Structural Classification of Proteins
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Fold: Aminoacid dehydrogenase-like, N-terminal domain

core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Aminoacid dehydrogenase-like, N-terminal domain [53222]
    core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134

Superfamilies:

  1. Aminoacid dehydrogenase-like, N-terminal domain [53223] (5)
    link to SUPERFAMILY database - Superfamily
    1. Aminoacid dehydrogenases [53224] (10)
      dimerisation domain; contains additional structures including two extra N-terminal strands in the beta-sheet
      1. Glutamate dehydrogenase [53225]
        1. Clostridium symbiosum [TaxId: 1512] [53226] (4) picpic
        2. Archaeon Pyrococcus furiosus [TaxId: 2261] [53227] (1) picpic
        3. Archaeon Thermococcus profundus [TaxId: 49899] [64106] (1) picpic
        4. Archaeon Thermococcus litoralis [TaxId: 2265] [53228] (1) picpic
        5. Thermotoga maritima [TaxId: 2336] [53229] (3) picpic
        6. Cow (Bos taurus) [TaxId: 9913] [53230] (5) picpic
        7. Human (Homo sapiens) [TaxId: 9606] [75252] (2) picpic
        8. Pyrobaculum islandicum [TaxId: 2277] [117471] (1) picpic
          SQ Q9Y8I4
      2. Leucine dehydrogenase [53231]
        1. Bacillus sphaericus [TaxId: 1421] [53232] (1) picpic
      3. Phenylalanine dehydrogenase [53233]
        1. Rhodococcus sp., M4 [TaxId: 1831] [53234] (4) picpic
    2. Tetrahydrofolate dehydrogenase/cyclohydrolase [53235] (3)
      1. Tetrahydrofolate dehydrogenase/cyclohydrolase [53236]
        the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated
        1. Human (Homo sapiens) [TaxId: 9606] [53237] (4) picpic
        2. Escherichia coli [TaxId: 562] [53238] (1) picpic
        3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [53239] (2) picpic
    3. Methylene-tetrahydromethanopterin dehydrogenase [82333] (1)
      1. Methylene-tetrahydromethanopterin dehydrogenase [82334]
        1. Methylobacterium extorquens [TaxId: 408] [82335] (2) picpic
    4. Shikimate dehydrogenase-like [82336] (5)
      1. Putative shikimate dehydrogenase YdiB [82337]
        1. Escherichia coli [TaxId: 562] [82338] (3) picpic
      2. Shikimate 5-dehydrogenase-like protein HI0607 [89582]
        1. Haemophilus influenzae [TaxId: 727] [89583] (1) picpic
      3. Shikimate 5-dehydrogenase AroE [89584]
        1. Escherichia coli [TaxId: 562] [89585] (1) picpic
        2. Haemophilus influenzae [TaxId: 727] [102224] (2) picpic
        3. Archaeon Methanococcus jannaschii [TaxId: 2190] [89586] (1) picpic
          MJ1084
    5. Malic enzyme N-domain [53240] (4)
      Pfam 00390; decorated with additional structures; includes N-terminal additional subdomains and extra N-terminal strand
      1. Mitochondrial NAD(P)-dependent malic enzyme [53241]
        1. Human (Homo sapiens) [TaxId: 9606] [53242] (10) picpic
        2. Domestic pigeon (Columba livia) [TaxId: 8932] [75253] (1) picpic
        3. Pig roundworm (Ascaris suum) [TaxId: 6253] [75254] (2) picpic
      2. Malate oxidoreductase (malic enzyme) [110452]
        1. Thermotoga maritima [TaxId: 2336] [110453] (5) picpic
          SQ Q9WZ12
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk