Structural Classification of Proteins
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Family: Transferrin

further duplication: composed of two two-domain lobes

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Periplasmic binding protein-like II [53849]
    consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
    mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest
  4. Superfamily: Periplasmic binding protein-like II [53850]
    Similar in architecture to the superfamily I but partly differs in topology
    link to SUPERFAMILY database - Superfamily
  5. Family: Transferrin [53888]
    further duplication: composed of two two-domain lobes

Protein Domains:

  1. Lactoferrin [53889]
    1. Human (Homo sapiens) [TaxId: 9606] [53890] (23)
      1. 1eh3 picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [35842] picpiclink
      2. 1h45 picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [76674] picpiclink
      3. 1h44 picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [76673] picpiclink
      4. 1lct picpic
        N-terminal lobe
        complexed with co3, fe
        1. chain a [35836] picpiclink
      5. 1cb6 picpic
        complexed with cl
        1. region a:1001-1334 [35840] picpiclink
        2. region a:1335-1691 [35841] picpiclink
      6. 1lcf picpic
        complexed with co3, cu, nag, oxl
        1. region a:1-334 [35838] picpiclink
        2. region a:335-691 [35839] picpiclink
      7. 1fck picpic
        complexed with ce, co3
        1. region a:1-334 [35843] picpiclink
        2. region a:335-691 [35844] picpiclink
      8. 1dsn picpic
        complexed with co3, fe; mutant
        1. chain a [35837] picpiclink
      9. 1h43 picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [76672] picpiclink
      10. 2bjj picpic
        automatically matched to d1n76a1
        complexed with co3, fe, nag
        1. region x:3-335 [128622] picpiclink
      11. 2bjj picpic
        automatically matched to d1n76a2
        complexed with co3, fe, nag
        1. region x:336-692 [128623] picpiclink
      12. 1lfg picpic
        complexed with co3, fe, fuc, nag
        1. region a:1-334 [35845] picpiclink
        2. region a:335-691 [35846] picpiclink
      13. 1b0l picpic
        complexed with crb, mtl; mutant
        1. region a:1-334 [35847] picpiclink
        2. region a:335-691 [35848] picpiclink
      14. 1hse picpic
        complexed with co3, fe; mutant
        1. chain a [35849] picpiclink
      15. 1sqy picpic
        complexed with co3, fe, nag
        1. region a:1-334 [98973] picpiclink
        2. region a:335-691 [98974] picpiclink
      16. 1bka picpic
        complexed with fe, oxl
        1. region a:4-334 [35852] picpiclink
        2. region a:335-691 [35853] picpiclink
      17. 1lfi picpic
        complexed with co3, cu, fuc, nag
        1. region a:1-334 [35850] picpiclink
        2. region a:335-691 [35851] picpiclink
      18. 1vfe picpic
        complexed with co3, fe; mutant
        1. chain a [35854] picpiclink
      19. 1l5t picpic
        N-terminal lobe
        mutant
        1. chain a [73601] picpiclink
        2. chain b [73602] picpiclink
      20. 1lfh picpic
        complexed with cl
        1. region a:1-334 [35856] picpiclink
        2. region a:335-691 [35857] picpiclink
      21. 1vfd picpic
        complexed with co3, fe; mutant
        1. chain a [35855] picpiclink
      22. 1n76 picpic
        complexed with co3, fe, na
        1. region a:2-334 [80226] picpiclink
        2. region a:335-691 [80227] picpiclink
      23. 1lgb picpicxref
        N2-fragment (one domain fragment)
        complexed with ca, fuc, gal, man, mn, nag
        1. chain c [35858] picpiclink
    2. Cow (Bos taurus) [TaxId: 9913] [53891] (44)
      1. 2b6d picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, dif, eoh, fe, man, nag, so4, zn
        1. region a:342-685 [127985] picpiclink
      2. 2b65 picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, mal, man, nag, so4, zn
        1. region a:342-685 [127953] picpiclink
      3. 2g93 picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, mma, nag, so4, zn
        1. region a:342-685 [134789] picpiclink
      4. 2ays picpic
        automatically matched to d1nkxa_
        complexed with a2g, bma, co3, fe, man, nag, so4, zn
        1. region a:342-685 [127570] picpiclink
      5. 2p1s picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, gfg, man, nag, so4, zn
        1. region a:342-685 [139458] picpiclink
      6. 1nkx picpic
        C-terminal lobe
        complexed with co3, fe, man, nag, zn
        1. chain a [91943] picpiclink
      7. 2dyx picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, lak, man, nag, so4, zn
        1. region a:342-685 [131955] picpiclink
      8. 2r71 picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, ins, man, nag, so4, zn
        1. region a:342-685 [151625] picpiclink
      9. 2dxy picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, so4, tre, zn
        1. region a:342-685 [131879] picpiclink
      10. 2g5j picpic
        automatically matched to d1nkxa_
        complexed with ain, bma, co3, eoh, fe, man, nag, ndg, so4, zn; mutant
        1. region a:342-685 [134666] picpiclink
      11. 2dwa picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, fuc, man, nag, so4, zn; mutant
        1. region a:342-685 [131848] picpiclink
      12. 2e0s picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, ram, so4, zn
        1. region a:342-685 [131956] picpiclink
      13. 1sdx picpic
        C-terminal lobe
        complexed with co3, man, nag, so4, zn; mutant
        1. chain a,e [98812] picpiclink
      14. 2o1l picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, man, nag, so4, zn
        1. region a:342-685 [138873] picpiclink
      15. 2alu picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, ndg, so4, zn; mutant
        1. region a:342-685 [126981] picpiclink
      16. 2dwi picpic
        automatically matched to d1nkxa_
        complexed with bma, cbi, co3, fe, man, nag, so4, zn; mutant
        1. region a:342-685 [131852] picpiclink
      17. 3cfl picpic
        automatically matched to d1nkxa_
        complexed with 5ch, co3, fe, nag, so4, zn
        1. region a:342-685 [156613] picpiclink
      18. 2dwj picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, fru, gal, glc, man, nag, so4, zn
        1. region a:342-685 [131853] picpiclink
      19. 2ocu picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, so4, tyl, zn
        1. region a:342-685 [139020] picpiclink
      20. 2nwj picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, so4, zn
        1. region a:342-685 [138719] picpiclink
      21. 2nuv picpic
        automatically matched to d1nkxa_
        complexed with 2tn, co3, fe, man, nag, so4, zn
        1. region a:342-685 [138623] picpiclink
      22. 2alt picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, imn, man, nag, so4, zn; mutant
        1. region a:342-685 [126980] picpiclink
      23. 2dp8 picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, man, nag, so4, zn
        1. region a:342-685 [131608] picpiclink
      24. 3ci8 picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, nag, nio, so4, zn
        1. region a:342-685 [156663] picpiclink
      25. 2fa7 picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, ndg, so4, zn; mutant
        1. region a:342-685 [133184] picpiclink
      26. 2qje picpic
        automatically matched to d1nkxa_
        complexed with bad, co3, fe, man, nag, so4, zn
        1. region a:342-685 [150829] picpiclink
      27. 2doj picpic
        automatically matched to d1nkxa_
        complexed with adn, bma, co3, fe, man, nag, ndg, so4, zn
        1. region a:342-685 [131604] picpiclink
      28. 3crb picpic
        automatically matched to d1nkxa_
        complexed with co3, cou, fe, nag, so4, zn
        1. region a:342-685 [156945] picpiclink
      29. 2h4i picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, lbt, man, nag, so4, zn
        1. region a:342-685 [136075] picpiclink
      30. 2px1 picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, nag, ndg, rip, so4, zn
        1. region a:342-685 [139774] picpiclink
      31. 2dqv picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, gal, man, nag, so4, zn
        1. region a:342-685 [131643] picpiclink
      32. 2dvc picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, man, nag, so4, suc, zn; mutant
        1. region a:342-685 [131777] picpiclink
      33. 3e9x picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, man, nag, nim, so4, zn
        1. region a:342-685 [158073] picpiclink
      34. 2e1s picpic
        automatically matched to d1nkxa_
        complexed with ara, bma, co3, fe, man, nag, so4, zn
        1. region a:342-685 [131971] picpiclink
      35. 2dwh picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, nag, so4, zn; mutant
        1. region a:342-685 [131851] picpiclink
      36. 2dxr picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, man, nag, so4, sor, zn; mutant
        1. region a:342-685 [131878] picpiclink
      37. 2zmb picpic
        automatically matched to d1nkxa_
        complexed with bgc, co3, fe, man, nag, pxb, so4, zn
        1. region a:342-685 [154689] picpiclink
      38. 2o51 picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, fru, man, nag, so4, zn
        1. region a:342-685 [138917] picpiclink
      39. 2r9j picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, nag, nca, so4, zn
        1. region a:342-685 [151788] picpiclink
      40. 2q8j picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, m2p, man, nag, so4, zn
        1. region a:342-685 [139890] picpiclink
      41. 2hca picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, glc, man, nag, so4, zn
        1. region a:342-685 [136324] picpiclink
      42. 2dsf picpic
        automatically matched to d1nkxa_
        complexed with bma, co3, fe, lxc, man, nag, ndg, so4, zn
        1. region a:342-685 [131688] picpiclink
      43. 2ds9 picpic
        automatically matched to d1nkxa_
        complexed with co3, fe, man, nag, so4, zn
        1. region a:342-685 [131687] picpiclink
      44. 1blf picpic
        complexed with co3, fe, man, nag
        1. region a:5-333 [35859] picpiclink
        2. region a:334-689 [35860] picpiclink
    3. Domestic water buffalo (Bubalus arnee bubalis) [TaxId: 89462] [53892] (2)
      1. 1ce2 picpic
        complexed with co3, fe
        1. region a:1-333 [35861] picpiclink
        2. region a:334-689 [35862] picpiclink
      2. 1biy picpic
        complexed with co3, fe
        1. region a:1-333 [35863] picpiclink
        2. region a:334-689 [35864] picpiclink
    4. Goat (Capra hircus) [TaxId: 9925] [89791] (1)
      1. 1jw1 picpic
        complexed with fe
        1. region a:1-333 [84234] picpiclink
        2. region a:334-689 [84235] picpiclink
    5. Horse (Equus caballus) [TaxId: 9796] [53893] (8)
      1. 1b1x picpic
        complexed with co3, fe
        1. region a:1-333 [35865] picpiclink
        2. region a:334-689 [35866] picpiclink
      2. 1f9b picpic
        complexed with 3id, bct, fe
        1. region a:1-333 [35869] picpiclink
        2. region a:334-689 [35870] picpiclink
      3. 1b7z picpic
        complexed with fe, oxl
        1. region a:1-333 [35867] picpiclink
        2. region a:334-689 [35868] picpiclink
      4. 3cr9 picpic
        automatically matched to d1b1xa1
        complexed with fe, glc
        1. region a:1-333 [156943] picpiclink
      5. 3cr9 picpic
        automatically matched to d1b1xa2
        complexed with fe, glc
        1. region a:334-689 [156944] picpiclink
      6. 1qjm picpic
        complexed with co3, sm
        1. region a:1-333 [35871] picpiclink
        2. region a:334-689 [35872] picpiclink
      7. 1i6b picpic
        1. region a:1-333 [66036] picpiclink
        2. region a:334-689 [66037] picpiclink
      8. 1b7u picpic
        1. region a:1-333 [35873] picpiclink
        2. region a:334-689 [35874] picpiclink
    6. Arabian camel (Camelus dromedarius) [TaxId: 9838] [64195] (2)
      1. 1dtz picpic
        1. region a:1-333 [59134] picpiclink
        2. region a:334-689 [59135] picpiclink
      2. 1i6q picpic
        complexed with co3, fe
        1. region a:1-333 [66043] picpiclink
        2. region a:334-689 [66044] picpiclink
  2. Ovotransferrin [53894]
    1. Duck (Anas platyrhynchos) [TaxId: 8839] [53895] (5)
      1. 1gv8 picpic
        domain II in the N-terminal lobe
        complexed with co3, fe, gly
        1. chain a [65606] picpiclink
      2. 1gvc picpic
        domain II in the N-terminal lobe
        complexed with co3, fe, nta
        1. chain a [65607] picpiclink
      3. 1ovb picpic
        domain II in the N-terminal lobe
        complexed with co3, fe
        1. chain a [35875] picpiclink
      4. 1dot picpic
        complexed with co3, fe, fuc, nag
        1. region a:1-334 [35876] picpiclink
        2. region a:335-686 [35877] picpiclink
      5. 1aov picpic
        1. region a:1-334 [35878] picpiclink
        2. region a:335-686 [35879] picpiclink
    2. Chicken (Gallus gallus) [TaxId: 9031] [53896] (11)
      SQ P02789
      1. 1iej picpic
        N-terminal lobe only
        complexed with co3, fe
        1. chain a [62328] picpiclink
      2. 1tfa picpic
        N-terminal lobe only
        complexed with so4
        1. chain a [35880] picpiclink
      3. 2d3i picpic
        automatically matched to d1aiv_1
        complexed with al, bct
        1. region a:5-334 [131208] picpiclink
      4. 2d3i picpic
        automatically matched to d1aiv_2
        complexed with al, bct
        1. region a:335-686 [131209] picpiclink
      5. 1nft picpic
        N-terminal lobe only
        complexed with fe, nta, so4
        1. chain a [35881] picpiclink
      6. 1iq7 picpic
        C-terminal lobe only
        complexed with nag, so4
        1. chain a [66261] picpiclink
      7. 1ovt picpic
        complexed with co3, fe
        1. region a:5-334 [35882] picpiclink
        2. region a:335-686 [35883] picpiclink
      8. 1nnt picpic
        N-terminal lobe only
        complexed with co3, fe
        1. chain a [35884] picpiclink
      9. 1n04 picpic
        complexed with co3, fca, fe
        1. region a:4-334 [91504] picpiclink
        2. region a:335-686 [91505] picpiclink
      10. 1aiv picpic
        complexed with nag
        1. region a:1-334 [35885] picpiclink
        2. region a:335-686 [35886] picpiclink
      11. 1ryx picpic
        1. region a:1-334 [105128] picpiclink
        2. region a:335-686 [105129] picpiclink
  3. Transferrin [53897]
    1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [53898] (6)
      1. 1jnf picpic
        complexed with cl, co3, fe
        1. region a:3-334 [63196] picpiclink
        2. region a:335-676 [63197] picpiclink
      2. 2hav picpic
        automatically matched to d1jnfa1
        complexed with cit, gol
        1. region a:340-664 [136297] picpiclink
      3. 2hav picpic
        automatically matched to d1jnfa1
        complexed with cit, gol
        1. region b:340-664 [136298] picpiclink
      4. 2hau picpic
        automatically matched to d1jnfa1
        complexed with cit, gol; mutant
        1. region a:340-664 [136295] picpiclink
      5. 2hau picpic
        automatically matched to d1jnfa1
        complexed with cit, gol; mutant
        1. region b:340-664 [136296] picpiclink
      6. 1tfd picpic
        N-terminal lobe
        complexed with co3, fe
        1. chain a [35887] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [53899] (17)
      1. 1ryo picpic
        N-terminal lobe
        complexed with fe, oxl
        1. chain a [98108] picpiclink
      2. 1a8e picpic
        N-terminal lobe
        complexed with co3, fe
        1. chain a [35888] picpiclink
      3. 1fqe picpic
        N-terminal lobe
        complexed with co3, fe, k; mutant
        1. chain a [59988] picpiclink
      4. 1jqf picpic
        N-terminal lobe
        complexed with co3, fe, k; mutant
        1. chain a [67086] picpiclink
      5. 1d3k picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [35889] picpiclink
      6. 1a8f picpic
        N-terminal lobe
        complexed with co3, fe
        1. chain a [35890] picpiclink
      7. 1oqg picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [87304] picpiclink
      8. 1d4n picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [35891] picpiclink
      9. 1n7x picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [85379] picpiclink
      10. 1n84 picpic
        N-terminal lobe
        complexed with co3, fe
        1. chain a [85389] picpiclink
      11. 1fqf picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [59989] picpiclink
      12. 1n7w picpic
        N-terminal lobe
        complexed with co3, fe; mutant
        1. chain a [85378] picpiclink
      13. 1bp5 picpic
        N-terminal lobe
        1. chain a [35892] picpiclink
        2. chain b [35893] picpiclink
        3. chain c [35894] picpiclink
        4. chain d [35895] picpiclink
      14. 1dtg picpic
        N-terminal lobe
        1. chain a [35896] picpiclink
      15. 1oqh picpic
        N-terminal lobe
        complexed with co3, fe, k; mutant
        1. chain a [87305] picpiclink
      16. 1b3e picpic
        N-terminal lobe
        complexed with co3, fe
        1. chain a [35897] picpiclink
      17. 1btj picpic
        N-terminal lobe
        1. chain a [35898] picpiclink
        2. chain b [35899] picpiclink
    3. Pig (Sus scrofa) [TaxId: 9823] [69626] (1)
      1. 1h76 picpic
        complexed with co3, fe, nag
        1. region a:3-333 [65699] picpiclink
        2. region a:342-687 [65700] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk