Structural Classification of Proteins
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Fold: Aminoacid dehydrogenase-like, N-terminal domain

core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Aminoacid dehydrogenase-like, N-terminal domain [53222]
    core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134

Superfamilies:

  1. Aminoacid dehydrogenase-like, N-terminal domain [53223] (5)
    link to SUPERFAMILY database - Superfamily
    1. Aminoacid dehydrogenases [53224] (10)
      dimerisation domain; contains additional structures including two extra N-terminal strands in the beta-sheet
      1. Glutamate dehydrogenase [53225]
        1. Clostridium symbiosum [TaxId: 1512] [53226] (4)
          1. 1bgv picpicxref
            1. region a:1-194 [33865] picpiclink
          2. 1k89 picpicxref
            mutant
            1. region a:1-194 [33866] picpiclink
          3. 1hrd picpicxref
            1. region a:1-194 [33867] picpiclink
            2. region b:1-194 [33868] picpiclink
            3. region c:1-194 [33869] picpiclink
          4. 1aup picpicxref
            mutant
            1. region a:1-192 [33870] picpiclink
        2. Archaeon Pyrococcus furiosus [TaxId: 2261] [53227] (1)
          1. 1gtm picpicxref
            complexed with so4
            1. region a:3-180 [33871] picpiclink
            2. region b:3-180 [33872] picpiclink
            3. region c:3-180 [33873] picpiclink
        3. Archaeon Thermococcus profundus [TaxId: 49899] [64106] (1)
          1. 1euz picpicxref
            complexed with so4
            1. region a:4-180 [59514] picpiclink
            2. region b:4-180 [59516] picpiclink
            3. region c:4-180 [59518] picpiclink
            4. region d:4-180 [59520] picpiclink
            5. region e:4-180 [59522] picpiclink
            6. region f:3-180 [59524] picpiclink
        4. Archaeon Thermococcus litoralis [TaxId: 2265] [53228] (1)
          1. 1bvu picpicxref
            1. region a:3-180 [33874] picpiclink
            2. region b:3-180 [33875] picpiclink
            3. region c:3-180 [33876] picpiclink
            4. region d:3-180 [33877] picpiclink
            5. region e:3-180 [33878] picpiclink
            6. region f:3-180 [33879] picpiclink
        5. Thermotoga maritima [TaxId: 2336] [53229] (3)
          1. 1b26 picpicxref
            1. region a:4-178 [33880] picpiclink
            2. region b:4-178 [33881] picpiclink
            3. region c:4-178 [33882] picpiclink
            4. region d:4-178 [33883] picpiclink
            5. region e:4-178 [33884] picpiclink
            6. region f:4-178 [33885] picpiclink
          2. 2tmg picpicxref
            1. region a:4-178 [33886] picpiclink
            2. region b:4-178 [33887] picpiclink
            3. region c:4-178 [33888] picpiclink
            4. region d:4-178 [33889] picpiclink
            5. region e:4-178 [33890] picpiclink
            6. region f:4-178 [33891] picpiclink
          3. 1b3b picpicxref
            1. region a:4-178 [33892] picpiclink
            2. region b:4-178 [33893] picpiclink
            3. region c:4-178 [33894] picpiclink
            4. region d:4-178 [33895] picpiclink
            5. region e:4-178 [33896] picpiclink
            6. region f:4-178 [33897] picpiclink
        6. Cow (Bos taurus) [TaxId: 9913] [53230] (5)
          1. 1hwx picpicxref
            complexed with glu, gtp, nai
            1. region a:1-208 [33898] picpiclink
            2. region b:1-208 [33899] picpiclink
            3. region c:1-208 [33900] picpiclink
            4. region d:1-208 [33901] picpiclink
            5. region e:1-208 [33902] picpiclink
            6. region f:1-208 [33903] picpiclink
          2. 1nr7 picpicxref
            1. region a:6-208 [86096] picpiclink
            2. region b:6-208 [86098] picpiclink
            3. region c:6-208 [86100] picpiclink
            4. region d:6-208 [86102] picpiclink
            5. region e:6-208 [86104] picpiclink
            6. region f:6-208 [86106] picpiclink
            7. region g:6-208 [86108] picpiclink
            8. region h:6-208 [86110] picpiclink
            9. region i:6-208 [86112] picpiclink
            10. region j:6-208 [86114] picpiclink
            11. region k:6-208 [86116] picpiclink
            12. region l:6-208 [86118] picpiclink
          3. 1hwz picpicxref
            complexed with glu, gtp, ndp
            1. region a:1-208 [33904] picpiclink
            2. region b:1-208 [33905] picpiclink
            3. region c:1-208 [33906] picpiclink
            4. region d:1-208 [33907] picpiclink
            5. region e:1-208 [33908] picpiclink
            6. region f:1-208 [33909] picpiclink
          4. 1hwy picpicxref
            complexed with akg, nad, po4
            1. region a:1-208 [33910] picpiclink
            2. region b:1-208 [33911] picpiclink
            3. region c:1-208 [33912] picpiclink
            4. region d:1-208 [33913] picpiclink
            5. region e:1-208 [33914] picpiclink
            6. region f:1-208 [33915] picpiclink
          5. 1nqt picpicxref
            complexed with adp
            1. region a:6-208 [86053] picpiclink
            2. region b:6-208 [86055] picpiclink
            3. region c:6-208 [86057] picpiclink
            4. region d:6-208 [86059] picpiclink
            5. region e:6-208 [86061] picpiclink
            6. region f:6-208 [86063] picpiclink
            7. region g:6-208 [86065] picpiclink
            8. region h:6-208 [86067] picpiclink
            9. region i:6-208 [86069] picpiclink
            10. region j:6-208 [86071] picpiclink
            11. region k:6-208 [86073] picpiclink
            12. region l:6-208 [86075] picpiclink
        7. Human (Homo sapiens) [TaxId: 9606] [75252] (2)
          1. 1l1f picpicxref
            1. region a:10-212 [73457] picpiclink
            2. region b:10-212 [73459] picpiclink
            3. region c:10-212 [73461] picpiclink
            4. region d:10-212 [73463] picpiclink
            5. region e:10-212 [73465] picpiclink
            6. region f:10-212 [73467] picpiclink
          2. 1nr1 picpicxref
            mutant
            1. region a:10-212 [86081] picpiclink
            2. region b:10-212 [86083] picpiclink
            3. region c:10-212 [86085] picpiclink
            4. region d:10-212 [86087] picpiclink
            5. region e:10-212 [86089] picpiclink
            6. region f:10-212 [86091] picpiclink
        8. Pyrobaculum islandicum [TaxId: 2277] [117471] (1)
          SQ Q9Y8I4
          1. 1v9l picpicxref
            complexed with nad
            1. region a:4-179 [113584] picpiclink
            2. region b:4-179 [113586] picpiclink
            3. region c:4-179 [113588] picpiclink
            4. region d:4-179 [113590] picpiclink
            5. region e:4-179 [113592] picpiclink
            6. region f:4-179 [113594] picpiclink
      2. Leucine dehydrogenase [53231]
        1. Bacillus sphaericus [TaxId: 1421] [53232] (1)
          1. 1leh picpicxref
            1. region a:1-134 [33916] picpiclink
            2. region b:1-134 [33917] picpiclink
      3. Phenylalanine dehydrogenase [53233]
        1. Rhodococcus sp., M4 [TaxId: 1831] [53234] (4)
          1. 1c1d picpicxref
            complexed with ioh, k, na, nad, phe, po4
            1. region a:1-148 [33918] picpiclink
            2. region b:1-148 [33919] picpiclink
          2. 1c1x picpicxref
            complexed with ioh, k, lla, na, nad, po4
            1. region a:1-148 [33920] picpiclink
            2. region b:1-148 [33921] picpiclink
          3. 1bw9 picpicxref
            complexed with 1py, edo, ipa, k, na, nad, po4
            1. region a:1-148 [33922] picpiclink
            2. region b:401-548 [33923] picpiclink
          4. 1bxg picpicxref
            complexed with hci, k, nad, po4
            1. region a:1-148 [33924] picpiclink
            2. region b:401-548 [33925] picpiclink
    2. Tetrahydrofolate dehydrogenase/cyclohydrolase [53235] (3)
      1. Tetrahydrofolate dehydrogenase/cyclohydrolase [53236]
        the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated
        1. Human (Homo sapiens) [TaxId: 9606] [53237] (4)
          1. 1a4i picpicxref
            complexed with ndp
            1. region a:2-126 [33926] picpiclink
            2. region b:2-126 [33927] picpiclink
          2. 1dig picpicxref
            complexed with act, l37, nap
            1. region a:2-126 [33930] picpiclink
            2. region b:1002-1126 [33931] picpiclink
          3. 1dia picpicxref
            complexed with l24, nap
            1. region a:2-126 [33928] picpiclink
            2. region b:1002-1126 [33929] picpiclink
          4. 1dib picpicxref
            complexed with l34, nap
            1. region a:2-126 [33932] picpiclink
            2. region b:1002-1126 [33933] picpiclink
        2. Escherichia coli [TaxId: 562] [53238] (1)
          1. 1b0a picpicxref
            1. region a:2-122 [33934] picpiclink
        3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [53239] (2)
          1. 1edz picpicxref
            1. region a:3-148 [33935] picpiclink
          2. 1ee9 picpicxref
            complexed with nad
            1. region a:3-148 [33936] picpiclink
    3. Methylene-tetrahydromethanopterin dehydrogenase [82333] (1)
      1. Methylene-tetrahydromethanopterin dehydrogenase [82334]
        1. Methylobacterium extorquens [TaxId: 408] [82335] (2)
          1. 1lua picpicxref
            complexed with nap
            1. region a:2-97 [78217] picpiclink
            2. region b:2-97 [78219] picpiclink
            3. region c:2-97 [78221] picpiclink
          2. 1lu9 picpicxref
            1. region a:2-97 [78211] picpiclink
            2. region b:2-97 [78213] picpiclink
            3. region c:2-97 [78215] picpiclink
    4. Shikimate dehydrogenase-like [82336] (5)
      1. Putative shikimate dehydrogenase YdiB [82337]
        1. Escherichia coli [TaxId: 562] [82338] (3)
          1. 1vi2 picpicxref
            structural genomics
            complexed with nad, so4
            1. region a:5-106 [100727] picpiclink
            2. region b:6-106 [100729] picpiclink
          2. 1npd picpicxref
            structural genomics
            complexed with mse, nad
            1. region a:1-106 [80682] picpiclink
            2. region b:1-106 [80684] picpiclink
          3. 1o9b picpicxref
            complexed with mse, nad, po4
            1. region a:7-106 [81238] picpiclink
            2. region b:7-106 [81240] picpiclink
      2. Shikimate 5-dehydrogenase-like protein HI0607 [89582]
        1. Haemophilus influenzae [TaxId: 727] [89583] (1)
          1. 1npy picpicxref
            structural genomics
            complexed with ace
            1. region a:1-102 [85996] picpiclink
            2. region b:1-102 [85998] picpiclink
            3. region c:1-102 [86000] picpiclink
            4. region d:1-102 [86002] picpiclink
      3. Shikimate 5-dehydrogenase AroE [89584]
        1. Escherichia coli [TaxId: 562] [89585] (1)
          1. 1nyt picpicxref
            complexed with dtt, nap, so4
            1. region a:1-101 [86418] picpiclink
            2. region b:1-101 [86420] picpiclink
            3. region c:1-101 [86422] picpiclink
            4. region d:1-101 [86424] picpiclink
        2. Haemophilus influenzae [TaxId: 727] [102224] (2)
          1. 1p77 picpicxref
            complexed with act, atr
            1. region a:1-101 [94215] picpiclink
          2. 1p74 picpicxref
            1. region a:1-101 [94207] picpiclink
            2. region b:1-101 [94209] picpiclink
        3. Archaeon Methanococcus jannaschii [TaxId: 2190] [89586] (1)
          MJ1084
          1. 1nvt picpicxref
            structural genomics
            complexed with nap, zn
            1. region a:1-110 [86271] picpiclink
            2. region b:1-110 [86273] picpiclink
    5. Malic enzyme N-domain [53240] (4)
      Pfam 00390; decorated with additional structures; includes N-terminal additional subdomains and extra N-terminal strand
      1. Mitochondrial NAD(P)-dependent malic enzyme [53241]
        1. Human (Homo sapiens) [TaxId: 9606] [53242] (10)
          1. 1pj3 picpicxref
            complexed with fum, mn, nad, pyr
            1. region a:21-279 [94727] picpiclink
            2. region b:1021-1279 [94729] picpiclink
            3. region c:2021-2279 [94731] picpiclink
            4. region d:3021-3279 [94733] picpiclink
          2. 1gz3 picpicxref
            complexed with atp, fum, mn, oxl; mutant
            1. region a:20-279 [83394] picpiclink
            2. region b:20-279 [83396] picpiclink
            3. region c:20-279 [83398] picpiclink
            4. region d:20-279 [83400] picpiclink
          3. 1gz4 picpicxref
            complexed with atp, fum, mn, mse, ttn
            1. region a:23-279 [70795] picpiclink
            2. region b:23-279 [70797] picpiclink
            3. region c:23-279 [70799] picpiclink
            4. region d:23-279 [70801] picpiclink
          4. 1pj2 picpicxref
            complexed with fum, mlt, mn, nai
            1. region a:21-279 [94719] picpiclink
            2. region b:1021-1279 [94721] picpiclink
            3. region c:2021-2279 [94723] picpiclink
            4. region d:3021-3279 [94725] picpiclink
          5. 1pj4 picpicxref
            complexed with atp, fum, mlt, mn
            1. region a:22-279 [94735] picpiclink
            2. region b:1022-1279 [94737] picpiclink
            3. region c:2022-2279 [94739] picpiclink
            4. region d:3022-3279 [94741] picpiclink
          6. 1do8 picpicxref
            complexed with mn, nad, oxl; mutant
            1. region a:21-279 [33937] picpiclink
            2. region b:21-279 [33938] picpiclink
            3. region c:21-279 [33939] picpiclink
            4. region d:21-279 [33940] picpiclink
          7. 1qr6 picpicxref
            complexed with nad; mutant
            1. region a:23-279 [33941] picpiclink
            2. region b:1023-1279 [33942] picpiclink
          8. 1efl picpicxref
            complexed with mg, nad, ttn
            1. region a:21-279 [33943] picpiclink
            2. region b:21-279 [33944] picpiclink
            3. region c:21-279 [33945] picpiclink
            4. region d:21-279 [33946] picpiclink
          9. 1efk picpicxref
            complexed with mak, mo1, nad
            1. region a:21-279 [33947] picpiclink
            2. region b:21-279 [33948] picpiclink
            3. region c:21-279 [33949] picpiclink
            4. region d:21-279 [33950] picpiclink
          10. 1pjl picpicxref
            complexed with lu, mse, nad
            1. region a:23-279 [88124] picpiclink
            2. region b:1023-1279 [88126] picpiclink
            3. region c:2023-2279 [88128] picpiclink
            4. region d:3023-3279 [88130] picpiclink
            5. region e:4023-4279 [88132] picpiclink
            6. region f:5023-5279 [88134] picpiclink
            7. region g:6023-6279 [88136] picpiclink
            8. region h:7023-7279 [88138] picpiclink
        2. Domestic pigeon (Columba livia) [TaxId: 8932] [75253] (1)
          1. 1gq2 picpicxref
            complexed with cl, mn, mse, na, nap, oxl
            1. region a:23-279 [70309] picpiclink
            2. region b:23-279 [70311] picpiclink
            3. region c:23-279 [70313] picpiclink
            4. region d:23-279 [70315] picpiclink
            5. region e:23-279 [70317] picpiclink
            6. region f:23-279 [70319] picpiclink
            7. region g:23-279 [70321] picpiclink
            8. region h:23-279 [70323] picpiclink
            9. region i:23-279 [70325] picpiclink
            10. region j:23-279 [70327] picpiclink
            11. region k:23-279 [70329] picpiclink
            12. region l:23-279 [70331] picpiclink
            13. region m:23-279 [70333] picpiclink
            14. region n:23-279 [70335] picpiclink
            15. region o:23-279 [70337] picpiclink
            16. region p:23-279 [70339] picpiclink
        3. Pig roundworm (Ascaris suum) [TaxId: 6253] [75254] (2)
          1. 1o0s picpicxref
            complexed with nai, ttn
            1. region a:2-295 [86541] picpiclink
            2. region b:2-295 [86543] picpiclink
          2. 1llq picpicxref
            complexed with nad
            1. region a:2-295 [74009] picpiclink
            2. region b:2-295 [74011] picpiclink
      2. Malate oxidoreductase (malic enzyme) [110452]
        1. Thermotoga maritima [TaxId: 2336] [110453] (5)
          SQ Q9WZ12
          1. 1vl6 picpicxref
            Structural genomics target
            1. region a:1-154 [108725] picpiclink
            2. region b:1-154 [108727] picpiclink
            3. region c:1-154 [108729] picpiclink
            4. region d:1-154 [108731] picpiclink
          2. 2hae picpicxrefxrefxrefxref
            automatically matched to d1vl6a2
            complexed with nad, zn
            1. region a:2-154 [136279] picpiclink
          3. 2hae picpicxrefxrefxrefxref
            automatically matched to d1vl6a2
            complexed with nad, zn
            1. region b:2-154 [136281] picpiclink
          4. 2hae picpicxrefxrefxrefxref
            automatically matched to d1vl6a2
            complexed with nad, zn
            1. region c:2-154 [136283] picpiclink
          5. 2hae picpicxrefxrefxrefxref
            automatically matched to d1vl6a2
            complexed with nad, zn
            1. region d:2-154 [136285] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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