Structural Classification of Proteins
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Family: Fibroblast growth factors (FGF)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: beta-Trefoil [50352]
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
  4. Superfamily: Cytokine [50353]
    link to SUPERFAMILY database - Superfamily
  5. Family: Fibroblast growth factors (FGF) [50354]

Protein Domains:

  1. Basic FGF (FGF2) [50355]
    1. Human (Homo sapiens) [TaxId: 9606] [50356] (16)
      1. 1bfg picpic
        mutant
        1. chain a [25485] picpiclink
      2. 4fgf picpic
        complexed with seo, so4
        1. chain a [25486] picpiclink
      3. 2fgf picpic
        complexed with so4
        1. chain a [25487] picpiclink
      4. 1bas picpic
        mutant
        1. chain a [25488] picpiclink
      5. 1bfb picpic
        complexed with idu, sgn, uap; mutant
        1. chain a [25490] picpiclink
      6. 1bff picpic
        154 residue form
        complexed with bme, po4
        1. chain a [25489] picpiclink
      7. 1ev2 picpicxref
        complexed with so4; mutant
        1. chain a [25493] picpiclink
        2. chain b [25494] picpiclink
        3. chain c [25495] picpiclink
        4. chain d [25496] picpiclink
      8. 1bfc picpic
        complexed with idu, sgn, uap; mutant
        1. chain a [25492] picpiclink
      9. 1iil picpicxref
        mutant
        1. chain a [62433] picpiclink
        2. chain b [62434] picpiclink
        3. chain c [62435] picpiclink
        4. chain d [62436] picpiclink
      10. 1fga picpic
        complexed with se4, seo
        1. chain a [25491] picpiclink
      11. 2bfh picpic
        1. chain a [25497] picpiclink
      12. 1cvs picpicxref
        1. chain a [25498] picpiclink
        2. chain b [25499] picpiclink
      13. 1ii4 picpicxref
        mutant
        1. chain a [62400] picpiclink
        2. chain b [62401] picpiclink
        3. chain c [62402] picpiclink
        4. chain d [62403] picpiclink
      14. 1fq9 picpicxref
        complexed with idu, sgn, uap; mutant
        1. chain a [25500] picpiclink
        2. chain b [25501] picpiclink
      15. 1bla picpic
        mutant
        1. chain a [25502] picpiclink
      16. 1bld picpic
        mutant
        1. chain a [25503] picpiclink
  2. Acidic FGF (FGF1) [50357]
    1. Cow (Bos taurus) [TaxId: 9913] [50358] (2)
      1. 1bar picpic
        mutant
        1. chain a [25504] picpiclink
        2. chain b [25505] picpiclink
      2. 1afc picpic
        complexed with scr; mutant
        1. chain a [25506] picpiclink
        2. chain b [25507] picpiclink
        3. chain c [25508] picpiclink
        4. chain d [25509] picpiclink
        5. chain e [25510] picpiclink
        6. chain f [25511] picpiclink
        7. chain g [25512] picpiclink
        8. chain h [25513] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [50359] (28)
      SQ P05230 16-152 ! SQ P05230
      1. 1rg8 picpic
        complexed with fmt
        1. chain a [111801] picpiclink
        2. chain b [111802] picpiclink
      2. 1p63 picpic
        complexed with fmt, so4; mutant
        1. chain a [94153] picpiclink
        2. chain b [94154] picpiclink
      3. 1jqz picpic
        complexed with fmt
        1. chain a [67109] picpiclink
        2. chain b [67110] picpiclink
      4. 1q04 picpic
        complexed with fmt; mutant
        1. chain a [104402] picpiclink
        2. chain b [104403] picpiclink
      5. 1jtc picpic
        complexed with fmt; mutant
        1. chain a [67260] picpiclink
        2. chain b [67261] picpiclink
        3. chain c [67262] picpiclink
        4. chain d [67263] picpiclink
      6. 1jt7 picpic
        complexed with fmt, so4; mutant
        1. chain a [67255] picpiclink
        2. chain b [67256] picpiclink
        3. chain c [67257] picpiclink
        4. chain d [67258] picpiclink
      7. 1jt4 picpic
        complexed with fmt; mutant
        1. chain a [67243] picpiclink
        2. chain b [67244] picpiclink
      8. 1jy0 picpic
        complexed with fmt; mutant
        1. chain a [90923] picpiclink
        2. chain b [90924] picpiclink
      9. 1pzz picpic
        complexed with fmt, so4; mutant
        1. chain a [104398] picpiclink
        2. chain b [104399] picpiclink
      10. 1m16 picpic
        complexed with fmt, so4; mutant
        1. chain a [91164] picpiclink
        2. chain b [91165] picpiclink
      11. 1q03 picpic
        mutant
        1. chain a [104400] picpiclink
        2. chain b [104401] picpiclink
      12. 1jt5 picpic
        complexed with so4; mutant
        1. chain a [67245] picpiclink
        2. chain b [67246] picpiclink
      13. 1nzk picpic
        complexed with fmt, so4; mutant
        1. chain a [92378] picpiclink
        2. chain b [92379] picpiclink
        3. chain c [92380] picpiclink
        4. chain d [92381] picpiclink
      14. 1jt3 picpic
        complexed with so4; mutant
        1. chain a [67241] picpiclink
        2. chain b [67242] picpiclink
      15. 1hkn picpic
        complexed with n2m
        1. chain a [90638] picpiclink
        2. chain b [90639] picpiclink
        3. chain c [90640] picpiclink
        4. chain d [90641] picpiclink
        5. chain e [90642] picpiclink
        6. chain f [90643] picpiclink
      16. 1k5u picpic
        complexed with so4; mutant
        1. chain a [68207] picpiclink
        2. chain b [68208] picpiclink
        3. chain c [68209] picpiclink
      17. 1k5v picpic
        complexed with so4; mutant
        1. chain a [68210] picpiclink
        2. chain b [68211] picpiclink
      18. 2afg picpic
        complexed with so4
        1. chain a [25514] picpiclink
        2. chain b [25515] picpiclink
        3. chain c [25516] picpiclink
        4. chain d [25517] picpiclink
      19. 1djs picpicxref
        1. chain b [25518] picpiclink
      20. 2axm picpic
        Heparin-linked biologically-active dimer
        complexed with ids, sgn
        1. chain a [25519] picpiclink
        2. chain b [25520] picpiclink
      21. 1evt picpicxref
        complexed with so4
        1. chain a [25527] picpiclink
        2. chain b [25528] picpiclink
      22. 1axm picpic
        heparin-linked biologically-active dimer
        complexed with ids, sgn
        1. chain a [25521] picpiclink
        2. chain b [25522] picpiclink
        3. chain c [25523] picpiclink
        4. chain d [25524] picpiclink
        5. chain e [25525] picpiclink
        6. chain f [25526] picpiclink
      23. 1e0o picpicxref
        complexed with 2si, ni, sgn, so4
        1. chain a [25529] picpiclink
        2. chain c [25530] picpiclink
      24. 2erm picpic
        automatically matched to d1jtca_
        complexed with gns, idr, ids, ipa, ngs
        1. region b:22-151 [132302] picpiclink
      25. 1ry7 picpicxref
        1. chain a [98091] picpiclink
      26. 1dzd picpic
        1. chain a [25532] picpiclink
      27. 1dzc picpic
        mutant
        1. chain a [25531] picpiclink
      28. 1rml picpic
        complexed with nts
        1. chain a [25533] picpiclink
    3. Eastern newt (Notophthalmus viridescens) [TaxId: 8316] [63778] (1)
      1. 1fmm picpic
        1. chain s [59883] picpiclink
  3. Fibroblast growth factor 4 (FGF4) [63779]
    1. Human (Homo sapiens) [TaxId: 9606] [63780] (1)
      1. 1ijt picpic
        complexed with so4; mutant
        1. chain a [62510] picpiclink
  4. Keratinocyte growth factor, FGF7 [50360]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50361] (2)
      1. 1qqk picpic
        1. chain a [25535] picpiclink
        2. chain b [25536] picpiclink
      2. 1qql picpic
        Rat FGF7 + human FGF1 chimera
        1. chain a [25534] picpiclink
  5. Fibroblast growth factor 9, FGF9 [63781]
    1. Human (Homo sapiens) [TaxId: 9606] [63782] (2)
      1. 1ihk picpic
        complexed with po4
        1. chain a [62384] picpiclink
      2. 1g82 picpic
        complexed with fuc, nag, so4
        1. chain a [60337] picpiclink
        2. chain b [60338] picpiclink
        3. chain c [60339] picpiclink
        4. chain d [60340] picpiclink
  6. Fibroblast growth factor-10, FGF10 [82107]
    1. Human (Homo sapiens) [TaxId: 9606] [82108] (1)
      1. 1nun picpicxref
        complexed with 15p, mse, so4
        1. chain a [80734] picpiclink
  7. Fibrobast growth factor homologous factor 1 (FHF1b, FGF12b) [101776]
    1. Human (Homo sapiens) [TaxId: 9606] [101777] (1)
      1. 1q1u picpic
        complexed with so4; mutant
        1. chain a [95608] picpiclink
  8. Fibroblast growth factor-19 (FGF19) [101778]
    1. Human (Homo sapiens) [TaxId: 9606] [101779] (3)
      1. 1pwa picpic
        complexed with gol, so4, trs
        1. chain a [95211] picpiclink
      2. 2p23 picpic
        automatically matched to d1pwaa_
        1. region a:41-175 [139459] picpiclink
      3. 2p23 picpic
        automatically matched to d1pwaa_
        1. region b:1041-1175 [139460] picpiclink
  9. Fibroblast growth factor 8, FGF8 [159145]
    1. Human (Homo sapiens) [TaxId: 9606] [159146] (2)
      SQ P55075 52-198
      1. 2fdb picpicxrefxrefxrefxref
        1. region m:34-180 [145162] picpiclink
      2. 2fdb picpicxrefxrefxrefxref
        automatically matched to 2FDB M:34-180
        1. region n:1034-1179 [145163] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk