Structural Classification of Proteins
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Family: Ribonuclease H

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Ribonuclease H-like motif [53066]
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
  4. Superfamily: Ribonuclease H-like [53098]
    consists of one domain of this fold
    link to SUPERFAMILY database - Superfamily
  5. Family: Ribonuclease H [53099]

Protein Domains:

  1. RNase H (RNase HI) [53100]
    1. Escherichia coli [TaxId: 562] [53101] (37)
      SQ P0A7Y4
      1. 1jl1 picpic
        mutant
        1. chain a [66821] picpiclink
      2. 1f21 picpic
        mutant
        1. chain a [33550] picpiclink
      3. 2rn2 picpic
        1. chain a [33551] picpiclink
      4. 1jxb picpic
        mutant
        1. chain a [71931] picpiclink
      5. 1rbu picpic
        mutant
        1. chain a [33552] picpiclink
      6. 1rbv picpic
        mutant
        1. chain a [33553] picpiclink
      7. 1rbt picpic
        mutant
        1. chain a [33555] picpiclink
      8. 1wsh picpic
        mutant
        1. chain a [114849] picpiclink
        2. chain b [114850] picpiclink
        3. chain c [114851] picpiclink
        4. chain d [114852] picpiclink
      9. 1lav picpic
        mutant
        1. chain a [33554] picpiclink
      10. 1law picpic
        mutant
        1. chain a [33557] picpiclink
      11. 1g15 picpic
        complexed with mn; mutant
        1. chain a [60197] picpiclink
      12. 1rbr picpic
        mutant
        1. chain a [33556] picpiclink
      13. 1kva picpic
        mutant
        1. chain a [33559] picpiclink
      14. 1rdb picpic
        mutant
        1. chain a [33561] picpiclink
      15. 1wsi picpic
        mutant
        1. chain a [114853] picpiclink
        2. chain b [114854] picpiclink
        3. chain c [114855] picpiclink
        4. chain d [114856] picpiclink
      16. 1rbs picpic
        mutant
        1. chain a [33558] picpiclink
      17. 1kvc picpic
        mutant
        1. chain a [33560] picpiclink
      18. 1wsj picpic
        mutant
        1. chain a [114857] picpiclink
        2. chain b [114858] picpiclink
        3. chain c [114859] picpiclink
        4. chain d [114860] picpiclink
        5. chain e [114861] picpiclink
        6. chain f [114862] picpiclink
        7. chain g [114863] picpiclink
        8. chain h [114864] picpiclink
      19. 1kvb picpic
        mutant
        1. chain a [33562] picpiclink
      20. 1rnh picpic
        complexed with so4
        1. chain a [33563] picpiclink
      21. 1wsg picpic
        complexed with mn; mutant
        1. region a:1-155 [121234] picpiclink
      22. 1wsg picpic
        automatically matched to 1WSG A:1-155
        complexed with mn; mutant
        1. region b:1-155 [121235] picpiclink
      23. 1wsg picpic
        automatically matched to 1WSG A:1-155
        complexed with mn; mutant
        1. region c:1-155 [121236] picpiclink
      24. 1wsg picpic
        automatically matched to 1WSG A:1-155
        complexed with mn; mutant
        1. region d:1-155 [121237] picpiclink
      25. 1gob picpic
        mutant
        1. chain a [33565] picpiclink
      26. 1goa picpic
        mutant
        1. chain a [33564] picpiclink
      27. 1goc picpic
        mutant
        1. chain a [33566] picpiclink
      28. 1rda picpic
        mutant
        1. chain a [33567] picpiclink
      29. 1wsf picpic
        complexed with mn; mutant
        1. region a:1-155 [121230] picpiclink
      30. 1wsf picpic
        automatically matched to 1WSF A:1-155
        complexed with mn; mutant
        1. region b:1-155 [121231] picpiclink
      31. 1wsf picpic
        automatically matched to 1WSF A:1-155
        complexed with mn; mutant
        1. region c:1-155 [121232] picpiclink
      32. 1wsf picpic
        automatically matched to 1WSF A:1-155
        complexed with mn; mutant
        1. region d:1-155 [121233] picpiclink
      33. 1wse picpic
        complexed with mn; mutant
        1. region a:1-155 [121228] picpiclink
      34. 1wse picpic
        automatically matched to 1WSE A:1-155
        complexed with mn; mutant
        1. region b:1-155 [121229] picpiclink
      35. 1rdc picpic
        mutant
        1. chain a [33568] picpiclink
      36. 1rdd picpic
        complexed with mg
        1. chain a [33569] picpiclink
      37. 1rch picpic
        1. chain a [33570] picpiclink
    2. Thermus thermophilus [TaxId: 274] [53102] (1)
      1. 1ril picpic
        1. chain a [33571] picpiclink
    3. synthetic, Escherichia coli/Thermus thermophilus chimera [69532] (1)
      1. 1jl2 picpic
        1. chain a [66822] picpiclink
        2. chain b [66823] picpiclink
        3. chain c [66824] picpiclink
        4. chain d [66825] picpiclink
  2. Class II ribonuclease H (RNase HII) [53103]
    1. Archaeon Methanococcus jannaschii [TaxId: 2190] [53104] (1)
      1. 1eke picpic
        complexed with mes
        1. chain a [33572] picpiclink
        2. chain b [33573] picpiclink
    2. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [64093] (2)
      1. 1i39 picpic
        1. chain a [61585] picpiclink
      2. 1i3a picpic
        complexed with nco
        1. chain a [61586] picpiclink
    3. Archaeon Thermococcus kodakaraensis [TaxId: 311400] [64094] (2)
      1. 1io2 picpic
        1. chain a [62612] picpiclink
      2. 2dfh picpic
        automatically matched to d1io2a_
        mutant
        1. region a:1-212 [131472] picpiclink
    4. Archaeon Pyrococcus horikoshii [TaxId: 53953] [110639] (2)
      SQ O59351
      1. 1uax picpic
        1. chain a [107764] picpiclink
        2. chain b [107765] picpiclink
      2. 1x1p picpic
        automatically matched to d1uaxa_
        1. region a:1-196 [121594] picpiclink
    5. Thermotoga maritima [TaxId: 2336] [142489] (1)
      SQ Q9X017 1-221
      1. 2etj picpic
        complexed with cl, edo, mg
        1. region a:1-221 [132360] picpiclink
  3. HIV RNase H (Domain of reverse transcriptase) [53105]
    1. Human immunodeficiency virus type 1 [TaxId: 11676] [53106] (88)
      SQ P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! SQ P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! SQ P04585 158-698 # chain A coverage; chain B is shorter: 159-595
      1. 1vrt picpicxrefxref
        complexed with cya, mg, nev
        1. region a:430-539 [33574] picpiclink
      2. 1s1t picpicxref
        complexed with po4, uc1; mutant
        1. region a:430-539 [105205] picpiclink
      3. 1c1b picpicxrefxref
        complexed with gca
        1. region a:430-543 [33605] picpiclink
      4. 1vru picpicxrefxref
        complexed with aap, cya
        1. region a:430-539 [33575] picpiclink
      5. 1jla picpicxrefxref
        complexed with tnk; mutant
        1. region a:430-553 [66833] picpiclink
      6. 1rt1 picpicxref
        complexed with mkc
        1. region a:430-539 [33579] picpiclink
      7. 1rth picpicxref
        complexed with cya, u05
        1. region a:430-543 [33576] picpiclink
      8. 1eet picpicxrefxref
        complexed with bfu; mutant
        1. region a:430-557 [33608] picpiclink
      9. 1jkh picpicxrefxref
        complexed with efz; mutant
        1. region a:430-554 [66797] picpiclink
      10. 1ikx picpicxrefxref
        complexed with pnu; mutant
        1. region a:430-557 [62533] picpiclink
      11. 1c0u picpicxrefxref
        complexed with bm5
        1. region a:430-539 [33610] picpiclink
      12. 1hrh picpic
        1. region a:432-556 [33577] picpiclink
        2. region b:432-554 [33578] picpiclink
      13. 1rt2 picpicxrefxref
        complexed with tnk
        1. region a:430-543 [33580] picpiclink
      14. 1tkt picpicxref
        complexed with h12, mg, po4
        1. region a:430-537 [112482] picpiclink
      15. 1rev picpicxrefxref
        complexed with mg, trb
        1. region a:430-539 [33582] picpiclink
      16. 1c0t picpicxrefxref
        complexed with bm1
        1. region a:430-539 [33606] picpiclink
      17. 1fk9 picpicxrefxref
        complexed with efz
        1. region a:430-539 [33607] picpiclink
      18. 1klm picpicxrefxref
        complexed with spp
        1. region a:430-539 [33583] picpiclink
      19. 1c1c picpicxrefxref
        complexed with 612
        1. region a:430-539 [33609] picpiclink
      20. 1lwc picpicxrefxref
        complexed with csd, nvp, po4; mutant
        1. region a:430-537 [78262] picpiclink
      21. 1s1w picpicxref
        complexed with uc1; mutant
        1. region a:430-539 [105214] picpiclink
      22. 1jlg picpicxrefxref
        complexed with uc1; mutant
        1. region a:430-539 [66848] picpiclink
      23. 1s1v picpicxref
        complexed with tnk; mutant
        1. region a:430-539 [105211] picpiclink
      24. 1hmv picpicxrefxrefxrefxrefxrefxrefxrefxref
        complexed with mg
        1. region a:430-554 [33587] picpiclink
      25. 1hmv picpicxrefxrefxrefxrefxrefxrefxrefxref
        duplicate of 1HMV A:430-554
        complexed with mg
        1. region c:430-554 [118502] picpiclink
      26. 1hmv picpicxrefxrefxrefxrefxrefxrefxrefxref
        duplicate of 1HMV A:430-554
        complexed with mg
        1. region e:430-554 [118505] picpiclink
      27. 1hmv picpicxrefxrefxrefxrefxrefxrefxrefxref
        duplicate of 1HMV A:430-554
        complexed with mg
        1. region g:430-554 [118508] picpiclink
      28. 1rtj picpicxref
        complexed with cya
        1. region a:430-543 [33581] picpiclink
      29. 1tkx picpicxref
        complexed with gwb
        1. region a:430-537 [112485] picpiclink
      30. 1ep4 picpicxrefxref
        complexed with s11
        1. region a:430-539 [33614] picpiclink
      31. 1lwe picpicxrefxref
        complexed with csd, nvp, po4; mutant
        1. region a:430-554 [78267] picpiclink
      32. 1dtt picpicxrefxref
        complexed with ftc
        1. region a:430-543 [33611] picpiclink
      33. 1tl3 picpicxref
        complexed with h20, po4
        1. region a:430-537 [112496] picpiclink
      34. 1tkz picpicxref
        complexed with h16, po4
        1. region a:430-537 [112490] picpiclink
      35. 1jlf picpicxrefxref
        complexed with nvp; mutant
        1. region a:430-539 [66845] picpiclink
      36. 1iky picpicxrefxref
        complexed with msd; mutant
        1. region a:430-557 [62536] picpiclink
      37. 1ikw picpicxrefxref
        complexed with efz; mutant
        1. region a:430-557 [62530] picpiclink
      38. 1fko picpicxrefxref
        complexed with efz; mutant
        1. region a:430-543 [33612] picpiclink
      39. 1rt6 picpicxref
        complexed with po4, uc3
        1. region a:430-539 [33613] picpiclink
      40. 1rt5 picpicxrefxref
        complexed with po4, uc2
        1. region a:430-542 [33615] picpiclink
      41. 1rt4 picpicxrefxref
        complexed with po4, uc1
        1. region a:430-542 [33618] picpiclink
      42. 1rti picpicxref
        complexed with cya, hef
        1. region a:430-543 [33585] picpiclink
      43. 1lwf picpicxrefxref
        complexed with csd, nvp; mutant
        1. region a:430-554 [78270] picpiclink
      44. 1jlb picpicxrefxref
        complexed with nvp; mutant
        1. region a:430-554 [66836] picpiclink
      45. 1lw0 picpicxrefxref
        complexed with csd, nvp, po4; mutant
        1. region a:430-537 [78248] picpiclink
      46. 1dlo picpicxrefxref
        mutant
        1. region a:430-556 [33584] picpiclink
      47. 1s1x picpicxref
        complexed with nvp; mutant
        1. region a:430-539 [105217] picpiclink
      48. 1dtq picpicxrefxref
        complexed with fpt
        1. region a:430-539 [33616] picpiclink
      49. 1fkp picpicxrefxref
        complexed with nvp; mutant
        1. region a:430-542 [33617] picpiclink
      50. 1tl1 picpicxref
        complexed with h18, po4
        1. region a:430-537 [112493] picpiclink
      51. 1tv6 picpicxref
        complexed with cp9
        1. region a:430-539 [107347] picpiclink
      52. 1jlq picpicxrefxref
        complexed with sbn
        1. region a:430-540 [63173] picpiclink
      53. 1lw2 picpicxrefxref
        complexed with csd, po4, u05; mutant
        1. region a:430-539 [78251] picpiclink
      54. 1s9e picpicxrefxref
        complexed with adb; mutant
        1. region a:430-552 [98752] picpiclink
      55. 1r0a picpicxrefxrefxrefxrefxref
        complexed with 2da, glc, gol, mg
        1. region a:430-558 [104676] picpiclink
      56. 1ikv picpicxrefxref
        complexed with efz; mutant
        1. region a:430-557 [62527] picpiclink
      57. 1rt3 picpicxrefxref
        complexed with u05; mutant
        1. region a:430-537 [33590] picpiclink
      58. 1jlc picpicxrefxref
        complexed with ftc; mutant
        1. region a:430-547 [66839] picpiclink
      59. 1hqe picpicxrefxref
        mutant
        1. region a:430-554 [61130] picpiclink
      60. 1s9g picpicxrefxref
        complexed with abz; mutant
        1. region a:430-543 [98755] picpiclink
      61. 1s1u picpicxref
        complexed with nvp; mutant
        1. region a:430-539 [105208] picpiclink
      62. 1rt7 picpicxref
        complexed with po4, uc4
        1. region a:430-539 [33619] picpiclink
      63. 1hni picpicxrefxref
        complexed with aaa; mutant
        1. region a:430-558 [33586] picpiclink
      64. 1rtd picpicxrefxref
        complexed with mg, ttp; mutant
        1. region a:430-554 [33591] picpiclink
        2. region c:430-554 [33592] picpiclink
      65. 1jle picpicxrefxref
        mutant
        1. region a:430-549 [66842] picpiclink
      66. 1rdh picpic
        CA-atoms only
        1. region a:432-556 [33588] picpiclink
        2. region b:432-556 [33589] picpiclink
      67. 1hqu picpicxrefxref
        complexed with hby; mutant
        1. region a:430-556 [61157] picpiclink
      68. 1qe1 picpicxrefxref
        mutant
        1. region a:430-556 [33593] picpiclink
      69. 1s6q picpicxrefxref
        complexed with tpb; mutant
        1. region a:430-552 [98601] picpiclink
      70. 1hpz picpicxrefxref
        complexed with aap; mutant
        1. region a:430-556 [61119] picpiclink
      71. 1t03 picpicxrefxrefxrefxrefxrefxref
        complexed with mg, mrg, tfo; mutant
        1. region a:430-558 [99053] picpiclink
      72. 1sv5 picpicxrefxref
        complexed with 65b; mutant
        1. region a:430-552 [99016] picpiclink
      73. 2hmi picpicxrefxrefxrefxrefxrefxref
        protein/protein/DNA complex; mutant
        1. region a:430-558 [33604] picpiclink
      74. 1hnv picpicxrefxref
        complexed with tbo; mutant
        1. region a:430-558 [33594] picpiclink
      75. 1s6p picpicxrefxref
        complexed with iet, mg; mutant
        1. region a:430-552 [98598] picpiclink
      76. 1suq picpicxrefxref
        complexed with 185, mg; mutant
        1. region a:430-552 [99003] picpiclink
      77. 1n6q picpicxrefxrefxrefxrefxrefxref
        complexed with atm, mg, mrg; mutant
        1. region a:430-558 [80204] picpiclink
      78. 1t05 picpicxrefxref
        complexed with ddg, gol, mg, mrg, tnv; mutant
        1. region a:430-554 [99060] picpiclink
      79. 1n5y picpicxrefxrefxrefxrefxrefxref
        complexed with atm, mg, mrg; mutant
        1. region a:430-558 [80057] picpiclink
      80. 1uwb picpicxrefxref
        complexed with tbo; mutant
        1. region a:430-558 [33596] picpiclink
      81. 1bqm picpicxrefxref
        complexed with hby; mutant
        1. region a:430-556 [33597] picpiclink
      82. 1tvr picpicxrefxref
        complexed with tb9; mutant
        1. region a:430-558 [33595] picpiclink
      83. 1hys picpicxrefxrefxrefxrefxrefxref
        mutant
        1. region a:430-553 [61417] picpiclink
      84. 1bqn picpicxrefxref
        complexed with hby; mutant
        1. region a:430-558 [33599] picpiclink
      85. 3hvt picpicxrefxref
        complexed with nev
        1. region a:430-556 [33598] picpiclink
      86. 1j5o picpicxrefxrefxrefxrefxrefxref
        mutant
        1. region a:430-558 [71568] picpiclink
      87. 1hvu picpicxrefxref
        protein/RNA complex
        1. region a:430-554 [33600] picpiclink
        2. region d:430-554 [33601] picpiclink
        3. region g:430-554 [33602] picpiclink
        4. region j:430-554 [33603] picpiclink
      88. 1o1w picpic
        RNase H domain only
        1. chain a [81078] picpiclink
    2. Human immunodeficiency virus type 2 [TaxId: 11709] [82443] (1)
      1. 1mu2 picpicxrefxref
        complexed with gol, so4; mutant
        1. region a:430-555 [79469] picpiclink
  4. BH0863-like Ribonuclease H [142490]
    new class of RNase H
    1. Bacillus halodurans [TaxId: 86665] [142491] (15)
      SQ Q9KEI9 61-193! SQ Q9KEI9 62-193
      BH0863
      1. 1zbf picpic
        complexed with so4; mutant
        1. region a:62-193 [124850] picpiclink
      2. 2g8k picpic
        automatically matched to 1ZBL A:62-193
        complexed with ca; mutant
        1. region a:62-193 [134774] picpiclink
      3. 2g8i picpic
        automatically matched to 1ZBL A:62-193
        complexed with cl, mn, mpd; mutant
        1. region a:62-193 [134772] picpiclink
      4. 2g8f picpic
        complexed with cl, mg; mutant
        1. region a:61-193 [134770] picpiclink
      5. 2r7y picpic
        automatically matched to d1zbfa1
        complexed with mg, po4, sdg; mutant
        1. region a:62-193 [151657] picpiclink
      6. 2g8v picpic
        automatically matched to 2G8F A:61-193
        complexed with eoh, mg; mutant
        1. region a:61-193 [134787] picpiclink
      7. 2g8h picpic
        automatically matched to 1ZBL A:62-193
        complexed with mg, vo4; mutant
        1. region a:62-193 [134771] picpiclink
      8. 3d0p picpic
        automatically matched to d1zbfa1
        complexed with na; mutant
        1. region a:62-193 [157172] picpiclink
      9. 3d0p picpic
        automatically matched to d1zbfa1
        complexed with na; mutant
        1. region c:62-193 [157173] picpiclink
      10. 1zbi picpic
        automatically matched to 1ZBF A:62-193
        complexed with mg; mutant
        1. region a:62-193 [124853] picpiclink
      11. 1zbi picpic
        automatically matched to 1ZBF A:62-193
        complexed with mg; mutant
        1. region b:62-193 [124854] picpiclink
      12. 2g8w picpic
        automatically matched to 2G8F A:61-193
        complexed with ca; mutant
        1. region a:61-193 [134788] picpiclink
      13. 1zbl picpic
        complexed with mg; mutant
        1. region a:62-193 [124856] picpiclink
      14. 1zbl picpic
        automatically matched to 1ZBL A:62-193
        complexed with mg; mutant
        1. region b:62-193 [124857] picpiclink
      15. 2g8u picpic
        automatically matched to 1ZBF A:62-193
        complexed with mg; mutant
        1. region a:62-193 [134786] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk