Structural Classification of Proteins

Superfamily: Snake toxin-like

: uperfamily

Lineage:

Root: scop
Class: Small proteins [56992]
Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold: Snake toxin-like [57301]
disulfide-rich fold: nearly all-beta
Superfamily: Snake toxin-like [57302]
uperfamily

Families:

Snake venom toxins [57303] (36)
1. Erabutoxin B (also neurotoxin B) [57304]
  1. Sea snake (Laticauda semifasciata) [TaxId: 8631] [57305] (7)
2. gamma-Cardiotoxin [57306]
  1. Snake (Naja nigricollis) [TaxId: 8654] [57307] (3)
3. Fasciculin [57308]
  different isoforms
  1. Green mamba (Dendroaspis angusticeps) [TaxId: 8618] [57309] (8)
4. Muscarinic toxin [90152]
  acetylcholine receptor binding protein
  1. Green mamba (Dendroaspis angusticeps) [TaxId: 8618] [90153] (1)
5. Erabutoxin A [57310]
  1. Broad-banded blue sea snake (Laticauda semifasciata) [TaxId: 8631] [57311] (3)
6. Neurotoxin I [57312]
  1. Snake (Naja naja oxiana) [TaxId: 8657] [57313] (2)
    SQ P01382
7. Cardiotoxin V4II (Toxin III) [57314]
  1. Naja mossambica mossambica [TaxId: 196380] [57315] (1)
8. Cardiotoxin V [57316]
  1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57317] (2)
9. alpha-Cobratoxin [57318]
  1. Cobra (Naja siamensis) [TaxId: 84476] [57319] (7)
  2. Monocled cobra (Naja naja kaouthia) [TaxId: 8649] [82899] (2)
    identical sequence to the Naja naja siamensis toxin
10. Long neurotoxin 1 (component LSIII) [57320]
  1. Sea snake (Laticauda semifasciata) [TaxId: 8631] [57321] (1)
11. FS2 toxin [57322]
  1. Black mamba (Dendroaspis polylepis polylepis) [TaxId: 8620] [57323] (1)
12. Bungarotoxin [57324]
  1. Many-banded krait (Bungarus multicinctus), Alpha-bungarotoxin [TaxId: 8616] [57325] (22)
  2. Many-banded krait (Bungarus multicinctus), kappa-bungarotoxin [TaxId: 8616] [57326] (1)
  3. Many-banded krait (Bungarus multicinctus), neuronal bungarotoxin [TaxId: 8616] [57327] (1)
  4. Many-banded krait (Bungarus multicinctus), gamma-bungarotoxin [TaxId: 8616] [111403] (1)
    SQ Q9YGJ0 22-89
13. Bucandin [57328]
  1. Malayan krait (Bungarus candidus) [TaxId: 92438] [57329] (2)
14. Cardiotoxin CTXI [57330]
  1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57331] (1)
15. Cardiotoxin CTX IIB [57332]
  1. Naja mossambica mossambica [TaxId: 196380] [57333] (1)
16. Cardiotoxin II [57334]
  1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57335] (3)
  2. Central asian cobra (Naja naja oxiana) [TaxId: 8657] [57336] (3)
17. Cardiotoxin III [57337]
  1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57338] (7)
    SQ P60301 22-81
18. Cardiotoxin IV [57339]
  1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57340] (2)
19. Cobrotoxin II (ct2) [57341]
  1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57342] (3)
    SQ P60770 22-83
  2. Monocled cobra (Naja kaouthia) [TaxId: 8649] [57343] (1)
20. alpha-Toxin [57344]
  1. Spitting cobra (Naja nigricollis) [TaxId: 8654] [57345] (2)
  2. Black mamba (Dendroaspis polylepis polylepis) [TaxId: 8620] [57346] (1)
21. Neurotoxin II (Nt2, cobrotoxin B) [57347]
  1. Central asian cobra (Naja naja oxiana) [TaxId: 8657] [57348] (1)
  2. Monocled cobra (Naja kaouthia) [TaxId: 8649] [64550] (1)
  3. Chinese cobra (Naja atra) [TaxId: 8656] [103569] (2)
    SQ P80958 22-82
22. Toxin B (long neurotoxin) [57349]
  1. King cobra (Ophiophagus hannah) [TaxId: 8665] [57350] (2)
23. Candoxin [69949]
  1. Malayan krait (Bungarus candidus) [TaxId: 92438] [69950] (1)
24. Bucain [111404]
  1. Malaysian krait (Bungarus candidus) [TaxId: 92438] [111405] (3)
    SQ P83346
25. Irditoxin subunit A [144103]
  1. Brown tree snake (Boiga irregularis) [TaxId: 92519] [144104] (1)
    SQ A0S864 35-109
26. Irditoxin subunit B [144105]
  1. Brown tree snake (Boiga irregularis) [TaxId: 92519] [144106] (1)
    SQ A0S865 35-111
27. Denmotoxin [144107]
  1. Mangrove snake (Boiga dendrophila) [TaxId: 46286] [144108] (2)
    SQ Q06ZW0 33-111
Dendroaspin [57351] (1)
1. Dendroaspin [57352]
  lacks neurotoxicity; acts as the disintegrins: contains RGD-motif
  1. Dendroaspis jamesoni kaimosae [TaxId: 8619] [57353] (1)
Extracellular domain of cell surface receptors [57354] (9)
1. CD59 [57355]
  1. Human (Homo sapiens) [TaxId: 9606] [57356] (10)
2. Type II activin receptor [57357]
  1. Mouse (Mus musculus) [TaxId: 10090] [57358] (4)
  2. Rat (Rattus norvegicus) [TaxId: 10116] [90154] (2)
  3. Mouse (Mus musculus), isoform IIB [TaxId: 10090] [111406] (3)
    SQ P27040 23-120; 100% sequence identity to the rat domain of the same type IIb (scop_sp 90154)
3. BMP receptor Ia ectodomain [57359]
  1. Human (Homo sapiens) [TaxId: 9606] [57360] (6)
4. TGF-beta type II receptor extracellular domain [69951]
  elaborated with additional structures resulting in a beta-sandwich fold
  1. Human (Homo sapiens) [TaxId: 9606] [69952] (4)
  2. Chicken (Gallus gallus) [TaxId: 9031] [82900] (1)
5. Urokinase plasminogen activator surface receptor uPAR [161128]
  duplication: tandem repeat of three similar domains; the N-terminal and C-terminal domains belong to Pfam 00021; uPAR/Ly6
  1. Human (Homo sapiens) [TaxId: 9606] [161129] (12)
    SQ Q03405 109-209! SQ Q03405 210-299! SQ Q03405 23-108
6. Urokinase plasminogen activator surface receptor, UPAR [161130]
  duplication; comprises three domains of this fold
  1. Human (Homo sapiens) [TaxId: 9606] [161131] (33)
    SQ Q03405 111-210! SQ Q03405 114-210! SQ Q03405 211-297! SQ Q03405 211-301! SQ Q03405 23-102! SQ Q03405 23-104