Structural Classification of Proteins
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Fold: Dihydrofolate reductase-like

3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Dihydrofolate reductase-like [53596]
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

Superfamilies:

  1. Dihydrofolate reductase-like [53597] (2)
    link to SUPERFAMILY database - Superfamily
    1. Dihydrofolate reductases [53598] (12)
      1. Dihydrofolate reductase, prokaryotic type [53599]
        1. Escherichia coli [TaxId: 562] [53600] (46) picpic
        2. Lactobacillus casei [TaxId: 1582] [53601] (8) picpic
        3. Mycobacterium tuberculosis [TaxId: 1773] [53602] (4) picpic
        4. Thermotoga maritima [TaxId: 2336] [53603] (2) picpic
        5. Haloferax volcanii [TaxId: 2246] [53604] (1) picpic
        6. Bacteriophage T4 [TaxId: 10665] [102635] (1) picpic
      2. Dihydrofolate reductases, eukaryotic type [53605]
        1. Chicken (Gallus gallus) [TaxId: 9031] [53606] (8) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [53607] (27) picpic
        3. Fungus (Pneumocystis carinii) [TaxId: 4754] [53608] (14) picpic
        4. Yeast (Candida albicans) [TaxId: 5476] [53609] (9) picpic
      3. Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610]
        1. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [88963] (3) picpic
        2. Cryptosporidium hominis [TaxId: 237895] [102636] (7) picpic
          SQ Q5CGA3 Q27552
    2. RibD C-terminal domain-like [142701] (3)
      Pfam 01872
      1. Riboflavin biosynthesis protein RibD [142702]
        1. Bacillus subtilis [TaxId: 1423] [142703] (8) picpic
          SQ P17618 146-359
        2. Thermotoga maritima [TaxId: 2336] [142704] (1) picpic
          SQ Q9X2E8 148-345
      2. HTP reductase [142705]
        monofunctional 5-amino-6-(5-phosphoribosylamino)uracil reductase
        1. Methanococcus jannaschii [TaxId: 2190] [142706] (6) picpic
          SQ Q58085 6-224
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk