Structural Classification of Proteins
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Fold: SIS domain

3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: SIS domain [53696]
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

Superfamilies:

  1. SIS domain [53697] (3)
    link to SUPERFAMILY database - Superfamily
    1. mono-SIS domain [69599] (8)
      dimer of mono-domain subunits
      1. Probable 3-hexulose-6-phosphate isomerase MJ1247 [69600]
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [69601] (1)
          1. 1jeo picpic
            structural genomics
            complexed with cit
            1. chain a [66611] picpiclink
      2. Hypothetical protein YckF [82534]
        1. Bacillus subtilis [TaxId: 1423] [82535] (2)
          1. 1m3s picpic
            structural genomics
            CASP5
            1. chain a [78573] picpiclink
            2. chain b [78574] picpiclink
          2. 1viv picpic
            structural genomics
            1. chain a [100775] picpiclink
            2. chain b [100776] picpiclink
      3. Hypothetical protein HI0754 [89778]
        1. Haemophilus influenzae [TaxId: 727] [89779] (1)
          1. 1nri picpic
            structural genomics
            complexed with mse
            1. chain a [86123] picpiclink
      4. Hypothetical protein AF1796 [102670]
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [102671] (1)
          1. 1vim picpic
            structural genomics
            complexed with fmt
            1. chain a [100758] picpiclink
            2. chain b [100759] picpiclink
            3. chain c [100760] picpiclink
            4. chain d [100761] picpiclink
      5. Phosphoheptose isomerase GmhA1 [110723]
        1. Campylobacter jejuni [TaxId: 197] [110724] (1)
          SQ Q9PNE6
          1. 1tk9 picpic
            Structural genomics target
            1. chain a [107082] picpiclink
            2. chain b [107083] picpiclink
            3. chain c [107084] picpiclink
            4. chain d [107085] picpiclink
        2. Vibrio cholerae [TaxId: 666] [110725] (1)
          SQ Q9KPY2
          1. 1x94 picpic
            Structural genomics target
            1. chain a [109522] picpiclink
            2. chain b [109523] picpiclink
        3. Pseudomonas aeruginosa [TaxId: 287] [117729] (1)
          SQ Q9HVZ0
          1. 1x92 picpic
            complexed with m7p
            1. chain a [114976] picpiclink
            2. chain b [114977] picpiclink
        4. Pseudomonas aeruginosa str. PAO1 (Pseudomonas aeruginosa PAO1) [TaxId: 208964] [159784] (4)
          1. 3bjz picpic
            automatically matched to d1x92b_
            complexed with cl, so4
            1. region a:2-194 [155338] picpiclink
          2. 3bjz picpic
            automatically matched to d1x92b_
            complexed with cl, so4
            1. region b:2-194 [155339] picpiclink
          3. 3bjz picpic
            automatically matched to d1x92b_
            complexed with cl, so4
            1. region c:2-194 [155340] picpiclink
          4. 3bjz picpic
            automatically matched to d1x92b_
            complexed with cl, so4
            1. region d:2-194 [155341] picpiclink
    2. double-SIS domain [53698] (4)
      duplication: consists of two SIS domains related by pseudo dyad
      1. Hypothetical protein TM0813 [75314]
        1. Thermotoga maritima [TaxId: 2336] [75315] (1)
          1. 1j5x picpic
            structural genomics
            complexed with mse
            1. chain a [71591] picpiclink
      2. "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS) [53699]
        1. Escherichia coli [TaxId: 562] [53700] (11)
          1. 1moq picpic
            complexed with glp, mes, mpd, na, so4
            1. chain a [35302] picpiclink
          2. 1mor picpic
            complexed with g6p
            1. chain a [35303] picpiclink
          3. 1mos picpic
            complexed with agp, mes, na, so4
            1. chain a [35304] picpiclink
          4. 2bpl picpicxrefxrefxref
            automatically matched to d1jxaa1
            complexed with f6r
            1. region a:241-608 [128938] picpiclink
          5. 2bpl picpicxrefxrefxref
            automatically matched to d1jxaa1
            complexed with f6r
            1. region b:241-608 [128940] picpiclink
          6. 2bpl picpicxrefxrefxref
            automatically matched to d1jxaa1
            complexed with f6r
            1. region c:241-608 [128942] picpiclink
          7. 2j6h picpicxrefxref
            automatically matched to d1jxaa1
            complexed with g6q, onl
            1. region a:241-608 [138084] picpiclink
          8. 2j6h picpicxrefxref
            automatically matched to d1jxaa1
            complexed with g6q, onl
            1. region b:241-608 [138086] picpiclink
          9. 2vf5 picpic
            automatically matched to d2j6ha1
            complexed with glp
            1. region x:243-601 [153028] picpiclink
          10. 2vf4 picpic
            automatically matched to d2j6ha1
            1. region x:243-601 [153027] picpiclink
          11. 1jxa picpicxref
            complexed with g6q
            1. region a:241-608 [67407] picpiclink
            2. region b:241-608 [67409] picpiclink
            3. region c:241-608 [67411] picpiclink
      3. Glucose-6-phosphate isomerase, conjectural [110726]
        1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [110727] (4)
          SQ Q8ZWV0
          1. 1x9i picpic
            complexed with g6q, gol
            1. chain a [114997] picpiclink
            2. chain b [114998] picpiclink
          2. 1tzb picpic
            complexed with gol, so4
            1. chain a [107470] picpiclink
            2. chain b [107471] picpiclink
          3. 1tzc picpic
            complexed with gol, pa5, so4
            1. chain a [107472] picpiclink
            2. chain b [107473] picpiclink
          4. 1x9h picpic
            complexed with fpc, gol, so4
            1. chain a [114995] picpiclink
            2. chain b [114996] picpiclink
      4. Glucose-6-phosphate isomerase-like protein TTHA1346 [117730]
        1. Thermus thermophilus [TaxId: 274] [117731] (1)
          SQ Q5SIM3
          1. 1wiw picpic
            Structural genomics target
            1. chain a [114681] picpiclink
            2. chain b [114682] picpiclink
    3. Phosphoglucose isomerase, PGI [53701] (6)
      permutation of the double-SIS domain fold
      1. Phosphoglucose isomerase, PGI [53702]
        moonlights as neuroleukin, autocrine motility factor, and differentiation mediator
        1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [53703] (8)
          1. 1hm5 picpic
            1. chain a [76717] picpiclink
            2. chain b [76718] picpiclink
          2. 1g98 picpic
            complexed with 5-phosphoarabinonate, a transition state analogue
            complexed with pa5
            1. chain a [60396] picpiclink
            2. chain b [60397] picpiclink
          3. 1xtb picpic
            automatically matched to d1hm5a_
            complexed with s6p
            1. region a:1-556 [122295] picpiclink
          4. 1xtb picpic
            automatically matched to d1hm5a_
            complexed with s6p
            1. region b:1001-1556 [122296] picpiclink
          5. 1koj picpic
            complexed with pan
            1. chain a [72821] picpiclink
            2. chain b [72822] picpiclink
          6. 1hox picpic
            complexed with f6p
            1. chain a [61108] picpiclink
            2. chain b [61109] picpiclink
          7. 1n8t picpic
            1. chain a [85454] picpiclink
            2. chain b [85455] picpiclink
          8. 1dqr picpic
            1. chain a [35305] picpiclink
            2. chain b [35306] picpiclink
        2. Human (Homo sapiens) [TaxId: 9606] [64176] (5)
          1. 1iat picpic
            complexed with bme, sul
            1. chain a [62123] picpiclink
          2. 1jiq picpic
            1. chain a [71689] picpiclink
            2. chain b [71690] picpiclink
            3. chain c [71691] picpiclink
            4. chain d [71692] picpiclink
          3. 1jlh picpic
            1. chain a [77131] picpiclink
            2. chain b [77132] picpiclink
            3. chain c [77133] picpiclink
            4. chain d [77134] picpiclink
          4. 1iri picpic
            complexed with e4p
            1. chain a [71343] picpiclink
            2. chain b [71344] picpiclink
            3. chain c [71345] picpiclink
            4. chain d [71346] picpiclink
          5. 1nuh picpic
            complexed with pa5, so4
            1. chain a [80733] picpiclink
        3. Pig (Sus scrofa) [TaxId: 9823] [75316] (2)
          1. 1gzd picpic
            complexed with so4
            1. chain a [70804] picpiclink
          2. 1gzv picpic
            complexed with pa5
            1. chain a [76432] picpiclink
        4. Bacillus stearothermophilus [TaxId: 1422] [53704] (4)
          1. 1c7q picpic
            complexed with be1
            1. chain a [35307] picpiclink
          2. 1b0z picpic
            1. chain a [35309] picpiclink
          3. 2pgi picpic
            1. chain a [35308] picpiclink
          4. 1c7r picpic
            complexed with pa5
            1. chain a [35310] picpiclink
        5. Leishmania mexicana [TaxId: 5665] [110728] (2)
          SQ P42861
          1. 1q50 picpic
            1. chain a [104535] picpiclink
          2. 1t10 picpic
            complexed with f6p
            1. chain a [106235] picpiclink
        6. Mouse (Mus musculus) [TaxId: 10090] [117732] (3)
          SQ P06745
          1. 1u0f picpic
            complexed with bme, g6p, g6q, gol, so4
            1. chain a [112912] picpiclink
            2. chain b [112913] picpiclink
          2. 1u0e picpic
            complexed with bme, gol, so4
            1. chain a [112910] picpiclink
            2. chain b [112911] picpiclink
          3. 1u0g picpic
            complexed with bme, e4p, gol, so4
            1. chain a [112914] picpiclink
            2. chain b [112915] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk