Structural Classification of Proteins
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Fold: DEATH domain

6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: DEATH domain [47985]
    6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

Superfamilies:

  1. DEATH domain [47986] (4)
    link to SUPERFAMILY database - Superfamily
    1. DEATH domain, DD [81312] (9)
      Pfam 00531
      1. p75 low affinity neurotrophin receptor [47988]
        residues 334-418
        1. Rat (Rattus norvegicus) [TaxId: 10116] [47989] (1)
          1. 1ngr picpic
            1. chain a [18422] picpiclink
      2. Fas [47990]
        1. Human (Homo sapiens) [TaxId: 9606] [47991] (1)
          1. 1ddf picpic
            1. chain a [18423] picpiclink
      3. FADD (Mort1) [47992]
        contains two domains of this superfamily: DED and DD, in this order
        1. Human (Homo sapiens) [TaxId: 9606] [47993] (3)
          1. 2gf5 picpicxref
            automatically matched to d1e3ya_
            mutant
            1. region a:89-191 [135075] picpiclink
          2. 1e41 picpic
            mutant
            1. chain a [18424] picpiclink
          3. 1e3y picpic
            mutant
            1. chain a [18426] picpiclink
        2. Mouse (Mus musculus) [TaxId: 10090] [47994] (1)
          1. 1fad picpic
            mutant
            1. chain a [18428] picpiclink
      4. Pelle death domain [48003]
        1. Drosophila melanogaster [TaxId: 7227] [48004] (3)
          1. 1d2z picpicxref
            complexed with Tube death domain
            1. chain a [18437] picpiclink
            2. chain c [18438] picpiclink
          2. 1ik7 picpic
            complexed with mpd, trs
            1. chain a [71241] picpiclink
            2. chain b [71242] picpiclink
          3. 1ygo picpic
            automatically matched to d1d2zc_
            1. region a:1-108 [123146] picpiclink
      5. Tube death domain [48005]
        complexed with Pelle death domain
        1. Drosophila melanogaster [TaxId: 7227] [48006] (1)
          1. 1d2z picpicxref
            1. chain b [18439] picpiclink
            2. chain d [18440] picpiclink
      6. Tumor necrosis factor receptor-1 death domain [74741]
        1. Human (Homo sapiens) [TaxId: 9606] [74742] (1)
          1. 1ich picpic
            mutant
            1. chain a [71182] picpiclink
      7. Interleukin-1 receptor-associated kinase 4, IRAK4 [116951]
        1. Mouse (Mus musculus) [TaxId: 10090] [116952] (1)
          SQ Q8R4K2 1-114
          1. 1wh4 picpic
            Structural genomics target
            1. chain a [114632] picpiclink
      8. Netrin receptor UNC5B [116953]
        1. Mouse (Mus musculus) [TaxId: 10090] [116954] (1)
          SQ Q8K1S3 854-943
          1. 1wmg picpic
            complexed with so3, so4
            1. chain a [114738] picpiclink
            2. chain b [114739] picpiclink
            3. chain c [114740] picpiclink
            4. chain d [114741] picpiclink
            5. chain e [114742] picpiclink
            6. chain f [114743] picpiclink
    2. DEATH effector domain, DED [81388] (2)
      1. FADD (Mort1) [81387]
        contains two domains of this superfamily: DED and DD, in this order
        1. Human (Homo sapiens) [TaxId: 9606] [81386] (3)
          1. 2gf5 picpicxref
            automatically matched to d1a1w__
            mutant
            1. region a:2-83 [135076] picpiclink
          2. 1a1w picpic
            mutant
            1. chain a [18425] picpiclink
          3. 1a1z picpic
            mutant
            1. chain a [18427] picpiclink
      2. PEA-15 (phosphoprotein enriched in astrocytes 15 kDa) [81818]
        DED is followed by an irregular C-terminal tail
        1. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [81819] (1)
          1. 1n3k picpic
            1. chain a [79965] picpiclink
    3. Caspase recruitment domain, CARD [81313] (5)
      1. Raidd CARD domain [47995]
        1. Human (Homo sapiens) [TaxId: 9606] [47996] (1)
          1. 3crd picpic
            1. chain a [18429] picpiclink
      2. Apoptotic protease activating factor 1, APAF-1 [47997]
        1. Human (Homo sapiens) [TaxId: 9606] [47998] (6)
          1. 1cy5 picpic
            complexed with bme, zn
            1. chain a [18430] picpiclink
          2. 2ygs picpic
            1. chain a [18431] picpiclink
          3. 2p1h picpic
            automatically matched to d1cwwa_
            complexed with zn
            1. region a:1-94 [139457] picpiclink
          4. 3ygs picpicxref
            1. chain c [18432] picpiclink
          5. 1c15 picpic
            1. chain a [18433] picpiclink
          6. 1cww picpic
            1. chain a [18434] picpiclink
      3. Procaspase 9 prodomain [47999]
        1. Human (Homo sapiens) [TaxId: 9606] [48000] (1)
          1. 3ygs picpicxref
            1. chain p [18435] picpiclink
      4. Iceberg [48001]
        an inhibitor of interleukin-1beta generation
        1. Human (Homo sapiens) [TaxId: 9606] [48002] (1)
          1. 1dgn picpic
            1. chain a [18436] picpiclink
      5. Cell death protein 4, CED-4 [158663]
        1. Caenorhabditis elegans [TaxId: 6239] [158664] (1)
          SQ P30429 1-108
          1. 2a5y picpicxrefxrefxref
            complexed with atp, mg; mutant
            1. region b:1-108 [144787] picpiclink
    4. Pyrin domain, PYD [101298] (2)
      1. Apoptosis-associated speck-like protein Asc [101299]
        1. Human (Homo sapiens) [TaxId: 9606] [101300] (1)
          1. 1ucp picpic
            1. chain a [99186] picpiclink
      2. NALP1 [101301]
        1. Human (Homo sapiens) [TaxId: 9606] [101302] (1)
          1. 1pn5 picpic
            1. region a:59-151 [94948] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk