Structural Classification of Proteins
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Fold: Rhodanese/Cell cycle control phosphatase

3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Rhodanese/Cell cycle control phosphatase [52820]
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451

Superfamilies:

  1. Rhodanese/Cell cycle control phosphatase [52821] (4)
    Pfam 00581
    the active site structure is similar to those of the families I and II protein phosphatases; the topology can be related by a different circular permutation to the family I topology
    link to SUPERFAMILY database - Superfamily
    1. Cell cycle control phosphatase, catalytic domain [52822] (4)
      1. CDC25a [52823]
        1. Human (Homo sapiens) [TaxId: 9606] [52824] (1)
          1. 1c25 picpic
            mutant
            1. chain a [32698] picpiclink
      2. CDC25b [52825]
        1. Human (Homo sapiens) [TaxId: 9606] [52826] (15)
          1. 1ymk picpic
            automatically matched to d1cwsa_
            complexed with cl
            1. region a:377-550 [123699] picpiclink
          2. 1ymd picpic
            automatically matched to d1cwsa_
            complexed with cl
            1. region a:377-550 [123698] picpiclink
          3. 1yml picpic
            automatically matched to d1cwsa_
            complexed with cl
            1. region a:377-550 [123700] picpiclink
          4. 1qb0 picpic
            complexed with bme, cl, so4
            1. chain a [32699] picpiclink
          5. 1ys0 picpic
            automatically matched to d1cwsa_
            complexed with cl
            1. region a:377-550 [123952] picpiclink
          6. 1cws picpic
            complexed with bme, cl, so4, wo4
            1. chain a [32700] picpiclink
          7. 1ym9 picpic
            automatically matched to d1cwsa_
            complexed with cl
            1. region a:377-550 [123697] picpiclink
          8. 1cwr picpic
            complexed with bme, so4
            1. chain a [32701] picpiclink
          9. 2uzq picpic
            automatically matched to d1cwsa_
            complexed with po4
            1. region a:377-545 [152353] picpiclink
          10. 2uzq picpic
            automatically matched to d1cwsa_
            complexed with po4
            1. region b:377-545 [152354] picpiclink
          11. 2uzq picpic
            automatically matched to d1cwsa_
            complexed with po4
            1. region c:377-545 [152355] picpiclink
          12. 2uzq picpic
            automatically matched to d1cwsa_
            complexed with po4
            1. region d:377-545 [152356] picpiclink
          13. 2uzq picpic
            automatically matched to d1cwsa_
            complexed with po4
            1. region e:377-545 [152357] picpiclink
          14. 2uzq picpic
            automatically matched to d1cwsa_
            complexed with po4
            1. region f:377-545 [152358] picpiclink
          15. 1cwt picpic
            complexed with cl, hgc, so4
            1. chain a [32702] picpiclink
      3. Erk2 binding domain of Mapk phosphatase mkp-3 [69507]
        1. Human (Homo sapiens) [TaxId: 9606] [69508] (1)
          1. 1hzm picpic
            1. chain a [65975] picpiclink
      4. Dual specificity phosphatase Cdc25 [110598]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [110599] (1)
          SQ Q8GY31
          1. 1t3k picpic
            complexed with zn; mutant
            1. chain a [106357] picpiclink
    2. Single-domain sulfurtransferase [69509] (3)
      1. Sulfurtransferase GlpE [69510]
        single-domain rhodanese
        1. Escherichia coli [TaxId: 562] [69511] (2)
          1. 1gmx picpic
            complexed with act, edo
            1. chain a [65355] picpiclink
          2. 1gn0 picpic
            complexed with edo, na
            1. chain a [65358] picpiclink
      2. Polysulfide-sulfur transferase (sulfide dehydrogenase, Sud) [102425]
        1. Wolinella succinogenes [TaxId: 844] [102426] (1)
          1. 1qxn picpic
            complexed with ps5
            1. chain a [96537] picpiclink
            2. chain b [96538] picpiclink
      3. Thiosulfate sulfurtransferase/Senescence-associated protein [110600]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [110601] (1)
          SQ Q39129
          1. 1tq1 picpic
            Structural genomics target
            1. chain a [107198] picpiclink
    3. Multidomain sulfurtransferase (rhodanese) [52827] (6)
      duplication: consists of two domains of this fold
      1. Rhodanese [52828]
        1. Cow (Bos taurus) [TaxId: 9913] [52829] (7)
          1. 1rhs picpic
            1. region a:1-149 [32703] picpiclink
            2. region a:150-293 [32704] picpiclink
          2. 1dp2 picpic
            complex with lipoate
            complexed with lpa
            1. region a:1-149 [32705] picpiclink
            2. region a:150-293 [32706] picpiclink
          3. 1boi picpic
            1. region a:8-149 [32709] picpiclink
            2. region a:150-293 [32710] picpiclink
          4. 1boh picpic
            1. region a:1-149 [32713] picpiclink
            2. region a:150-293 [32714] picpiclink
          5. 2ora picpic
            1. region a:1-149 [32707] picpiclink
            2. region a:150-293 [32708] picpiclink
          6. 1orb picpic
            complexed with act
            1. region a:1-149 [32711] picpiclink
            2. region a:150-293 [32712] picpiclink
          7. 1rhd picpic
            complexed with s s
            1. region a:1-149 [32715] picpiclink
            2. region a:150-293 [32716] picpiclink
      2. Sulfurtransferase [52830]
        1. Azotobacter vinelandii [TaxId: 354] [52831] (3)
          1. 1e0c picpic
            complexed with edo, mo6, so4
            1. region a:1-135 [32717] picpiclink
            2. region a:136-271 [32718] picpiclink
          2. 1h4k picpic
            complexed with edo, po2, so4
            1. region x:1-135 [70869] picpiclink
            2. region x:136-271 [70870] picpiclink
          3. 1h4m picpic
            complexed with edo
            1. region x:1-135 [70875] picpiclink
            2. region x:136-271 [70876] picpiclink
        2. Thermus thermophilus [TaxId: 274] [110602] (1)
          SQ Q5SJI0
          1. 1uar picpic
            complexed with gol
            1. region a:2-144 [107762] picpiclink
            2. region a:145-285 [107763] picpiclink
      3. 3-mercaptopyruvate sulfurtransferase [102427]
        1. Leishmania major [TaxId: 5664] [102428] (1)
          1. 1okg picpicxref
            complexed with ca, csr, so3; mutant
            1. region a:7-162 [93250] picpiclink
            2. region a:163-301 [93251] picpiclink
        2. Escherichia coli [TaxId: 562] [102429] (1)
          1. 1urh picpic
            complexed with so3
            1. region a:2-148 [99829] picpiclink
            2. region a:149-268 [99830] picpiclink
            3. region b:2-148 [99831] picpiclink
            4. region b:149-268 [99832] picpiclink
      4. Thiosulfate sulfurtransferase PA2603 [142351]
        1. Pseudomonas aeruginosa [TaxId: 287] [142352] (4)
          SQ Q9I0N4 105-240! SQ Q9I0N4 241-370! SQ Q9I0N4 371-527! SQ Q9I0N4 4-104
          1. 1yt8 picpic
            complexed with gol, so3
            1. region a:107-242 [123996] picpiclink
          2. 1yt8 picpic
            complexed with gol, so3
            1. region a:6-106 [123997] picpiclink
          3. 1yt8 picpic
            complexed with gol, so3
            1. region a:373-529 [123998] picpiclink
          4. 1yt8 picpic
            complexed with gol, so3
            1. region a:243-372 [123999] picpiclink
    4. Ubiquitin carboxyl-terminal hydrolase 8, USP8 [117586] (1)
      1. Ubiquitin carboxyl-terminal hydrolase 8, USP8 [117587]
        1. Human (Homo sapiens) [TaxId: 9606] [117588] (4)
          SQ P40818 174-317
          1. 2gwf picpicxrefxrefxref
            automatically matched to d1whba_
            1. region a:181-315 [135802] picpiclink
          2. 2gwf picpicxrefxrefxref
            automatically matched to d1whba_
            1. region c:181-313 [135803] picpiclink
          3. 2gwf picpicxrefxrefxref
            automatically matched to d1whba_
            1. region e:181-315 [135804] picpiclink
          4. 1whb picpic
            Structural genomics target
            1. chain a [114639] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk