Structural Classification of Proteins

Fold: Snake toxin-like

: disulfide-rich fold: nearly all-beta

Lineage:

Root: scop
Class: Small proteins [56992]
Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold: Snake toxin-like [57301]
disulfide-rich fold: nearly all-beta

Superfamilies:

Snake toxin-like [57302] (3)
uperfamily
1. Snake venom toxins [57303] (36)
  1. Erabutoxin B (also neurotoxin B) [57304]
    1. Sea snake (Laticauda semifasciata) [TaxId: 8631] [57305] (7)
  2. gamma-Cardiotoxin [57306]
    1. Snake (Naja nigricollis) [TaxId: 8654] [57307] (3)
  3. Fasciculin [57308]
    different isoforms
    1. Green mamba (Dendroaspis angusticeps) [TaxId: 8618] [57309] (8)
  4. Muscarinic toxin [90152]
    acetylcholine receptor binding protein
    1. Green mamba (Dendroaspis angusticeps) [TaxId: 8618] [90153] (1)
  5. Erabutoxin A [57310]
    1. Broad-banded blue sea snake (Laticauda semifasciata) [TaxId: 8631] [57311] (3)
  6. Neurotoxin I [57312]
    1. Snake (Naja naja oxiana) [TaxId: 8657] [57313] (2)
      SQ P01382
  7. Cardiotoxin V4II (Toxin III) [57314]
    1. Naja mossambica mossambica [TaxId: 196380] [57315] (1)
  8. Cardiotoxin V [57316]
    1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57317] (2)
  9. alpha-Cobratoxin [57318]
    1. Cobra (Naja siamensis) [TaxId: 84476] [57319] (7)
    2. Monocled cobra (Naja naja kaouthia) [TaxId: 8649] [82899] (2)
      identical sequence to the Naja naja siamensis toxin
  10. Long neurotoxin 1 (component LSIII) [57320]
    1. Sea snake (Laticauda semifasciata) [TaxId: 8631] [57321] (1)
  11. FS2 toxin [57322]
    1. Black mamba (Dendroaspis polylepis polylepis) [TaxId: 8620] [57323] (1)
  12. Bungarotoxin [57324]
    1. Many-banded krait (Bungarus multicinctus), Alpha-bungarotoxin [TaxId: 8616] [57325] (22)
    2. Many-banded krait (Bungarus multicinctus), kappa-bungarotoxin [TaxId: 8616] [57326] (1)
    3. Many-banded krait (Bungarus multicinctus), neuronal bungarotoxin [TaxId: 8616] [57327] (1)
    4. Many-banded krait (Bungarus multicinctus), gamma-bungarotoxin [TaxId: 8616] [111403] (1)
      SQ Q9YGJ0 22-89
  13. Bucandin [57328]
    1. Malayan krait (Bungarus candidus) [TaxId: 92438] [57329] (2)
  14. Cardiotoxin CTXI [57330]
    1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57331] (1)
  15. Cardiotoxin CTX IIB [57332]
    1. Naja mossambica mossambica [TaxId: 196380] [57333] (1)
  16. Cardiotoxin II [57334]
    1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57335] (3)
    2. Central asian cobra (Naja naja oxiana) [TaxId: 8657] [57336] (3)
  17. Cardiotoxin III [57337]
    1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57338] (7)
      SQ P60301 22-81
  18. Cardiotoxin IV [57339]
    1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57340] (2)
  19. Cobrotoxin II (ct2) [57341]
    1. Taiwan cobra (Naja naja atra) [TaxId: 8656] [57342] (3)
      SQ P60770 22-83
    2. Monocled cobra (Naja kaouthia) [TaxId: 8649] [57343] (1)
  20. alpha-Toxin [57344]
    1. Spitting cobra (Naja nigricollis) [TaxId: 8654] [57345] (2)
    2. Black mamba (Dendroaspis polylepis polylepis) [TaxId: 8620] [57346] (1)
  21. Neurotoxin II (Nt2, cobrotoxin B) [57347]
    1. Central asian cobra (Naja naja oxiana) [TaxId: 8657] [57348] (1)
    2. Monocled cobra (Naja kaouthia) [TaxId: 8649] [64550] (1)
    3. Chinese cobra (Naja atra) [TaxId: 8656] [103569] (2)
      SQ P80958 22-82
  22. Toxin B (long neurotoxin) [57349]
    1. King cobra (Ophiophagus hannah) [TaxId: 8665] [57350] (2)
  23. Candoxin [69949]
    1. Malayan krait (Bungarus candidus) [TaxId: 92438] [69950] (1)
  24. Bucain [111404]
    1. Malaysian krait (Bungarus candidus) [TaxId: 92438] [111405] (3)
      SQ P83346
  25. Irditoxin subunit A [144103]
    1. Brown tree snake (Boiga irregularis) [TaxId: 92519] [144104] (1)
      SQ A0S864 35-109
  26. Irditoxin subunit B [144105]
    1. Brown tree snake (Boiga irregularis) [TaxId: 92519] [144106] (1)
      SQ A0S865 35-111
  27. Denmotoxin [144107]
    1. Mangrove snake (Boiga dendrophila) [TaxId: 46286] [144108] (2)
      SQ Q06ZW0 33-111
2. Dendroaspin [57351] (1)
  1. Dendroaspin [57352]
    lacks neurotoxicity; acts as the disintegrins: contains RGD-motif
    1. Dendroaspis jamesoni kaimosae [TaxId: 8619] [57353] (1)
3. Extracellular domain of cell surface receptors [57354] (9)
  1. CD59 [57355]
    1. Human (Homo sapiens) [TaxId: 9606] [57356] (10)
  2. Type II activin receptor [57357]
    1. Mouse (Mus musculus) [TaxId: 10090] [57358] (4)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [90154] (2)
    3. Mouse (Mus musculus), isoform IIB [TaxId: 10090] [111406] (3)
      SQ P27040 23-120; 100% sequence identity to the rat domain of the same type IIb (scop_sp 90154)
  3. BMP receptor Ia ectodomain [57359]
    1. Human (Homo sapiens) [TaxId: 9606] [57360] (6)
  4. TGF-beta type II receptor extracellular domain [69951]
    elaborated with additional structures resulting in a beta-sandwich fold
    1. Human (Homo sapiens) [TaxId: 9606] [69952] (4)
    2. Chicken (Gallus gallus) [TaxId: 9031] [82900] (1)
  5. Urokinase plasminogen activator surface receptor uPAR [161128]
    duplication: tandem repeat of three similar domains; the N-terminal and C-terminal domains belong to Pfam 00021; uPAR/Ly6
    1. Human (Homo sapiens) [TaxId: 9606] [161129] (12)
      SQ Q03405 109-209! SQ Q03405 210-299! SQ Q03405 23-108
  6. Urokinase plasminogen activator surface receptor, UPAR [161130]
    duplication; comprises three domains of this fold
    1. Human (Homo sapiens) [TaxId: 9606] [161131] (33)
      SQ Q03405 111-210! SQ Q03405 114-210! SQ Q03405 211-297! SQ Q03405 211-301! SQ Q03405 23-102! SQ Q03405 23-104