Structural Classification of Proteins

Superfamily: Caspase-like

: mature protein may be composed of two chains folded in a single domain
uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: Caspase-like [52128]
3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
Superfamily: Caspase-like [52129]
mature protein may be composed of two chains folded in a single domain
uperfamily

Families:

Caspase catalytic domain [52130] (7)
1. Apopain (caspase-3, cpp32) [52131]
  1. Human (Homo sapiens) [TaxId: 9606] [52132] (31)
    1. 1nme
      complexed with 158, 159
      1. chain a,b [85874]
    2. 1nms
      complexed with 161
      1. chain a [85879]
      2. chain b [85880]
    3. 1qx3
      1. chain a [96515]
    4. 1rhj
      complexed with pzn
      1. chain a,b [97481]
      2. chain c,d [97482]
    5. 1cp3
      complexed with ace
      1. chain a [30992]
      2. chain b [30993]
    6. 1pau
      complexed with ace
      1. chain a,b [30994]
    7. 1rhu
      complexed with 3cy
      1. chain a,b [97489]
    8. 1re1
      complexed with na3
      1. chain a,b [97319]
    9. 1rhk
      complexed with ace, fpr
      1. chain a,b [97483]
    10. 1rhm
      complexed with na4
      1. chain a,b [97484]
      2. chain c,d [97485]
    11. 3dek
      automatically matched to d1nmqa_
      complexed with rxd
      1. region a:34-277 [157588]
    12. 3dek
      automatically matched to d1nmqa_
      complexed with rxd
      1. region b:34-277 [157589]
    13. 3dek
      automatically matched to d1nmqa_
      complexed with rxd
      1. region c:34-277 [157590]
    14. 3dek
      automatically matched to d1nmqa_
      complexed with rxd
      1. region d:34-277 [157591]
    15. 1nmq
      complexed with 160
      1. chain a [85877]
      2. chain b [85878]
    16. 3deh
      automatically matched to d1nmqa_
      complexed with rxa
      1. region a:34-277 [157576]
    17. 3deh
      automatically matched to d1nmqa_
      complexed with rxa
      1. region b:34-277 [157577]
    18. 3deh
      automatically matched to d1nmqa_
      complexed with rxa
      1. region c:34-277 [157578]
    19. 3deh
      automatically matched to d1nmqa_
      complexed with rxa
      1. region d:34-276 [157579]
    20. 3dej
      automatically matched to d1nmqa_
      complexed with rxc
      1. region a:34-277 [157584]
    21. 3dej
      automatically matched to d1nmqa_
      complexed with rxc
      1. region b:34-277 [157585]
    22. 3dej
      automatically matched to d1nmqa_
      complexed with rxc
      1. region c:34-277 [157586]
    23. 3dej
      automatically matched to d1nmqa_
      complexed with rxc
      1. region d:34-276 [157587]
    24. 1gfw
      complexed with msi
      1. chain a,b [30995]
    25. 1i3o
      complexed to xiap-bir2
      complexed with zn; mutant
      1. chain a,b [61603]
      2. chain c,d [61604]
    26. 3dei
      automatically matched to d1nmqa_
      complexed with rxb
      1. region a:34-277 [157580]
    27. 3dei
      automatically matched to d1nmqa_
      complexed with rxb
      1. region b:34-277 [157581]
    28. 3dei
      automatically matched to d1nmqa_
      complexed with rxb
      1. region c:34-277 [157582]
    29. 3dei
      automatically matched to d1nmqa_
      complexed with rxb
      1. region d:34-276 [157583]
    30. 1rhr
      complexed with cne
      1. chain a,b [97488]
    31. 1rhq
      complexed with ace, bop, ptf
      1. chain a,b [97486]
      2. chain d,e [97487]
2. Interleukin-1beta converting enzyme (a cysteine protease) [52133]
  1. Human (Homo sapiens) [TaxId: 9606] [52134] (14)
    SQ P29466 125-297,317-404
    1. 1sc3
      complexed with mli; mutant
      1. chain a,b [105416]
    2. 1rwx
      complexed with ybh
      1. chain a,b [111958]
    3. 1rwn
      complexed with 4qb
      1. chain a,b [111948]
    4. 1rwo
      complexed with bth
      1. chain a,b [111949]
    5. 1rwv
      complexed with 5ph
      1. chain a,b [111956]
    6. 1rwp
      complexed with hqc
      1. chain a,b [111950]
    7. 1sc4
      mutant
      1. chain a,b [105417]
    8. 1rwk
      complexed with 158
      1. chain a,b [111946]
    9. 1ibc
      complexed with ace; mutant
      1. chain a,b [30997]
    10. 1ice
      1. chain a,b [30996]
    11. 1rww
      complexed with oqb
      1. chain a,b [111957]
    12. 1rwm
      complexed with q2y
      1. chain a,b [111947]
    13. 1bmq
      complexed with mno
      1. chain a,b [30998]
    14. 1sc1
      complexed with cl; mutant
      1. chain a,b [105415]
3. Caspase-1 [102526]
  1. Fall armyworm (Spodoptera frugiperda) [TaxId: 7108] [102527] (1)
    1. 1m72
      complexed with ace, edo
      1. chain a [91208]
      2. chain b [91209]
      3. chain c [91210]
4. Caspase-2 [102528]
  1. Human (Homo sapiens) [TaxId: 9606] [102529] (1)
    1. 1pyo
      complexed with ace
      1. chain a,b [95370]
      2. chain c,d [95371]
5. Caspase-7 [63961]
  1. Human (Homo sapiens) [TaxId: 9606] [63962] (9)
    SQ P55210 57-303
    1. 1f1j
      complex with acetyl-Asp-Glu-Val-Asp-CHO
      complexed with ace, so4
      1. chain a [59596]
      2. chain b [59597]
    2. 1i4o
      Complexed to the xiap linker (chains C and D)
      1. chain a [61721]
      2. chain b [61722]
    3. 1i51
      complexed to the xiap-bir2 fragment (chains E and F)
      mutant
      1. chain a,b [66029]
      2. chain c,d [66030]
    4. 1k86
      mutant
      1. chain a [68288]
      2. chain b [68289]
    5. 1kmc
      complexed to the xiap-bir2 fragment (chains C and D)
      mutant
      1. chain a [68690]
      2. chain b [68691]
    6. 1k88
      mutant
      1. chain a [68290]
      2. chain b [68291]
    7. 1shl
      complexed with fxn; mutant
      1. chain a [105556]
      2. chain b [105557]
    8. 1gqf
      complexed with so4
      1. chain a [65470]
      2. chain b [65471]
    9. 1shj
      complexed with nxn, so4; mutant
      1. chain a [105554]
      2. chain b [105555]
6. Caspase-8 [52135]
  1. Human (Homo sapiens) [TaxId: 9606] [52136] (6)
    1. 1qtn
      complexed with ace, dtd
      1. chain a,b [30999]
    2. 1f9e
      complexed with phq
      1. chain a,b [59732]
      2. chain c,d [59733]
      3. chain e,f [59734]
      4. chain g,h [59735]
      5. chain i,j [59736]
      6. chain k,l [59737]
    3. 1qdu
      complexed with phq
      1. chain a,b [31000]
      2. chain c,d [31001]
      3. chain e,f [31002]
      4. chain g,h [31003]
      5. chain i,j [31004]
      6. chain k,l [31005]
    4. 2fun
      automatically matched to d1i4eb_
      1. region b:2222-2479 [134181]
    5. 2fun
      automatically matched to d1i4eb_
      1. region d:3222-3477 [134183]
    6. 1i4e
      complexed to p35
      complexed with ace
      1. chain b [61686]
7. Caspase-9 [69443]
  1. Human (Homo sapiens) [TaxId: 9606] [69444] (2)
    1. 1nw9
      complexed to the xiap-bir3
      complexed with zn
      1. chain b [86294]
    2. 1jxq
      complexed with cbz
      1. chain a [67426]
      2. chain b [67427]
      3. chain c [67428]
      4. chain d [67429]
Gingipain R (RgpB), N-terminal domain [52137] (1)
contains extra N-terminal alpha/beta subdomain
1. Gingipain R (RgpB), N-terminal domain [52138]
  Arginine-specific cysteine proteinase
  1. Porphyromonas gingivalis [TaxId: 837] [52139] (1)
    1. 1cvr
      complexed with ca, zn
      1. region a:1-350 [31006]