Structural Classification of Proteins
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Fold: beta-Trefoil

barrel, closed; n=6, S=12; and a hairpin triplet; meander
duplication: has internal pseudo threefold symmetry

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: beta-Trefoil [50352]
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry

Superfamilies:

  1. Cytokine [50353] (2)
    link to SUPERFAMILY database - Superfamily
    1. Fibroblast growth factors (FGF) [50354] (11)
      1. Basic FGF (FGF2) [50355]
        1. Human (Homo sapiens) [TaxId: 9606] [50356] (16) picpic
      2. Acidic FGF (FGF1) [50357]
        1. Cow (Bos taurus) [TaxId: 9913] [50358] (2) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [50359] (28) picpic
          SQ P05230 16-152 ! SQ P05230
        3. Eastern newt (Notophthalmus viridescens) [TaxId: 8316] [63778] (1) picpic
      3. Fibroblast growth factor 4 (FGF4) [63779]
        1. Human (Homo sapiens) [TaxId: 9606] [63780] (1) picpic
      4. Keratinocyte growth factor, FGF7 [50360]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [50361] (2) picpic
      5. Fibroblast growth factor 9, FGF9 [63781]
        1. Human (Homo sapiens) [TaxId: 9606] [63782] (2) picpic
      6. Fibroblast growth factor-10, FGF10 [82107]
        1. Human (Homo sapiens) [TaxId: 9606] [82108] (1) picpic
      7. Fibrobast growth factor homologous factor 1 (FHF1b, FGF12b) [101776]
        1. Human (Homo sapiens) [TaxId: 9606] [101777] (1) picpic
      8. Fibroblast growth factor-19 (FGF19) [101778]
        1. Human (Homo sapiens) [TaxId: 9606] [101779] (3) picpic
      9. Fibroblast growth factor 8, FGF8 [159145]
        1. Human (Homo sapiens) [TaxId: 9606] [159146] (2) picpic
          SQ P55075 52-198
    2. Interleukin-1 (IL-1) [50362] (6)
      1. Interleukin-1beta [50363]
        1. Human (Homo sapiens) [TaxId: 9606] [50364] (20) picpic
          SQ P01584 117-269
        2. Mouse (Mus musculus) [TaxId: 10090] [50365] (2) picpic
      2. Interleukin-1 receptor antagonist protein [50366]
        1. Human (Homo sapiens) [TaxId: 9606] [50367] (5) picpic
      3. Interleukin-1alpha [50368]
        1. Human (Homo sapiens) [TaxId: 9606] [50369] (1) picpic
      4. Interleukin-1F5 [101780]
        1. Mouse (Mus musculus) [TaxId: 10090] [101781] (1) picpic
      5. Interleukin-18 [101782]
        1. Human (Homo sapiens) [TaxId: 9606] [101783] (1) picpic
  2. MIR domain [82109] (1)
    link to SUPERFAMILY database - Superfamily
    1. MIR domain [82110] (2)
      Pfam 02815
      1. IP3 receptor type 1 binding core, domain 1 [82111]
        1. Mouse (Mus musculus) [TaxId: 10090] [82112] (1) picpic
      2. Hypothetical protein R12E2.13 (1D10) [110205]
        1. Caenorhabditis elegans [TaxId: 6239] [110206] (1) picpic
          SQ O61793
  3. Ricin B-like lectins [50370] (3)
    link to SUPERFAMILY database - Superfamily
    1. Ricin B-like [50371] (18)
      1. Plant cytotoxin B-chain (lectin) [50372]
        duplication: consists of two domains of this fold
        1. Castor bean (Ricinus communis), Ricin [TaxId: 3988] [50373] (2) picpic
          SQ P06750 303-564
        2. Abrus precatorius [TaxId: 3816] [50374] (1) picpic
        3. Mongolian snake-gourd (Trichosanthes kirilowii), Lectin 1 [TaxId: 3677] [89337] (1) picpic
        4. European mistletoe (Viscum album) [TaxId: 3972] [50375] (18) picpic
          different sequence variants
          SQ Q6ITZ3 266-520; SQ P81446 269-531 # 91% sequence identity
        5. Sambucus ebulus, ebulin [TaxId: 28503] [50376] (4) picpic
      2. Xylan binding domain, CBM13 (Endo-1,4-beta-xylanase C-terminal domain) [50377]
        1. Streptomyces olivaceoviridis [TaxId: 1921] [50378] (11) picpic
        2. Streptomyces lividans [TaxId: 1916] [74958] (3) picpic
      3. Hemagglutinin component Ha1 [101784]
        1. Clostridium botulinum D phage [TaxId: 29342] [101785] (1) picpic
        2. Clostridium botulinum [TaxId: 1491] [159147] (12) picpic
      4. Cytolethal distending toxin subunit A [110207]
        1. Haemophilus ducreyi [TaxId: 730] [110208] (1) picpic
          SQ O06522 57-223
        2. Actinobacillus actinomycetemcomitans [TaxId: 714] [141329] (2) picpic
          SQ O87120 70-222
      5. Cytolethal distending toxin subunit C [110209]
        1. Haemophilus ducreyi [TaxId: 730] [110210] (1) picpic
          SQ O06524 25-178
        2. Actinobacillus actinomycetemcomitans [TaxId: 714] [141330] (2) picpic
          SQ Q7DK11 25-178
      6. Hemolytic lectin CEL-III, domains 1 and 2 [110211]
        1. Cucumaria echinata [TaxId: 40245] [110212] (9) picpic
          SQ Q868M7 11-442
      7. Polypeptide N-acetylgalactosaminyltransferase 1, C-terminal domain [117210]
        1. Mouse (Mus musculus) [TaxId: 10090] [117211] (1) picpic
          SQ O08912
      8. 29-kDa galactose-binding lectin [159148]
        duplication: tadem repeat of two Ricin B-like domains
        1. Lumbricus terrestris [TaxId: 6398] [159149] (4) picpic
          SQ O96048 131-260
      9. Agglutinin-1 chain B [159150]
        1. Abrus precatorius [TaxId: 3816] [159151] (2) picpic
          SQ Q9M6E9 287-420! SQ Q9M6E9 421-547
      10. Agglutinin MOA, N-terminal domain [159152]
        1. Fairy-ring mushroom (Marasmius oreades) [TaxId: 181124] [159153] (1) picpic
          SQ Q8X123 2-155
    2. Cysteine rich domain [50379] (1)
      1. Mannose receptor [50380]
        1. Mouse (Mus musculus) [TaxId: 10090] [50381] (4) picpic
    3. GlcNAc-alpha-1,4-Gal-releasing endo-beta-galactosidase, GngC, C-terminal domain [117212] (1)
      1. GlcNAc-alpha-1,4-Gal-releasing endo-beta-galactosidase, GngC, C-terminal domain [117213]
        1. Clostridium perfringens [TaxId: 1502] [117214] (1) picpic
          SQ Q934G8 17-420
  4. Agglutinin [50382] (1)
    this superfamily is distinct from the ricin B-like lectin superfamily
    link to SUPERFAMILY database - Superfamily
    1. Agglutinin [50383] (1)
      1. Agglutinin [50384]
        duplication: the tandem repeat of beta-trefoil domains
        1. Love-lies-bleeding (Amaranthus caudatus) [TaxId: 3567] [50385] (2) picpic
  5. STI-like [50386] (2)
    link to SUPERFAMILY database - Superfamily
    1. Kunitz (STI) inhibitors [50387] (7)
      1. Winged bean albumin 1 [50388]
        1. Goa bean (Psophocarpus tetragonolobus) [TaxId: 3891] [50389] (1) picpic
      2. Erythrina cafra trypsin inhibitor [50390]
        1. Erythrina caffra [TaxId: 3842] [50391] (1) picpic
      3. chymotrypsin inhibitor WCI [50392]
        1. Winged bean (Psophocarpus tetragonolobus) [TaxId: 3891] [50393] (6) picpic
      4. Soybean trypsin inhibitor [50394]
        1. Soybean (Glycine max) [TaxId: 3847] [50395] (4) picpic
      5. Amylase/subtilisin inhibitor [50396]
        1. Barley (Hordeum vulgare), seed [TaxId: 4513] [50397] (3) picpic
      6. Serine protease inhibitor DrTI [110213]
        1. Royal poinciana (Delonix regia) [TaxId: 72433] [110214] (1) picpic
          SQ P83667
      7. Two-chain trypsin inhibitor [110215]
        1. Balsam copaiba (Copaifera langsdorffii) [TaxId: 280048] [110216] (1) picpic
          SQ P84144,P84145 # two chains probably resulted from a single chain precursor
    2. Clostridium neurotoxins, C-terminal domain [50399] (3)
      overall fold is very similar to that of the STI family
      1. Tetanus neurotoxin [50400]
        1. Clostridium tetani [TaxId: 1513] [50401] (10) picpic
      2. Botulinum neurotoxin [50402]
        1. Clostridium botulinum, serotype A [TaxId: 1491] [50403] (1) picpic
        2. Clostridium botulinum, serotype B [TaxId: 1491] [50404] (17) picpic
  6. Actin-crosslinking proteins [50405] (2)
    link to SUPERFAMILY database - Superfamily
    1. Fascin [50406] (1)
      1. Fascin [50407]
        duplication: tandem repeat of four domains
        1. Human (Homo sapiens) [TaxId: 9606] [50408] (1) picpic
    2. Histidine-rich actin-binding protein (hisactophilin) [50409] (1)
      1. Histidine-rich actin-binding protein (hisactophilin) [50410]
        1. Dictyostelium discoideum [TaxId: 44689] [50411] (2) picpic
  7. DNA-binding protein LAG-1 (CSL) [110217] (1)
    contains rudiment hairpin triplet lacking one hairpin
    link to SUPERFAMILY database - Superfamily
    1. DNA-binding protein LAG-1 (CSL) [110218] (1)
      1. DNA-binding protein LAG-1 (CSL) [110219]
        1. Caenorhabditis elegans [TaxId: 6239] [110220] (4) picpic
          SQ Q9TYY1 195-660
  8. AbfB domain [110221] (1)
    link to SUPERFAMILY database - Superfamily
    1. AbfB domain [110222] (1)
      Pfam 05270
      1. Alpha-L-arabinofuranosidase B (AbfB), C-terminal domain [110223]
        1. Aspergillus kawachii [TaxId: 40384] [110224] (4) picpic
          SQ Q8NK89 19-499
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk