Structural Classification of Proteins

Superfamily: Terpenoid cyclases/Protein prenyltransferases

: uperfamily

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: alpha/alpha toroid [48207]
multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
Superfamily: Terpenoid cyclases/Protein prenyltransferases [48239]
uperfamily

Families:

Terpenoid cyclase N-terminal domain [48240] (2)
incomplete toroid made of four hairpins
1. 5-Epi-aristolochene synthase [48241]
  1. Tobacco (Nicotiana tabacum) [TaxId: 4097] [48242] (7)
    1. 5eas
      complexed with mg; mutant
      1. region a:24-220 [18852]
    2. 5eau
      complexed with fff, mg; mutant
      1. region a:21-220 [18851]
    3. 1hxa
      complexed with fhp, mg; mutant
      1. region a:21-220 [83641]
    4. 1hxc
      complexed with fhp; mutant
      1. region a:21-220 [83643]
    5. 5eat
      complexed with fhp, mg
      1. region a:17-220 [18853]
    6. 1hxg
      complexed with mg; mutant
      1. region a:15-220 [83645]
    7. 1hx9
      complexed with fhp, mg; mutant
      1. region a:21-220 [83639]
2. (+)-bornyl diphosphate synthase [81857]
  1. Garden sage (Salvia officinalis) [TaxId: 38868] [81858] (7)
    1. 1n1b
      complexed with hg, mg
      1. region a:64-270 [79799]
      2. region b:62-270 [79801]
    2. 1n24
      complexed with bp2, mg
      1. region a:54-270 [79846]
      2. region b:62-270 [79848]
    3. 1n20
      complexed with 3ag, mg
      1. region a:54-270 [79832]
      2. region b:61-270 [79834]
    4. 1n1z
      complexed with btb, mg, pop
      1. region a:54-270 [79828]
      2. region b:65-270 [79830]
    5. 1n23
      complexed with 2bn, mg, pop
      1. region a:55-270 [79842]
      2. region b:61-270 [79844]
    6. 1n22
      complexed with 7a8, mg, pop
      1. region a:54-270 [79838]
      2. region b:64-270 [79840]
    7. 1n21
      complexed with 3ag, mg
      1. region a:53-270 [79836]
Terpene synthases [48243] (2)
consists of two toroid domains: one of six and one of five hairpins
1. Squalene-hopene cyclase [48244]
  1. Alicyclobacillus acidocaldarius [TaxId: 405212] [48245] (16)
    1. 2sqc
      complexed with c8e; mutant
      1. region a:8-36,a:308-630 [18854]
      2. region a:37-307 [18855]
      3. region b:8-36,b:308-630 [18856]
      4. region b:37-307 [18857]
    2. 1ump
      complexed with c8e, sqa
      1. region a:10-36,a:308-629 [99619]
      2. region a:37-307 [99620]
      3. region b:10-36,b:308-629 [99621]
      4. region b:37-307 [99622]
      5. region c:10-36,c:308-629 [99623]
      6. region c:37-307 [99624]
    3. 1sqc
      complexed with lda
      1. region a:10-36,a:308-628 [18858]
      2. region a:37-307 [18859]
    4. 1h36
      complexed with c8e, r88
      1. region a:10-36,a:308-629 [90556]
      2. region a:37-307 [90557]
      3. region b:10-36,b:308-629 [90558]
      4. region b:37-307 [90559]
      5. region c:10-36,c:308-629 [90560]
      6. region c:37-307 [90561]
    5. 1o6r
      complexed with c8e, r19
      1. region a:10-36,a:308-629 [92583]
      2. region a:37-307 [92584]
      3. region b:10-36,b:308-629 [92585]
      4. region b:37-307 [92586]
      5. region c:10-36,c:308-629 [92587]
      6. region c:37-307 [92588]
    6. 1o6h
      complexed with c8e, w37
      1. region a:10-36,a:308-629 [92568]
      2. region a:37-307 [92569]
      3. region b:10-36,b:308-629 [92570]
      4. region b:37-307 [92571]
      5. region c:10-36,c:308-629 [92572]
      6. region c:37-307 [92573]
    7. 1h3b
      complexed with c8e, r46
      1. region a:10-36,a:308-629 [90580]
      2. region a:37-307 [90581]
      3. region b:10-36,b:308-629 [90582]
      4. region b:37-307 [90583]
      5. region c:10-36,c:308-629 [90584]
      6. region c:37-307 [90585]
    8. 1h35
      complexed with c8e, r01
      1. region a:10-36,a:308-629 [90550]
      2. region a:37-307 [90551]
      3. region b:10-36,b:308-629 [90552]
      4. region b:37-307 [90553]
      5. region c:10-36,c:308-629 [90554]
      6. region c:37-307 [90555]
    9. 1h37
      complexed with c8e, r02
      1. region a:10-36,a:308-629 [90562]
      2. region a:37-307 [90563]
      3. region b:10-36,b:308-629 [90564]
      4. region b:37-307 [90565]
      5. region c:10-36,c:308-629 [90566]
      6. region c:37-307 [90567]
    10. 1h39
      complexed with c8e, r03
      1. region a:10-36,a:308-629 [90568]
      2. region a:37-307 [90569]
      3. region b:10-36,b:308-629 [90570]
      4. region b:37-307 [90571]
      5. region c:10-36,c:308-629 [90572]
      6. region c:37-307 [90573]
    11. 3sqc
      mutant
      1. region a:10-36,a:308-628 [18860]
      2. region a:37-307 [18861]
      3. region b:10-36,b:308-628 [18862]
      4. region b:37-307 [18863]
      5. region c:10-36,c:308-628 [18864]
      6. region c:37-307 [18865]
    12. 1h3a
      complexed with c8e, r04
      1. region a:10-36,a:308-629 [90574]
      2. region a:37-307 [90575]
      3. region b:10-36,b:308-629 [90576]
      4. region b:37-307 [90577]
      5. region c:10-36,c:308-629 [90578]
      6. region c:37-307 [90579]
    13. 1o6q
      complexed with c8e, r17
      1. region a:10-36,a:308-629 [92577]
      2. region a:37-307 [92578]
      3. region b:10-36,b:308-629 [92579]
      4. region b:37-307 [92580]
      5. region c:10-36,c:308-629 [92581]
      6. region c:37-307 [92582]
    14. 1gsz
      complexed with c8e, r71
      1. region a:10-36,a:308-628 [76329]
      2. region a:37-307 [76330]
      3. region b:10-36,b:308-628 [76331]
      4. region b:37-307 [76332]
      5. region c:10-36,c:308-628 [76333]
      6. region c:37-307 [76334]
    15. 1o79
      complexed with c8e, r23
      1. region a:10-36,a:308-629 [92602]
      2. region a:37-307 [92603]
      3. region b:10-36,b:308-629 [92604]
      4. region b:37-307 [92605]
      5. region c:10-36,c:308-629 [92606]
      6. region c:37-307 [92607]
    16. 1h3c
      complexed with c8e, r79
      1. region a:10-36,a:308-629 [90586]
      2. region a:37-307 [90587]
      3. region b:10-36,b:308-629 [90588]
      4. region b:37-307 [90589]
      5. region c:10-36,c:308-629 [90590]
      6. region c:37-307 [90591]
2. Lanosterol synthase [116989]
  1. Human (Homo sapiens) [TaxId: 9606] [116990] (2)
    SQ P48449
    1. 1w6k
      complexed with bog, lan
      1. region a:6-99,a:379-732 [114271]
      2. region a:100-378 [114272]
    2. 1w6j
      complexed with bog, c14, r71
      1. region a:6-99,a:379-732 [114269]
      2. region a:100-378 [114270]
Protein prenyltransferases [48246] (3)
1. Protein farnesyltransferase, beta-subunit [48247]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [48248] (29)
    SQ Q02293 22-418 P53610
    1. 1d8d
      complex with K-ras4b peptide substrate
      1. chain b [18866]
    2. 1jcr
      complexed with acy, fpp, zn
      1. chain b [66507]
    3. 1kzp
      complex with k-ras4b peptide product
      complexed with acy, far, zn
      1. chain b [77641]
    4. 1jcs
      complexed with acy, fii, zn
      1. chain b [66509]
    5. 1kzo
      complex with k-ras4b peptide product and farnesyl diphosphate substrate bound simultaneously
      complexed with acy, far, fpp, zn
      1. chain b [77639]
    6. 2r2l
      automatically matched to d1ft1b_
      complexed with fpp, pb9, zn
      1. region b:23-423 [151536]
    7. 1o1t
      complexed with 2nh, mg, zn
      1. chain b [86552]
    8. 1o5m
      complexed with 336, fpp, zn
      1. chain b [92508]
    9. 1o1r
      complexed with grg, zn
      1. chain b [86548]
    10. 1o1s
      complexed with 1nh, zn
      1. chain b [86550]
    11. 1ft1
      complexed with zn
      1. chain b [18867]
    12. 1sa5
      complexed with acy, bmv, fpp, zn
      1. chain b [105405]
    13. 1s64
      complexed with 778, cl, mes, so4, zn
      1. chain b [105288]
      2. chain d [105290]
      3. chain f [105292]
      4. chain h [105294]
      5. chain j [105296]
      6. chain l [105298]
    14. 1n4q
      complexed with cl, mgm, tth, zn
      1. chain b [91636]
      2. chain d [91638]
      3. chain f [91640]
      4. chain h [91642]
      5. chain j [91644]
      6. chain l [91646]
    15. 1n4s
      complexed with cl, grg, tth, zn
      1. chain b [91660]
      2. chain d [91662]
      3. chain f [91664]
      4. chain h [91666]
      5. chain j [91668]
      6. chain l [91670]
    16. 2bed
      automatically matched to d1ft1b_
      complexed with 736, fpp, zn
      1. region b:23-423 [128376]
    17. 1qbq
      complexed with ace, act, hfp, zn
      1. chain b [18868]
    18. 1n4p
      complexed with cl, grg, tth, zn
      1. chain b [91624]
      2. chain d [91626]
      3. chain f [91628]
      4. chain h [91630]
      5. chain j [91632]
      6. chain l [91634]
    19. 3dpy
      automatically matched to d1ft1b_
      complexed with acy, fpp, zn
      1. region b:22-423 [157826]
    20. 1n4r
      complexed with cl, mes, so4, tth, zn
      1. chain b [91648]
      2. chain d [91650]
      3. chain f [91652]
      4. chain h [91654]
      5. chain j [91656]
      6. chain l [91658]
    21. 1d8e
      complex with k-ras4b peptide substrate and FPP analog
      complexed with ace, fii
      1. chain b [18869]
    22. 1nl4
      complexed with ftl, hfp, zn; mutant
      1. chain b [80618]
    23. 1n95
      complexed with fth, hfp, zn
      1. chain b [80334]
    24. 1ft2
      complexed with fpp, zn
      1. chain b [18871]
    25. 1fpp
      complexed with fpp, po4, zn
      1. chain b [18870]
    26. 1ni1
      complexed with 2c5, hfp, zn
      1. chain b [91889]
    27. 1x81
      complexed with jan, zn
      1. chain b [114954]
    28. 1n9a
      complexed with fti, hfp, zn
      1. chain b [80339]
    29. 1n94
      complexed with hfp, tin, zn
      1. chain b [80332]
  2. Human (Homo sapiens) [TaxId: 9606] [69090] (19)
    SQ P49356
    1. 2h6f
      automatically matched to d1jcqb_
      complexed with acy, far, suc, zn; mutant
      1. region b:521-921 [136186]
    2. 2h6h
      complexed with acy, far, suc, zn; mutant
      1. region b:515-924 [145283]
    3. 1tn6
      complexed with acy, fii, suc, zn; mutant
      1. chain b [112528]
    4. 2iej
      automatically matched to d1jcqb_
      complexed with act, fii, s48, suc, zn
      1. region b:521-921 [137314]
    5. 1s63
      complexed with 778, fpp, suc, zn
      1. chain b [105286]
    6. 1ld8
      complexed with acy, fpp, suc, u49, zn
      1. chain b [73839]
    7. 1mzc
      complexed with bne, fpp, suc, zn
      1. chain b [85240]
    8. 1sa4
      complexed with fpp, jan, suc, zn
      1. chain b [105403]
    9. 1ld7
      complexed with fpp, suc, u66, zn
      1. chain b [73837]
    10. 1jcq
      complexed with 739, acy, fpp, suc, zn; mutant
      1. chain b [66505]
    11. 1tn7
      complexed with acy, fii, zn
      1. chain b [112530]
    12. 1tn8
      complexed with acy, fii, zn; mutant
      1. chain b [112532]
    13. 1tno
      complexed with cl, mes, mgm, zn
      1. chain b [112546]
      2. chain d [112548]
      3. chain f [112550]
      4. chain h [112552]
      5. chain j [112554]
      6. chain l [112556]
    14. 1tny
      complexed with cl, mes, mgm, zn
      1. chain b [112570]
      2. chain d [112572]
      3. chain f [112574]
      4. chain h [112576]
      5. chain j [112578]
      6. chain l [112580]
    15. 1tnu
      complexed with cl, mes, mgm, zn
      1. chain b [112558]
      2. chain d [112560]
      3. chain f [112562]
      4. chain h [112564]
      5. chain j [112566]
      6. chain l [112568]
    16. 1tnb
      complexed with cl, mes, mgm, zn
      1. chain b [112534]
      2. chain d [112536]
      3. chain f [112538]
      4. chain h [112540]
      5. chain j [112542]
      6. chain l [112544]
    17. 1tnz
      complexed with cl, mes, mgm, zn
      1. chain b [112582]
      2. chain d [112584]
      3. chain f [112586]
      4. chain h [112588]
      5. chain j [112590]
      6. chain l [112592]
    18. 2f0y
      automatically matched to d1jcqb_
      complexed with 3mn, fpp, zn
      1. region b:21-421 [132682]
    19. 2h6i
      complexed with ger, suc, zn; mutant
      1. region b:515-924 [145284]
2. Rab geranylgeranyltransferase, beta subunit [48249]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [48250] (9)
    1. 3dss
      automatically matched to d1dceb_
      complexed with ca, zn
      1. region b:7-331 [157841]
    2. 3dst
      automatically matched to d1dceb_
      complexed with ca, grg, zn
      1. region b:7-331 [157842]
    3. 3dsu
      automatically matched to d1dceb_
      complexed with ca, fpp, zn
      1. region b:7-331 [157843]
    4. 3dsv
      automatically matched to d1dceb_
      complexed with ca, ger, zn
      1. region b:7-331 [157844]
    5. 3dsx
      automatically matched to d1dceb_
      complexed with ca, ger, zn
      1. region b:7-331 [157846]
    6. 3dsw
      automatically matched to d1dceb_
      complexed with ca, ger, zn
      1. region b:7-330 [157845]
    7. 1dce
      complexed with zn
      1. chain b [18872]
      2. chain d [18873]
    8. 3c72
      automatically matched to d1dceb_
      complexed with ca, cx1, zn
      1. region b:7-331 [155997]
    9. 1ltx
      complexed with cl, far, zn2; mutant
      1. chain b [84714]
Complement components [48251] (3)
probably related to other families, but has no known enzymatic activity
1. C3D, a C3 fragment and ligand for complement receptor 2 [48252]
  1. Human (Homo sapiens) [TaxId: 9606] [48253] (11)
    1. 1c3d
      complexed with gol; mutant
      1. chain a [18874]
    2. 1ghq
      complexed with nag, zn; mutant
      1. chain a [60521]
    3. 3d5r
      automatically matched to d1ghqa_
      mutant
      1. region a:12-297 [157403]
    4. 3d5r
      automatically matched to d1ghqa_
      mutant
      1. region b:12-297 [157404]
    5. 3d5s
      automatically matched to d1ghqa_
      mutant
      1. region a:12-297 [157407]
    6. 3d5s
      automatically matched to d1ghqa_
      mutant
      1. region b:12-297 [157408]
    7. 2noj
      automatically matched to d1ghqa_
      mutant
      1. region a:1001-1286 [148324]
    8. 2noj
      automatically matched to d1ghqa_
      mutant
      1. region c:1001-1286 [148326]
    9. 2noj
      automatically matched to d1ghqa_
      mutant
      1. region e:1001-1286 [148328]
    10. 2noj
      automatically matched to d1ghqa_
      mutant
      1. region g:1001-1286 [148330]
    11. 1w2s
      automatically matched to d1ghqa_
      1. region a:1-307 [120604]
  2. Rat (Rattus norvegicus) [TaxId: 10116] [48254] (2)
    1. 1qqf
      N-terminally truncated fragment
      1. chain a [18875]
    2. 1qsj
      N-terminally truncated fragment
      mutant
      1. chain a [18876]
      2. chain b [18877]
      3. chain c [18878]
      4. chain d [18879]
2. C4adg fragment of complement factor C4a [81859]
  1. Human (Homo sapiens) [TaxId: 9606] [81860] (1)
    1. 1hzf
      complexed with mse
      1. chain a [76731]