Structural Classification of Proteins
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Family: Caspase catalytic domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Caspase-like [52128]
    3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
  4. Superfamily: Caspase-like [52129]
    mature protein may be composed of two chains folded in a single domain
    link to SUPERFAMILY database - Superfamily
  5. Family: Caspase catalytic domain [52130]

Protein Domains:

  1. Apopain (caspase-3, cpp32) [52131]
    1. Human (Homo sapiens) [TaxId: 9606] [52132] (31)
      1. 1nme picpic
        complexed with 158, 159
        1. chain a,b [85874] picpiclink
      2. 1nms picpic
        complexed with 161
        1. chain a [85879] picpiclink
        2. chain b [85880] picpiclink
      3. 1qx3 picpic
        1. chain a [96515] picpiclink
      4. 1rhj picpic
        complexed with pzn
        1. chain a,b [97481] picpiclink
        2. chain c,d [97482] picpiclink
      5. 1cp3 picpic
        complexed with ace
        1. chain a [30992] picpiclink
        2. chain b [30993] picpiclink
      6. 1pau picpic
        complexed with ace
        1. chain a,b [30994] picpiclink
      7. 1rhu picpic
        complexed with 3cy
        1. chain a,b [97489] picpiclink
      8. 1re1 picpic
        complexed with na3
        1. chain a,b [97319] picpiclink
      9. 1rhk picpic
        complexed with ace, fpr
        1. chain a,b [97483] picpiclink
      10. 1rhm picpic
        complexed with na4
        1. chain a,b [97484] picpiclink
        2. chain c,d [97485] picpiclink
      11. 3dek picpic
        automatically matched to d1nmqa_
        complexed with rxd
        1. region a:34-277 [157588] picpiclink
      12. 3dek picpic
        automatically matched to d1nmqa_
        complexed with rxd
        1. region b:34-277 [157589] picpiclink
      13. 3dek picpic
        automatically matched to d1nmqa_
        complexed with rxd
        1. region c:34-277 [157590] picpiclink
      14. 3dek picpic
        automatically matched to d1nmqa_
        complexed with rxd
        1. region d:34-277 [157591] picpiclink
      15. 1nmq picpic
        complexed with 160
        1. chain a [85877] picpiclink
        2. chain b [85878] picpiclink
      16. 3deh picpic
        automatically matched to d1nmqa_
        complexed with rxa
        1. region a:34-277 [157576] picpiclink
      17. 3deh picpic
        automatically matched to d1nmqa_
        complexed with rxa
        1. region b:34-277 [157577] picpiclink
      18. 3deh picpic
        automatically matched to d1nmqa_
        complexed with rxa
        1. region c:34-277 [157578] picpiclink
      19. 3deh picpic
        automatically matched to d1nmqa_
        complexed with rxa
        1. region d:34-276 [157579] picpiclink
      20. 3dej picpic
        automatically matched to d1nmqa_
        complexed with rxc
        1. region a:34-277 [157584] picpiclink
      21. 3dej picpic
        automatically matched to d1nmqa_
        complexed with rxc
        1. region b:34-277 [157585] picpiclink
      22. 3dej picpic
        automatically matched to d1nmqa_
        complexed with rxc
        1. region c:34-277 [157586] picpiclink
      23. 3dej picpic
        automatically matched to d1nmqa_
        complexed with rxc
        1. region d:34-276 [157587] picpiclink
      24. 1gfw picpic
        complexed with msi
        1. chain a,b [30995] picpiclink
      25. 1i3o picpicxref
        complexed to xiap-bir2
        complexed with zn; mutant
        1. chain a,b [61603] picpiclink
        2. chain c,d [61604] picpiclink
      26. 3dei picpic
        automatically matched to d1nmqa_
        complexed with rxb
        1. region a:34-277 [157580] picpiclink
      27. 3dei picpic
        automatically matched to d1nmqa_
        complexed with rxb
        1. region b:34-277 [157581] picpiclink
      28. 3dei picpic
        automatically matched to d1nmqa_
        complexed with rxb
        1. region c:34-277 [157582] picpiclink
      29. 3dei picpic
        automatically matched to d1nmqa_
        complexed with rxb
        1. region d:34-276 [157583] picpiclink
      30. 1rhr picpic
        complexed with cne
        1. chain a,b [97488] picpiclink
      31. 1rhq picpic
        complexed with ace, bop, ptf
        1. chain a,b [97486] picpiclink
        2. chain d,e [97487] picpiclink
  2. Interleukin-1beta converting enzyme (a cysteine protease) [52133]
    1. Human (Homo sapiens) [TaxId: 9606] [52134] (14)
      SQ P29466 125-297,317-404
      1. 1sc3 picpic
        complexed with mli; mutant
        1. chain a,b [105416] picpiclink
      2. 1rwx picpic
        complexed with ybh
        1. chain a,b [111958] picpiclink
      3. 1rwn picpic
        complexed with 4qb
        1. chain a,b [111948] picpiclink
      4. 1rwo picpic
        complexed with bth
        1. chain a,b [111949] picpiclink
      5. 1rwv picpic
        complexed with 5ph
        1. chain a,b [111956] picpiclink
      6. 1rwp picpic
        complexed with hqc
        1. chain a,b [111950] picpiclink
      7. 1sc4 picpic
        mutant
        1. chain a,b [105417] picpiclink
      8. 1rwk picpic
        complexed with 158
        1. chain a,b [111946] picpiclink
      9. 1ibc picpic
        complexed with ace; mutant
        1. chain a,b [30997] picpiclink
      10. 1ice picpic
        1. chain a,b [30996] picpiclink
      11. 1rww picpic
        complexed with oqb
        1. chain a,b [111957] picpiclink
      12. 1rwm picpic
        complexed with q2y
        1. chain a,b [111947] picpiclink
      13. 1bmq picpic
        complexed with mno
        1. chain a,b [30998] picpiclink
      14. 1sc1 picpic
        complexed with cl; mutant
        1. chain a,b [105415] picpiclink
  3. Caspase-1 [102526]
    1. Fall armyworm (Spodoptera frugiperda) [TaxId: 7108] [102527] (1)
      1. 1m72 picpic
        complexed with ace, edo
        1. chain a [91208] picpiclink
        2. chain b [91209] picpiclink
        3. chain c [91210] picpiclink
  4. Caspase-2 [102528]
    1. Human (Homo sapiens) [TaxId: 9606] [102529] (1)
      1. 1pyo picpic
        complexed with ace
        1. chain a,b [95370] picpiclink
        2. chain c,d [95371] picpiclink
  5. Caspase-7 [63961]
    1. Human (Homo sapiens) [TaxId: 9606] [63962] (9)
      SQ P55210 57-303
      1. 1f1j picpic
        complex with acetyl-Asp-Glu-Val-Asp-CHO
        complexed with ace, so4
        1. chain a [59596] picpiclink
        2. chain b [59597] picpiclink
      2. 1i4o picpic
        Complexed to the xiap linker (chains C and D)
        1. chain a [61721] picpiclink
        2. chain b [61722] picpiclink
      3. 1i51 picpic
        complexed to the xiap-bir2 fragment (chains E and F)
        mutant
        1. chain a,b [66029] picpiclink
        2. chain c,d [66030] picpiclink
      4. 1k86 picpic
        mutant
        1. chain a [68288] picpiclink
        2. chain b [68289] picpiclink
      5. 1kmc picpic
        complexed to the xiap-bir2 fragment (chains C and D)
        mutant
        1. chain a [68690] picpiclink
        2. chain b [68691] picpiclink
      6. 1k88 picpic
        mutant
        1. chain a [68290] picpiclink
        2. chain b [68291] picpiclink
      7. 1shl picpic
        complexed with fxn; mutant
        1. chain a [105556] picpiclink
        2. chain b [105557] picpiclink
      8. 1gqf picpic
        complexed with so4
        1. chain a [65470] picpiclink
        2. chain b [65471] picpiclink
      9. 1shj picpic
        complexed with nxn, so4; mutant
        1. chain a [105554] picpiclink
        2. chain b [105555] picpiclink
  6. Caspase-8 [52135]
    1. Human (Homo sapiens) [TaxId: 9606] [52136] (6)
      1. 1qtn picpic
        complexed with ace, dtd
        1. chain a,b [30999] picpiclink
      2. 1f9e picpic
        complexed with phq
        1. chain a,b [59732] picpiclink
        2. chain c,d [59733] picpiclink
        3. chain e,f [59734] picpiclink
        4. chain g,h [59735] picpiclink
        5. chain i,j [59736] picpiclink
        6. chain k,l [59737] picpiclink
      3. 1qdu picpic
        complexed with phq
        1. chain a,b [31000] picpiclink
        2. chain c,d [31001] picpiclink
        3. chain e,f [31002] picpiclink
        4. chain g,h [31003] picpiclink
        5. chain i,j [31004] picpiclink
        6. chain k,l [31005] picpiclink
      4. 2fun picpicxrefxref
        automatically matched to d1i4eb_
        1. region b:2222-2479 [134181] picpiclink
      5. 2fun picpicxrefxref
        automatically matched to d1i4eb_
        1. region d:3222-3477 [134183] picpiclink
      6. 1i4e picpicxref
        complexed to p35
        complexed with ace
        1. chain b [61686] picpiclink
  7. Caspase-9 [69443]
    1. Human (Homo sapiens) [TaxId: 9606] [69444] (2)
      1. 1nw9 picpicxref
        complexed to the xiap-bir3
        complexed with zn
        1. chain b [86294] picpiclink
      2. 1jxq picpic
        complexed with cbz
        1. chain a [67426] picpiclink
        2. chain b [67427] picpiclink
        3. chain c [67428] picpiclink
        4. chain d [67429] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk