Structural Classification of Proteins
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Fold: Inhibitor of apoptosis (IAP) repeat

metal(zinc)-bound alpha+beta fold

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Inhibitor of apoptosis (IAP) repeat [57923]
    metal(zinc)-bound alpha+beta fold

Superfamilies:

  1. Inhibitor of apoptosis (IAP) repeat [57924] (1)
    link to SUPERFAMILY database - Superfamily
    1. Inhibitor of apoptosis (IAP) repeat [57925] (7)
      1. 2MIHB/C-IAP-1 [57926]
        baculoviral inhibitor of apoptosis
        1. Human (Homo sapiens) [TaxId: 9606] [57927] (4)
          1. 3d9t picpic
            automatically matched to d1qbha_
            complexed with zn
            1. region a:260-346 [157463] picpiclink
          2. 3d9t picpic
            automatically matched to d1qbha_
            complexed with zn
            1. region b:260-346 [157464] picpiclink
          3. 3d9u picpic
            automatically matched to d1qbha_
            complexed with zn
            1. region a:260-345 [157465] picpiclink
          4. 1qbh picpic
            complexed with zn
            1. chain a [45374] picpiclink
      2. BIR domains of XIAP [57928]
        1. Human (Homo sapiens) [TaxId: 9606] [57929] (14)
          SQ P98170 241-356
          1. 2vsl picpic
            automatically matched to d1f9xa_
            complexed with 15p, zn
            1. region a:250-345 [153528] picpiclink
          2. 1g73 picpicxref
            BIR3 domain complexed to smac
            complexed with zn; mutant
            1. chain c [45375] picpiclink
            2. chain d [45376] picpiclink
          3. 1nw9 picpicxref
            BIR3 domain complexed to caspase 9
            complexed with zn
            1. chain a [86293] picpiclink
          4. 2opy picpic
            automatically matched to d1f9xa_
            complexed with co9, zn
            1. region a:249-354 [139215] picpiclink
          5. 1i3o picpicxref
            BIR2 domain complexed to caspase 3
            complexed with zn; mutant
            1. chain e [61605] picpiclink
            2. chain f [61606] picpiclink
          6. 2opz picpic
            automatically matched to d1f9xa_
            complexed with zn
            1. region a:249-356 [139216] picpiclink
          7. 2opz picpic
            automatically matched to d1f9xa_
            complexed with zn
            1. region b:249-356 [139217] picpiclink
          8. 2opz picpic
            automatically matched to d1f9xa_
            complexed with zn
            1. region c:249-356 [139218] picpiclink
          9. 2opz picpic
            automatically matched to d1f9xa_
            complexed with zn
            1. region d:249-356 [139219] picpiclink
          10. 1tfq picpic
            complexed with 998, zn
            1. chain a [106858] picpiclink
          11. 1c9q picpic
            BIR2 domain
            complexed with zn; mutant
            1. chain a [45377] picpiclink
          12. 1g3f picpic
            BIR3 domain complexed to a 9 residue peptide from smac/diablo
            complexed with zn
            1. chain a [45378] picpiclink
          13. 1f9x picpic
            BIR3 domain
            complexed with zn
            1. chain a [59748] picpiclink
          14. 1tft picpic
            automatically matched to d1f9xa_
            complexed with 997, zn
            1. region a:240-356 [119235] picpiclink
      3. BIR domains of DIAP1 [69974]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [69975] (6)
          1. 1se0 picpic
            BIR1 complexed with a grim peptide
            complexed with zn
            1. chain a [98814] picpiclink
          2. 1jd5 picpic
            BIR2 complexed with grim peptide
            complexed with zn
            1. chain a [66544] picpiclink
          3. 1sdz picpic
            BIR1 complexed with a reaper peptide
            complexed with zn
            1. chain a [98813] picpiclink
          4. 1q4q picpic
            BIR2 complexed with dronc peptide
            complexed with zn
            1. chain a [95813] picpiclink
            2. chain b [95814] picpiclink
            3. chain c [95815] picpiclink
            4. chain d [95816] picpiclink
            5. chain e [95817] picpiclink
            6. chain f [95818] picpiclink
            7. chain g [95819] picpiclink
            8. chain h [95820] picpiclink
            9. chain i [95821] picpiclink
            10. chain j [95822] picpiclink
          5. 1jd6 picpic
            BIR2 complexed with hid peptide
            complexed with zn
            1. chain a [66545] picpiclink
          6. 1jd4 picpic
            complexed with zn
            1. chain a [66542] picpiclink
            2. chain b [66543] picpiclink
      4. Anti-apoptotic protein survivin [57930]
        contains a long alpha-helix after the common fold
        1. Human (Homo sapiens) [TaxId: 9606] [57931] (7)
          1. 2qfa picpic
            automatically matched to d1e31b_
            complexed with mes, zn
            1. region a:5-141 [150733] picpiclink
          2. 2raw picpic
            automatically matched to d1e31b_
            complexed with zn
            1. region a:5-141 [151834] picpiclink
          3. 1e31 picpic
            complexed with co, zn
            1. chain a [45379] picpiclink
            2. chain b [45380] picpiclink
          4. 1f3h picpic
            complexed with so4, zn2; mutant
            1. chain a [45381] picpiclink
            2. chain b [45382] picpiclink
          5. 2rax picpic
            automatically matched to d1xoxa1
            complexed with zn
            1. region a:7-117 [151835] picpiclink
          6. 2rax picpic
            automatically matched to d1xoxa1
            complexed with zn
            1. region e:7-117 [151836] picpiclink
          7. 2rax picpic
            automatically matched to d1xoxa1
            complexed with zn
            1. region x:7-117 [151837] picpiclink
        2. Mouse (Mus musculus) [TaxId: 10090] [82925] (3)
          1. 1m4m picpic
            complexed with zn
            1. chain a [78605] picpiclink
          2. 1xox picpic
            automatically matched to d1m4ma_
            complexed with zn
            1. region a:7-117 [122208] picpiclink
          3. 1xox picpic
            automatically matched to d1m4ma_
            complexed with zn
            1. region b:7-117 [122209] picpiclink
      5. BIR-containing protein 7 (ML-IAP, livin) [103630]
        1. Human (Homo sapiens) [TaxId: 9606] [103631] (8)
          SQ Q96CA5 78-159
          1. 2i3h picpic
            automatically matched to d1tw6b_
            complexed with btb, edo, li, zn; mutant
            1. region a:78-167 [137023] picpiclink
          2. 2i3h picpic
            automatically matched to d1tw6b_
            complexed with btb, edo, li, zn; mutant
            1. region b:78-167 [137024] picpiclink
          3. 1tw6 picpic
            BIR2; alternative splicing
            complexed with btb, edo, li, zn; mutant
            1. chain a [112694] picpiclink
            2. chain b [112695] picpiclink
          4. 1oxn picpic
            complexed with a peptide antagonist, chain F
            complexed with p33, zn
            1. chain a [93704] picpiclink
            2. chain b [93705] picpiclink
            3. chain c [93706] picpiclink
            4. chain d [93707] picpiclink
            5. chain e [93708] picpiclink
          5. 2i3i picpic
            automatically matched to d1tw6b_
            complexed with 618, btb, edo, li, zn; mutant
            1. region a:78-167 [137025] picpiclink
          6. 2i3i picpic
            automatically matched to d1tw6b_
            complexed with 618, btb, edo, li, zn; mutant
            1. region b:78-167 [137026] picpiclink
          7. 1oxq picpic
            complexed with a peptide antagonist, chain F
            complexed with p33, zn
            1. chain a [93709] picpiclink
            2. chain b [93710] picpiclink
            3. chain c [93711] picpiclink
            4. chain d [93712] picpiclink
            5. chain e [93713] picpiclink
          8. 1oy7 picpic
            complexed with a peptide antagonist, chain F
            complexed with p33, zn
            1. chain a [93721] picpiclink
            2. chain b [93722] picpiclink
            3. chain c [93723] picpiclink
            4. chain d [93724] picpiclink
            5. chain e [93725] picpiclink
      6. BIR-containing protein 8 [118349]
        1. Human (Homo sapiens) [TaxId: 9606] [118350] (2)
          SQ Q96P09 1-84
          1. 1xb0 picpic
            first BIR domain; complexed with a diablo homolog peptide, chains G, H, I, J, K, L
            complexed with zn
            1. chain a [115042] picpiclink
            2. chain b [115043] picpiclink
            3. chain c [115044] picpiclink
            4. chain d [115045] picpiclink
            5. chain e [115046] picpiclink
            6. chain f [115047] picpiclink
          2. 1xb1 picpic
            first BIR domain; complexed with a diablo homolog peptide, chains G, H, I, J, K, L
            complexed with zn
            1. chain a [115048] picpiclink
            2. chain b [115049] picpiclink
            3. chain c [115050] picpiclink
            4. chain d [115051] picpiclink
            5. chain e [115052] picpiclink
            6. chain f [115053] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk