Structural Classification of Proteins

Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685]
consists of two similar domains related by pseudo dyad; duplication
core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53686]
uperfamily

Families:

Tryptophan synthase beta subunit-like PLP-dependent enzymes [53687] (22)
1. Tryptophan synthase, beta-subunit [53688]
  1. Salmonella typhimurium [TaxId: 90371] [53689] (47)
    1. 1qop
      complexed with ipl, na, plp
      1. chain b [35270]
    2. 1tjp
      automatically matched to d1k3ub_
      complexed with hpf, na, plp
      1. region b:2-395 [119291]
    3. 1wbj
      automatically matched to d1k3ub_
      complexed with g3p, na, plp
      1. region b:2-391 [120849]
    4. 2clk
      automatically matched to d1k3ub_
      complexed with g3h, na, plp
      1. region b:2-391 [130579]
    5. 1k8y
      complexed with g3p, na, plp; mutant
      1. chain b [72184]
    6. 1kfc
      complexed with ipl, na, plp; mutant
      1. chain b [77372]
    7. 2cle
      automatically matched to d1bksb_
      complexed with f6f, na, plp
      1. region b:3-394 [130573]
    8. 2clm
      automatically matched to d1bksb_
      complexed with f6f, na, pls
      1. region b:3-394 [130583]
    9. 1k3u
      complexed with iad, na, plp
      1. chain b [72031]
    10. 2clo
      automatically matched to d1bksb_
      complexed with f19, na, pls
      1. region b:3-392 [130585]
    11. 2clf
      automatically matched to d1bksb_
      complexed with f6f, na, plp
      1. region b:3-394 [146413]
    12. 2rh9
      automatically matched to d1k3ub_
      complexed with igp, na, plp
      1. region b:2-395 [152035]
    13. 2cli
      automatically matched to d1k3ub_
      complexed with f9f, na, plp
      1. region b:2-395 [130577]
    14. 1qoq
      complexed with igp, plp
      1. chain b [35271]
    15. 2cll
      automatically matched to d1k3ub_
      complexed with f9f, na, pls
      1. region b:2-395 [130581]
    16. 2clh
      automatically matched to d1bksb_
      complexed with f19, na, plp
      1. region b:3-394 [130575]
    17. 1kfe
      complexed with na, pls; mutant
      1. chain b [77374]
    18. 1kfb
      complexed with igp, plp; mutant
      1. chain b [77370]
    19. 1k7x
      complexed with na, plp; mutant
      1. chain b [72135]
    20. 1kfj
      complexed with na, pls
      1. chain b [90959]
    21. 1k8x
      complexed with na, plp; mutant
      1. chain b [77289]
    22. 1k8z
      complexed with iag, na, plp; mutant
      1. chain b [72186]
    23. 2tys
      complexed with na, plt; mutant
      1. chain b [35272]
    24. 2rhg
      automatically matched to d1k3ub_
      complexed with igp, na, plp
      1. region b:2-391 [152051]
    25. 2j9x
      automatically matched to d1k3ub_
      complexed with cs, dms, g3p, p1t
      1. region b:2-395 [147947]
    26. 1k7f
      complexed with iav, plp
      1. chain b [72100]
    27. 3cep
      automatically matched to d1k3ub_
      complexed with cs, g3h, idm, plp, sri
      1. region b:2-394 [156533]
    28. 1beu
      complexed with ipl, k, pls; mutant
      1. chain b [35274]
    29. 1ubs
      complexed with na, plp; mutant
      1. chain b [35273]
    30. 1a5b
      complexed with igp, k, plp; mutant
      1. chain b [35275]
    31. 1a5a
      complexed with k, plp; mutant
      1. chain b [35276]
    32. 1kfk
      complexed with na, plp
      1. chain b [90961]
    33. 1ttq
      complexed with k p, plp
      1. chain b [35268]
    34. 1k7e
      complexed with iag, na, plp
      1. chain b [72098]
    35. 1fuy
      complexed with fip, na, plp; mutant
      1. chain b [35279]
    36. 1a50
      complexed with fip, na, plp
      1. chain b [35280]
    37. 2trs
      complexed with ipl, na, pls; mutant
      1. chain b [35277]
    38. 1cw2
      1. chain b [35278]
    39. 1a5s
      complexed with fip, na, plp
      1. chain b [35281]
    40. 1c8v
      1. chain b [35282]
    41. 1bks
      complexed with na, plp
      1. chain b [35285]
    42. 1ttp
      complexed with cs, plp
      1. chain b [35269]
    43. 2tsy
      complexed with g3p, na, pls; mutant
      1. chain b [35283]
    44. 1cx9
      1. chain b [35284]
    45. 1c9d
      1. chain b [35286]
    46. 1c29
      1. chain b [35287]
    47. 2wsy
      complexed with na, plp
      1. chain b [35288]
  2. Archaeon Pyrococcus furiosus [TaxId: 2261] [142741] (10)
    SQ Q8U093 1-386
    1. 1v8z
      complexed with na, plp
      1. region a:1-386 [119873]
    2. 1v8z
      automatically matched to 1V8Z A:1-386
      complexed with na, plp
      1. region b:1-386 [119874]
    3. 1v8z
      automatically matched to 1V8Z A:1-386
      complexed with na, plp
      1. region c:1-386 [119875]
    4. 1v8z
      automatically matched to 1V8Z A:1-386
      complexed with na, plp
      1. region d:1-386 [119876]
    5. 1wdw
      automatically matched to 1V8Z A:1-386
      complexed with plp
      1. region b:1-385 [120917]
    6. 1wdw
      automatically matched to 1V8Z A:1-386
      complexed with plp
      1. region d:1-385 [120919]
    7. 1wdw
      automatically matched to 1V8Z A:1-386
      complexed with plp
      1. region f:1-385 [120921]
    8. 1wdw
      automatically matched to 1V8Z A:1-386
      complexed with plp
      1. region h:1-385 [120923]
    9. 1wdw
      automatically matched to 1V8Z A:1-386
      complexed with plp
      1. region j:1-385 [120925]
    10. 1wdw
      automatically matched to 1V8Z A:1-386
      complexed with plp
      1. region l:1-385 [120927]
2. O-acetylserine sulfhydrylase (Cysteine synthase) [53690]
  1. Salmonella typhimurium [TaxId: 90371] [53691] (3)
    1. 1fcj
      complexed with cl, plp, so4
      1. chain a [35289]
      2. chain b [35290]
      3. chain c [35291]
      4. chain d [35292]
    2. 1oas
      1. chain a [35293]
      2. chain b [35294]
    3. 1d6s
      complexed with met, plp; mutant
      1. chain a [35295]
      2. chain b [35296]
  2. Thermotoga maritima [TaxId: 2336] [75312] (1)
    TM0665
    1. 1o58
      structural genomics
      complexed with po4
      1. chain a [92491]
      2. chain b [92492]
      3. chain c [92493]
      4. chain d [92494]
  3. Archaeon Aeropyrum pernix [TaxId: 56636] [142742] (2)
    SQ Q9YBL2 1-382
    1. 1wkv
      complexed with act, plp
      1. region a:2-383 [120989]
    2. 1wkv
      automatically matched to 1WKV A:2-383
      complexed with act, plp
      1. region b:2-383 [120990]
  4. Thermus thermophilus [TaxId: 274] [142743] (5)
    SQ Q5SLE6 1-302
    1. 1ve1
      complexed with plp
      1. region a:1-302 [120007]
    2. 2ecq
      automatically matched to d1ve1a1
      complexed with 3hl, plp
      1. region a:1-302 [146791]
    3. 2eco
      automatically matched to d1ve1a1
      complexed with 4mv, plp
      1. region a:1-302 [146790]
    4. 2efy
      automatically matched to d1ve1a1
      complexed with 4at, plp
      1. region a:1-302 [146824]
    5. 2efy
      automatically matched to d1ve1a1
      complexed with 4at, plp
      1. region b:1-302 [146825]
  5. Escherichia coli, isoform B (CysM) [TaxId: 562] [142744] (8)
    SQ P16703 2-293
    1. 2bhs
      complexed with plp
      1. region a:2-293 [128546]
    2. 2bhs
      automatically matched to 2BHS A:2-293
      complexed with plp
      1. region b:2-292 [128547]
    3. 2bhs
      automatically matched to 2BHS A:2-293
      complexed with plp
      1. region c:2-292 [128548]
    4. 2bhs
      automatically matched to 2BHS A:2-293
      complexed with plp
      1. region d:2-292 [128549]
    5. 2bht
      mutant
      1. region a:2-293 [128550]
    6. 2bht
      automatically matched to 2BHT A:2-293
      mutant
      1. region b:2-293 [128551]
    7. 2bht
      automatically matched to 2BHT A:2-293
      mutant
      1. region c:2-292 [128552]
    8. 2bht
      automatically matched to 2BHT A:2-293
      mutant
      1. region d:2-293 [128553]
  6. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [142745] (2)
    SQ P47998 3-322
    1. 1z7w
      complexed with plp, so4
      1. region a:3-322 [124674]
    2. 1z7y
      complexed with aa5; mutant
      1. region a:3-322 [124679]
  7. Haemophilus influenzae [TaxId: 727] [142746] (1)
    SQ P45040 2-311
    1. 1y7l
      complexed with so4
      1. region a:2-311 [122695]
3. Threonine deaminase [53692]
  1. Escherichia coli [TaxId: 562] [53693] (1)
    1. 1tdj
      CASP2
      complexed with plp
      1. region a:5-335 [35297]
  2. Thermus thermophilus [TaxId: 274] [142747] (4)
    SQ Q5SLL4 2-311
    1. 1ve5
      complexed with ca, plp
      1. region a:2-311 [120013]
    2. 1ve5
      automatically matched to 1VE5 A:2-311
      complexed with ca, plp
      1. region b:2-311 [120014]
    3. 1ve5
      automatically matched to 1VE5 A:2-311
      complexed with ca, plp
      1. region c:2-311 [120015]
    4. 1ve5
      automatically matched to 1VE5 A:2-311
      complexed with ca, plp
      1. region d:2-311 [120016]
4. Threonine synthase [64172]
  1. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [64173] (1)
    1. 1e5x
      complexed with mso
      1. chain a [59283]
      2. chain b [59284]
  2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75313] (1)
    1. 1kl7
      complexed with mse, plp
      1. chain a [72678]
      2. chain b [72679]
  3. Thermus thermophilus [TaxId: 274] [102667] (3)
    1. 1v7c
      complexed with hey
      1. chain a [100446]
      2. chain b [100447]
      3. chain c [100448]
      4. chain d [100449]
    2. 1uim
      complexed with plp
      1. chain a [99425]
      2. chain b [99426]
    3. 1uin
      complexed with plp, so4
      1. chain a [99427]
      2. chain b [99428]
  4. Escherichia coli [TaxId: 562] [142748] (1)
    SQ P00934 1-428
    1. 1vb3
      complexed with kpa, so4
      1. region a:1-428 [119942]
5. L-serine dehydratase [102668]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [102669] (2)
    1. 1pwh
      complexed with k, plv
      1. chain a [95224]
      2. chain b [95225]
      3. chain c [95226]
      4. chain d [95227]
    2. 1pwe
      1. chain a [95218]
      2. chain b [95219]
      3. chain c [95220]
      4. chain d [95221]
      5. chain e [95222]
      6. chain f [95223]
  2. Human (Homo sapiens) [TaxId: 9606] [110721] (1)
    SQ P20132
    1. 1p5j
      complexed with plp; mutant
      1. chain a [104067]
6. 1-aminocyclopropane-1-carboxylate deaminase [53694]
  1. Yeast (Hansenula saturnus) [TaxId: 4906] [53695] (4)
    1. 1f2d
      complexed with plp, so4
      1. chain a [35298]
      2. chain b [35299]
      3. chain c [35300]
      4. chain d [35301]
    2. 1j0d
      complexed with 5pa; mutant
      1. chain a [83902]
      2. chain b [83903]
      3. chain c [83904]
      4. chain d [83905]
    3. 1j0e
      complexed with 1ac, plp; mutant
      1. chain a [83906]
      2. chain b [83907]
      3. chain c [83908]
      4. chain d [83909]
    4. 1j0c
      complexed with plp; mutant
      1. chain a [83898]
      2. chain b [83899]
      3. chain c [83900]
      4. chain d [83901]
  2. Archaeon Pyrococcus horikoshii [TaxId: 53953] [89777] (2)
    1. 1j0a
      complexed with ioh, plp, so4
      1. chain a [83871]
      2. chain b [83872]
      3. chain c [83873]
    2. 1j0b
      complexed with 5pa
      1. chain a [83874]
      2. chain b [83875]
      3. chain c [83876]
      4. chain d [83877]
      5. chain e [83878]
      6. chain f [83879]
      7. chain g [83880]
      8. chain h [83881]
      9. chain i [83882]
      10. chain j [83883]
      11. chain k [83884]
      12. chain l [83885]
      13. chain m [83886]
      14. chain n [83887]
      15. chain o [83888]
      16. chain p [83889]
      17. chain q [83890]
      18. chain r [83891]
      19. chain s [83892]
      20. chain t [83893]
      21. chain u [83894]
      22. chain v [83895]
      23. chain w [83896]
      24. chain x [83897]
  3. Pseudomonas sp., strain ACP [TaxId: 306] [110722] (6)
    SQ Q00740
    1. 1tyz
      complexed with plp, so4
      1. chain a [112852]
      2. chain b [112853]
      3. chain c [112854]
      4. chain d [112855]
    2. 1tzj
      complexed with a3b, plp, so4
      1. chain a [112868]
      2. chain b [112869]
      3. chain c [112870]
      4. chain d [112871]
    3. 1tzk
      complexed with 2kt, plp, so4
      1. chain a [112872]
      2. chain b [112873]
      3. chain c [112874]
      4. chain d [112875]
    4. 1tz2
      complexed with 1ac, plp
      1. chain a [112856]
      2. chain b [112857]
      3. chain c [112858]
      4. chain d [112859]
    5. 1tzm
      complexed with c2n, nak, plp, so4
      1. chain a [112892]
      2. chain b [112893]
      3. chain c [112894]
      4. chain d [112895]
    6. 1rqx
      complexed with mlp, plp
      1. chain a [105069]
      2. chain b [105070]
      3. chain c [105071]
      4. chain d [105072]
7. Cystathionine beta-synthase [64174]
  PLP-dependent hemoprotein
  1. Human (Homo sapiens) [TaxId: 9606] [64175] (2)
    1. 1jbq
      complexed with hem, plp; mutant
      1. chain a [62850]
      2. chain b [62851]
      3. chain c [62852]
      4. chain d [62853]
      5. chain e [62854]
      6. chain f [62855]
    2. 1m54
      complexed with hem, plp; mutant
      1. chain a [74463]
      2. chain b [74464]
      3. chain c [74465]
      4. chain d [74466]
      5. chain e [74467]
      6. chain f [74468]
8. Hypothetical protein C320.14 (SPCC320.14, SPCC330.15c) [142749]
  1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [142750] (2)
    SQ O59791 6-323
    1. 1v71
      complexed with mg, plp
      1. region a:6-323 [119859]
    2. 1wtc
      automatically matched to 1V71 A:6-323
      complexed with acp, mg, plp
      1. region a:6-323 [121257]