Structural Classification of Proteins
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Fold: SIS domain

3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: SIS domain [53696]
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

Superfamilies:

  1. SIS domain [53697] (3)
    link to SUPERFAMILY database - Superfamily
    1. mono-SIS domain [69599] (8)
      dimer of mono-domain subunits
      1. Probable 3-hexulose-6-phosphate isomerase MJ1247 [69600]
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [69601] (1) picpic
      2. Hypothetical protein YckF [82534]
        1. Bacillus subtilis [TaxId: 1423] [82535] (2) picpic
      3. Hypothetical protein HI0754 [89778]
        1. Haemophilus influenzae [TaxId: 727] [89779] (1) picpic
      4. Hypothetical protein AF1796 [102670]
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [102671] (1) picpic
      5. Phosphoheptose isomerase GmhA1 [110723]
        1. Campylobacter jejuni [TaxId: 197] [110724] (1) picpic
          SQ Q9PNE6
        2. Vibrio cholerae [TaxId: 666] [110725] (1) picpic
          SQ Q9KPY2
        3. Pseudomonas aeruginosa [TaxId: 287] [117729] (1) picpic
          SQ Q9HVZ0
        4. Pseudomonas aeruginosa str. PAO1 (Pseudomonas aeruginosa PAO1) [TaxId: 208964] [159784] (4) picpic
    2. double-SIS domain [53698] (4)
      duplication: consists of two SIS domains related by pseudo dyad
      1. Hypothetical protein TM0813 [75314]
        1. Thermotoga maritima [TaxId: 2336] [75315] (1) picpic
      2. "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS) [53699]
        1. Escherichia coli [TaxId: 562] [53700] (11) picpic
      3. Glucose-6-phosphate isomerase, conjectural [110726]
        1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [110727] (4) picpic
          SQ Q8ZWV0
      4. Glucose-6-phosphate isomerase-like protein TTHA1346 [117730]
        1. Thermus thermophilus [TaxId: 274] [117731] (1) picpic
          SQ Q5SIM3
    3. Phosphoglucose isomerase, PGI [53701] (6)
      permutation of the double-SIS domain fold
      1. Phosphoglucose isomerase, PGI [53702]
        moonlights as neuroleukin, autocrine motility factor, and differentiation mediator
        1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [53703] (8) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [64176] (5) picpic
        3. Pig (Sus scrofa) [TaxId: 9823] [75316] (2) picpic
        4. Bacillus stearothermophilus [TaxId: 1422] [53704] (4) picpic
        5. Leishmania mexicana [TaxId: 5665] [110728] (2) picpic
          SQ P42861
        6. Mouse (Mus musculus) [TaxId: 10090] [117732] (3) picpic
          SQ P06745
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk