Structural Classification of Proteins
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Fold: FYVE/PHD zinc finger

dimetal(zinc)-bound alpha+beta fold

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: FYVE/PHD zinc finger [57902]
    dimetal(zinc)-bound alpha+beta fold

Superfamilies:

  1. FYVE/PHD zinc finger [57903] (3)
    link to SUPERFAMILY database - Superfamily
    1. FYVE, a phosphatidylinositol-3-phosphate binding domain [57904] (6)
      1. vps27p protein [57905]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [57906] (1)
          1. 1vfy picpic
            complexed with zn; mutant
            1. chain a [45357] picpiclink
      2. Eea1 [64583]
        1. Human (Homo sapiens) [TaxId: 9606] [64584] (3)
          1. 1joc picpicxref
            complexed with itp, zn
            1. region a:1348-1411 [66990] picpiclink
            2. region b:1348-1411 [66992] picpiclink
          2. 1hyi picpic
            complexed with inositol 1,3-bisphosphate
            complexed with itp, zn
            1. chain a [61406] picpiclink
          3. 1hyj picpic
            complexed with zn
            1. chain a [61407] picpiclink
      3. Hrs [57907]
        protein involved in membrane trafficking and signal transduction
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [57908] (1)
          1. 1dvp picpicxref
            complexed with cit, zn
            1. region a:149-220 [45358] picpiclink
      4. Effector domain of rabphilin-3a [57909]
        contains additional N-terminal long alpha-helix
        1. Rat (Rattus norvegicus) [TaxId: 10116] [57910] (1)
          1. 1zbd picpicxref
            complexed with gtp, mg, zn; mutant
            1. chain b [45359] picpiclink
      5. Zinc finger FYVE domain containing protein 19 [118324]
        1. Mouse (Mus musculus) [TaxId: 10090] [118325] (1)
          SQ Q9DAZ9 1-75
          1. 1wfk picpic
            Structural genomics target
            complexed with zn
            1. chain a [114585] picpiclink
      6. Rififylin (FYVE-RING finger protein Sakura) [118326]
        1. Human (Homo sapiens) [TaxId: 9606] [118327] (1)
          SQ Q8WZ73 45-139
          1. 1y02 picpicxref
            complexed with zn
            1. region a:20-70 [116279] picpiclink
    2. PHD domain [57911] (14)
      1. Williams-Beuren syndrome transcription factor, WSTF [57912]
        1. Human (Homo sapiens) [TaxId: 9606] [57913] (1)
          1. 1f62 picpic
            complexed with zn
            1. chain a [45360] picpiclink
      2. Nuclear corepressor KAP-1 (TIF-1beta) [57914]
        1. Human (Homo sapiens) [TaxId: 9606] [57915] (1)
          1. 1fp0 picpic
            complexed with zn
            1. region a:19-88 [45361] picpiclink
      3. Mi2-beta (CHD4) [90226]
        chromodomain-helicase-DNA-binding protein 4
        1. Human (Homo sapiens) [TaxId: 9606] [90227] (2)
          1. 1mm3 picpic
            second PHD domain with the C-terminal loop replaced by the corresponding loop from WSTF
            complexed with zn
            1. chain a [85016] picpiclink
          2. 1mm2 picpic
            second PHD domain
            complexed with zn
            1. chain a [85015] picpiclink
      4. PHD finger protein At5g26210 [118328]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [118329] (1)
          SQ O81488 201-251
          1. 1we9 picpic
            Structural genomics target
            complexed with zn
            1. chain a [114549] picpiclink
      5. PHD finger protein At1g33420 [118330]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [118331] (1)
          SQ Q9C810 595-653
          1. 1wee picpic
            Structural genomics target
            complexed with zn
            1. chain a [114550] picpiclink
      6. Death associated transcription factor 1, Datf1 (DIO-1) [118332]
        1. Mouse (Mus musculus) [TaxId: 10090] [118333] (1)
          SQ Q8C9B9 257-319
          1. 1wem picpic
            Structural genomics target
            complexed with zn
            1. chain a [114559] picpiclink
      7. Inhibitor of growth protein 4, Ing4 [118334]
        1. Mouse (Mus musculus) [TaxId: 10090] [118335] (2)
          SQ Q8C0D7 188-245
          1. 1wen picpic
            Structural genomics target
            complexed with zn
            1. chain a [114560] picpiclink
          2. 1weu picpic
            Structural genomics target; the extra N-terminal region (168-187) is unstructured
            complexed with zn
            1. chain a [114565] picpiclink
        2. Homo sapiens [TaxId: 9606] [161223] (5)
          1. 2pnx picpic
            automatically matched to d1wena_
            complexed with m3l, zn
            1. region a:195-245 [149708] picpiclink
          2. 2vnf picpic
            automatically matched to d1wena_
            complexed with dtt, dtu, m3l, na, zn
            1. region a:195-244 [153333] picpiclink
          3. 2vnf picpic
            automatically matched to d1wena_
            complexed with dtt, dtu, m3l, na, zn
            1. region c:191-244 [153334] picpiclink
          4. 2pnx picpic
            automatically matched to d1wena_
            complexed with m3l, zn
            1. region c:195-244 [149709] picpiclink
          5. 2k1j picpic
            automatically matched to d1wena_
            complexed with zn
            1. region a:188-245 [148257] picpiclink
      8. PHD finger protein 8 [118336]
        1. Mouse (Mus musculus) [TaxId: 10090] [118337] (1)
          SQ Q80TJ7 1-66
          1. 1wep picpic
            Structural genomics target
            complexed with zn
            1. chain a [114562] picpiclink
      9. PHD finger protein 7 (NYD-SP6) [118338]
        1. Mouse (Mus musculus) [TaxId: 10090] [118339] (1)
          SQ Q9DAG9 232-304
          1. 1weq picpic
            Structural genomics target
            complexed with zn
            1. chain a [114563] picpiclink
      10. PHD Inhibitor of growth protein 2, Ing2 [118340]
        1. Mouse (Mus musculus) [TaxId: 10090] [118341] (1)
          SQ Q9ESK4 205-262
          1. 1wes picpic
            Structural genomics target
            complexed with zn
            1. chain a [114564] picpiclink
      11. PHD finger protein 22 [118342]
        1. Mouse (Mus musculus) [TaxId: 10090] [118343] (1)
          SQ Q9D168 150-224
          1. 1wev picpic
            Structural genomics target
            complexed with zn
            1. chain a [114566] picpiclink
      12. Sumoylation ligase E3, SIZ1 [118344]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [118345] (1)
          SQ Q680Q4 104-168
          1. 1wew picpic
            Structural genomics target
            complexed with zn
            1. chain a [114567] picpiclink
      13. V(D)J recombination-activating protein 2, Rag2 [161224]
        1. Mouse (Mus musculus) [TaxId: 10090] [161225] (14)
          SQ P21784 414-487
          1. 2v89 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, zn
            1. region a:1414-1487 [152778] picpiclink
          2. 2v89 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, zn
            1. region b:414-487 [152779] picpiclink
          3. 2v86 picpic
            automatically matched to 2JWO A:414-487
            complexed with da2, m3l, zn
            1. region a:414-487 [152772] picpiclink
          4. 2v86 picpic
            automatically matched to 2JWO A:414-487
            complexed with da2, m3l, zn
            1. region b:414-487 [152773] picpiclink
          5. 2v87 picpic
            automatically matched to 2JWO A:414-487
            complexed with 2mr, m3l, zn
            1. region a:414-487 [152774] picpiclink
          6. 2v87 picpic
            automatically matched to 2JWO A:414-487
            complexed with 2mr, m3l, zn
            1. region b:414-487 [152775] picpiclink
          7. 2v85 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, nmm, zn
            1. region a:414-487 [152770] picpiclink
          8. 2v85 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, nmm, zn
            1. region b:414-487 [152771] picpiclink
          9. 2v88 picpic
            automatically matched to 2JWO A:414-487
            complexed with 2mr, mly, zn
            1. region a:414-487 [152776] picpiclink
          10. 2v88 picpic
            automatically matched to 2JWO A:414-487
            complexed with 2mr, mly, zn
            1. region b:414-487 [152777] picpiclink
          11. 2v83 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, zn
            1. region a:414-485 [152767] picpiclink
          12. 2v83 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, zn
            1. region b:414-487 [152768] picpiclink
          13. 2v83 picpic
            automatically matched to 2JWO A:414-487
            complexed with m3l, zn
            1. region c:414-483 [152769] picpiclink
          14. 2jwo picpic
            complexed with zn
            1. region a:414-487 [148229] picpiclink
    3. variant PHD-like domain [118346] (1)
      1. Hypothetical protein KIAA1045 [118347]
        1. Human (Homo sapiens) [TaxId: 9606] [118348] (1)
          SQ Q9UPV7 123-198
          1. 1wil picpic
            Structural genomics target
            complexed with zn
            1. chain a [114676] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk