Structural Classification of Proteins
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Superfamily: STI-like

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: beta-Trefoil [50352]
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
  4. Superfamily: STI-like [50386]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Kunitz (STI) inhibitors [50387] (7)
    1. Winged bean albumin 1 [50388]
      1. Goa bean (Psophocarpus tetragonolobus) [TaxId: 3891] [50389] (1)
        1. 1wba picpic
          1. chain a [25591] picpiclink
    2. Erythrina cafra trypsin inhibitor [50390]
      1. Erythrina caffra [TaxId: 3842] [50391] (1)
        1. 1tie picpic
          1. chain a [25592] picpiclink
    3. chymotrypsin inhibitor WCI [50392]
      1. Winged bean (Psophocarpus tetragonolobus) [TaxId: 3891] [50393] (6)
        1. 1eyl picpic
          complexed with so4
          1. chain a [25593] picpiclink
        2. 1fmz picpic
          complexed with so4; mutant
          1. chain a [25594] picpiclink
        3. 1fn0 picpic
          complexed with sul; mutant
          1. chain a [25595] picpiclink
        4. 4wbc picpic
          complexed with so4
          1. chain a [25596] picpiclink
        5. 2wbc picpic
          1. chain a [25597] picpiclink
        6. 1wbc picpic
          1. chain a [25598] picpiclink
    4. Soybean trypsin inhibitor [50394]
      1. Soybean (Glycine max) [TaxId: 3847] [50395] (4)
        1. 1avw picpicxref
          complexed with ca
          1. chain b [25599] picpiclink
        2. 1avx picpicxref
          complexed with ca
          1. chain b [25600] picpiclink
        3. 1ba7 picpic
          1. chain a [25601] picpiclink
          2. chain b [25602] picpiclink
        4. 1avu picpic
          1. chain a [25603] picpiclink
    5. Amylase/subtilisin inhibitor [50396]
      1. Barley (Hordeum vulgare), seed [TaxId: 4513] [50397] (3)
        1. 3bx1 picpicxrefxref
          automatically matched to d1avac_
          complexed with ca, cl, na
          1. region c:1-181 [155704] picpiclink
        2. 3bx1 picpicxrefxref
          automatically matched to d1avac_
          complexed with ca, cl, na
          1. region d:1-181 [155705] picpiclink
        3. 1ava picpicxrefxref
          complexed with ca
          1. chain c [25604] picpiclink
          2. chain d [25605] picpiclink
    6. Serine protease inhibitor DrTI [110213]
      1. Royal poinciana (Delonix regia) [TaxId: 72433] [110214] (1)
        SQ P83667
        1. 1r8n picpic
          1. chain a [104851] picpiclink
    7. Two-chain trypsin inhibitor [110215]
      1. Balsam copaiba (Copaifera langsdorffii) [TaxId: 280048] [110216] (1)
        SQ P84144,P84145 # two chains probably resulted from a single chain precursor
        1. 1r8o picpic
          1. chain a,b [104852] picpiclink
  2. Clostridium neurotoxins, C-terminal domain [50399] (3)
    overall fold is very similar to that of the STI family
    1. Tetanus neurotoxin [50400]
      1. Clostridium tetani [TaxId: 1513] [50401] (10)
        1. 1a8d picpicxref
          complexed with au; mutant
          1. region a:248-452 [25607] picpiclink
        2. 1dll picpicxref
          complexed with gol, lat
          1. region a:1111-1315 [25608] picpiclink
        3. 1diw picpicxref
          complexed with gal
          1. region a:1111-1315 [25609] picpiclink
        4. 1d0h picpicxref
          complexed with nga, so4; mutant
          1. region a:1111-1315 [25610] picpiclink
        5. 1yxw picpicxref
          automatically matched to d1a8d_2
          complexed with glu, trp, tyr
          1. region a:1111-1315 [124202] picpiclink
        6. 1yyn picpicxref
          automatically matched to d1a8d_2
          complexed with gla, glc, sia
          1. region a:1111-1315 [124243] picpiclink
        7. 1af9 picpicxref
          mutant
          1. region a:1111-1315 [25611] picpiclink
        8. 1fv2 picpicxref
          complexed with ceq, gal, glc, nan, nga, po4, slb
          1. region a:1111-1315 [60037] picpiclink
        9. 1fv3 picpicxref
          complexed with ceq, gal, glc, nan, nga, po4, slb
          1. region a:1111-1315 [60039] picpiclink
          2. region b:1111-1315 [60041] picpiclink
        10. 1dfq picpicxref
          complexed with sia
          1. region a:1111-1315 [25612] picpiclink
    2. Botulinum neurotoxin [50402]
      1. Clostridium botulinum, serotype A [TaxId: 1491] [50403] (1)
        1. 3bta picpicxrefxrefxref
          complexed with zn
          1. region a:1079-1295 [25613] picpiclink
      2. Clostridium botulinum, serotype B [TaxId: 1491] [50404] (17)
        1. 1epw picpicxrefxrefxref
          complexed with so4, zn
          1. region a:1080-1290 [25614] picpiclink
        2. 1s0e picpicxrefxrefxref
          complexed with ca, zn
          1. region a:1080-1290 [98278] picpiclink
        3. 1s0b picpicxrefxrefxref
          complexed with ca
          1. region a:1080-1290 [98266] picpiclink
        4. 1g9b picpicxrefxrefxref
          complexed with bab, zn
          1. region a:1080-1290 [76205] picpiclink
        5. 1g9a picpicxrefxrefxref
          complexed with bab, zn
          1. region a:1080-1290 [76201] picpiclink
        6. 2nm1 picpicxref
          automatically matched to d1epwa2
          1. region a:1081-1291 [138370] picpiclink
        7. 1s0c picpicxrefxrefxref
          complexed with ca, zn
          1. region a:1080-1290 [98270] picpiclink
        8. 1z0h picpicxrefxref
          automatically matched to d1epwa2
          1. region a:1080-1290 [124315] picpiclink
        9. 1z0h picpicxrefxref
          automatically matched to d1epwa2
          1. region b:1080-1290 [124317] picpiclink
        10. 1s0d picpicxrefxrefxref
          complexed with ca, zn
          1. region a:1080-1290 [98274] picpiclink
        11. 1g9c picpicxrefxrefxref
          complexed with bab, zn
          1. region a:1080-1290 [76209] picpiclink
        12. 1i1e picpicxrefxrefxref
          complexed with dm2, so4, zn
          1. region a:1080-1290 [65979] picpiclink
        13. 1s0f picpicxrefxrefxref
          complexed with ca, zn
          1. region a:1080-1290 [98282] picpiclink
        14. 1s0g picpicxrefxrefxref
          1. region a:1080-1290 [98286] picpiclink
        15. 2np0 picpicxrefxrefxref
          automatically matched to d1epwa2
          complexed with ca, cl, zn
          1. region a:1080-1290 [138417] picpiclink
        16. 1g9d picpicxrefxrefxref
          complexed with bab, zn
          1. region a:1080-1290 [76213] picpiclink
        17. 1f31 picpicxrefxrefxref
          complexed with gal, glc, sia, so4, zn
          1. region a:1080-1290 [25615] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk