Fold: Alkaline phosphatase-like

core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Alkaline phosphatase-like [53648]
   core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest

Superfamilies:

1. Alkaline phosphatase-like [53649] (5)
   uperfamily
   1. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [64162] (1)
      1. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [64163]
         1. Bacillus stearothermophilus [TaxId: 1422] [64164] (4)
   2. Alkaline phosphatase [53650] (3)
      common fold is decorated with several large insertions
      1. Alkaline phosphatase [53651]
         1. Escherichia coli [TaxId: 562] [53652] (33)
         2. Human (Homo sapiens) [TaxId: 9606] [64165] (5)
         3. Northern shrimp (Pandalus borealis) [TaxId: 6703] [75300] (3)
            SQ Q9BHT8 # fragment
   3. Arylsulfatase [53653] (4)
      includes additional C-terminal alpha+beta (sub)domain
      1. Arylsulfatase A [53654]
         1. Human (Homo sapiens) [TaxId: 9606] [53655] (7)
      2. Arylsulfatase B (4-sulfatase) [53656]
         1. Human (Homo sapiens) [TaxId: 9606] [53657] (1)
         2. Pseudomonas aeruginosa [TaxId: 287] [69591] (1)
      3. Steryl-sulfatase [102649]
         contains membrane-anchoring alpha-hairpin insertion
         1. Human (Homo sapiens) [TaxId: 9606] [102650] (1)
            placental estrone/DHEA sulfatase
   4. Phosphonoacetate hydrolase [102651] (1)
      contains alpha+beta subdomain inserted near C-terminus
      1. Phosphonoacetate hydrolase [102652]
         1. Pseudomonas fluorescens [TaxId: 294] [102653] (1)
   5. DeoB catalytic domain-like [142735] (1)
      Pfam 08342 in the N-terminal part; Pfam 01676 in the C-terminal part; there is an alpha+beta domain between the two parts, inserted in the same location as the substrate-binding domain of 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase
      1. Phosphopentomutase DeoB [142736]
         1. Streptococcus mutans [TaxId: 1309] [142737] (2)
            SQ Q8DTU0 2-107,227-403

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk