Structural Classification of Proteins
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Family: Neurotrophin

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Cystine-knot cytokines [57500]
    disulfide-rich fold; common core is all-beta
  4. Superfamily: Cystine-knot cytokines [57501]
    link to SUPERFAMILY database - Superfamily
  5. Family: Neurotrophin [57520]

Protein Domains:

  1. Brain-derived neurotrophic factor, BDNF [88882]
    1. Human (Homo sapiens) [TaxId: 9606] [88883] (2)
      1. 1bnd picpicxref
        heterodimer with NT3
        complexed with ipa
        1. chain a [44793] picpiclink
      2. 1b8m picpicxref
        heterodimer with NT4
        1. chain a [44797] picpiclink
  2. Neurotrophin 3, NT3 [88884]
    1. Human (Homo sapiens) [TaxId: 9606] [88885] (5)
      1. 1bnd picpicxref
        heterodimer with BDNF
        complexed with ipa
        1. chain b [44794] picpiclink
      2. 1b8k picpic
        1. chain a [44795] picpiclink
      3. 1nt3 picpic
        1. chain a [44796] picpiclink
      4. 3buk picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1nt3a_
        complexed with nag
        1. region a:8-115 [155610] picpiclink
      5. 3buk picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1nt3a_
        complexed with nag
        1. region b:8-115 [155611] picpiclink
  3. Neurotrophin 4, NT4 [57523]
    1. Human (Homo sapiens) [TaxId: 9606] [57524] (3)
      1. 1hcf picpicxref
        homodimer
        complexed with so4
        1. chain a [65788] picpiclink
        2. chain b [65789] picpiclink
      2. 1b8m picpicxref
        heterodimer with BDNF
        1. chain b [44798] picpiclink
      3. 1b98 picpic
        homodimer
        complexed with cl
        1. chain a [44799] picpiclink
        2. chain m [44800] picpiclink
  4. beta-Nerve growth factor [57525]
    1. Mouse (Mus musculus) [TaxId: 10090] [57526] (3)
      1. 1bet picpic
        1. chain a [44801] picpiclink
      2. 1btg picpic
        complexed with zn; mutant
        1. chain a [44802] picpiclink
        2. chain b [44803] picpiclink
        3. chain c [44804] picpiclink
      3. 1sgf picpicxref
        complexed with nag, zn
        1. chain b [44805] picpiclink
        2. chain y [44806] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [57527] (4)
      SQ P01138
      1. 1www picpicxref
        1. chain v [44807] picpiclink
        2. chain w [44808] picpiclink
      2. 1sg1 picpicxref
        complexed with cl
        1. chain a [105513] picpiclink
        2. chain b [105514] picpiclink
      3. 2ifg picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1wwww_
        complexed with bma, man, nag, ndg
        1. region e:2-115 [137341] picpiclink
      4. 2ifg picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1wwww_
        complexed with bma, man, nag, ndg
        1. region f:2-115 [137342] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk