Structural Classification of Proteins
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Family: Extracellular domain of cell surface receptors

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Snake toxin-like [57301]
    disulfide-rich fold: nearly all-beta
  4. Superfamily: Snake toxin-like [57302]
    link to SUPERFAMILY database - Superfamily
  5. Family: Extracellular domain of cell surface receptors [57354]

Protein Domains:

  1. CD59 [57355]
    1. Human (Homo sapiens) [TaxId: 9606] [57356] (10)
      1. 2j8b picpic
        automatically matched to d1cdqa_
        1. region a:1-77 [147908] picpiclink
      2. 2uwr picpic
        automatically matched to d1cdqa_
        1. region a:1-77 [152220] picpiclink
      3. 2ux2 picpic
        automatically matched to d1cdqa_
        1. region a:1-77 [152249] picpiclink
      4. 2ux2 picpic
        automatically matched to d1cdqa_
        1. region b:1-77 [152250] picpiclink
      5. 2ux2 picpic
        automatically matched to d1cdqa_
        1. region c:1-77 [152251] picpiclink
      6. 1erh picpic
        CA-atoms only
        1. chain a [44458] picpiclink
      7. 1cds picpic
        complexed with nag
        1. chain a [44461] picpiclink
      8. 1cdq picpic
        1. chain a [44459] picpiclink
      9. 1cdr picpic
        complexed with fuc, nag
        1. chain a [44460] picpiclink
      10. 1erg picpic
        1. chain a [44462] picpiclink
  2. Type II activin receptor [57357]
    1. Mouse (Mus musculus) [TaxId: 10090] [57358] (4)
      1. 1bte picpic
        complexed with nag
        1. chain a [44463] picpiclink
        2. chain b [44464] picpiclink
      2. 2goo picpicxrefxrefxrefxref
        automatically matched to d1btea_
        complexed with ndg
        1. region c:8-99 [135443] picpiclink
      3. 2goo picpicxrefxrefxrefxref
        automatically matched to d1btea_
        complexed with ndg
        1. region f:8-99 [135446] picpiclink
      4. 1lx5 picpicxref
        complexed with BMP7
        complexed with man, nag
        1. chain b [84733] picpiclink
    2. Rat (Rattus norvegicus) [TaxId: 10116] [90154] (2)
      1. 1nys picpicxref
        complexed with activin A
        1. chain a [86413] picpiclink
        2. chain c [86415] picpiclink
      2. 1nyu picpicxref
        complexed with activin A
        1. chain a [86425] picpiclink
        2. chain c [86427] picpiclink
    3. Mouse (Mus musculus), isoform IIB [TaxId: 10090] [111406] (3)
      SQ P27040 23-120; 100% sequence identity to the rat domain of the same type IIb (scop_sp 90154)
      1. 2h62 picpicxrefxrefxref
        automatically matched to d1s4yc_
        1. region d:8-98 [136180] picpiclink
      2. 2h64 picpicxrefxref
        automatically matched to d1s4yc_
        mutant
        1. region c:8-99 [136182] picpiclink
      3. 1s4y picpicxref
        Structural genomics target
        1. chain a [105256] picpiclink
        2. chain c [105258] picpiclink
  3. BMP receptor Ia ectodomain [57359]
    1. Human (Homo sapiens) [TaxId: 9606] [57360] (6)
      1. 2h62 picpicxrefxrefxref
        automatically matched to d1es7d_
        1. region c:34-117 [136179] picpiclink
      2. 2h64 picpicxrefxref
        automatically matched to d1es7d_
        mutant
        1. region b:34-118 [136181] picpiclink
      3. 1rew picpicxref
        1. chain c [97336] picpiclink
        2. chain d [97337] picpiclink
      4. 2goo picpicxrefxrefxrefxref
        automatically matched to d1es7d_
        complexed with ndg
        1. region b:34-118 [135442] picpiclink
      5. 2goo picpicxrefxrefxrefxref
        automatically matched to d1es7d_
        complexed with ndg
        1. region e:34-118 [135445] picpiclink
      6. 1es7 picpicxref
        1. chain b [44465] picpiclink
        2. chain d [44466] picpiclink
  4. TGF-beta type II receptor extracellular domain [69951]
    elaborated with additional structures resulting in a beta-sandwich fold
    1. Human (Homo sapiens) [TaxId: 9606] [69952] (4)
      1. 1m9z picpic
        complexed with cry; mutant
        1. chain a [78881] picpiclink
      2. 1ktz picpicxref
        complex with tgf-beta3
        1. chain b [68868] picpiclink
      3. 2pjy picpicxref
        automatically matched to d1ploa_
        mutant
        1. region b:19-126 [149584] picpiclink
      4. 1plo picpic
        mutant
        1. chain a [94886] picpiclink
    2. Chicken (Gallus gallus) [TaxId: 9031] [82900] (1)
      1. 1ks6 picpic
        1. chain a [77517] picpiclink
  5. Urokinase plasminogen activator surface receptor uPAR [161128]
    duplication: tandem repeat of three similar domains; the N-terminal and C-terminal domains belong to Pfam 00021; uPAR/Ly6
    1. Human (Homo sapiens) [TaxId: 9606] [161129] (12)
      SQ Q03405 109-209! SQ Q03405 210-299! SQ Q03405 23-108
      1. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        complexed with bma, nag, so4; mutant
        1. region e:188-277 [145508] picpiclink
      2. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        complexed with bma, nag, so4; mutant
        1. region e:1-86 [145509] picpiclink
      3. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        complexed with bma, nag, so4; mutant
        1. region e:87-187 [145510] picpiclink
      4. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:188-277
        complexed with bma, nag, so4; mutant
        1. region f:188-277 [145511] picpiclink
      5. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:1-86
        complexed with bma, nag, so4; mutant
        1. region f:1-86 [145512] picpiclink
      6. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:87-187
        complexed with bma, nag, so4; mutant
        1. region f:87-187 [145513] picpiclink
      7. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:188-277
        complexed with bma, nag, so4; mutant
        1. region g:188-277 [145514] picpiclink
      8. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:1-86
        complexed with bma, nag, so4; mutant
        1. region g:1-82 [145515] picpiclink
      9. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:87-187
        complexed with bma, nag, so4; mutant
        1. region g:94-187 [145516] picpiclink
      10. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:188-277
        complexed with bma, nag, so4; mutant
        1. region h:188-277 [145517] picpiclink
      11. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:1-86
        complexed with bma, nag, so4; mutant
        1. region h:1-82 [145518] picpiclink
      12. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2I9B E:87-187
        complexed with bma, nag, so4; mutant
        1. region h:94-187 [145519] picpiclink
  6. Urokinase plasminogen activator surface receptor, UPAR [161130]
    duplication; comprises three domains of this fold
    1. Human (Homo sapiens) [TaxId: 9606] [161131] (33)
      SQ Q03405 111-210! SQ Q03405 114-210! SQ Q03405 211-297! SQ Q03405 211-301! SQ Q03405 23-102! SQ Q03405 23-104
      1. 2fd6 picpicxrefxrefxrefxrefxrefxref
        complexed with edo, etx, fuc, nag, pg4, pge, so4
        1. region u:1-80 [145159] picpiclink
      2. 2fd6 picpicxrefxrefxrefxrefxrefxref
        complexed with edo, etx, fuc, nag, pg4, pge, so4
        1. region u:189-275 [145160] picpiclink
      3. 2fd6 picpicxrefxrefxrefxrefxrefxref
        complexed with edo, etx, fuc, nag, pg4, pge, so4
        1. region u:92-188 [145161] picpiclink
      4. 3bt2 picpicxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2FD6 U:1-80
        complexed with nag
        1. region u:1-80 [155547] picpiclink
      5. 3bt2 picpicxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2FD6 U:189-275
        complexed with nag
        1. region u:189-275 [155548] picpiclink
      6. 3bt2 picpicxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2FD6 U:92-188
        complexed with nag
        1. region u:92-188 [155549] picpiclink
      7. 1ywh picpic
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region a:89-188 [145925] picpiclink
      8. 1ywh picpic
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region a:1-82 [145926] picpiclink
      9. 1ywh picpic
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region a:189-279 [145927] picpiclink
      10. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region c:91-188 [145928] picpiclink
      11. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region c:1-80 [145929] picpiclink
      12. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region c:189-275 [145930] picpiclink
      13. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region e:89-188 [145931] picpiclink
      14. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region e:1-79 [145932] picpiclink
      15. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region e:189-278 [145933] picpiclink
      16. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region g:92-188 [145934] picpiclink
      17. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region g:1-79 [145935] picpiclink
      18. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region g:189-276 [145936] picpiclink
      19. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region i:92-188 [145937] picpiclink
      20. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region i:1-82 [145938] picpiclink
      21. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region i:189-275 [145939] picpiclink
      22. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region k:90-188 [145940] picpiclink
      23. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region k:1-78 [145941] picpiclink
      24. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region k:189-276 [145942] picpiclink
      25. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region m:89-188 [145943] picpiclink
      26. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region m:1-81 [145944] picpiclink
      27. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region m:189-277 [145945] picpiclink
      28. 1ywh picpic
        automatically matched to 1YWH A:89-188
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region o:92-188 [145946] picpiclink
      29. 1ywh picpic
        automatically matched to 1YWH A:1-82
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region o:1-81 [145947] picpiclink
      30. 1ywh picpic
        automatically matched to 1YWH A:189-279
        complexed with alc, bma, fuc, man, nag, ndg, so4
        1. region o:189-276 [145948] picpiclink
      31. 3bt1 picpicxrefxrefxref
        automatically matched to 2FD6 U:1-80
        complexed with man, nag
        1. region u:1-80 [155537] picpiclink
      32. 3bt1 picpicxrefxrefxref
        automatically matched to 2FD6 U:189-275
        complexed with man, nag
        1. region u:189-275 [155538] picpiclink
      33. 3bt1 picpicxrefxrefxref
        automatically matched to 2FD6 U:92-188
        complexed with man, nag
        1. region u:92-188 [155539] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk