Structural Classification of Proteins
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Superfamily: SIS domain

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: SIS domain [53696]
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
  4. Superfamily: SIS domain [53697]
    link to SUPERFAMILY database - Superfamily

Families:

  1. mono-SIS domain [69599] (8)
    dimer of mono-domain subunits
    1. Probable 3-hexulose-6-phosphate isomerase MJ1247 [69600]
      1. Archaeon Methanococcus jannaschii [TaxId: 2190] [69601] (1) picpic
    2. Hypothetical protein YckF [82534]
      1. Bacillus subtilis [TaxId: 1423] [82535] (2) picpic
    3. Hypothetical protein HI0754 [89778]
      1. Haemophilus influenzae [TaxId: 727] [89779] (1) picpic
    4. Hypothetical protein AF1796 [102670]
      1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [102671] (1) picpic
    5. Phosphoheptose isomerase GmhA1 [110723]
      1. Campylobacter jejuni [TaxId: 197] [110724] (1) picpic
        SQ Q9PNE6
      2. Vibrio cholerae [TaxId: 666] [110725] (1) picpic
        SQ Q9KPY2
      3. Pseudomonas aeruginosa [TaxId: 287] [117729] (1) picpic
        SQ Q9HVZ0
      4. Pseudomonas aeruginosa str. PAO1 (Pseudomonas aeruginosa PAO1) [TaxId: 208964] [159784] (4) picpic
  2. double-SIS domain [53698] (4)
    duplication: consists of two SIS domains related by pseudo dyad
    1. Hypothetical protein TM0813 [75314]
      1. Thermotoga maritima [TaxId: 2336] [75315] (1) picpic
    2. "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS) [53699]
      1. Escherichia coli [TaxId: 562] [53700] (11) picpic
    3. Glucose-6-phosphate isomerase, conjectural [110726]
      1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [110727] (4) picpic
        SQ Q8ZWV0
    4. Glucose-6-phosphate isomerase-like protein TTHA1346 [117730]
      1. Thermus thermophilus [TaxId: 274] [117731] (1) picpic
        SQ Q5SIM3
  3. Phosphoglucose isomerase, PGI [53701] (6)
    permutation of the double-SIS domain fold
    1. Phosphoglucose isomerase, PGI [53702]
      moonlights as neuroleukin, autocrine motility factor, and differentiation mediator
      1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [53703] (8) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [64176] (5) picpic
      3. Pig (Sus scrofa) [TaxId: 9823] [75316] (2) picpic
      4. Bacillus stearothermophilus [TaxId: 1422] [53704] (4) picpic
      5. Leishmania mexicana [TaxId: 5665] [110728] (2) picpic
        SQ P42861
      6. Mouse (Mus musculus) [TaxId: 10090] [117732] (3) picpic
        SQ P06745
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk