Structural Classification of Proteins
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Fold: Alkaline phosphatase-like

core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Alkaline phosphatase-like [53648]
    core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest

Superfamilies:

  1. Alkaline phosphatase-like [53649] (5)
    link to SUPERFAMILY database - Superfamily
    1. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [64162] (1)
      1. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [64163]
        1. Bacillus stearothermophilus [TaxId: 1422] [64164] (4)
          1. 1o98 picpicxref
            complexed with 2pg, mn, so4; mutant
            1. region a:2-76,a:311-510 [86685] picpiclink
          2. 1eqj picpicxref
            complexed with 2pg, mn; mutant
            1. region a:3-76,a:311-510 [59496] picpiclink
          3. 1ejj picpicxref
            complexed with 3pg, mn; mutant
            1. region a:3-76,a:311-510 [59423] picpiclink
          4. 1o99 picpicxref
            complexed with 2pg, mn, so4; mutant
            1. region a:2-76,a:311-511 [81236] picpiclink
    2. Alkaline phosphatase [53650] (3)
      common fold is decorated with several large insertions
      1. Alkaline phosphatase [53651]
        1. Escherichia coli [TaxId: 562] [53652] (33)
          1. 1y6v picpic
            automatically matched to d1b8ja_
            complexed with co, po4, so4
            1. region a:1-449 [122674] picpiclink
          2. 1y6v picpic
            automatically matched to d1b8ja_
            complexed with co, po4, so4
            1. region b:1-449 [122675] picpiclink
          3. 1ed8 picpic
            complexed with mg, po4, so4, zn
            1. chain a [34988] picpiclink
            2. chain b [34989] picpiclink
          4. 1ed9 picpic
            complexed with mg, so4, zn
            1. chain a [34990] picpiclink
            2. chain b [34991] picpiclink
          5. 1b8j picpic
            complexed with mo3, so4, zn
            1. chain a [34992] picpiclink
            2. chain b [34993] picpiclink
          6. 1ura picpic
            complexed with po4, zn; mutant
            1. chain a [35002] picpiclink
            2. chain b [35003] picpiclink
          7. 1kh5 picpic
            complexed with af3, mg, zn; mutant
            1. chain a [72475] picpiclink
            2. chain b [72476] picpiclink
          8. 1ew9 picpic
            complexed with mmq, mo3, so4, zn, zo3
            1. chain a [70135] picpiclink
            2. chain b [70136] picpiclink
          9. 1urb picpic
            complexed with mg, po4, zn; mutant
            1. chain a [35000] picpiclink
            2. chain b [35001] picpiclink
          10. 1ali picpic
            complexed with mg, po4, zn; mutant
            1. chain a [34996] picpiclink
            2. chain b [34997] picpiclink
          11. 1hqa picpic
            complexed with zn; mutant
            1. chain a [34998] picpiclink
            2. chain b [34999] picpiclink
          12. 1alk picpic
            complexed with mg, po4, zn
            1. chain a [34994] picpiclink
            2. chain b [34995] picpiclink
          13. 1khj picpic
            complexed with af3, zn; mutant
            1. chain a [72481] picpiclink
            2. chain b [72482] picpiclink
          14. 2anh picpic
            complexed with po4, zn; mutant
            1. chain a [35004] picpiclink
            2. chain b [35005] picpiclink
          15. 1alh picpic
            complexed with po4, so4, zn; mutant
            1. chain a [35016] picpiclink
            2. chain b [35017] picpiclink
          16. 1anj picpic
            complexed with po4, zn; mutant
            1. chain a [35008] picpiclink
            2. chain b [35009] picpiclink
          17. 1kh7 picpic
            complexed with mg, so4, zn; mutant
            1. chain a [72477] picpiclink
            2. chain b [72478] picpiclink
          18. 1ew8 picpic
            complexed with mo3, pae, po4, so4, zn, zo3
            1. chain a [70133] picpiclink
            2. chain b [70134] picpiclink
          19. 1ajb picpic
            complexed with mg, so4, zn; mutant
            1. chain a [35012] picpiclink
            2. chain b [35013] picpiclink
          20. 1ani picpic
            complexed with po4, zn; mutant
            1. chain a [35018] picpiclink
            2. chain b [35019] picpiclink
          21. 1khk picpic
            complexed with mg, zn; mutant
            1. chain a [72483] picpiclink
            2. chain b [72484] picpiclink
          22. 1ajc picpic
            complexed with mg, zn; mutant
            1. chain a [35014] picpiclink
            2. chain b [35015] picpiclink
          23. 1aja picpic
            mutant
            1. chain a [35010] picpiclink
            2. chain b [35011] picpiclink
          24. 1alj picpic
            complexed with mg, po4, zn; mutant
            1. chain a [35024] picpiclink
            2. chain b [35025] picpiclink
          25. 1khl picpic
            complexed with po4, zn; mutant
            1. chain a [72485] picpiclink
            2. chain b [72486] picpiclink
          26. 1hjk picpic
            complexed with mg, so4, zn; mutant
            1. chain a [35006] picpiclink
            2. chain b [35007] picpiclink
          27. 1kh9 picpic
            complexed with af3, mg, zn; mutant
            1. chain a [72479] picpiclink
            2. chain b [72480] picpiclink
          28. 1kh4 picpic
            complexed with mg, po4, zn; mutant
            1. chain a [72473] picpiclink
            2. chain b [72474] picpiclink
          29. 1elz picpic
            complexed with mg, po4, zn; mutant
            1. chain a [35022] picpiclink
            2. chain b [35023] picpiclink
          30. 1ajd picpic
            complexed with mg, zn; mutant
            1. chain a [35020] picpiclink
            2. chain b [35021] picpiclink
          31. 1elx picpic
            complexed with mg, po4, zn; mutant
            1. chain a [35026] picpiclink
            2. chain b [35027] picpiclink
          32. 1ely picpic
            complexed with mg, po4, zn; mutant
            1. chain a [35028] picpiclink
            2. chain b [35029] picpiclink
          33. 1khn picpic
            complexed with zn; mutant
            1. chain a [72487] picpiclink
            2. chain b [72488] picpiclink
        2. Human (Homo sapiens) [TaxId: 9606] [64165] (5)
          1. 1zed picpic
            automatically matched to d1ew2a_
            complexed with ca, mg, nag, pnp, po3, zn
            1. region a:1-479 [124980] picpiclink
          2. 2glq picpic
            automatically matched to d1ew2a_
            complexed with mg, nag, po3, sr, zn
            1. region a:1-479 [135345] picpiclink
          3. 1zef picpic
            automatically matched to d1ew2a_
            complexed with ca, mg, nag, phe, po3, zn
            1. region a:1-479 [124983] picpiclink
          4. 1zeb picpic
            automatically matched to d1ew2a_
            complexed with ca, mg, nag, po3, zn
            1. region a:1-479 [124979] picpiclink
          5. 1ew2 picpic
            complexed with mg, nag, po4, zn
            1. chain a [59525] picpiclink
        3. Northern shrimp (Pandalus borealis) [TaxId: 6703] [75300] (3)
          SQ Q9BHT8 # fragment
          1. 1k7h picpic
            complexed with mae, nag, so4, zn
            1. chain a [72101] picpiclink
            2. chain b [72102] picpiclink
          2. 1shn picpic
            complexed with nag, po4, so4, zn
            1. chain a [105558] picpiclink
            2. chain b [105559] picpiclink
          3. 1shq picpic
            complexed with mg, nag, so4, zn
            1. chain a [105560] picpiclink
            2. chain b [105561] picpiclink
    3. Arylsulfatase [53653] (4)
      includes additional C-terminal alpha+beta (sub)domain
      1. Arylsulfatase A [53654]
        1. Human (Homo sapiens) [TaxId: 9606] [53655] (7)
          1. 1e2s picpic
            complexed with csn, mg, nag; mutant
            1. chain p [35031] picpiclink
          2. 1auk picpic
            complexed with fgl, mg, nag
            1. chain a [35030] picpiclink
          3. 1n2k picpic
            covalent reaction intermediate
            complexed with ca, fgp, nag
            1. chain a [91559] picpiclink
          4. 1e1z picpic
            complexed with mg, nag; mutant
            1. chain p [59158] picpiclink
          5. 1n2l picpic
            covalent reaction intermediate
            complexed with ca, fgp, nag
            1. chain a [91560] picpiclink
          6. 1e3c picpic
            complexed with mg, nag; mutant
            1. chain p [59187] picpiclink
          7. 1e33 picpic
            complexed with fgl, mg, nag; mutant
            1. chain p [59186] picpiclink
      2. Arylsulfatase B (4-sulfatase) [53656]
        1. Human (Homo sapiens) [TaxId: 9606] [53657] (1)
          1. 1fsu picpic
            complexed with als, ca, cl, nag
            1. chain a [35032] picpiclink
        2. Pseudomonas aeruginosa [TaxId: 287] [69591] (1)
          1. 1hdh picpic
            complexed with ca, fgl, so4
            1. chain a [65805] picpiclink
            2. chain b [65806] picpiclink
      3. Steryl-sulfatase [102649]
        contains membrane-anchoring alpha-hairpin insertion
        1. Human (Homo sapiens) [TaxId: 9606] [102650] (1)
          placental estrone/DHEA sulfatase
          1. 1p49 picpic
            complexed with als, bog, ca, nag, po4
            1. chain a [94089] picpiclink
    4. Phosphonoacetate hydrolase [102651] (1)
      contains alpha+beta subdomain inserted near C-terminus
      1. Phosphonoacetate hydrolase [102652]
        1. Pseudomonas fluorescens [TaxId: 294] [102653] (1)
          1. 1ei6 picpic
            complexed with ppf, tar, zn
            1. chain a [90443] picpiclink
            2. chain b [90444] picpiclink
            3. chain c [90445] picpiclink
            4. chain d [90446] picpiclink
    5. DeoB catalytic domain-like [142735] (1)
      Pfam 08342 in the N-terminal part; Pfam 01676 in the C-terminal part; there is an alpha+beta domain between the two parts, inserted in the same location as the substrate-binding domain of 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase
      1. Phosphopentomutase DeoB [142736]
        1. Streptococcus mutans [TaxId: 1309] [142737] (2)
          SQ Q8DTU0 2-107,227-403
          1. 2i09 picpicxrefxref
            1. region a:2-107,a:227-403 [136946] picpiclink
          2. 2i09 picpicxrefxref
            automatically matched to 2I09 A:2-107,A:227-403
            1. region b:2-107,b:227-403 [136948] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk