Structural Classification of Proteins

Fold: PRTase-like

: core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: PRTase-like [53270]
core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest

Superfamilies:

PRTase-like [53271] (2)
uperfamily
1. Phosphoribosyltransferases (PRTases) [53272] (36)
  1. Xanthine-guanine PRTase (XPRTase) [53273]
    1. Escherichia coli [TaxId: 562] [53274] (5)
    2. Thermoanaerobacter tengcongensis [TaxId: 119072] [142552] (2)
      SQ Q8R7L0 3-180
  2. Hypoxanthine-guanine-xanthine PRTase [53275]
    1. Tritrichomonas foetus [TaxId: 5724] [53276] (1)
    2. Toxoplasma gondii [TaxId: 5811] [53277] (5)
    3. Leishmania tarentolae [TaxId: 5689] [110658] (1)
      SQ Q9NJI5
  3. Glutamine PRPP amidotransferase, C-terminal domain [53278]
    1. Bacillus subtilis [TaxId: 1423] [53279] (2)
    2. Escherichia coli [TaxId: 562] [53280] (5)
  4. Guanine PRTase [53281]
    1. Giardia lamblia [TaxId: 5741] [53282] (2)
  5. Hypoxanthine-guanine PRTase (HGPRTase) [53283]
    1. Human (Homo sapiens) [TaxId: 9606] [53284] (7)
    2. Plasmodium falciparum [TaxId: 5833] [53285] (1)
    3. Thermoanaerobacter tengcongensis [TaxId: 119072] [117671] (1)
      SQ Q8R7L0
  6. Hypoxanthine PRTase [53286]
    1. Trypanosoma cruzi [TaxId: 5693] [53287] (9)
      SQ Q27796
    2. Escherichia coli [TaxId: 562] [75255] (3)
    3. Salmonella typhimurium [TaxId: 90371] [89728] (1)
  7. Adenine PRTase [53288]
    1. Leishmania donovani [TaxId: 5661] [53289] (4)
    2. Leishmania tarentolae [TaxId: 5689] [102535] (1)
    3. Giardia lamblia [TaxId: 5741] [82455] (2)
    4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [69541] (2)
    5. Human (Homo sapiens) [TaxId: 9606] [102536] (7)
  8. Orotate PRTase [53290]
    1. Salmonella typhimurium [TaxId: 90371] [53291] (3)
    2. Escherichia coli [TaxId: 562] [53292] (1)
    3. Streptococcus pyogenes [TaxId: 1314] [142553] (2)
      SQ Q9A076 1-208
  9. Uracil PRTase, Upp [53293]
    1. Bacillus caldolyticus [TaxId: 1394] [75256] (1)
    2. Thermotoga maritima [TaxId: 2336] [102538] (1)
      TM0721
    3. Toxoplasma gondii [TaxId: 5811] [53295] (6)
    4. Thermus thermophilus [TaxId: 274] [142554] (4)
      SQ Q72J35 1-208
    5. Sulfolobus solfataricus [TaxId: 2287] [142555] (20)
      SQ Q980Q4 2-216
  10. Pyrimidine operon regulator PyrR [109612]
    bifunctional protein; contains the uracil PRTase and Pyr RNA-binding activities
    1. Bacillus subtilis [TaxId: 1423] [53294] (2)
    2. Thermus thermophilus [TaxId: 274] [102537] (1)
      TT1027
    3. Bacillus caldolyticus [TaxId: 1394] [110659] (7)
      SQ P41007
    4. Mycobacterium tuberculosis [TaxId: 1773] [117672] (1)
      SQ P71807
  11. Pur operon repressor (PurR), C-terminal domain [102539]
    1. Bacillus subtilis [TaxId: 1423] [102540] (2)
  12. Putative phosphoribosyltransferase TT1426 (TTHA1462) [117673]
    1. Thermus thermophilus [TaxId: 274] [117674] (1)
      SQ Q5SIB2
  13. Xanthine phosphoribosyltransferase [142556]
    1. Bacillus subtilis [TaxId: 1423] [142557] (6)
      SQ P42085 1-191
  14. Putative phosphoribosyltransferase TTHA1613 [142558]
    putative APRTase in UniProt
    1. Thermus thermophilus [TaxId: 274] [142559] (5)
      SQ Q5SHW7 2-175
  15. Pprobable purine phosphoribosyltransferase PH0095 [142560]
    1. Pyrococcus horikoshii [TaxId: 53953] [142561] (12)
      SQ O57827 1-153
2. Phosphoribosylpyrophosphate synthetase-like [53296] (3)
  duplication: consists of two domains of this fold
  1. Phosphoribosylpyrophosphate synthetase [53297]
    1. Bacillus subtilis [TaxId: 1423] [53298] (3)
    2. Methanocaldococcus jannaschii [TaxId: 2190] [142562] (16)
      SQ Q58761 1-155! SQ Q58761 156-284
  2. PRPP synthetase-associated protein 1 [142563]
    1. Human (Homo sapiens) [TaxId: 9606] [142564] (12)
      SQ Q14558 167-350! SQ Q14558 7-166