Structural Classification of Proteins
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Fold: Terpenoid synthases

multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: Terpenoid synthases [48575]
    multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

Superfamilies:

  1. Terpenoid synthases [48576] (5)
    duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J
    link to SUPERFAMILY database - Superfamily
    1. Isoprenyl diphosphate synthases [48577] (5)
      1. Farnesyl diphosphate synthase (geranyltranstransferase) [48578]
        1. Chicken (Gallus gallus) [TaxId: 9031] [48579] (5)
          1. 1fps picpic
            1. chain a [19436] picpiclink
          2. 1uby picpic
            complexed with dma, mg; mutant
            1. chain a [19435] picpiclink
          3. 1ubv picpic
            mutant
            1. chain a [19437] picpiclink
          4. 1ubw picpic
            complexed with gpp, mg; mutant
            1. chain a [19438] picpiclink
          5. 1ubx picpic
            complexed with fpp, mg; mutant
            1. chain a [19439] picpiclink
        2. Escherichia coli [TaxId: 562] [101453] (2)
          1. 1rqj picpic
            complexed with ipr, mg, ris
            1. chain a [97744] picpiclink
            2. chain b [97745] picpiclink
          2. 1rqi picpic
            complexed with dpo, dst, ipr, mg
            1. chain a [97742] picpiclink
            2. chain b [97743] picpiclink
        3. Staphylococcus aureus [TaxId: 1280] [101454] (1)
          1. 1rtr picpic
            1. chain a [97820] picpiclink
            2. chain b [97821] picpiclink
      2. Octoprenyl-diphosphate synthase [101455]
        1. Thermotoga maritima [TaxId: 2336] [101456] (10)
          SQ Q9X1M1
          1. 1v4e picpic
            complexed with so4
            1. chain a [100296] picpiclink
            2. chain b [100297] picpiclink
          2. 1v4i picpic
            complexed with so4; mutant
            1. chain a [100299] picpiclink
          3. 1v4k picpic
            complexed with so4; mutant
            1. chain a [100302] picpiclink
          4. 1vg3 picpic
            complexed with so4; mutant
            1. chain a [108601] picpiclink
          5. 1v4h picpic
            complexed with so4; mutant
            1. chain a [100298] picpiclink
          6. 1v4j picpic
            complexed with so4; mutant
            1. chain a [100300] picpiclink
            2. chain b [100301] picpiclink
          7. 1vg6 picpic
            mutant
            1. chain a [108604] picpiclink
          8. 1vg2 picpic
            mutant
            1. chain a [108600] picpiclink
          9. 1vg7 picpic
            mutant
            1. chain a [108605] picpiclink
          10. 1vg4 picpic
            mutant
            1. chain a [108602] picpiclink
            2. chain b [108603] picpiclink
      3. Geranylgeranyl pyrophosphate synthetase [158813]
        1. Human (Homo sapiens) [TaxId: 9606] [158814] (6)
          SQ O95749 6-296
          1. 2q80 picpic
            complexed with grg, mg
            1. region a:6-296 [150112] picpiclink
          2. 2q80 picpic
            automatically matched to 2Q80 A:6-296
            complexed with grg, mg
            1. region b:6-295 [150113] picpiclink
          3. 2q80 picpic
            automatically matched to 2Q80 A:6-296
            complexed with grg, mg
            1. region c:6-295 [150114] picpiclink
          4. 2q80 picpic
            automatically matched to 2Q80 A:6-296
            complexed with grg, mg
            1. region d:6-295 [150115] picpiclink
          5. 2q80 picpic
            automatically matched to 2Q80 A:6-296
            complexed with grg, mg
            1. region e:6-295 [150116] picpiclink
          6. 2q80 picpic
            automatically matched to 2Q80 A:6-296
            complexed with grg, mg
            1. region f:6-295 [150117] picpiclink
    2. Squalene synthase [48580] (1)
      1. Squalene synthase [48581]
        synonym: Farnesyl diphosphate farnesyltransferase
        1. Human (Homo sapiens) [TaxId: 9606] [48582] (1)
          1. 1ezf picpic
            complexed with in0; mutant
            1. chain a [19440] picpiclink
            2. chain b [19441] picpiclink
            3. chain c [19442] picpiclink
    3. Terpenoid cyclase C-terminal domain [48583] (2)
      1. 5-Epi-aristolochene synthase [48584]
        1. Tobacco (Nicotiana tabacum) [TaxId: 4097] [48585] (7)
          1. 5eas picpicxref
            complexed with mg; mutant
            1. region a:221-548 [19444] picpiclink
          2. 5eau picpicxref
            complexed with fff, mg; mutant
            1. region a:221-548 [19443] picpiclink
          3. 1hxa picpicxref
            complexed with fhp, mg; mutant
            1. region a:221-548 [83642] picpiclink
          4. 1hxc picpicxref
            complexed with fhp; mutant
            1. region a:221-548 [83644] picpiclink
          5. 5eat picpicxref
            complexed with fhp, mg
            1. region a:221-548 [19445] picpiclink
          6. 1hxg picpicxref
            complexed with mg; mutant
            1. region a:221-548 [83646] picpiclink
          7. 1hx9 picpicxref
            complexed with fhp, mg; mutant
            1. region a:221-548 [83640] picpiclink
      2. (+)-bornyl diphosphate synthase [81920]
        1. Garden sage (Salvia officinalis) [TaxId: 38868] [81921] (7)
          1. 1n1b picpicxref
            complexed with hg, mg
            1. region a:271-598 [79800] picpiclink
            2. region b:271-598 [79802] picpiclink
          2. 1n24 picpicxref
            complexed with bp2, mg
            1. region a:271-598 [79847] picpiclink
            2. region b:271-598 [79849] picpiclink
          3. 1n20 picpicxref
            complexed with 3ag, mg
            1. region a:271-598 [79833] picpiclink
            2. region b:271-598 [79835] picpiclink
          4. 1n1z picpicxref
            complexed with btb, mg, pop
            1. region a:271-598 [79829] picpiclink
            2. region b:271-598 [79831] picpiclink
          5. 1n23 picpicxref
            complexed with 2bn, mg, pop
            1. region a:271-598 [79843] picpiclink
            2. region b:271-598 [79845] picpiclink
          6. 1n22 picpicxref
            complexed with 7a8, mg, pop
            1. region a:271-598 [79839] picpiclink
            2. region b:271-598 [79841] picpiclink
          7. 1n21 picpicxref
            complexed with 3ag, mg
            1. region a:271-598 [79837] picpiclink
    4. Aristolochene/pentalenene synthase [48586] (2)
      1. Aristolochene synthase [48587]
        1. Fungus (Penicillium roqueforti) [TaxId: 5082] [48588] (2)
          1. 1di1 picpic
            1. chain a [19446] picpiclink
            2. chain b [19447] picpiclink
          2. 1dgp picpic
            complexed with foh
            1. chain a [19448] picpiclink
            2. chain b [19449] picpiclink
      2. Pentalenene synthase [48589]
        1. Streptomyces sp., UC5319 [TaxId: 1931] [48590] (3)
          1. 1ps1 picpic
            complexed with pbm
            1. chain a [19450] picpiclink
            2. chain b [19451] picpiclink
          2. 1hm7 picpic
            mutant
            1. chain a [76719] picpiclink
            2. chain b [76720] picpiclink
          3. 1hm4 picpic
            mutant
            1. chain a [76715] picpiclink
            2. chain b [76716] picpiclink
    5. Trichodiene synthase [69113] (1)
      1. Trichodiene synthase [69114]
        1. Fusarium sporotrichioides [TaxId: 5514] [69115] (12)
          1. 1kiy picpic
            complexed with edo; mutant
            1. chain a [72555] picpiclink
            2. chain b [72556] picpiclink
          2. 1jfa picpic
            complexed with edo
            1. chain a [66622] picpiclink
            2. chain b [66623] picpiclink
          3. 1jfg picpic
            complexed with gol, mo1, mo3, pop
            1. chain a [66636] picpiclink
            2. chain b [66637] picpiclink
          4. 1kiz picpic
            complexed with edo, mg, pop; mutant
            1. chain a [72557] picpiclink
            2. chain b [72558] picpiclink
          5. 2q9z picpic
            automatically matched to d1jfaa_
            complexed with edo, mg, pop
            1. region a:3-354 [150171] picpiclink
          6. 2q9z picpic
            automatically matched to d1jfaa_
            complexed with edo, mg, pop
            1. region b:3-354 [150172] picpiclink
          7. 1yyt picpic
            automatically matched to d1kiya_
            complexed with mg, pop, saz; mutant
            1. region a:1-354 [124250] picpiclink
          8. 1yyt picpic
            automatically matched to d1kiya_
            complexed with mg, pop, saz; mutant
            1. region b:1-354 [124251] picpiclink
          9. 2q9y picpic
            automatically matched to d1jfaa_
            complexed with btm, edo, mg, pop
            1. region a:3-354 [150169] picpiclink
          10. 2q9y picpic
            automatically matched to d1jfaa_
            complexed with btm, edo, mg, pop
            1. region b:3-354 [150170] picpiclink
          11. 1yyu picpic
            automatically matched to d1kiya_
            complexed with edo, mg, pop, raz, saz; mutant
            1. region a:1-354 [124252] picpiclink
          12. 1yyu picpic
            automatically matched to d1kiya_
            complexed with edo, mg, pop, raz, saz; mutant
            1. region b:1-354 [124253] picpiclink

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site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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