Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes

consists of two similar domains related by pseudo dyad; duplication
core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685]
   consists of two similar domains related by pseudo dyad; duplication
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214

Superfamilies:

1. Tryptophan synthase beta subunit-like PLP-dependent enzymes [53686] (1)
   uperfamily
   1. Tryptophan synthase beta subunit-like PLP-dependent enzymes [53687] (22)
      1. Tryptophan synthase, beta-subunit [53688]
         1. Salmonella typhimurium [TaxId: 90371] [53689] (47)
            1. 1qop
               complexed with ipl, na, plp
               1. chain b [35270]
            2. 1tjp
               automatically matched to d1k3ub_
               complexed with hpf, na, plp
               1. region b:2-395 [119291]
            3. 1wbj
               automatically matched to d1k3ub_
               complexed with g3p, na, plp
               1. region b:2-391 [120849]
            4. 2clk
               automatically matched to d1k3ub_
               complexed with g3h, na, plp
               1. region b:2-391 [130579]
            5. 1k8y
               complexed with g3p, na, plp; mutant
               1. chain b [72184]
            6. 1kfc
               complexed with ipl, na, plp; mutant
               1. chain b [77372]
            7. 2cle
               automatically matched to d1bksb_
               complexed with f6f, na, plp
               1. region b:3-394 [130573]
            8. 2clm
               automatically matched to d1bksb_
               complexed with f6f, na, pls
               1. region b:3-394 [130583]
            9. 1k3u
               complexed with iad, na, plp
               1. chain b [72031]
            10. 2clo
                automatically matched to d1bksb_
                complexed with f19, na, pls
                1. region b:3-392 [130585]
            11. 2clf
                automatically matched to d1bksb_
                complexed with f6f, na, plp
                1. region b:3-394 [146413]
            12. 2rh9
                automatically matched to d1k3ub_
                complexed with igp, na, plp
                1. region b:2-395 [152035]
            13. 2cli
                automatically matched to d1k3ub_
                complexed with f9f, na, plp
                1. region b:2-395 [130577]
            14. 1qoq
                complexed with igp, plp
                1. chain b [35271]
            15. 2cll
                automatically matched to d1k3ub_
                complexed with f9f, na, pls
                1. region b:2-395 [130581]
            16. 2clh
                automatically matched to d1bksb_
                complexed with f19, na, plp
                1. region b:3-394 [130575]
            17. 1kfe
                complexed with na, pls; mutant
                1. chain b [77374]
            18. 1kfb
                complexed with igp, plp; mutant
                1. chain b [77370]
            19. 1k7x
                complexed with na, plp; mutant
                1. chain b [72135]
            20. 1kfj
                complexed with na, pls
                1. chain b [90959]
            21. 1k8x
                complexed with na, plp; mutant
                1. chain b [77289]
            22. 1k8z
                complexed with iag, na, plp; mutant
                1. chain b [72186]
            23. 2tys
                complexed with na, plt; mutant
                1. chain b [35272]
            24. 2rhg
                automatically matched to d1k3ub_
                complexed with igp, na, plp
                1. region b:2-391 [152051]
            25. 2j9x
                automatically matched to d1k3ub_
                complexed with cs, dms, g3p, p1t
                1. region b:2-395 [147947]
            26. 1k7f
                complexed with iav, plp
                1. chain b [72100]
            27. 3cep
                automatically matched to d1k3ub_
                complexed with cs, g3h, idm, plp, sri
                1. region b:2-394 [156533]
            28. 1beu
                complexed with ipl, k, pls; mutant
                1. chain b [35274]
            29. 1ubs
                complexed with na, plp; mutant
                1. chain b [35273]
            30. 1a5b
                complexed with igp, k, plp; mutant
                1. chain b [35275]
            31. 1a5a
                complexed with k, plp; mutant
                1. chain b [35276]
            32. 1kfk
                complexed with na, plp
                1. chain b [90961]
            33. 1ttq
                complexed with k p, plp
                1. chain b [35268]
            34. 1k7e
                complexed with iag, na, plp
                1. chain b [72098]
            35. 1fuy
                complexed with fip, na, plp; mutant
                1. chain b [35279]
            36. 1a50
                complexed with fip, na, plp
                1. chain b [35280]
            37. 2trs
                complexed with ipl, na, pls; mutant
                1. chain b [35277]
            38. 1cw2
                1. chain b [35278]
            39. 1a5s
                complexed with fip, na, plp
                1. chain b [35281]
            40. 1c8v
                1. chain b [35282]
            41. 1bks
                complexed with na, plp
                1. chain b [35285]
            42. 1ttp
                complexed with cs, plp
                1. chain b [35269]
            43. 2tsy
                complexed with g3p, na, pls; mutant
                1. chain b [35283]
            44. 1cx9
                1. chain b [35284]
            45. 1c9d
                1. chain b [35286]
            46. 1c29
                1. chain b [35287]
            47. 2wsy
                complexed with na, plp
                1. chain b [35288]
         2. Archaeon Pyrococcus furiosus [TaxId: 2261] [142741] (10)
            SQ Q8U093 1-386
            1. 1v8z
               complexed with na, plp
               1. region a:1-386 [119873]
            2. 1v8z
               automatically matched to 1V8Z A:1-386
               complexed with na, plp
               1. region b:1-386 [119874]
            3. 1v8z
               automatically matched to 1V8Z A:1-386
               complexed with na, plp
               1. region c:1-386 [119875]
            4. 1v8z
               automatically matched to 1V8Z A:1-386
               complexed with na, plp
               1. region d:1-386 [119876]
            5. 1wdw
               automatically matched to 1V8Z A:1-386
               complexed with plp
               1. region b:1-385 [120917]
            6. 1wdw
               automatically matched to 1V8Z A:1-386
               complexed with plp
               1. region d:1-385 [120919]
            7. 1wdw
               automatically matched to 1V8Z A:1-386
               complexed with plp
               1. region f:1-385 [120921]
            8. 1wdw
               automatically matched to 1V8Z A:1-386
               complexed with plp
               1. region h:1-385 [120923]
            9. 1wdw
               automatically matched to 1V8Z A:1-386
               complexed with plp
               1. region j:1-385 [120925]
            10. 1wdw
                automatically matched to 1V8Z A:1-386
                complexed with plp
                1. region l:1-385 [120927]
      2. O-acetylserine sulfhydrylase (Cysteine synthase) [53690]
         1. Salmonella typhimurium [TaxId: 90371] [53691] (3)
            1. 1fcj
               complexed with cl, plp, so4
               1. chain a [35289]
               2. chain b [35290]
               3. chain c [35291]
               4. chain d [35292]
            2. 1oas
               1. chain a [35293]
               2. chain b [35294]
            3. 1d6s
               complexed with met, plp; mutant
               1. chain a [35295]
               2. chain b [35296]
         2. Thermotoga maritima [TaxId: 2336] [75312] (1)
            TM0665
            1. 1o58
               structural genomics
               complexed with po4
               1. chain a [92491]
               2. chain b [92492]
               3. chain c [92493]
               4. chain d [92494]
         3. Archaeon Aeropyrum pernix [TaxId: 56636] [142742] (2)
            SQ Q9YBL2 1-382
            1. 1wkv
               complexed with act, plp
               1. region a:2-383 [120989]
            2. 1wkv
               automatically matched to 1WKV A:2-383
               complexed with act, plp
               1. region b:2-383 [120990]
         4. Thermus thermophilus [TaxId: 274] [142743] (5)
            SQ Q5SLE6 1-302
            1. 1ve1
               complexed with plp
               1. region a:1-302 [120007]
            2. 2ecq
               automatically matched to d1ve1a1
               complexed with 3hl, plp
               1. region a:1-302 [146791]
            3. 2eco
               automatically matched to d1ve1a1
               complexed with 4mv, plp
               1. region a:1-302 [146790]
            4. 2efy
               automatically matched to d1ve1a1
               complexed with 4at, plp
               1. region a:1-302 [146824]
            5. 2efy
               automatically matched to d1ve1a1
               complexed with 4at, plp
               1. region b:1-302 [146825]
         5. Escherichia coli, isoform B (CysM) [TaxId: 562] [142744] (8)
            SQ P16703 2-293
            1. 2bhs
               complexed with plp
               1. region a:2-293 [128546]
            2. 2bhs
               automatically matched to 2BHS A:2-293
               complexed with plp
               1. region b:2-292 [128547]
            3. 2bhs
               automatically matched to 2BHS A:2-293
               complexed with plp
               1. region c:2-292 [128548]
            4. 2bhs
               automatically matched to 2BHS A:2-293
               complexed with plp
               1. region d:2-292 [128549]
            5. 2bht
               mutant
               1. region a:2-293 [128550]
            6. 2bht
               automatically matched to 2BHT A:2-293
               mutant
               1. region b:2-293 [128551]
            7. 2bht
               automatically matched to 2BHT A:2-293
               mutant
               1. region c:2-292 [128552]
            8. 2bht
               automatically matched to 2BHT A:2-293
               mutant
               1. region d:2-293 [128553]
         6. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [142745] (2)
            SQ P47998 3-322
            1. 1z7w
               complexed with plp, so4
               1. region a:3-322 [124674]
            2. 1z7y
               complexed with aa5; mutant
               1. region a:3-322 [124679]
         7. Haemophilus influenzae [TaxId: 727] [142746] (1)
            SQ P45040 2-311
            1. 1y7l
               complexed with so4
               1. region a:2-311 [122695]
      3. Threonine deaminase [53692]
         1. Escherichia coli [TaxId: 562] [53693] (1)
            1. 1tdj
               CASP2
               complexed with plp
               1. region a:5-335 [35297]
         2. Thermus thermophilus [TaxId: 274] [142747] (4)
            SQ Q5SLL4 2-311
            1. 1ve5
               complexed with ca, plp
               1. region a:2-311 [120013]
            2. 1ve5
               automatically matched to 1VE5 A:2-311
               complexed with ca, plp
               1. region b:2-311 [120014]
            3. 1ve5
               automatically matched to 1VE5 A:2-311
               complexed with ca, plp
               1. region c:2-311 [120015]
            4. 1ve5
               automatically matched to 1VE5 A:2-311
               complexed with ca, plp
               1. region d:2-311 [120016]
      4. Threonine synthase [64172]
         1. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [64173] (1)
            1. 1e5x
               complexed with mso
               1. chain a [59283]
               2. chain b [59284]
         2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75313] (1)
            1. 1kl7
               complexed with mse, plp
               1. chain a [72678]
               2. chain b [72679]
         3. Thermus thermophilus [TaxId: 274] [102667] (3)
            1. 1v7c
               complexed with hey
               1. chain a [100446]
               2. chain b [100447]
               3. chain c [100448]
               4. chain d [100449]
            2. 1uim
               complexed with plp
               1. chain a [99425]
               2. chain b [99426]
            3. 1uin
               complexed with plp, so4
               1. chain a [99427]
               2. chain b [99428]
         4. Escherichia coli [TaxId: 562] [142748] (1)
            SQ P00934 1-428
            1. 1vb3
               complexed with kpa, so4
               1. region a:1-428 [119942]
      5. L-serine dehydratase [102668]
         1. Rat (Rattus norvegicus) [TaxId: 10116] [102669] (2)
            1. 1pwh
               complexed with k, plv
               1. chain a [95224]
               2. chain b [95225]
               3. chain c [95226]
               4. chain d [95227]
            2. 1pwe
               1. chain a [95218]
               2. chain b [95219]
               3. chain c [95220]
               4. chain d [95221]
               5. chain e [95222]
               6. chain f [95223]
         2. Human (Homo sapiens) [TaxId: 9606] [110721] (1)
            SQ P20132
            1. 1p5j
               complexed with plp; mutant
               1. chain a [104067]
      6. 1-aminocyclopropane-1-carboxylate deaminase [53694]
         1. Yeast (Hansenula saturnus) [TaxId: 4906] [53695] (4)
            1. 1f2d
               complexed with plp, so4
               1. chain a [35298]
               2. chain b [35299]
               3. chain c [35300]
               4. chain d [35301]
            2. 1j0d
               complexed with 5pa; mutant
               1. chain a [83902]
               2. chain b [83903]
               3. chain c [83904]
               4. chain d [83905]
            3. 1j0e
               complexed with 1ac, plp; mutant
               1. chain a [83906]
               2. chain b [83907]
               3. chain c [83908]
               4. chain d [83909]
            4. 1j0c
               complexed with plp; mutant
               1. chain a [83898]
               2. chain b [83899]
               3. chain c [83900]
               4. chain d [83901]
         2. Archaeon Pyrococcus horikoshii [TaxId: 53953] [89777] (2)
            1. 1j0a
               complexed with ioh, plp, so4
               1. chain a [83871]
               2. chain b [83872]
               3. chain c [83873]
            2. 1j0b
               complexed with 5pa
               1. chain a [83874]
               2. chain b [83875]
               3. chain c [83876]
               4. chain d [83877]
               5. chain e [83878]
               6. chain f [83879]
               7. chain g [83880]
               8. chain h [83881]
               9. chain i [83882]
               10. chain j [83883]
               11. chain k [83884]
               12. chain l [83885]
               13. chain m [83886]
               14. chain n [83887]
               15. chain o [83888]
               16. chain p [83889]
               17. chain q [83890]
               18. chain r [83891]
               19. chain s [83892]
               20. chain t [83893]
               21. chain u [83894]
               22. chain v [83895]
               23. chain w [83896]
               24. chain x [83897]
         3. Pseudomonas sp., strain ACP [TaxId: 306] [110722] (6)
            SQ Q00740
            1. 1tyz
               complexed with plp, so4
               1. chain a [112852]
               2. chain b [112853]
               3. chain c [112854]
               4. chain d [112855]
            2. 1tzj
               complexed with a3b, plp, so4
               1. chain a [112868]
               2. chain b [112869]
               3. chain c [112870]
               4. chain d [112871]
            3. 1tzk
               complexed with 2kt, plp, so4
               1. chain a [112872]
               2. chain b [112873]
               3. chain c [112874]
               4. chain d [112875]
            4. 1tz2
               complexed with 1ac, plp
               1. chain a [112856]
               2. chain b [112857]
               3. chain c [112858]
               4. chain d [112859]
            5. 1tzm
               complexed with c2n, nak, plp, so4
               1. chain a [112892]
               2. chain b [112893]
               3. chain c [112894]
               4. chain d [112895]
            6. 1rqx
               complexed with mlp, plp
               1. chain a [105069]
               2. chain b [105070]
               3. chain c [105071]
               4. chain d [105072]
      7. Cystathionine beta-synthase [64174]
         PLP-dependent hemoprotein
         1. Human (Homo sapiens) [TaxId: 9606] [64175] (2)
            1. 1jbq
               complexed with hem, plp; mutant
               1. chain a [62850]
               2. chain b [62851]
               3. chain c [62852]
               4. chain d [62853]
               5. chain e [62854]
               6. chain f [62855]
            2. 1m54
               complexed with hem, plp; mutant
               1. chain a [74463]
               2. chain b [74464]
               3. chain c [74465]
               4. chain d [74466]
               5. chain e [74467]
               6. chain f [74468]
      8. Hypothetical protein C320.14 (SPCC320.14, SPCC330.15c) [142749]
         1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [142750] (2)
            SQ O59791 6-323
            1. 1v71
               complexed with mg, plp
               1. region a:6-323 [119859]
            2. 1wtc
               automatically matched to 1V71 A:6-323
               complexed with acp, mg, plp
               1. region a:6-323 [121257]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk