-423 [125857] picpiclink
        14. 1zyr picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, std, zn
          1. region p:319-423 [125867] picpiclink
        15. 2cw0 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, zn
          1. region f:319-423 [130906] picpiclink
        16. 2cw0 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1iw7f2
          complexed with mg, zn
          1. region p:319-423 [130916] picpiclink
      2. Escherichia coli [TaxId: 562] [116816] (2)
        SQ P00579 546-613
        1. 2p7v picpic
          automatically matched to d1tlhb_
          complexed with mg
          1. region b:546-613 [149292] picpiclink
        2. 1tlh picpicxref
          sigma4 region only
          1. chain b [112507] picpiclink
      3. Thermotoga maritima [TaxId: 2336] [116817] (1)
        SQ P77994 313-399
        1. 1tty picpic
          1. chain a [112638] picpiclink
      4. Thermus aquaticus [TaxId: 271] [88669] (3)
        1. 1ku3 picpic
          sigma4 domain only
          mutant
          1. chain a [73000] picpiclink
        2. 1rio picpicxref
          complexed with ca, mpd
          1. chain h [97515] picpiclink
        3. 1ku7 picpic
          sigma4 domain only
          mutant
          1. chain a [73001] picpiclink
          2. chain d [73002] picpiclink
    2. SigmaE factor (RpoE) [88993]
      1. Escherichia coli [TaxId: 562] [88994] (3)
        1. 1or7 picpicxrefxref
          1. region a:120-187 [87332] picpiclink
          2. region b:120-190 [87334] picpiclink
        2. 2h27 picpic
          automatically matched to d1or7b1
          complexed with mpd
          1. region a:122-190 [135993] picpiclink
        3. 2h27 picpic
          automatically matched to d1or7b1
          complexed with mpd
          1. region d:122-190 [135994] picpiclink
    3. SigmaF [74769]
      1. Bacillus stearothermophilus [TaxId: 1422] [74770] (1)
        1. 1l0o picpicxref
          sigma4 domain only
          complexed with adp, mg; mutant
          1. chain c [73405] picpiclink
    4. Sigma factor sigma-28 (FliA) [101057]
      1. Aquifex aeolicus [TaxId: 63363] [101058] (2)
        1. 1rp3 picpicxrefxrefxref
          1. region a:164-234 [97679] picpiclink
          2. region c:164-235 [97683] picpiclink
          3. region e:164-236 [97687] picpiclink
          4. region g:167-236 [97691] picpiclink
        2. 1sc5 picpicxrefxrefxref
          1. region a:168-233 [98799] picpiclink
  3. YlxM/p13-like [109706] (2)
    Pfam 04297; UPF0122
    structural and detectable sequence similarity to Sigma4 domain; contains extra C-terminal all-alpha oligomerization subdomain; forms different, helix-swapped dimers
    1. Hypothetical protein SPy1201 [109707]
      1. Streptococcus pyogenes [TaxId: 1314] [109708] (1)
        SQ P67253
        1. 1s7o picpic
          Structural genomics target
          1. chain a [105354] picpiclink
          2. chain b [105355] picpiclink
          3. chain c [105356] picpiclink
    2. Hypothetical protein SAV1236 [116818]
      1. Staphylococcus aureus, strain Mu50 / ATCC 700699 [TaxId: 1280] [116819] (1)
        SQ P67248
        1. 1xsv picpic
          1. chain a [116003] picpiclink
          2. chain b [116004] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk