Structural Classification of Proteins
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Superfamily: SIS domain

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: SIS domain [53696]
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
  4. Superfamily: SIS domain [53697]
    link to SUPERFAMILY database - Superfamily

Families:

  1. mono-SIS domain [69599] (8)
    dimer of mono-domain subunits
    1. Probable 3-hexulose-6-phosphate isomerase MJ1247 [69600]
      1. Archaeon Methanococcus jannaschii [TaxId: 2190] [69601] (1)
        1. 1jeo picpic
          structural genomics
          complexed with cit
          1. chain a [66611] picpiclink
    2. Hypothetical protein YckF [82534]
      1. Bacillus subtilis [TaxId: 1423] [82535] (2)
        1. 1m3s picpic
          structural genomics
          CASP5
          1. chain a [78573] picpiclink
          2. chain b [78574] picpiclink
        2. 1viv picpic
          structural genomics
          1. chain a [100775] picpiclink
          2. chain b [100776] picpiclink
    3. Hypothetical protein HI0754 [89778]
      1. Haemophilus influenzae [TaxId: 727] [89779] (1)
        1. 1nri picpic
          structural genomics
          complexed with mse
          1. chain a [86123] picpiclink
    4. Hypothetical protein AF1796 [102670]
      1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [102671] (1)
        1. 1vim picpic
          structural genomics
          complexed with fmt
          1. chain a [100758] picpiclink
          2. chain b [100759] picpiclink
          3. chain c [100760] picpiclink
          4. chain d [100761] picpiclink
    5. Phosphoheptose isomerase GmhA1 [110723]
      1. Campylobacter jejuni [TaxId: 197] [110724] (1)
        SQ Q9PNE6
        1. 1tk9 picpic
          Structural genomics target
          1. chain a [107082] picpiclink
          2. chain b [107083] picpiclink
          3. chain c [107084] picpiclink
          4. chain d [107085] picpiclink
      2. Vibrio cholerae [TaxId: 666] [110725] (1)
        SQ Q9KPY2
        1. 1x94 picpic
          Structural genomics target
          1. chain a [109522] picpiclink
          2. chain b [109523] picpiclink
      3. Pseudomonas aeruginosa [TaxId: 287] [117729] (1)
        SQ Q9HVZ0
        1. 1x92 picpic
          complexed with m7p
          1. chain a [114976] picpiclink
          2. chain b [114977] picpiclink
      4. Pseudomonas aeruginosa str. PAO1 (Pseudomonas aeruginosa PAO1) [TaxId: 208964] [159784] (4)
        1. 3bjz picpic
          automatically matched to d1x92b_
          complexed with cl, so4
          1. region a:2-194 [155338] picpiclink
        2. 3bjz picpic
          automatically matched to d1x92b_
          complexed with cl, so4
          1. region b:2-194 [155339] picpiclink
        3. 3bjz picpic
          automatically matched to d1x92b_
          complexed with cl, so4
          1. region c:2-194 [155340] picpiclink
        4. 3bjz picpic
          automatically matched to d1x92b_
          complexed with cl, so4
          1. region d:2-194 [155341] picpiclink
  2. double-SIS domain [53698] (4)
    duplication: consists of two SIS domains related by pseudo dyad
    1. Hypothetical protein TM0813 [75314]
      1. Thermotoga maritima [TaxId: 2336] [75315] (1)
        1. 1j5x picpic
          structural genomics
          complexed with mse
          1. chain a [71591] picpiclink
    2. "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS) [53699]
      1. Escherichia coli [TaxId: 562] [53700] (11)
        1. 1moq picpic
          complexed with glp, mes, mpd, na, so4
          1. chain a [35302] picpiclink
        2. 1mor picpic
          complexed with g6p
          1. chain a [35303] picpiclink
        3. 1mos picpic
          complexed with agp, mes, na, so4
          1. chain a [35304] picpiclink
        4. 2bpl picpicxrefxrefxref
          automatically matched to d1jxaa1
          complexed with f6r
          1. region a:241-608 [128938] picpiclink
        5. 2bpl picpicxrefxrefxref
          automatically matched to d1jxaa1
          complexed with f6r
          1. region b:241-608 [128940] picpiclink
        6. 2bpl picpicxrefxrefxref
          automatically matched to d1jxaa1
          complexed with f6r
          1. region c:241-608 [128942] picpiclink
        7. 2j6h picpicxrefxref
          automatically matched to d1jxaa1
          complexed with g6q, onl
          1. region a:241-608 [138084] picpiclink
        8. 2j6h picpicxrefxref
          automatically matched to d1jxaa1
          complexed with g6q, onl
          1. region b:241-608 [138086] picpiclink
        9. 2vf5 picpic
          automatically matched to d2j6ha1
          complexed with glp
          1. region x:243-601 [153028] picpiclink
        10. 2vf4 picpic
          automatically matched to d2j6ha1
          1. region x:243-601 [153027] picpiclink
        11. 1jxa picpicxref
          complexed with g6q
          1. region a:241-608 [67407] picpiclink
          2. region b:241-608 [67409] picpiclink
          3. region c:241-608 [67411] picpiclink
    3. Glucose-6-phosphate isomerase, conjectural [110726]
      1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [110727] (4)
        SQ Q8ZWV0
        1. 1x9i picpic
          complexed with g6q, gol
          1. chain a [114997] picpiclink
          2. chain b [114998] picpiclink
        2. 1tzb picpic
          complexed with gol, so4
          1. chain a [107470] picpiclink
          2. chain b [107471] picpiclink
        3. 1tzc picpic
          complexed with gol, pa5, so4
          1. chain a [107472] picpiclink
          2. chain b [107473] picpiclink
        4. 1x9h picpic
          complexed with fpc, gol, so4
          1. chain a [114995] picpiclink
          2. chain b [114996] picpiclink
    4. Glucose-6-phosphate isomerase-like protein TTHA1346 [117730]
      1. Thermus thermophilus [TaxId: 274] [117731] (1)
        SQ Q5SIM3
        1. 1wiw picpic
          Structural genomics target
          1. chain a [114681] picpiclink
          2. chain b [114682] picpiclink
  3. Phosphoglucose isomerase, PGI [53701] (6)
    permutation of the double-SIS domain fold
    1. Phosphoglucose isomerase, PGI [53702]
      moonlights as neuroleukin, autocrine motility factor, and differentiation mediator
      1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [53703] (8)
        1. 1hm5 picpic
          1. chain a [76717] picpiclink
          2. chain b [76718] picpiclink
        2. 1g98 picpic
          complexed with 5-phosphoarabinonate, a transition state analogue
          complexed with pa5
          1. chain a [60396] picpiclink
          2. chain b [60397] picpiclink
        3. 1xtb picpic
          automatically matched to d1hm5a_
          complexed with s6p
          1. region a:1-556 [122295] picpiclink
        4. 1xtb picpic
          automatically matched to d1hm5a_
          complexed with s6p
          1. region b:1001-1556 [122296] picpiclink
        5. 1koj picpic
          complexed with pan
          1. chain a [72821] picpiclink
          2. chain b [72822] picpiclink
        6. 1hox picpic
          complexed with f6p
          1. chain a [61108] picpiclink
          2. chain b [61109] picpiclink
        7. 1n8t picpic
          1. chain a [85454] picpiclink
          2. chain b [85455] picpiclink
        8. 1dqr picpic
          1. chain a [35305] picpiclink
          2. chain b [35306] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [64176] (5)
        1. 1iat picpic
          complexed with bme, sul
          1. chain a [62123] picpiclink
        2. 1jiq picpic
          1. chain a [71689] picpiclink
          2. chain b [71690] picpiclink
          3. chain c [71691] picpiclink
          4. chain d [71692] picpiclink
        3. 1jlh picpic
          1. chain a [77131] picpiclink
          2. chain b [77132] picpiclink
          3. chain c [77133] picpiclink
          4. chain d [77134] picpiclink
        4. 1iri picpic
          complexed with e4p
          1. chain a [71343] picpiclink
          2. chain b [71344] picpiclink
          3. chain c [71345] picpiclink
          4. chain d [71346] picpiclink
        5. 1nuh picpic
          complexed with pa5, so4
          1. chain a [80733] picpiclink
      3. Pig (Sus scrofa) [TaxId: 9823] [75316] (2)
        1. 1gzd picpic
          complexed with so4
          1. chain a [70804] picpiclink
        2. 1gzv picpic
          complexed with pa5
          1. chain a [76432] picpiclink
      4. Bacillus stearothermophilus [TaxId: 1422] [53704] (4)
        1. 1c7q picpic
          complexed with be1
          1. chain a [35307] picpiclink
        2. 1b0z picpic
          1. chain a [35309] picpiclink
        3. 2pgi picpic
          1. chain a [35308] picpiclink
        4. 1c7r picpic
          complexed with pa5
          1. chain a [35310] picpiclink
      5. Leishmania mexicana [TaxId: 5665] [110728] (2)
        SQ P42861
        1. 1q50 picpic
          1. chain a [104535] picpiclink
        2. 1t10 picpic
          complexed with f6p
          1. chain a [106235] picpiclink
      6. Mouse (Mus musculus) [TaxId: 10090] [117732] (3)
        SQ P06745
        1. 1u0f picpic
          complexed with bme, g6p, g6q, gol, so4
          1. chain a [112912] picpiclink
          2. chain b [112913] picpiclink
        2. 1u0e picpic
          complexed with bme, gol, so4
          1. chain a [112910] picpiclink
          2. chain b [112911] picpiclink
        3. 1u0g picpic
          complexed with bme, e4p, gol, so4
          1. chain a [112914] picpiclink
          2. chain b [112915] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk