Structural Classification of Proteins
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Fold: I/LWEQ domain

5 helices; bundle, closed, left-handed twist

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: I/LWEQ domain [109884]
    5 helices; bundle, closed, left-handed twist

Superfamilies:

  1. I/LWEQ domain [109885] (1)
    link to SUPERFAMILY database - Superfamily
    1. I/LWEQ domain [109886] (2)
      Pfam 01608
      actin-binding motif that adopts different folds; possibly refolds upon binding
      1. Huntingtin interacting protein 12 [109887]
        Hip1r thatch domain core
        1. Human (Homo sapiens) [TaxId: 9606] [109888] (1)
          SQ O75146 773-965
          1. 1r0d picpic
            1. chain a [104715] picpiclink
            2. chain b [104716] picpiclink
            3. chain d [104717] picpiclink
            4. chain e [104718] picpiclink
            5. chain f [104719] picpiclink
            6. chain g [104720] picpiclink
            7. chain h [104721] picpiclink
            8. chain i [104722] picpiclink
      2. Talin 1 [109889]
        4-helical bundle of the Bromodomain-like fold (scop_cf 47363); similar to helices 2-5 of the Huntingtin interacting protein 12
        1. Mouse (Mus musculus) [TaxId: 10090] [109890] (2)
          SQ P26039 486-782
          1. 1sj8 picpicxref
            1. region a:658-782 [105607] picpiclink
          2. 1u89 picpic
            2nd domain; annotated as VBS2 domain; but has a different topology than VBS3 domain (PDB 2b0h)
            1. region a:752-889 [119625] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk