Structural Classification of Proteins
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Family: Eukaryotic glutathione synthetase, substrate-binding domain

circularly permuted version of prokaryotic enzyme

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: PreATP-grasp domain [52439]
    3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
    possible rudiment form of Rossmann-fold domain
  4. Superfamily: PreATP-grasp domain [52440]
    precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function
    link to SUPERFAMILY database - Superfamily
  5. Family: Eukaryotic glutathione synthetase, substrate-binding domain [52460]
    circularly permuted version of prokaryotic enzyme

Protein Domains:

  1. Eukaryotic glutathione synthetase, substrate-binding domain [52461]
    1. Human (Homo sapiens) [TaxId: 9606] [52462] (1)
      1. 2hgs picpicxref
        complexed with adp, gsh, mg, sul
        1. region a:202-303 [31722] picpiclink
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82378] (2)
      1. 1m0w picpicxref
        complexed with 3gc, anp, mg, so4
        1. region a:216-323 [78363] picpiclink
        2. region b:1217-1323 [78365] picpiclink
      2. 1m0t picpicxref
        complexed with so4
        1. region a:214-323 [78355] picpiclink
        2. region b:1214-1323 [78357] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk