Structural Classification of Proteins

Family: Phosphoribosyltransferases (PRTases)

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: PRTase-like [53270]
core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
Superfamily: PRTase-like [53271]
uperfamily
Family: Phosphoribosyltransferases (PRTases) [53272]

Protein Domains:

Xanthine-guanine PRTase (XPRTase) [53273]
1. Escherichia coli [TaxId: 562] [53274] (5)
  1. 1nul
    complexed with mo5, so4
    1. chain a [34011]
    2. chain b [34012]
  2. 1a95
    complexed with bo3, gun, mo2, pcp
    1. chain a [34013]
    2. chain b [34014]
    3. chain c [34015]
    4. chain d [34016]
  3. 1a96
    complexed with bo3, mo2, pcp, xan
    1. chain a [34017]
    2. chain b [34018]
    3. chain c [34019]
    4. chain d [34020]
  4. 1a98
    mutant
    1. chain a [34021]
    2. chain b [34022]
  5. 1a97
    complexed with 5gp, bo3; mutant
    1. chain a [34023]
    2. chain b [34024]
    3. chain c [34025]
    4. chain d [34026]
2. Thermoanaerobacter tengcongensis [TaxId: 119072] [142552] (2)
  SQ Q8R7L0 3-180
  1. 1yfz
    complexed with act, imp, mg; mutant
    1. region a:3-180 [123098]
  2. 1yfz
    automatically matched to 1YFZ A:3-180
    complexed with act, imp, mg; mutant
    1. region b:4-180 [123099]
Hypoxanthine-guanine-xanthine PRTase [53275]
1. Tritrichomonas foetus [TaxId: 5724] [53276] (1)
  1. 1hgx
    complexed with 5gp, so4
    1. chain a [34027]
    2. chain b [34028]
2. Toxoplasma gondii [TaxId: 5811] [53277] (5)
  1. 1fsg
    complexed with 9dg, mo2, mo3, prp
    1. chain a [34029]
    2. chain c [34030]
  2. 1qk3
    complexed with 5gp
    1. chain a [34031]
    2. chain b [34032]
    3. chain c [34033]
    4. chain d [34034]
  3. 1qk5
    complexed with mg, pop, xmp; mutant
    1. chain a [34035]
    2. chain b [34036]
  4. 1qk4
    complexed with imp
    1. chain a [34037]
    2. chain b [34038]
    3. chain c [34039]
    4. chain d [34040]
  5. 1dbr
    complexed with mg
    1. chain a [34041]
    2. chain b [34042]
    3. chain c [34043]
    4. chain d [34044]
3. Leishmania tarentolae [TaxId: 5689] [110658] (1)
  SQ Q9NJI5
  1. 1pzm
    complexed with 5gp
    1. chain a [104395]
    2. chain b [104396]
Glutamine PRPP amidotransferase, C-terminal domain [53278]
1. Bacillus subtilis [TaxId: 1423] [53279] (2)
  1. 1gph
    complexed with amp, fs4
    1. region 1:235-465 [34045]
    2. region 2:235-465 [34046]
    3. region 3:235-465 [34047]
    4. region 4:235-465 [34048]
  2. 1ao0
    complexed with 5gp, adp, fs4, mg
    1. region a:235-459 [34049]
    2. region b:235-459 [34050]
    3. region c:235-459 [34051]
    4. region d:235-459 [34052]
2. Escherichia coli [TaxId: 562] [53280] (5)
  1. 1ecf
    complexed with pin
    1. region a:250-492 [34053]
    2. region b:250-500 [34054]
  2. 1ecg
    complexed with onl, pin
    1. region a:250-492 [34055]
    2. region b:250-500 [34056]
  3. 1ecj
    complexed with amp
    1. region a:250-492 [34059]
    2. region b:250-492 [34060]
    3. region c:250-492 [34061]
    4. region d:250-492 [34062]
  4. 1ecc
    complexed with mn, onl, pcp
    1. region a:250-492 [34057]
    2. region b:250-492 [34058]
  5. 1ecb
    complexed with 5gp, mg
    1. region a:250-481 [34063]
    2. region b:250-478 [34064]
    3. region c:250-482 [34065]
    4. region d:250-481 [34066]
Guanine PRTase [53281]
1. Giardia lamblia [TaxId: 5741] [53282] (2)
  1. 1dqn
    complexed with imu, ipa, mg, pop
    1. chain a [34067]
    2. chain b [34068]
  2. 1dqp
    complexed with img, ipa
    1. chain a [34069]
    2. chain b [34070]
Hypoxanthine-guanine PRTase (HGPRTase) [53283]
1. Human (Homo sapiens) [TaxId: 9606] [53284] (7)
  1. 1z7g
    automatically matched to d1bzya_
    1. region a:4-217 [124624]
  2. 1z7g
    automatically matched to d1bzya_
    1. region b:4-217 [124625]
  3. 1z7g
    automatically matched to d1bzya_
    1. region c:4-217 [124626]
  4. 1z7g
    automatically matched to d1bzya_
    1. region d:4-217 [124627]
  5. 1bzy
    complexed with imu, mg, pop
    1. chain a [34071]
    2. chain b [34072]
    3. chain c [34073]
    4. chain d [34074]
  6. 1hmp
    complexed with 5gp
    1. chain a [34075]
    2. chain b [34076]
  7. 1d6n
    1. chain a [34077]
    2. chain b [34078]
2. Plasmodium falciparum [TaxId: 5833] [53285] (1)
  1. 1cjb
    complexed with irp, mg, pop
    1. chain a [34079]
    2. chain b [34080]
    3. chain c [34081]
    4. chain d [34082]
3. Thermoanaerobacter tengcongensis [TaxId: 119072] [117671] (1)
  SQ Q8R7L0
  1. 1r3u
    complexed with act, mg
    1. chain a [111681]
    2. chain b [111682]
Hypoxanthine PRTase [53286]
1. Trypanosoma cruzi [TaxId: 5693] [53287] (9)
  SQ Q27796
  1. 1tc1
    complexed with fmb, mes
    1. chain a [34083]
    2. chain b [34084]
  2. 1i0l
    complexed with 7hp, mo2, mo3, prp; mutant
    1. chain a [71096]
    2. chain b [71097]
  3. 1tc2
    complexed with 7hp, mo2, mo3, mw2, prp
    1. chain a [34085]
    2. chain b [34086]
  4. 1i13
    complexed with 7hp, fmt, mo2, mo3, prp; mutant
    1. chain a [71098]
    2. chain b [71099]
  5. 1i14
    complexed with 7hp, mo2, mo3, prp; mutant
    1. chain a [71100]
    2. chain b [71101]
  6. 1i0i
    complexed with 7hp, mo2, mo3, prp; mutant
    1. chain a [71094]
    2. chain b [71095]
  7. 1p18
    complexed with 7hp, mo2, mo3, prp; mutant
    1. chain a [104053]
    2. chain b [104054]
  8. 1p17
    complexed with imp; mutant
    1. chain a [104049]
    2. chain b [104050]
    3. chain c [104051]
    4. chain d [104052]
  9. 1p19
    complexed with imp
    1. chain a [104055]
    2. chain b [104056]
    3. chain c [104057]
    4. chain d [104058]
2. Escherichia coli [TaxId: 562] [75255] (3)
  1. 1g9s
    complexed with imp
    1. chain a [70164]
    2. chain b [70165]
  2. 1g9t
    complexed with 5gp
    1. chain a [70166]
    2. chain b [70167]
  3. 1grv
    complexed with mg
    1. chain a [76321]
    2. chain b [76322]
3. Salmonella typhimurium [TaxId: 90371] [89728] (1)
  1. 1j7j
    complexed with mg
    1. chain a [84131]
    2. chain b [84132]
Adenine PRTase [53288]
1. Leishmania donovani [TaxId: 5661] [53289] (4)
  1. 1qb7
    complexed with ade, cit, mg
    1. chain a [34087]
  2. 1qcc
    complexed with cit
    1. chain a [34088]
  3. 1qb8
    complexed with amp, cit, mg
    1. chain a [34089]
  4. 1qcd
    complexed with so4
    1. chain a [34090]
2. Leishmania tarentolae [TaxId: 5689] [102535] (1)
  1. 1mzv
    complexed with amp, po4
    1. chain a [91502]
3. Giardia lamblia [TaxId: 5741] [82455] (2)
  1. 1l1q
    complexed with 9da, so4
    1. chain a [77653]
  2. 1l1r
    ternary complex
    complexed with 9da, mg, prp
    1. chain a [77654]
4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [69541] (2)
  1. 1g2q
    1. chain a [65117]
    2. chain b [65118]
  2. 1g2p
    complexed with so4
    1. chain a [65116]
5. Human (Homo sapiens) [TaxId: 9606] [102536] (7)
  1. 1zn7
    automatically matched to d1orea_
    complexed with ade, mg, po4, prp, rp5
    1. region a:3-180 [125374]
  2. 1zn7
    automatically matched to d1orea_
    complexed with ade, mg, po4, prp, rp5
    1. region b:3-180 [125375]
  3. 1zn8
    automatically matched to d1orea_
    complexed with amp, cl
    1. region a:3-180 [125376]
  4. 1zn8
    automatically matched to d1orea_
    complexed with amp, cl
    1. region b:3-180 [125377]
  5. 1ore
    complexed with amp, cl
    1. chain a [93452]
  6. 1zn9
    automatically matched to d1orea_
    complexed with amp
    1. region a:3-180 [125378]
  7. 1zn9
    automatically matched to d1orea_
    complexed with amp
    1. region b:3-180 [125379]
Orotate PRTase [53290]
1. Salmonella typhimurium [TaxId: 90371] [53291] (3)
  1. 1lh0
    complexed with mg, oro, prp
    1. chain a [73896]
    2. chain b [73897]
  2. 1opr
    complexed with mg, oro, prp
    1. chain a [34091]
  3. 1sto
    complexed with oh, omp
    1. chain a [34092]
2. Escherichia coli [TaxId: 562] [53292] (1)
  1. 1oro
    complexed with so4
    1. chain a [34093]
    2. chain b [34094]
3. Streptococcus pyogenes [TaxId: 1314] [142553] (2)
  SQ Q9A076 1-208
  1. 2aee
    complexed with cl, gol, so4
    1. region a:1-208 [126620]
  2. 2aee
    automatically matched to 2AEE A:1-208
    complexed with cl, gol, so4
    1. region b:1-208 [126621]
Uracil PRTase, Upp [53293]
1. Bacillus caldolyticus [TaxId: 1394] [75256] (1)
  1. 1i5e
    complexed with u5p
    1. chain a [71116]
    2. chain b [71117]
2. Thermotoga maritima [TaxId: 2336] [102538] (1)
  TM0721
  1. 1o5o
    structural genomics
    complexed with so4, u5p
    1. chain a [92509]
    2. chain b [92510]
    3. chain c [92511]
    4. chain d [92512]
3. Toxoplasma gondii [TaxId: 5811] [53295] (6)
  1. 1bd3
    complexed with po4; mutant
    1. chain a [34098]
    2. chain b [34099]
    3. chain c [34100]
    4. chain d [34101]
  2. 1jlr
    complexed with gtp, po4; mutant
    1. chain a [66859]
    2. chain b [66860]
    3. chain c [66861]
    4. chain d [66862]
  3. 1upf
    complexed with so4, urf; mutant
    1. chain a [34102]
    2. chain b [34103]
    3. chain c [34104]
    4. chain d [34105]
  4. 1upu
    complexed with po4, u5p; mutant
    1. chain a [34110]
    2. chain b [34111]
    3. chain c [34112]
    4. chain d [34113]
  5. 1bd4
    complexed with po4, ura; mutant
    1. chain a [34106]
    2. chain b [34107]
    3. chain c [34108]
    4. chain d [34109]
  6. 1jls
    complexed with mg, po4, prp, ura; mutant
    1. chain a [66863]
    2. chain b [66864]
    3. chain c [66865]
    4. chain d [66866]
4. Thermus thermophilus [TaxId: 274] [142554] (4)
  SQ Q72J35 1-208
  1. 1v9s
    complexed with so4
    1. region a:1-208 [119894]
  2. 1v9s
    automatically matched to 1V9S A:1-208
    complexed with so4
    1. region b:1-208 [119895]
  3. 1v9s
    automatically matched to 1V9S A:1-208
    complexed with so4
    1. region c:1-208 [119896]
  4. 1v9s
    automatically matched to 1V9S A:1-208
    complexed with so4
    1. region d:1-208 [119897]
5. Sulfolobus solfataricus [TaxId: 2287] [142555] (20)
  SQ Q980Q4 2-216
  1. 1xtt
    complexed with acy, u5p
    1. region a:2-216 [122300]
  2. 1xtt
    automatically matched to 1XTT A:2-216
    complexed with acy, u5p
    1. region b:2-216 [122301]
  3. 1xtt
    automatically matched to 1XTT A:2-216
    complexed with acy, u5p
    1. region c:2-216 [122302]
  4. 1xtt
    automatically matched to 1XTT A:2-216
    complexed with acy, u5p
    1. region d:2-216 [122303]
  5. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region a:2-216 [122304]
  6. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region b:2-216 [122305]
  7. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region c:2-216 [122306]
  8. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region d:2-216 [122307]
  9. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region e:2-216 [122308]
  10. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region f:2-216 [122309]
  11. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region g:2-216 [122310]
  12. 1xtu
    automatically matched to 1XTT A:2-216
    complexed with ctp, u5p
    1. region h:2-216 [122311]
  13. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region a:2-216 [122312]
  14. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region b:2-216 [122313]
  15. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region c:2-216 [122314]
  16. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region d:2-216 [122315]
  17. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region e:2-216 [122316]
  18. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region f:2-216 [122317]
  19. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region g:2-216 [122318]
  20. 1xtv
    automatically matched to 1XTT A:2-216
    complexed with u5p
    1. region h:2-216 [122319]
Pyrimidine operon regulator PyrR [109612]
bifunctional protein; contains the uracil PRTase and Pyr RNA-binding activities
1. Bacillus subtilis [TaxId: 1423] [53294] (2)
  1. 1a3c
    complexed with sm, so4
    1. chain a [34095]
  2. 1a4x
    complexed with so4
    1. chain a [34096]
    2. chain b [34097]
2. Thermus thermophilus [TaxId: 274] [102537] (1)
  TT1027
  1. 1ufr
    structural genomics
    complexed with cl
    1. chain a [99354]
    2. chain b [99355]
    3. chain c [99356]
    4. chain d [99357]
3. Bacillus caldolyticus [TaxId: 1394] [110659] (7)
  SQ P41007
  1. 2igb
    automatically matched to d1nona_
    complexed with edo, u5p
    1. region a:1-179 [147655]
  2. 2igb
    automatically matched to d1nona_
    complexed with edo, u5p
    1. region b:1-179 [147656]
  3. 1xzn
    automatically matched to d1nona_
    complexed with mg, so4
    1. region a:1-179 [122472]
  4. 1xzn
    automatically matched to d1nona_
    complexed with mg, so4
    1. region b:1-179 [122473]
  5. 1non
    1. chain a [103868]
    2. chain b [103869]
    3. chain c [103870]
    4. chain d [103871]
  6. 1xz8
    automatically matched to d1nona_
    complexed with 3gp, 5gp, mg, u5p
    1. region a:1-179 [122469]
  7. 1xz8
    automatically matched to d1nona_
    complexed with 3gp, 5gp, mg, u5p
    1. region b:1-179 [122470]
4. Mycobacterium tuberculosis [TaxId: 1773] [117672] (1)
  SQ P71807
  1. 1w30
    mutant
    1. chain a [114118]
    2. chain b [114119]
Pur operon repressor (PurR), C-terminal domain [102539]
1. Bacillus subtilis [TaxId: 1423] [102540] (2)
  1. 1o57
    complexed with 1pe, 2pe, epe, p6g, pg4, so4
    1. region a:75-276 [92484]
    2. region b:75-274 [92486]
    3. region c:75-274 [92488]
    4. region d:75-276 [92490]
  2. 1p4a
    complexed with pcp
    1. region a:75-276 [94091]
    2. region b:75-273 [94093]
    3. region c:75-273 [94095]
    4. region d:75-273 [94097]
Putative phosphoribosyltransferase TT1426 (TTHA1462) [117673]
1. Thermus thermophilus [TaxId: 274] [117674] (1)
  SQ Q5SIB2
  1. 1wd5
    complexed with mes
    1. chain a [114524]
Xanthine phosphoribosyltransferase [142556]
1. Bacillus subtilis [TaxId: 1423] [142557] (6)
  SQ P42085 1-191
  1. 1y0b
    complexed with g4p, na
    1. region a:1-191 [122476]
  2. 1y0b
    automatically matched to 1Y0B A:1-191
    complexed with g4p, na
    1. region b:1-191 [122477]
  3. 1y0b
    automatically matched to 1Y0B A:1-191
    complexed with g4p, na
    1. region c:1-189 [122478]
  4. 1y0b
    automatically matched to 1Y0B A:1-191
    complexed with g4p, na
    1. region d:1-191 [122479]
  5. 2fxv
    automatically matched to 1Y0B A:1-191
    complexed with 5gp, gol
    1. region a:1-190 [134342]
  6. 2fxv
    automatically matched to 1Y0B A:1-191
    complexed with 5gp, gol
    1. region b:1-190 [134343]
Putative phosphoribosyltransferase TTHA1613 [142558]
putative APRTase in UniProt
1. Thermus thermophilus [TaxId: 274] [142559] (5)
  SQ Q5SHW7 2-175
  1. 1vch
    complexed with acy, ca, cl
    1. region a:2-175 [119980]
  2. 1vch
    automatically matched to 1VCH A:2-175
    complexed with acy, ca, cl
    1. region b:2-175 [119981]
  3. 1vch
    automatically matched to 1VCH A:2-175
    complexed with acy, ca, cl
    1. region c:2-175 [119982]
  4. 1vch
    automatically matched to 1VCH A:2-175
    complexed with acy, ca, cl
    1. region d:2-175 [119983]
  5. 1vch
    automatically matched to 1VCH A:2-175
    complexed with acy, ca, cl
    1. region e:2-175 [119984]
Pprobable purine phosphoribosyltransferase PH0095 [142560]
1. Pyrococcus horikoshii [TaxId: 53953] [142561] (12)
  SQ O57827 1-153
  1. 1vdm
    1. region a:1-153 [119994]
  2. 1vdm
    automatically matched to 1VDM A:1-153
    1. region b:1-153 [119995]
  3. 1vdm
    automatically matched to 1VDM A:1-153
    1. region c:1-152 [119996]
  4. 1vdm
    automatically matched to 1VDM A:1-153
    1. region d:1-152 [119997]
  5. 1vdm
    automatically matched to 1VDM A:1-153
    1. region e:1-153 [119998]
  6. 1vdm
    automatically matched to 1VDM A:1-153
    1. region f:1-152 [119999]
  7. 1vdm
    automatically matched to 1VDM A:1-153
    1. region g:1-152 [120000]
  8. 1vdm
    automatically matched to 1VDM A:1-153
    1. region h:1-153 [120001]
  9. 1vdm
    automatically matched to 1VDM A:1-153
    1. region i:1-152 [120002]
  10. 1vdm
    automatically matched to 1VDM A:1-153
    1. region j:1-152 [120003]
  11. 1vdm
    automatically matched to 1VDM A:1-153
    1. region k:1-152 [120004]
  12. 1vdm
    automatically matched to 1VDM A:1-153
    1. region l:1-153 [120005]