Family: Transforming growth factor (TGF)-beta

Lineage:

1. Root: scop
2. Class: Small proteins [56992]
   Usually dominated by metal ligand, heme, and/or disulfide bridges
3. Fold: Cystine-knot cytokines [57500]
   disulfide-rich fold; common core is all-beta
4. Superfamily: Cystine-knot cytokines [57501]
   uperfamily
5. Family: Transforming growth factor (TGF)-beta [57507]

Protein Domains:

1. TGF-beta3 [57508]
   1. Human (Homo sapiens) [TaxId: 9606] [57509] (4)
      1. 1tgj
         complexed with dio
         1. chain a [44775]
      2. 1ktz
         complexed with the type II receptor extracellular domain
         1. chain a [68867]
      3. 2pjy
         automatically matched to d1tgja_
         mutant
         1. region a:1-112 [149583]
      4. 1tgk
         1. chain a [44776]
2. TGF-beta2 [57510]
   1. Human (Homo sapiens) [TaxId: 9606] [57511] (2)
      1. 2tgi
         1. chain a [44777]
      2. 1tfg
         1. chain a [44778]
3. TGF-beta1 [57512]
   1. Human (Homo sapiens) [TaxId: 9606] [57513] (3)
      1. 1kld
         1. chain a [44781]
         2. chain b [44782]
      2. 1kla
         1. chain a [44779]
         2. chain b [44780]
      3. 1klc
         1. chain a [44783]
         2. chain b [44784]
4. Bone morphogenetic protein-7 (BMP-7) [57514]
   1. Human (Homo sapiens) [TaxId: 9606] [57515] (4)
      1. 1lxi
         complexed with nag
         1. chain a [84735]
      2. 1m4u
         complexed with nag
         1. chain l [78626]
      3. 1bmp
         1. chain a [44785]
      4. 1lx5
         complexed with the extracellular domain of activin type II receptor
         complexed with man, nag
         1. chain a [84732]
5. Bone morphogenetic protein-2 (BMP-2) [57516]
   1. Human (Homo sapiens) [TaxId: 9606] [57517] (15)
      1. 2h62
         automatically matched to d3bmpa_
         1. region a:12-114 [136177]
      2. 2h62
         automatically matched to d3bmpa_
         1. region b:12-114 [136178]
      3. 2h64
         mutant
         1. region a:10-114 [145282]
      4. 1rew
         1. chain a [97334]
         2. chain b [97335]
      5. 2goo
         automatically matched to d3bmpa_
         complexed with ndg
         1. region a:12-114 [135441]
      6. 2goo
         automatically matched to d3bmpa_
         complexed with ndg
         1. region d:12-114 [135444]
      7. 2qj9
         automatically matched to d3bmpa_
         mutant
         1. region a:11-114 [150823]
      8. 2qj9
         automatically matched to d3bmpa_
         mutant
         1. region b:12-114 [150824]
      9. 1reu
         complexed with mpd; mutant
         1. chain a [97333]
      10. 3bmp
          complexed with mpd
          1. chain a [44788]
      11. 1es7
          1. chain a [44786]
          2. chain c [44787]
      12. 2qjb
          automatically matched to d3bmpa_
          complexed with cl; mutant
          1. region a:12-114 [150827]
      13. 2qjb
          automatically matched to d3bmpa_
          complexed with cl; mutant
          1. region b:11-114 [150828]
      14. 2qja
          automatically matched to d3bmpa_
          mutant
          1. region a:11-114 [150825]
      15. 2qja
          automatically matched to d3bmpa_
          mutant
          1. region b:11-114 [150826]
6. Activin A (Inhibin beta A) [90170]
   1. Human (Homo sapiens) [TaxId: 9606] [90171] (14)
      SQ P08476 311-426
      1. 2arp
         automatically matched to d1s4yb_
         complexed with 1pg, gol, ni
         1. region a:1-116 [127217]
      2. 2arv
         automatically matched to d1s4yb_
         complexed with 1pg, gol, so4
         1. region a:1-116 [127218]
      3. 2arv
         automatically matched to d1s4yb_
         complexed with 1pg, gol, so4
         1. region b:1-116 [127219]
      4. 3b4v
         automatically matched to d1s4yb_
         complexed with edo, nag, so4
         1. region a:1-116 [154825]
      5. 3b4v
         automatically matched to d1s4yb_
         complexed with edo, nag, so4
         1. region b:1-116 [154826]
      6. 3b4v
         automatically matched to d1s4yb_
         complexed with edo, nag, so4
         1. region e:1-116 [154827]
      7. 3b4v
         automatically matched to d1s4yb_
         complexed with edo, nag, so4
         1. region f:1-116 [154828]
      8. 1s4y
         Structural genomics target
         1. chain b [105257]
         2. chain d [105259]
      9. 2b0u
         automatically matched to d1s4yb_
         complexed with ir3, mli, mpd
         1. region a:1-116 [127648]
      10. 2b0u
          automatically matched to d1s4yb_
          complexed with ir3, mli, mpd
          1. region b:1-116 [127649]
      11. 1nys
          complexed with the extracellular domain of activin type II receptor
          1. chain b [86414]
          2. chain d [86416]
      12. 1nyu
          complexed with the extracellular domain of activin type II receptor
          1. chain b [86426]
          2. chain d [86428]
      13. 2p6a
          automatically matched to d1s4yb_
          1. region a:1-116 [139509]
      14. 2p6a
          automatically matched to d1s4yb_
          1. region b:1-116 [139510]
7. Glial cell-derived neurotrophic factor, GDNF [57518]
   1. Rat (Rattus norvegicus) [TaxId: 10116] [57519] (1)
      1. 1agq
         1. chain a [44789]
         2. chain b [44790]
         3. chain c [44791]
         4. chain d [44792]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk