Structural Classification of Proteins
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Fold: Glucocorticoid receptor-like (DNA-binding domain)

alpha+beta metal(zinc)-bound fold

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Glucocorticoid receptor-like (DNA-binding domain) [57715]
    alpha+beta metal(zinc)-bound fold

Superfamilies:

  1. Glucocorticoid receptor-like (DNA-binding domain) [57716] (18)
    link to SUPERFAMILY database - Superfamily
    1. Erythroid transcription factor GATA-1 [57717] (3)
      single zinc-binding motif
      1. Erythroid transcription factor GATA-1 [57718]
        1. Chicken (Gallus gallus) [TaxId: 9031] [57719] (8) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [57720] (2) picpic
        3. Emericella nidulans [TaxId: 162425] [161161] (24) picpic
    2. Nuclear receptor [57721] (12)
      duplication: two zinc-binding motifs
      1. Retinoid X receptor (RXR-alpha) DNA-binding domain [57722]
        1. Human (Homo sapiens) [TaxId: 9606] [57723] (7) picpic
      2. Thyroid hormone receptor (TR-beta) DNA-binding domain [57724]
        1. Human (Homo sapiens) [TaxId: 9606] [57725] (1) picpic
      3. Orphan nuclear receptor NGFI-B DNA-binding domain [57726]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [57727] (1) picpic
      4. Estrogen receptor DNA-binding domain [57728]
        1. Human and chicken (Homo sapiens) and (Gallus gallus) [TaxId: 9606] [57729] (2) picpic
          identical sequences
      5. Steroid hormone receptor Err2 DNA-binding domain [90201]
        1. Human (Homo sapiens) [TaxId: 9606] [90202] (1) picpic
      6. Ecdysone receptor DNA-binding domain [103601]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [103602] (3) picpic
      7. Ultraspiracle protein [103603]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [103604] (1) picpic
      8. Glucocorticoid receptor DNA-binding domain [57730]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [57731] (7) picpic
      9. Retinoic acid receptor DNA-binding domain [57732]
        1. Human (Homo sapiens) [TaxId: 9606] [57733] (2) picpic
      10. Orphan nuclear receptor reverb DNA-binding domain [57734]
        1. Human (Homo sapiens) [TaxId: 9606] [57735] (3) picpic
      11. Vitamin D3 receptor, VDR, DNA-binding domain [75686]
        1. Human (Homo sapiens) [TaxId: 9606] [75687] (4) picpic
      12. Androgen receptor [111439]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [111440] (1) picpic
          SQ P15207 538-611
    3. Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [103605] (1)
      1. Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [103606]
        protein-protein interaction module
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [103607] (1) picpic
    4. LIM domain [57736] (21)
      duplication: contains two (sub)domains of this fold
      1. Cysteine-rich (intestinal) protein, CRP, CRIP [57737]
        1. Chicken (Gallus gallus) [TaxId: 9031] [57738] (2) picpic
        2. Japanese quail (Coturnix coturnix japonica), CRP2 [TaxId: 93934] [57739] (4) picpic
        3. Rat (Rattus rattus) [TaxId: 10117] [57740] (1) picpic
        4. Human (Homo sapiens) [TaxId: 9606] [144160] (2) picpic
          SQ P52943 1-30! SQ P52943 31-63
          CRP2
      2. Pinch (particularly interesting new Cys-His) protein [57741]
        1. Human (Homo sapiens) [TaxId: 9606] [57742] (8) picpic
      3. Rhombotin-2 (Lmo2) [90203]
        1. Mouse (Mus musculus) [TaxId: 10090] [90204] (1) picpic
      4. LIM only 4 (Lmo4) [90205]
        1. Mouse (Mus musculus) [TaxId: 10090] [90206] (2) picpic
          SQ P61969 19-152
      5. Actin-binding LIM protein 2, abLIM2 [111441]
        1. Human (Homo sapiens) [TaxId: 9606] [111442] (2) picpic
          SQ Q6H8Q1 73-140, 212-271
      6. Four and a half LIM domains protein 2, FHL2 [144161]
        Skeletal muscle lim-protein 3
        1. Human (Homo sapiens) [TaxId: 9606] [144162] (6) picpic
          SQ Q14192 128-159! SQ Q14192 162-186! SQ Q14192 187-218! SQ Q14192 221-249! SQ Q14192 250-279! SQ Q14192 98-127
      7. Four and a half LIM domains protein 1, FHL-1 [144163]
        Skeletal muscle lim-protein 1
        1. Human (Homo sapiens) [TaxId: 9606] [144164] (7) picpic
          SQ Q13642 128-159! SQ Q13642 161-185! SQ Q13642 186-216! SQ Q13642 39-66! SQ Q13642 67-97! SQ Q13642 90-127! SQ Q13642 98-127
      8. Eplin, LIMA1 [144165]
        Epithelial protein lost in neoplasm
        1. Human (Homo sapiens) [TaxId: 9606] [144166] (2) picpic
          SQ Q9UHB6 381-417! SQ Q9UHB6 416-457
      9. Four and a half LIM domains 3, FHL3 [144167]
        Skeletal muscle lim-protein 2
        1. Human (Homo sapiens) [TaxId: 9606] [144168] (4) picpic
          SQ Q13643 127-159! SQ Q13643 152-186! SQ Q13643 187-218! SQ Q13643 98-126
      10. PDZ and LIM domain protein 5, Enigma [144169]
        1. Human (Homo sapiens) [TaxId: 9606] [144170] (2) picpic
          SQ Q96HC4 400-444! SQ Q96HC4 445-476
      11. PDZ and LIM domain protein 1 Elfin [144171]
        C-terminal LIM domain protein 1
        1. Human (Homo sapiens) [TaxId: 9606] [144172] (2) picpic
          SQ O00151 249-279! SQ O00151 280-314
      12. Nedd9 interacting protein with calponin homology, NICAL (MICAL1) [144173]
        1. Human (Homo sapiens) [TaxId: 9606] [144174] (2) picpic
          SQ Q8TDZ2 687-722! SQ Q8TDZ2 723-755
      13. Leupaxin [144175]
        1. Human (Homo sapiens) [TaxId: 9606] [144176] (2) picpic
          SQ O60711 260-295! SQ O60711 296-327
      14. Thyroid receptor interacting protein 6, TRIP6 [144177]
        1. Human (Homo sapiens) [TaxId: 9606] [144178] (4) picpic
          SQ Q15654 279-305! SQ Q15654 306-337! SQ Q15654 363-396! SQ Q15654 364-396
      15. Actin-binding LIM protein 3, abLIM-3 [144179]
        1. Human (Homo sapiens) [TaxId: 9606] [144180] (2) picpic
          SQ O94929 141-176! SQ O94929 177-207
      16. Four and a half LIM domains protein 5, FHL-5 [144181]
        1. Human (Homo sapiens) [TaxId: 9606] [144182] (2) picpic
          SQ Q5TD97 222-250! SQ Q5TD97 251-284
      17. Lim domain kinase 2 [144183]
        1. Human (Homo sapiens) [TaxId: 9606] [144184] (2) picpic
          SQ P53671 62-95! SQ P53671 96-129
      18. PDZ and LIM domain protein 3, PDLIM3 [144185]
        Alpha-actinin-2-associated LIM protein
        1. Mouse (Mus musculus) [TaxId: 10090] [144186] (2) picpic
          SQ O70209 270-301! SQ O70209 271-301
    5. LASP-1 [57743] (1)
      1. LASP-1 [57744]
        1. Pig (Sus scrofa) [TaxId: 9823] [57745] (1) picpic
    6. DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [57746] (1)
      1. DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [57747]
        1. Human (Homo sapiens) [TaxId: 9606] [57748] (2) picpic
    7. Ribosomal protein L24e [57749] (1)
      1. Ribosomal protein L24e [57750]
        1. Archaeon Haloarcula marismortui [TaxId: 2238] [57751] (44) picpic
          SQ P14116
    8. Hypothetical zinc finger protein YacG [82914] (1)
      Zn-binding site is particularly similar to that of ribosomal protein L24e
      1. Hypothetical zinc finger protein YacG [82915]
        1. Escherichia coli [TaxId: 562] [82916] (1) picpic
    9. Ribosomal protein S14 [57752] (2)
      1. Ribosomal protein S14 [57753]
        1. Thermus thermophilus [TaxId: 274] [57754] (45) picpic
          SQ P24320
        2. Escherichia coli [TaxId: 562] [161162] (24) picpic
          SQ P02370 1-100
    10. C-terminal, Zn-finger domain of MutM-like DNA repair proteins [81627] (6)
      1. DNA repair protein MutM (Fpg) [81622]
        1. Thermus thermophilus [TaxId: 274] [81610] (1) picpic
        2. Bacillus stearothermophilus [TaxId: 1422] [81613] (9) picpic
        3. Escherichia coli [TaxId: 562] [81618] (1) picpic
        4. Lactococcus lactis [TaxId: 1358] [81619] (7) picpic
          SQ P42371
      2. Endonuclease VIII [82917]
        1. Escherichia coli [TaxId: 562] [82918] (9) picpic
          SQ P50465
      3. Endonuclease VIII-like 1 (NEIL1) [111443]
        1. Human (Homo sapiens) [TaxId: 9606] [111444] (1) picpic
          SQ Q96FI4 1-333
    11. ClpX chaperone zinc binding domain [103608] (1)
      1. ClpX chaperone zinc binding domain [103609]
        1. Escherichia coli [TaxId: 562] [103610] (7) picpic
    12. PARP-type zinc finger [111445] (1)
      Pfam 00645
      1. DNA ligase III [111446]
        1. Human (Homo sapiens) [TaxId: 9606] [111447] (1) picpic
          SQ P49916 1-117
    13. Prokaryotic DksA/TraR C4-type zinc finger [111448] (1)
      Pfam 01258; Pfam coverage extends to the second helix of the upstream alpha-hairpin domain
      1. DnaK suppressor protein DksA, zinc finger domain [111449]
        1. Escherichia coli [TaxId: 562] [111450] (1) picpic
          SQ P18274 7-151
    14. Type II thymidine kinase zinc finger [118276] (3)
      C-terminal part of Pfam 00265
      1. Thymidine kinase, TK1, C-terminal domain [118277]
        1. Human (Homo sapiens) [TaxId: 9606] [118278] (3) picpic
          SQ P04183 18-191
        2. Ureaplasma urealyticum [TaxId: 2130] [118279] (8) picpic
          SQ Q9PPP5 11-211
        3. Clostridium acetobutylicum [TaxId: 1488] [118280] (1) picpic
          SQ Q97F65
    15. A20-like zinc finger [144187] (2)
      Pfam 01754
      1. RabGEF1 (Rabex-5), ubiquitin-binding domain [144188]
        binds to ubiquitin with the extended C-terminal helix
        1. Cow (Bos taurus) [TaxId: 9913] [144189] (4) picpic
          SQ O18973 14-73
        2. Human (Homo sapiens) [TaxId: 9606] [144190] (5) picpic
          SQ Q9UJ41 17-74
    16. THAP domain [161163] (1)
      Pfam 05485
      1. THAP domain-containing protein 2 [161164]
        1. Human (Homo sapiens) [TaxId: 9606] [161165] (1) picpic
          SQ Q9H0W7 1-86
    17. TRASH domain [161166] (1)
      SMART 00746
      1. Zinc finger MYM-type protein 5 [161167]
        1. Human (Homo sapiens) [TaxId: 9606] [161168] (1) picpic
          SQ Q9UJ78 229-277
    18. FwdE C-terminal domain-like [161169] (1)
      the C-terminus of PF02663; FwdE
      1. Uncharacterized protein Ta1109 [161170]
        1. Thermoplasma acidophilum [TaxId: 2303] [161171] (1) picpic
          SQ Q9HJ63 169-201
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk