Family: Small Kunitz-type inhibitors & BPTI-like toxins

Lineage:

1. Root: scop
2. Class: Small proteins [56992]
   Usually dominated by metal ligand, heme, and/or disulfide bridges
3. Fold: BPTI-like [57361]
   disulfide-rich alpha+beta fold
4. Superfamily: BPTI-like [57362]
   uperfamily
5. Family: Small Kunitz-type inhibitors & BPTI-like toxins [57363]

Protein Domains:

1. Pancreatic trypsin inhibitor, BPTI [57364]
   1. Cow (Bos taurus) [TaxId: 9913] [57365] (90)
      1. 1g6x
         Ultra high resolution structure; 0.86 Angstrom
         complexed with edo, so4; mutant
         1. chain a [60320]
      2. 1k6u
         a cyclic variant
         complexed with edo, so4
         1. chain a [68233]
      3. 5pti
         complexed with po4, unk
         1. chain a [44467]
      4. 1bpi
         complexed with po4
         1. chain a [44468]
      5. 9pti
         complexed with o o, po4
         1. chain a [44469]
      6. 1qlq
         complexed with so4; mutant
         1. chain a [44470]
      7. 1p2j
         complexed with ca, so4; mutant
         1. chain i [93936]
      8. 2ra3
         automatically matched to d1bpia_
         complexed with ca, so4; mutant
         1. region c:1-56 [151817]
      9. 2ra3
         automatically matched to d1bpia_
         complexed with ca, so4; mutant
         1. region i:1-58 [151818]
      10. 4pti
          1. chain a [44471]
      11. 2r9p
          automatically matched to d1bpia_
          complexed with so4; mutant
          1. region e:1-58 [151798]
      12. 2r9p
          automatically matched to d1bpia_
          complexed with so4; mutant
          1. region f:1-58 [151799]
      13. 2r9p
          automatically matched to d1bpia_
          complexed with so4; mutant
          1. region g:1-58 [151800]
      14. 2r9p
          automatically matched to d1bpia_
          complexed with so4; mutant
          1. region i:1-58 [151801]
      15. 1f7z
          complexed with ca, so4; mutant
          1. chain i [59682]
      16. 1p2k
          complexed with ca, so4; mutant
          1. chain i [93938]
      17. 2fi3
          complexed with ca, edo, na, so4; mutant
          1. region i:1-58 [145168]
      18. 2fi4
          complexed with ca, edo, ias, na, so4; mutant
          1. region i:1-58 [145169]
      19. 1d0d
          complexed with so4
          1. chain b [44475]
      20. 1f5r
          complexed with ca; mutant
          1. chain i [59655]
      21. 6pti
          complexed with po4
          1. chain a [44474]
      22. 1p2i
          complexed with ca, so4; mutant
          1. chain i [93934]
      23. 2ftl
          automatically matched to d1bpi__
          complexed with ca, edo, ias, na, so4
          1. region i:1-58 [134074]
      24. 2ftm
          automatically matched to d8pti__
          complexed with ca, edo, ias, na, so4; mutant
          1. region b:1-58 [134075]
      25. 1yld
          complexed with aba, ca, so4; mutant
          1. region b:1-56 [144701]
      26. 1t8l
          automatically matched to d3btmi_
          complexed with so4; mutant
          1. region b:3-58 [119176]
      27. 1t8o
          automatically matched to d3btwi_
          complexed with so4; mutant
          1. region b:3-58 [119188]
      28. 1t8l
          automatically matched to d3btmi_
          complexed with so4; mutant
          1. region d:3-58 [119178]
      29. 1t8o
          automatically matched to d3btwi_
          complexed with so4; mutant
          1. region d:3-58 [119190]
      30. 1ykt
          automatically matched to d1bpi__
          complexed with ca, so4; mutant
          1. region b:1-56 [123564]
      31. 1aal
          complexed with ips; mutant
          1. chain a [44472]
          2. chain b [44473]
      32. 1ylc
          complexed with aba, ca, so4; mutant
          1. region b:1-56 [144700]
      33. 3tgk
          complexed with ca, so4; mutant
          1. chain i [63339]
      34. 3bth
          complexed with ca, so4; mutant
          1. chain i [44479]
      35. 1nag
          complexed with po4; mutant
          1. chain a [44477]
      36. 1t8n
          automatically matched to d3btti_
          complexed with so4; mutant
          1. region b:3-58 [119184]
      37. 1t8n
          automatically matched to d3btti_
          complexed with so4; mutant
          1. region d:3-58 [119186]
      38. 1p2m
          complexed with so4; mutant
          1. chain b [93941]
          2. chain d [93943]
      39. 3btf
          complexed with ca, so4; mutant
          1. chain i [44482]
      40. 1t8m
          automatically matched to d3bthi_
          complexed with so4; mutant
          1. region b:3-58 [119180]
      41. 1t8m
          automatically matched to d3bthi_
          complexed with so4; mutant
          1. region d:3-58 [119182]
      42. 1fy8
          complexed with ca, so4
          1. chain i [44491]
      43. 1p2n
          complexed with so4; mutant
          1. chain b [93945]
          2. chain d [93947]
      44. 1p2q
          complexed with so4, trs; mutant
          1. chain b [93953]
          2. chain d [93955]
      45. 3btm
          complexed with ca, so4; mutant
          1. chain i [44481]
      46. 1t7c
          automatically matched to d3btei_
          complexed with so4; mutant
          1. region b:3-58 [119163]
      47. 1t7c
          automatically matched to d3btei_
          complexed with so4; mutant
          1. region d:3-58 [119165]
      48. 3btq
          complexed with ca, so4; mutant
          1. chain i [44487]
      49. 3btk
          complexed with ca, so4
          1. chain i [44483]
      50. 1ejm
          complexed with so4; mutant
          1. chain b [59425]
          2. chain d [59427]
          3. chain f [59429]
      51. 7pti
          complexed with po4; mutant
          1. chain a [44476]
      52. 3btd
          complexed with ca, so4; mutant
          1. chain i [44485]
      53. 3btt
          complexed with ca, so4; mutant
          1. chain i [44488]
      54. 3bte
          complexed with ca, so4; mutant
          1. chain i [44489]
      55. 3tgi
          complexed with ca, so4
          1. chain i [44480]
      56. 8pti
          mutant
          1. chain a [44478]
      57. 1tpa
          complexed with ca
          1. chain i [44486]
      58. 3btg
          complexed with ca, so4; mutant
          1. chain i [44492]
      59. 3tpi
          complexed with ca, so4
          1. chain i [44493]
      60. 1fan
          mutant
          1. chain a [44484]
      61. 2ptc
          complexed with ca
          1. chain i [44490]
      62. 2tgp
          complexed with ca, so4
          1. chain i [44494]
      63. 3btw
          complexed with ca, so4; mutant
          1. chain i [44496]
      64. 1p2o
          complexed with so4; mutant
          1. chain b [93949]
          2. chain d [93951]
      65. 1co7
          complexed with ca; mutant
          1. chain i [76136]
      66. 4tpi
          complexed with ca, so4
          1. chain i [44499]
      67. 1bzx
          complexed with ca
          1. chain i [44501]
      68. 2tpi
          complexed with hg
          1. chain i [44497]
      69. 1brb
          1. chain i [44500]
      70. 1bti
          mutant
          1. chain a [44498]
      71. 2hex
          dodecamer observed in the crystals
          complexed with so4
          1. chain a [44502]
          2. chain b [44503]
          3. chain c [44504]
          4. chain d [44505]
          5. chain e [44506]
      72. 1bpt
          complexed with po4; mutant
          1. chain a [44495]
      73. 3tgj
          complexed with ca, so4; mutant
          1. chain i [44507]
      74. 1bth
          mutant
          1. chain p [44508]
          2. chain q [44509]
      75. 2ijo
          automatically matched to d1bpi__
          mutant
          1. region i:1-56 [137480]
      76. 1bz5
          complexed with so4
          1. chain a [44510]
          2. chain b [44511]
          3. chain c [44512]
          4. chain d [44513]
          5. chain e [44514]
      77. 1fak
          1. chain i [44515]
      78. 1cbw
          complexed with so4
          1. chain d [44516]
          2. chain i [44517]
      79. 1b0c
          1. chain a [44518]
          2. chain b [44519]
          3. chain c [44520]
          4. chain d [44521]
          5. chain e [44522]
      80. 1bhc
          dodecamer observed in the crystals
          complexed with scn
          1. chain a [44523]
          2. chain b [44524]
          3. chain c [44525]
          4. chain d [44526]
          5. chain e [44527]
          6. chain f [44528]
          7. chain g [44529]
          8. chain h [44530]
          9. chain i [44531]
          10. chain j [44532]
      81. 2kai
          1. chain i [44533]
      82. 1eaw
          1. chain b [64886]
          2. chain d [64888]
      83. 1mtn
          complexed with so4
          1. chain d [44534]
          2. chain h [44535]
      84. 1uua
          1. chain a [100003]
      85. 1jv9
          mutant
          1. chain a [63306]
      86. 1pit
          1. chain a [44536]
      87. 1oa5
          1. chain 5 [92696]
      88. 1oa6
          1. chain 5 [92697]
      89. 1jv8
          mutant
          1. chain a [63305]
      90. 1uub
          mutant
          1. chain a [100004]
2. Collagen type VI (domain C5 from alpha 3 chain) [57366]
   1. Human (Homo sapiens) [TaxId: 9606] [57367] (6)
      1. 1kth
         complexed with po4
         1. chain a [68863]
      2. 2knt
         complexed with po4
         1. chain a [44537]
      3. 1knt
         complexed with so4
         1. chain a [44538]
      4. 1kun
         1. chain a [44539]
      5. 1ld6
         mutant
         1. chain a [77903]
      6. 1ld5
         mutant
         1. chain a [77902]
3. Tissue factor pathway inhibitor [57368]
   1. Human (Homo sapiens) [TaxId: 9606] [57369] (5)
      1. 1zr0
         first Kunitz domain of TFPI-2 isoform
         complexed with ca
         1. region b:1a-59 [144747]
      2. 1zr0
         automatically matched to 1ZR0 B:1A-59
         complexed with ca
         1. region d:1a-59 [144748]
      3. 1tfx
         second kunitz domain
         complexed with ca
         1. chain c [44540]
         2. chain d [44541]
      4. 1irh
         third kunitz domain
         1. chain a [66288]
      5. 1adz
         second kunitz domain
         mutant
         1. chain a [44542]
4. Alzheimer's amyloid B-protein precursor, APPI [57370]
   1. Human (Homo sapiens) [TaxId: 9606] [57371] (5)
      1. 1aap
         1. chain a [44543]
         2. chain b [44544]
      2. 1taw
         complexed with ca
         1. chain b [44545]
      3. 1ca0
         1. chain d [44546]
         2. chain i [44547]
      4. 1brc
         1. chain i [44548]
      5. 1zjd
         automatically matched to d1aapa_
         mutant
         1. region b:3-56 [125148]
5. Bikunin from inter-alpha-inhibitor complex [57372]
   1. Human (Homo sapiens) [TaxId: 9606] [57373] (1)
      1. 1bik
         complexed with nag, so4
         1. region a:25-78 [44549]
         2. region a:79-134 [44550]
6. alpha-Dendrotoxin [57374]
   1. Green mamba (Dendroaspis angusticeps) [TaxId: 8618] [57375] (1)
      1. 1dtx
         complexed with so4
         1. chain a [44551]
7. Venom basic protease inhibitor IX (VIIIb) [90155]
   1. Banded krait (Bungarus fasciatus) [TaxId: 8613] [90156] (1)
      1. 1jc6
         1. chain a [84152]
8. beta2-bungarotoxin, neurotoxin chain [57376]
   1. Many-banded krait (Bungarus multicinctus) [TaxId: 8616] [57377] (1)
      1. 1bun
         complexed with na
         1. chain b [44552]
9. Trypsin inhibitor [57378]
   1. Sea anemone (Stichodactyla helianthus) [TaxId: 6123] [57379] (1)
      1. 1shp
         1. chain a [44553]
10. Dendrotoxin K [57380]
    1. Black mamba (Dendroaspis polylepis polylepis) [TaxId: 8620] [57381] (1)
       1. 1dtk
          1. chain a [44554]
11. Dendrotoxin I [57382]
    1. African elapid snake (Dendroaspis polylepis polylepis) [TaxId: 8620] [57383] (2)
       1. 1dem
          1. chain a [44556]
       2. 1den
          1. chain a [44555]
12. Calcicludine (cac) [57384]
    1. Green mamba (Dendroaspis angusticeps) [TaxId: 8618] [57385] (1)
       1. 1bf0
          1. chain a [44557]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk