Structural Classification of Proteins

Fold: Thiolase-like

: consists of two similar domains related by pseudo dyad; duplication
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: Thiolase-like [53900]
consists of two similar domains related by pseudo dyad; duplication
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest

Superfamilies:

Thiolase-like [53901] (2)
uperfamily
1. Thiolase-related [53902] (12)
  1. Thiolase [53903]
    topology of each domain is similar to the first domain of phosphoglucomutase
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [53904] (2)
  2. Biosynthetic thiolase [53905]
    1. Zoogloea ramigera [TaxId: 350] [53906] (12)
      SQ P07097
  3. Beta-ketoacyl-ACP synthase I [53907]
    1. Escherichia coli [TaxId: 562] [53908] (135)
      SQ P14926
  4. Beta-ketoacyl-ACP synthase II [53909]
    1. Escherichia coli [TaxId: 562] [53910] (10)
    2. Synechocystis sp. [TaxId: 1143] [53911] (1)
    3. Thermus thermophilus [TaxId: 274] [89792] (1)
    4. Streptococcus pneumoniae [TaxId: 1313] [89793] (4)
    5. Thale cress (Arabidopsis thaliana), mitochondrial isoform [TaxId: 3702] [117749] (5)
      SQ Q8L3X9
  5. Actinorhodin polyketide putative beta-ketoacyl synthase 1, KasA [110752]
    1. Streptomyces coelicolor [TaxId: 1902] [110753] (1)
      SQ Q02059
  6. Actinorhodin polyketide putative beta-ketoacyl synthase 2, KasB [110754]
    1. Streptomyces coelicolor [TaxId: 1902] [110755] (1)
      SQ Q02062
  7. Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase) [110756]
    1. Pseudomonas fragi [TaxId: 296] [110757] (7)
      SQ P28790
  8. Beta-ketoadipyl CoA thiolase [117750]
    1. Thermus thermophilus [TaxId: 274] [117751] (1)
      SQ Q5SJM1
2. Chalcone synthase-like [53914] (10)
  1. Chalcone synthase [53915]
    1. Alfalfa (Medicago sativa) [TaxId: 3879] [53916] (16)
      SQ P30074
  2. Pyrone synthase (PyS, chalcone synthase 2) [53917]
    1. Gerbera hybrid cultivar [TaxId: 18101] [53918] (2)
  3. Ketoacyl-ACP synthase III (FabH) [53912]
    1. Escherichia coli [TaxId: 562] [53913] (15)
    2. Mycobacterium tuberculosis [TaxId: 1773] [64196] (42)
    3. Thermus thermophilus [TaxId: 274] [89794] (1)
  4. Priming beta-ketosynthase from the r1128 polyketide biosynthetic pathway [82561]
    1. Streptomyces sp. r1128 [TaxId: 140437] [82562] (1)
  5. Polyketide synthase PKS18 [110758]
    1. Mycobacterium tuberculosis [TaxId: 1773] [110759] (2)
      SQ Q79FQ0
  6. 3-hydroxy-3-methylglutaryl CoA synthase MvaS [110760]
    most similar to FabH
    1. Staphylococcus aureus [TaxId: 1280] [110761] (5)
      SQ Q7A3F6
  7. Putative polyketide synthase SCO1206 [110762]
    1. Streptomyces coelicolor [TaxId: 1902] [110763] (1)
      SQ Q9FCA7
  8. Dihydropinosylvin synthase [117752]
    1. Scots pine (Pinus sylvestris) [TaxId: 3349] [117753] (1)
      SQ Q02323