Structural Classification of Proteins
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Family: Elongation factors

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Reductase/isomerase/elongation factor common domain [50412]
    barrel, closed; n=6, S=10; greek-key
  4. Superfamily: Translation proteins [50447]
    link to SUPERFAMILY database - Superfamily
  5. Family: Elongation factors [50448]

Protein Domains:

  1. Elongation factor Tu (EF-Tu), domain 2 [50449]
    N-terminal domain is related to G proteins; C-terminal domain is (6,10) barrel of circularly permuted topology
    1. Escherichia coli [TaxId: 562] [50450] (8)
      SQ P02990
      1. 1efc picpicxrefxref
        complexed with gdp, mg
        1. region a:205-296 [25680] picpiclink
        2. region b:205-296 [25681] picpiclink
      2. 1dg1 picpicxrefxref
        1. region g:205-296 [25684] picpiclink
        2. region h:205-296 [25685] picpiclink
      3. 1efu picpicxrefxrefxrefxref
        1. region a:205-296 [25682] picpiclink
        2. region c:205-296 [25683] picpiclink
      4. 2bvn picpicxrefxrefxrefxref
        automatically matched to d1d8ta1
        complexed with enx, gnp, mg
        1. region a:205-296 [129282] picpiclink
      5. 2bvn picpicxrefxrefxrefxref
        automatically matched to d1d8ta1
        complexed with enx, gnp, mg
        1. region b:205-296 [129285] picpiclink
      6. 1d8t picpicxrefxref
        complexed with ace, gdp, gea, mg
        1. region a:205-296 [25686] picpiclink
        2. region b:205-296 [25687] picpiclink
      7. 2fx3 picpicxrefxref
        automatically matched to d1d8ta1
        complexed with gdp, mg
        1. region a:205-296 [134271] picpiclink
      8. 1ob2 picpicxrefxref
        complexed with 2mg, 5mc, 7mg, gnp, h2u, kir, m2g, mad, mg, omc, omg, pha, psu, suc, yg
        1. region a:205-296 [103900] picpiclink
    2. Thermus aquaticus [TaxId: 271] [50451] (4)
      1. 1b23 picpicxrefxref
        complexed with aac, gnp, h2u, mg, mia, psu, s4u, so4
        1. region p:213-312 [25689] picpiclink
      2. 1eft picpicxrefxref
        complexed with gnp, mg
        1. region a:213-312 [25688] picpiclink
      3. 1ttt picpicxrefxref
        protein/tRNA complex; complexed with 1ma, 2mg, 5mc, 5mu, 7mg, gnp, h2u, m2g, mg, omc, omg, psu, yg
        1. region a:213-313 [25690] picpiclink
        2. region b:213-312 [25691] picpiclink
        3. region c:213-312 [25692] picpiclink
      4. 1tui picpicxrefxref
        complexed with gdp, mg
        1. region a:213-313 [25693] picpiclink
        2. region b:213-312 [25694] picpiclink
        3. region c:213-312 [25695] picpiclink
    3. Thermus thermophilus [TaxId: 274] [50452] (9)
      1. 2c78 picpicxrefxref
        automatically matched to d1aipa1
        complexed with gnp, mg, pul
        1. region a:213-312 [130037] picpiclink
      2. 2c77 picpicxrefxref
        automatically matched to d1aipa1
        complexed with gea, gnp, mg, peg
        1. region a:213-312 [130034] picpiclink
      3. 1exm picpicxrefxref
        complexed with gnp, mg
        1. region a:213-312 [25696] picpiclink
      4. 1ha3 picpicxrefxref
        complexed with bme, gdp, mau, mg
        1. region a:213-312 [60869] picpiclink
        2. region b:213-312 [60872] picpiclink
      5. 1aip picpicxrefxrefxrefxref
        1. region a:213-312 [25697] picpiclink
        2. region b:213-312 [25698] picpiclink
        3. region e:213-312 [25699] picpiclink
        4. region f:213-312 [25700] picpiclink
      6. 1ob5 picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1aipa1
        complexed with 2mg, 5mc, 5mu, 7mg, c, enx, gnp, h2u, m2g, mad, mg, omc, omg, pha, psu, yg
        1. region a:213-312 [118691] picpiclink
      7. 1ob5 picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1aipa1
        complexed with 2mg, 5mc, 5mu, 7mg, c, enx, gnp, h2u, m2g, mad, mg, omc, omg, pha, psu, yg
        1. region c:213-312 [118694] picpiclink
      8. 1ob5 picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1aipa1
        complexed with 2mg, 5mc, 5mu, 7mg, c, enx, gnp, h2u, m2g, mad, mg, omc, omg, pha, psu, yg
        1. region e:213-312 [118697] picpiclink
      9. 1zc8 picpicxrefxrefxref
        automatically matched to d1aipa1
        complexed with du
        1. region y:213-312 [124893] picpiclink
    4. Cow (Bos taurus), mitochondrial [TaxId: 9913] [50453] (2)
      SQ P49410 56-452
      1. 1d2e picpicxrefxref
        complexed with gdp, mo2, mo4
        1. region a:251-348 [25701] picpiclink
        2. region b:251-348 [25702] picpiclink
        3. region c:251-348 [25703] picpiclink
        4. region d:251-348 [25704] picpiclink
      2. 1xb2 picpicxrefxrefxrefxref
        1. region a:251-348 [115054] picpiclink
  2. Elongation factor eEF-1alpha, domain 2 [50454]
    eukaryotic and archaeal homologue of EF-Tu
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [50455] (6)
      1. 1f60 picpicxrefxrefxref
        1. region a:241-334 [25705] picpiclink
      2. 2b7c picpicxrefxrefxref
        automatically matched to d1f60a1
        mutant
        1. region a:241-334 [128030] picpiclink
      3. 1g7c picpicxrefxrefxref
        complexed with 5gp
        1. region a:241-334 [25706] picpiclink
      4. 1ije picpicxrefxrefxref
        complexed with gdp
        1. region a:241-334 [62485] picpiclink
      5. 2b7b picpicxrefxrefxref
        automatically matched to d1f60a1
        complexed with gdp; mutant
        1. region a:241-334 [128027] picpiclink
      6. 1ijf picpicxrefxrefxref
        complexed with gdp, mg
        1. region a:241-334 [62489] picpiclink
    2. Archaeon Sulfolobus solfataricus [TaxId: 2287] [69276] (2)
      SQ P35021
      1. 1jny picpicxrefxref
        complexed with gdp
        1. region a:228-322 [66982] picpiclink
        2. region b:228-322 [66985] picpiclink
      2. 1skq picpicxrefxref
        complexed with gdp, mg
        1. region a:228-322 [105678] picpiclink
        2. region b:228-322 [105681] picpiclink
  3. Elongation factor G (EF-G), domain II [50456]
    1. Thermus thermophilus [TaxId: 274] [50457] (9)
      1. 2bv3 picpicxrefxrefxrefxref
        automatically matched to d1efga1
        complexed with gnp, mg; mutant
        1. region a:283-403 [129237] picpiclink
      2. 2efg picpicxrefxrefxref
        complexed with gdp
        1. region a:283-401 [25708] picpiclink
      3. 2bm0 picpicxrefxrefxrefxref
        automatically matched to d1efga1
        complexed with gdp, mg; mutant
        1. region a:283-403 [128748] picpiclink
      4. 1fnm picpicxrefxrefxref
        complexed with gdp, mg; mutant
        1. region a:283-403 [25709] picpiclink
      5. 1dar picpicxrefxrefxref
        complexed with gdp
        1. region a:283-400 [25707] picpiclink
      6. 2bm1 picpicxrefxrefxrefxref
        automatically matched to d1efga1
        complexed with gdp, mg; mutant
        1. region a:283-403 [128753] picpiclink
      7. 1efg picpicxrefxrefxref
        complexed with gdp
        1. region a:283-403 [25711] picpiclink
      8. 1elo picpicxrefxrefxref
        1. region a:283-399 [25710] picpiclink
      9. 1ktv picpicxrefxrefxref
        1. region a:283-399 [91027] picpiclink
        2. region b:283-399 [91031] picpiclink
    2. Thermus thermophilus, EF-G-2 [TaxId: 274] [141334] (2)
      SQ Q5SI76 268-370
      TTHA1498
      1. 2dy1 picpicxrefxrefxrefxref
        automatically matched to d1wdta1
        complexed with gtp, mg
        1. region a:275-377 [146607] picpiclink
      2. 1wdt picpicxrefxrefxrefxref
        complexed with gtp, mg
        1. region a:275-377 [120911] picpiclink
  4. Elongation factor 2 (eEF-2), domain II [82118]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82119] (22)
      SQ P32324
      1. 1n0u picpicxrefxrefxref
        complexed with so1
        1. region a:344-481 [79757] picpiclink
      2. 1u2r picpicxrefxrefxref
        complexed with apr, dde, gdp, mg, so1
        1. region a:344-481 [107617] picpiclink
      3. 1n0v picpicxrefxrefxref
        1. region c:344-481 [79762] picpiclink
        2. region d:344-481 [79767] picpiclink
      4. 2npf picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with gdp, mou
        1. region a:344-481 [138432] picpiclink
      5. 2npf picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with gdp, mou
        1. region b:344-481 [138437] picpiclink
      6. 1zm9 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde, p34
        1. region a:344-481 [125336] picpiclink
      7. 1zm9 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde, p34
        1. region c:344-481 [125342] picpiclink
      8. 1zm9 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde, p34
        1. region e:344-481 [125348] picpiclink
      9. 1zm4 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde, tad
        1. region a:344-481 [125316] picpiclink
      10. 1zm4 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde, tad
        1. region c:344-481 [125322] picpiclink
      11. 1zm4 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde, tad
        1. region e:344-481 [125328] picpiclink
      12. 2e1r picpicxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with gdp, sod
        1. region a:344-481 [131966] picpiclink
      13. 1zm3 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde
        1. region a:344-481 [125298] picpiclink
      14. 1zm3 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde
        1. region c:344-481 [125304] picpiclink
      15. 1zm3 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with dde
        1. region e:344-481 [125310] picpiclink
      16. 1zm2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with apr, dde
        1. region a:344-481 [125280] picpiclink
      17. 1zm2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with apr, dde
        1. region c:344-481 [125286] picpiclink
      18. 1zm2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with apr, dde
        1. region e:344-481 [125292] picpiclink
      19. 2p8z picpicxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with apr, dde, gnp, so1
        1. region t:344-481 [139551] picpiclink
      20. 2p8x picpicxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with apr, dde, gnp
        1. region t:344-481 [139541] picpiclink
      21. 2p8y picpicxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with apr, dde, gdp, so1
        1. region t:344-481 [139546] picpiclink
      22. 2p8w picpicxrefxrefxrefxref
        automatically matched to d1n0ua1
        complexed with gnp
        1. region t:344-481 [139536] picpiclink
  5. Initiation factor eIF2 gamma subunit, domain II [74962]
    1. Archaeon Pyrococcus abyssi [TaxId: 29292] [74963] (5)
      1. 1kk1 picpicxrefxref
        complexed with gnp, mg, zn; mutant
        1. region a:201-321 [72634] picpiclink
      2. 1kk3 picpicxrefxref
        complexed with gdp, mg, zn
        1. region a:201-321 [72640] picpiclink
      3. 1kjz picpicxrefxref
        complexed with zn; mutant
        1. region a:201-321 [72628] picpiclink
      4. 1kk0 picpicxrefxref
        complexed with mse, zn
        1. region a:201-321 [72631] picpiclink
      5. 1kk2 picpicxrefxref
        complexed with gdp, mg, zn; mutant
        1. region a:201-321 [72637] picpiclink
    2. Archaeon Methanococcus jannaschii [TaxId: 2190] [101788] (1)
      1. 1s0u picpicxrefxref
        structural genomics
        complexed with zn
        1. region a:230-347 [98302] picpiclink
    3. Sulfolobus solfataricus [TaxId: 2287] [141335] (6)
      SQ Q980A5 207-320
      1. 2qn6 picpicxrefxrefxref
        automatically matched to d2ahoa1
        complexed with gdp, mg
        1. region a:207-320 [150911] picpiclink
      2. 2pmd picpicxrefxrefxrefxref
        automatically matched to d2ahoa1
        complexed with gdp, gnp, ppv
        1. region a:207-320 [149663] picpiclink
      3. 2pmd picpicxrefxrefxrefxref
        automatically matched to d2ahoa1
        complexed with gdp, gnp, ppv
        1. region b:207-320 [149666] picpiclink
      4. 2plf picpicxrefxref
        automatically matched to d2ahoa1
        1. region a:207-320 [149625] picpiclink
      5. 2aho picpicxrefxrefxrefxrefxref
        complexed with gnp, mg, zn
        1. region a:207-320 [126767] picpiclink
      6. 2qmu picpicxrefxrefxref
        automatically matched to d2ahoa1
        complexed with gdp, po4, zn
        1. region a:207-320 [150894] picpiclink
  6. Initiation factor IF2/eIF5b, domains 2 and 4 [50458]
    the C-terminal domain 4 has the same fold as domain 2; it probably binds fMet-tRNAfmet
    1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [50459] (3)
      1. 1g7s picpicxrefxref
        complexed with gdp
        1. region a:228-328 [25712] picpiclink
        2. region a:460-587 [25713] picpiclink
      2. 1g7t picpicxrefxref
        complexed with gnp, mg
        1. region a:228-328 [25714] picpiclink
        2. region a:460-586 [25715] picpiclink
      3. 1g7r picpicxrefxref
        1. region a:228-328 [25716] picpiclink
        2. region a:460-585 [25717] picpiclink
    2. Bacillus stearothermophilus [TaxId: 1422] [50460] (1)
      1. 1d1n picpic
        domain 4 only
        1. chain a [25718] picpiclink
  7. Eukaryotic peptide chain release factor ERF2, post-G domain [110225]
    1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [110226] (3)
      SQ O74718
      1. 1r5b picpicxrefxref
        1. region a:460-554 [104803] picpiclink
      2. 1r5n picpicxrefxref
        complexed with gdp
        1. region a:460-554 [104806] picpiclink
      3. 1r5o picpicxrefxref
        complexed with gnp
        1. region a:460-554 [104809] picpiclink
  8. Hypothetical protein PF0907 [110227]
    stand-alone protein related to this domain
    1. Pyrococcus furiosus [TaxId: 2261] [110228] (1)
      SQ Q8U2D2 18-108
      1. 1xe1 picpic
        Structural genomics target
        complexed with so4
        1. chain a [109571] picpiclink
  9. Elongation factor SelB, domains 2 and 4 [117218]
    EF-Tu homologue, contains extra C-terminal domain (domain 4) of the same fold as the postG domain 2
    1. Methanococcus maripaludis [TaxId: 39152] [117219] (3)
      SQ Q8J307
      1. 1wb1 picpicxrefxref
        complexed with cmh, dxc, gdp, mg, so4
        1. region a:180-271 [114436] picpiclink
        2. region a:390-468 [114437] picpiclink
        3. region b:180-271 [114440] picpiclink
        4. region c:180-271 [114443] picpiclink
        5. region c:390-468 [114444] picpiclink
        6. region d:180-271 [114447] picpiclink
      2. 1wb2 picpicxrefxref
        complexed with cmh, dxc, so4
        1. region a:180-271 [114450] picpiclink
        2. region a:390-468 [114451] picpiclink
        3. region b:180-271 [114454] picpiclink
        4. region c:180-271 [114457] picpiclink
        5. region c:390-468 [114458] picpiclink
        6. region d:180-271 [114461] picpiclink
      3. 1wb3 picpicxrefxref
        complexed with cmh, dxc, gnp, mg, so4
        1. region a:180-271 [114464] picpiclink
        2. region a:390-468 [114465] picpiclink
        3. region b:180-271 [114468] picpiclink
        4. region c:180-271 [114471] picpiclink
        5. region c:390-468 [114472] picpiclink
        6. region d:180-271 [114475] picpiclink
  10. Sulfate adenylate transferase subunit cysN/C, EF-Tu domain 2-like domain [141336]
    1. Pseudomonas syringae pv. tomato [TaxId: 323] [141337] (1)
      SQ Q87WW1 238-329
      1. 1zun picpicxrefxrefxref
        complexed with ags, gdp, mg, na
        1. region b:238-329 [125677] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk