Structural Classification of Proteins

Fold: Ribbon-helix-helix

: core: 4 helices; array of 2 hairpins, opened

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: Ribbon-helix-helix [47597]
core: 4 helices; array of 2 hairpins, opened

Superfamilies:

Ribbon-helix-helix [47598] (11)
formerly Met repressor-like; dimeric proteins; the N-termini form a small beta-sheet ribbon
uperfamily
1. Arc/Mnt-like phage repressors [47599] (2)
  1. Arc repressor [47600]
    1. Salmonella bacteriophage P22 [TaxId: 10754] [47601] (12)
  2. Mnt repressor [47602]
    1. Salmonella bacteriophage P22 [TaxId: 10754] [47603] (1)
2. CopG-like [100970] (5)
  similar to the phage repressor family
  1. Transcriptional repressor CopG [47605]
    plasmid-encoded
    1. Streptococcus agalactiae [TaxId: 1311] [47606] (3)
  2. Plasmid partition protein ParG [101203]
    1. Salmonella enterica [TaxId: 28901] [101204] (1)
  3. Nickel responsive regulator NikR, N-terminal domain [101205]
    1. Escherichia coli [TaxId: 562] [101206] (11)
    2. Archaeon Pyrococcus horikoshii [TaxId: 53953] [140543] (12)
      SQ O58316 1-50
  4. Uncharacterized protein HP0222 [158480]
    1. Helicobacter pylori [TaxId: 210] [158481] (2)
      SQ O25010 31-73
3. Omega transcriptional repressor [100971] (1)
  plasmid-encoded, similar to the phage repressor family
  1. Omega transcriptional repressor [69031]
    1. Streptococcus pyogenes [TaxId: 1314] [69032] (13)
4. Met repressor, MetJ (MetR) [100972] (1)
  1. Met repressor, MetJ (MetR) [47607]
    1. Escherichia coli [TaxId: 562] [47608] (10)
5. NE0241-like [140544] (1)
  contains extra C-terminal long helix; currently consists of an orphan protein
  1. Hypothetical protein NE0241 [140545]
    1. Nitrosomonas europaea [TaxId: 915] [140546] (1)
      SQ Q82XL7 10-95
6. SeqA N-terminal domain-like [140547] (1)
  N-terminal part of Pfam 03925
  1. SeqA [140548]
    a negative modulator of replication initiation
    1. Escherichia coli [TaxId: 562] [140549] (4)
      SQ P0AFY8 1-35
7. Trafficking protein A-like [140550] (1)
  1. Trafficking protein A [140551]
    1. Neisseria gonorrhoeae [TaxId: 485] [140552] (8)
      SQ Q5F881 2-70
8. VCA0319-like [140553] (1)
  COG4453; extended and extra C-terminal helices; potential component of the bi-partite system also including an acetyltransferase
  1. Hypothetical protein VCA0482 (VCA0319) [140554]
    Proteins of identical sequence, VCA0482 VCA0319 are encoded by two different genes
    1. Vibrio cholerae [TaxId: 666] [140555] (2)
      SQ Q9K2J6 3-83
9. VirC2-like [158482] (1)
  Pfam 07181; duplicated ribbon-helix-helix motif; fold forms a trefoil knot
  1. VirC2 [158483]
    Encoded by Ti plasmid
    1. Agrobacterium tumefaciens [TaxId: 358] [158484] (1)
      SQ P07166 82-202
10. PutA pre-N-terminal region-like [158485] (1)
  in PutA it forms a separate ribbon-helix-helix domain connected to the N-terminal enzymatic domain by a flexible linker
  1. Bifunctional protein putA [158486]
    1. Escherichia coli [TaxId: 562] [158487] (6)
      SQ P09546 3-45
11. MJ0366-like [158488] (1)
  PfamB 022101; duplicated ribbon-helix-helix motif; forms trefoil knot; predicted DNA binding
  1. Uncharacterized protein MJ0366 [158489]
    1. Methanococcus jannaschii [TaxId: 2190] [158490] (1)
      SQ Q57812 6-87