Fold: beta-Trefoil

barrel, closed; n=6, S=12; and a hairpin triplet; meander
duplication: has internal pseudo threefold symmetry

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]
3. Fold: beta-Trefoil [50352]
   barrel, closed; n=6, S=12; and a hairpin triplet; meander
   duplication: has internal pseudo threefold symmetry

Superfamilies:

1. Cytokine [50353] (2)
   uperfamily
   1. Fibroblast growth factors (FGF) [50354] (11)
      1. Basic FGF (FGF2) [50355]
         1. Human (Homo sapiens) [TaxId: 9606] [50356] (16)
            1. 1bfg
               mutant
               1. chain a [25485]
            2. 4fgf
               complexed with seo, so4
               1. chain a [25486]
            3. 2fgf
               complexed with so4
               1. chain a [25487]
            4. 1bas
               mutant
               1. chain a [25488]
            5. 1bfb
               complexed with idu, sgn, uap; mutant
               1. chain a [25490]
            6. 1bff
               154 residue form
               complexed with bme, po4
               1. chain a [25489]
            7. 1ev2
               complexed with so4; mutant
               1. chain a [25493]
               2. chain b [25494]
               3. chain c [25495]
               4. chain d [25496]
            8. 1bfc
               complexed with idu, sgn, uap; mutant
               1. chain a [25492]
            9. 1iil
               mutant
               1. chain a [62433]
               2. chain b [62434]
               3. chain c [62435]
               4. chain d [62436]
            10. 1fga
                complexed with se4, seo
                1. chain a [25491]
            11. 2bfh
                1. chain a [25497]
            12. 1cvs
                1. chain a [25498]
                2. chain b [25499]
            13. 1ii4
                mutant
                1. chain a [62400]
                2. chain b [62401]
                3. chain c [62402]
                4. chain d [62403]
            14. 1fq9
                complexed with idu, sgn, uap; mutant
                1. chain a [25500]
                2. chain b [25501]
            15. 1bla
                mutant
                1. chain a [25502]
            16. 1bld
                mutant
                1. chain a [25503]
      2. Acidic FGF (FGF1) [50357]
         1. Cow (Bos taurus) [TaxId: 9913] [50358] (2)
            1. 1bar
               mutant
               1. chain a [25504]
               2. chain b [25505]
            2. 1afc
               complexed with scr; mutant
               1. chain a [25506]
               2. chain b [25507]
               3. chain c [25508]
               4. chain d [25509]
               5. chain e [25510]
               6. chain f [25511]
               7. chain g [25512]
               8. chain h [25513]
         2. Human (Homo sapiens) [TaxId: 9606] [50359] (28)
            SQ P05230 16-152 ! SQ P05230
            1. 1rg8
               complexed with fmt
               1. chain a [111801]
               2. chain b [111802]
            2. 1p63
               complexed with fmt, so4; mutant
               1. chain a [94153]
               2. chain b [94154]
            3. 1jqz
               complexed with fmt
               1. chain a [67109]
               2. chain b [67110]
            4. 1q04
               complexed with fmt; mutant
               1. chain a [104402]
               2. chain b [104403]
            5. 1jtc
               complexed with fmt; mutant
               1. chain a [67260]
               2. chain b [67261]
               3. chain c [67262]
               4. chain d [67263]
            6. 1jt7
               complexed with fmt, so4; mutant
               1. chain a [67255]
               2. chain b [67256]
               3. chain c [67257]
               4. chain d [67258]
            7. 1jt4
               complexed with fmt; mutant
               1. chain a [67243]
               2. chain b [67244]
            8. 1jy0
               complexed with fmt; mutant
               1. chain a [90923]
               2. chain b [90924]
            9. 1pzz
               complexed with fmt, so4; mutant
               1. chain a [104398]
               2. chain b [104399]
            10. 1m16
                complexed with fmt, so4; mutant
                1. chain a [91164]
                2. chain b [91165]
            11. 1q03
                mutant
                1. chain a [104400]
                2. chain b [104401]
            12. 1jt5
                complexed with so4; mutant
                1. chain a [67245]
                2. chain b [67246]
            13. 1nzk
                complexed with fmt, so4; mutant
                1. chain a [92378]
                2. chain b [92379]
                3. chain c [92380]
                4. chain d [92381]
            14. 1jt3
                complexed with so4; mutant
                1. chain a [67241]
                2. chain b [67242]
            15. 1hkn
                complexed with n2m
                1. chain a [90638]
                2. chain b [90639]
                3. chain c [90640]
                4. chain d [90641]
                5. chain e [90642]
                6. chain f [90643]
            16. 1k5u
                complexed with so4; mutant
                1. chain a [68207]
                2. chain b [68208]
                3. chain c [68209]
            17. 1k5v
                complexed with so4; mutant
                1. chain a [68210]
                2. chain b [68211]
            18. 2afg
                complexed with so4
                1. chain a [25514]
                2. chain b [25515]
                3. chain c [25516]
                4. chain d [25517]
            19. 1djs
                1. chain b [25518]
            20. 2axm
                Heparin-linked biologically-active dimer
                complexed with ids, sgn
                1. chain a [25519]
                2. chain b [25520]
            21. 1evt
                complexed with so4
                1. chain a [25527]
                2. chain b [25528]
            22. 1axm
                heparin-linked biologically-active dimer
                complexed with ids, sgn
                1. chain a [25521]
                2. chain b [25522]
                3. chain c [25523]
                4. chain d [25524]
                5. chain e [25525]
                6. chain f [25526]
            23. 1e0o
                complexed with 2si, ni, sgn, so4
                1. chain a [25529]
                2. chain c [25530]
            24. 2erm
                automatically matched to d1jtca_
                complexed with gns, idr, ids, ipa, ngs
                1. region b:22-151 [132302]
            25. 1ry7
                1. chain a [98091]
            26. 1dzd
                1. chain a [25532]
            27. 1dzc
                mutant
                1. chain a [25531]
            28. 1rml
                complexed with nts
                1. chain a [25533]
         3. Eastern newt (Notophthalmus viridescens) [TaxId: 8316] [63778] (1)
            1. 1fmm
               1. chain s [59883]
      3. Fibroblast growth factor 4 (FGF4) [63779]
         1. Human (Homo sapiens) [TaxId: 9606] [63780] (1)
            1. 1ijt
               complexed with so4; mutant
               1. chain a [62510]
      4. Keratinocyte growth factor, FGF7 [50360]
         1. Rat (Rattus norvegicus) [TaxId: 10116] [50361] (2)
            1. 1qqk
               1. chain a [25535]
               2. chain b [25536]
            2. 1qql
               Rat FGF7 + human FGF1 chimera
               1. chain a [25534]
      5. Fibroblast growth factor 9, FGF9 [63781]
         1. Human (Homo sapiens) [TaxId: 9606] [63782] (2)
            1. 1ihk
               complexed with po4
               1. chain a [62384]
            2. 1g82
               complexed with fuc, nag, so4
               1. chain a [60337]
               2. chain b [60338]
               3. chain c [60339]
               4. chain d [60340]
      6. Fibroblast growth factor-10, FGF10 [82107]
         1. Human (Homo sapiens) [TaxId: 9606] [82108] (1)
            1. 1nun
               complexed with 15p, mse, so4
               1. chain a [80734]
      7. Fibrobast growth factor homologous factor 1 (FHF1b, FGF12b) [101776]
         1. Human (Homo sapiens) [TaxId: 9606] [101777] (1)
            1. 1q1u
               complexed with so4; mutant
               1. chain a [95608]
      8. Fibroblast growth factor-19 (FGF19) [101778]
         1. Human (Homo sapiens) [TaxId: 9606] [101779] (3)
            1. 1pwa
               complexed with gol, so4, trs
               1. chain a [95211]
            2. 2p23
               automatically matched to d1pwaa_
               1. region a:41-175 [139459]
            3. 2p23
               automatically matched to d1pwaa_
               1. region b:1041-1175 [139460]
      9. Fibroblast growth factor 8, FGF8 [159145]
         1. Human (Homo sapiens) [TaxId: 9606] [159146] (2)
            SQ P55075 52-198
            1. 2fdb
               1. region m:34-180 [145162]
            2. 2fdb
               automatically matched to 2FDB M:34-180
               1. region n:1034-1179 [145163]
   2. Interleukin-1 (IL-1) [50362] (6)
      1. Interleukin-1beta [50363]
         1. Human (Homo sapiens) [TaxId: 9606] [50364] (20)
            SQ P01584 117-269
            1. 1l2h
               mutant
               1. chain a [77655]
            2. 2nvh
               automatically matched to d1iob__
               complexed with so4
               1. region a:1-152 [138630]
            3. 1i1b
               1. chain a [25537]
            4. 1too
               mutant
               1. chain a [112604]
            5. 1t4q
               mutant
               1. chain a [112244]
            6. 1twe
               mutant
               1. chain a [112724]
            7. 2i1b
               1. chain a [25538]
            8. 5i1b
               1. chain a [25539]
            9. 1twm
               mutant
               1. chain a [112765]
            10. 9ilb
                1. chain a [25543]
            11. 1s0l
                mutant
                1. chain a [98289]
            12. 4i1b
                1. chain a [25540]
            13. 21bi
                mutant
                1. chain a [25542]
            14. 31bi
                mutant
                1. chain a [25541]
            15. 1iob
                1. chain a [25547]
            16. 1hib
                mutant
                1. chain a [25544]
            17. 1itb
                1. chain a [25546]
            18. 41bi
                mutant
                1. chain a [25545]
            19. 7i1b
                1. chain a [25549]
            20. 6i1b
                1. chain a [25548]
         2. Mouse (Mus musculus) [TaxId: 10090] [50365] (2)
            1. 8i1b
               1. chain a [25550]
            2. 2mib
               1. chain a [25551]
      2. Interleukin-1 receptor antagonist protein [50366]
         1. Human (Homo sapiens) [TaxId: 9606] [50367] (5)
            1. 1ilr
               1. chain 1 [25552]
               2. chain 2 [25553]
            2. 1ira
               complexed with nag
               1. chain x [25556]
            3. 1ilt
               CA-atoms only
               1. chain a [25554]
               2. chain b [25555]
            4. 1irp
               1. chain a [25559]
            5. 2irt
               CA-atoms only
               1. chain a [25557]
               2. chain b [25558]
      3. Interleukin-1alpha [50368]
         1. Human (Homo sapiens) [TaxId: 9606] [50369] (1)
            1. 2ila
               CA-atoms only
               1. chain a [25560]
      4. Interleukin-1F5 [101780]
         1. Mouse (Mus musculus) [TaxId: 10090] [101781] (1)
            1. 1md6
               1. chain a [91242]
      5. Interleukin-18 [101782]
         1. Human (Homo sapiens) [TaxId: 9606] [101783] (1)
            1. 1j0s
               1. chain a [90747]
2. MIR domain [82109] (1)
   uperfamily
   1. MIR domain [82110] (2)
      Pfam 02815
      1. IP3 receptor type 1 binding core, domain 1 [82111]
         1. Mouse (Mus musculus) [TaxId: 10090] [82112] (1)
            1. 1n4k
               complexed with i3p
               1. region a:236-435 [79993]
      2. Hypothetical protein R12E2.13 (1D10) [110205]
         1. Caenorhabditis elegans [TaxId: 6239] [110206] (1)
            SQ O61793
            1. 1t9f
               Structural genomics target
               complexed with mli
               1. chain a [106710]
3. Ricin B-like lectins [50370] (3)
   uperfamily
   1. Ricin B-like [50371] (18)
      1. Plant cytotoxin B-chain (lectin) [50372]
         duplication: consists of two domains of this fold
         1. Castor bean (Ricinus communis), Ricin [TaxId: 3988] [50373] (2)
            SQ P06750 303-564
            1. 2aai
               complexed with gal, glc, man, nag
               1. region b:1-135 [25561]
               2. region b:136-262 [25562]
            2. 1rzo
               complexed with glb, so4
               1. region b:2001-2135 [111984]
               2. region b:2136-2262 [111985]
               3. region d:2001-2135 [111987]
               4. region d:2136-2262 [111988]
         2. Abrus precatorius [TaxId: 3816] [50374] (1)
            1. 1abr
               complexed with man, nag
               1. region b:1-140 [25563]
               2. region b:141-267 [25564]
         3. Mongolian snake-gourd (Trichosanthes kirilowii), Lectin 1 [TaxId: 3677] [89337] (1)
            1. 1ggp
               X-ray derived abrin-based sequence
               1. region b:11-140 [83286]
               2. region b:141-267 [83287]
         4. European mistletoe (Viscum album) [TaxId: 3972] [50375] (18)
            different sequence variants
            SQ Q6ITZ3 266-520; SQ P81446 269-531 # 91% sequence identity
            1. 1m2t
               complexed with ade, fuc, gol, nag
               1. region b:249-384 [84762]
               2. region b:385-510 [84763]
            2. 2rg9
               automatically matched to d1pumb1
               complexed with azi, cl, gol, nag, so4
               1. region b:1-137 [152008]
            3. 2rg9
               automatically matched to d1pumb2
               complexed with azi, cl, gol, nag, so4
               1. region b:138-263 [152009]
            4. 1onk
               complexed with azi, gol, nag, po4
               1. region b:1-137 [93360]
               2. region b:138-263 [93361]
            5. 1sz6
               complexed with azi, cl, gol, nag, so4
               1. region b:1-137 [112172]
               2. region b:138-263 [112173]
            6. 1puu
               complexed with cl, dox, fuc, gol, lat, nag, so4
               1. region b:248-384 [104318]
               2. region b:385-507 [104319]
            7. 1pum
               complexed with cl, fuc, glb, gol, nag, so4
               1. region b:1-137 [104315]
               2. region b:138-263 [104316]
            8. 3d7w
               automatically matched to d1m2tb1
               complexed with gol, nag, so4, zea, zez
               1. region b:250-384 [157434]
            9. 3d7w
               automatically matched to d1m2tb2
               complexed with gol, nag, so4, zea, zez
               1. region b:385-510 [157435]
            10. 1oql
                complexed with gal, nag
                1. region b:1-137 [87307]
                2. region b:138-263 [87308]
            11. 2r9k
                automatically matched to d1m2tb1
                complexed with cl, gol, nag, sgi, so4
                1. region b:249-384 [151790]
            12. 2r9k
                automatically matched to d1m2tb2
                complexed with cl, gol, nag, sgi, so4
                1. region b:385-510 [151791]
            13. 1yf8
                automatically matched to d1pc8b1
                complexed with gal, glc, man, nag, p6c
                1. region b:1-133 [123052]
            14. 1yf8
                automatically matched to d1pc8b2
                complexed with gal, glc, man, nag, p6c
                1. region b:134-255 [123053]
            15. 1tfm
                complexed with bgc, bma, glb, nag, p6c
                1. region b:1-133 [106856]
                2. region b:134-255 [106857]
            16. 1ce7
                complexed with nag
                1. region b:1-133 [25565]
                2. region b:134-255 [25566]
            17. 2mll
                complexed with nag
                1. region b:1-133 [25567]
                2. region b:134-255 [25568]
            18. 1pc8
                complexed with man, nag
                1. region b:1-133 [104105]
                2. region b:134-255 [104106]
         5. Sambucus ebulus, ebulin [TaxId: 28503] [50376] (4)
            1. 1hwm
               complexed with gal, man, nag
               1. region b:3-135 [25569]
               2. region b:136-266 [25570]
            2. 1hwo
               complexed with gal, glc, man, nag
               1. region b:2-135 [25571]
               2. region b:136-264 [25572]
            3. 1hwn
               complexed with gal, nag
               1. region b:2-135 [25573]
               2. region b:136-264 [25574]
            4. 1hwp
               complexed with gal, glc, man, nag, pt1
               1. region b:2-135 [25575]
               2. region b:136-264 [25576]
      2. Xylan binding domain, CBM13 (Endo-1,4-beta-xylanase C-terminal domain) [50377]
         1. Streptomyces olivaceoviridis [TaxId: 1921] [50378] (11)
            1. 1v6w
               complexed with gcv, xys
               1. region a:304-436 [100434]
               2. region b:804-936 [100436]
            2. 1isz
               complexed with gal
               1. region a:313-436 [66357]
               2. region b:813-936 [66359]
            3. 1xyf
               1. region a:313-436 [25577]
               2. region b:813-936 [25578]
            4. 1it0
               complexed with lat
               1. region a:313-436 [66361]
               2. region b:813-936 [66363]
            5. 1v6v
               complexed with ahr, xys
               1. region a:304-436 [100430]
               2. region b:804-936 [100432]
            6. 1isv
               complexed with xys
               1. region a:304-436 [66341]
               2. region b:804-936 [66343]
            7. 1isy
               complexed with glc
               1. region a:304-436 [66353]
               2. region b:804-936 [66355]
            8. 1isx
               complexed with xys
               1. region a:304-436 [66349]
               2. region b:804-936 [66351]
            9. 1v6x
               complexed with gcv, xys
               1. region a:304-436 [100438]
               2. region b:804-936 [100440]
            10. 1isw
                complexed with xys
                1. region a:304-436 [66345]
                2. region b:804-936 [66347]
            11. 1v6u
                complexed with ahr, xys
                1. region a:304-436 [100426]
                2. region b:804-936 [100428]
         2. Streptomyces lividans [TaxId: 1916] [74958] (3)
            1. 1knm
               complexed with gol, lat
               1. chain a [72781]
            2. 1knl
               complexed with gol
               1. chain a [72780]
            3. 1mc9
               complexed with gol, so4, xys
               1. chain a [78949]
      3. Hemagglutinin component Ha1 [101784]
         1. Clostridium botulinum D phage [TaxId: 29342] [101785] (1)
            1. 1qxm
               complexed with edo; mutant
               1. region a:4-148 [96533]
               2. region a:149-286 [96534]
               3. region b:4-148 [96535]
               4. region b:149-286 [96536]
         2. Clostridium botulinum [TaxId: 1491] [159147] (12)
            1. 2ehm
               automatically matched to d1qxma1
               complexed with nga
               1. region a:4-148 [146836]
            2. 2ehm
               automatically matched to d1qxma2
               complexed with nga
               1. region a:149-286 [146837]
            3. 2ehm
               automatically matched to d1qxma1
               complexed with nga
               1. region b:4-148 [146838]
            4. 2ehm
               automatically matched to d1qxma2
               complexed with nga
               1. region b:149-286 [146839]
            5. 2ehn
               automatically matched to d1qxma1
               complexed with gal
               1. region a:4-148 [146840]
            6. 2ehn
               automatically matched to d1qxma2
               complexed with gal
               1. region a:149-286 [146841]
            7. 2ehn
               automatically matched to d1qxma1
               complexed with gal
               1. region b:4-148 [146842]
            8. 2ehn
               automatically matched to d1qxma2
               complexed with gal
               1. region b:149-286 [146843]
            9. 2ehi
               automatically matched to d1qxma1
               complexed with sia
               1. region a:4-148 [146832]
            10. 2ehi
                automatically matched to d1qxma2
                complexed with sia
                1. region a:149-286 [146833]
            11. 2ehi
                automatically matched to d1qxma1
                complexed with sia
                1. region b:4-148 [146834]
            12. 2ehi
                automatically matched to d1qxma2
                complexed with sia
                1. region b:149-286 [146835]
      4. Cytolethal distending toxin subunit A [110207]
         1. Haemophilus ducreyi [TaxId: 730] [110208] (1)
            SQ O06522 57-223
            1. 1sr4
               complexed with br
               1. chain a [105948]
         2. Actinobacillus actinomycetemcomitans [TaxId: 714] [141329] (2)
            SQ O87120 70-222
            1. 2f2f
               1. region a:71-223 [132810]
            2. 2f2f
               automatically matched to 2F2F A:71-223
               1. region d:71-223 [132813]
      5. Cytolethal distending toxin subunit C [110209]
         1. Haemophilus ducreyi [TaxId: 730] [110210] (1)
            SQ O06524 25-178
            1. 1sr4
               complexed with br
               1. chain c [105950]
         2. Actinobacillus actinomycetemcomitans [TaxId: 714] [141330] (2)
            SQ Q7DK11 25-178
            1. 2f2f
               1. region c:25-178 [132812]
            2. 2f2f
               automatically matched to 2F2F C:25-178
               1. region f:25-178 [132815]
      6. Hemolytic lectin CEL-III, domains 1 and 2 [110211]
         1. Cucumaria echinata [TaxId: 40245] [110212] (9)
            SQ Q868M7 11-442
            1. 1vcl
               complexed with btb, ca, cl, mg
               1. region a:1-150 [108498]
               2. region a:151-283 [108499]
               3. region b:1-150 [108501]
               4. region b:151-283 [108502]
            2. 2z48
               automatically matched to d1vcla1
               complexed with a2g, ca, mg, nga
               1. region a:2-150 [154036]
            3. 2z48
               automatically matched to d1vcla2
               complexed with a2g, ca, mg, nga
               1. region a:151-283 [154037]
            4. 2z48
               automatically matched to d1vcla1
               complexed with a2g, ca, mg, nga
               1. region b:2-150 [154039]
            5. 2z48
               automatically matched to d1vcla2
               complexed with a2g, ca, mg, nga
               1. region b:151-283 [154040]
            6. 2z49
               automatically matched to d1vcla1
               complexed with amg, ca, mg
               1. region a:2-150 [154042]
            7. 2z49
               automatically matched to d1vcla2
               complexed with amg, ca, mg
               1. region a:151-283 [154043]
            8. 2z49
               automatically matched to d1vcla1
               complexed with amg, ca, mg
               1. region b:2-150 [154045]
            9. 2z49
               automatically matched to d1vcla2
               complexed with amg, ca, mg
               1. region b:151-283 [154046]
      7. Polypeptide N-acetylgalactosaminyltransferase 1, C-terminal domain [117210]
         1. Mouse (Mus musculus) [TaxId: 10090] [117211] (1)
            SQ O08912
            1. 1xhb
               complexed with ca, man, mn, nag
               1. region a:423-553 [115290]
      8. 29-kDa galactose-binding lectin [159148]
         duplication: tadem repeat of two Ricin B-like domains
         1. Lumbricus terrestris [TaxId: 6398] [159149] (4)
            SQ O96048 131-260
            1. 2zqn
               automatically matched to 2ZQO A:131-260
               complexed with bgc, gal, imd, po4
               1. region a:131-260 [154763]
            2. 2zqn
               automatically matched to 2ZQO A:131-260
               complexed with bgc, gal, imd, po4
               1. region b:131-260 [154764]
            3. 2zqo
               second domain only
               complexed with cd, imd, nga, po4
               1. region a:131-260 [154765]
            4. 2zqo
               automatically matched to 2ZQO A:131-260
               complexed with cd, imd, nga, po4
               1. region b:131-260 [154766]
      9. Agglutinin-1 chain B [159150]
         1. Abrus precatorius [TaxId: 3816] [159151] (2)
            SQ Q9M6E9 287-420! SQ Q9M6E9 421-547
            1. 2q3n
               complexed with nag
               1. region b:141-267 [150035]
            2. 2q3n
               complexed with nag
               1. region b:7-140 [150036]
      10. Agglutinin MOA, N-terminal domain [159152]
          1. Fairy-ring mushroom (Marasmius oreades) [TaxId: 181124] [159153] (1)
             SQ Q8X123 2-155
             1. 2iho
                complexed with gal, nag
                1. region a:2-155 [147681]
   2. Cysteine rich domain [50379] (1)
      1. Mannose receptor [50380]
         1. Mouse (Mus musculus) [TaxId: 10090] [50381] (4)
            1. 1dqg
               complexed with so4
               1. chain a [25579]
            2. 1fwu
               complexed with fuc, mag, sga
               1. chain a [25580]
            3. 1fwv
               complexed with fuc, mag, sga
               1. chain a [25581]
            4. 1dqo
               complexed with ngl
               1. chain a [25582]
   3. GlcNAc-alpha-1,4-Gal-releasing endo-beta-galactosidase, GngC, C-terminal domain [117212] (1)
      1. GlcNAc-alpha-1,4-Gal-releasing endo-beta-galactosidase, GngC, C-terminal domain [117213]
         1. Clostridium perfringens [TaxId: 1502] [117214] (1)
            SQ Q934G8 17-420
            1. 1ups
               complexed with ca
               1. region a:290-420 [113395]
               2. region b:290-420 [113397]
4. Agglutinin [50382] (1)
   this superfamily is distinct from the ricin B-like lectin superfamily
   uperfamily
   1. Agglutinin [50383] (1)
      1. Agglutinin [50384]
         duplication: the tandem repeat of beta-trefoil domains
         1. Love-lies-bleeding (Amaranthus caudatus) [TaxId: 3567] [50385] (2)
            1. 1jlx
               complexed with for, gal, mbn, nga
               1. region a:1-153 [25583]
               2. region a:154-299 [25584]
               3. region b:1-153 [25585]
               4. region b:154-299 [25586]
            2. 1jly
               complexed with for
               1. region a:1-153 [25587]
               2. region a:154-299 [25588]
               3. region b:1-153 [25589]
               4. region b:154-299 [25590]
5. STI-like [50386] (2)
   uperfamily
   1. Kunitz (STI) inhibitors [50387] (7)
      1. Winged bean albumin 1 [50388]
         1. Goa bean (Psophocarpus tetragonolobus) [TaxId: 3891] [50389] (1)
            1. 1wba
               1. chain a [25591]
      2. Erythrina cafra trypsin inhibitor [50390]
         1. Erythrina caffra [TaxId: 3842] [50391] (1)
            1. 1tie
               1. chain a [25592]
      3. chymotrypsin inhibitor WCI [50392]
         1. Winged bean (Psophocarpus tetragonolobus) [TaxId: 3891] [50393] (6)
            1. 1eyl
               complexed with so4
               1. chain a [25593]
            2. 1fmz
               complexed with so4; mutant
               1. chain a [25594]
            3. 1fn0
               complexed with sul; mutant
               1. chain a [25595]
            4. 4wbc
               complexed with so4
               1. chain a [25596]
            5. 2wbc
               1. chain a [25597]
            6. 1wbc
               1. chain a [25598]
      4. Soybean trypsin inhibitor [50394]
         1. Soybean (Glycine max) [TaxId: 3847] [50395] (4)
            1. 1avw
               complexed with ca
               1. chain b [25599]
            2. 1avx
               complexed with ca
               1. chain b [25600]
            3. 1ba7
               1. chain a [25601]
               2. chain b [25602]
            4. 1avu
               1. chain a [25603]
      5. Amylase/subtilisin inhibitor [50396]
         1. Barley (Hordeum vulgare), seed [TaxId: 4513] [50397] (3)
            1. 3bx1
               automatically matched to d1avac_
               complexed with ca, cl, na
               1. region c:1-181 [155704]
            2. 3bx1
               automatically matched to d1avac_
               complexed with ca, cl, na
               1. region d:1-181 [155705]
            3. 1ava
               complexed with ca
               1. chain c [25604]
               2. chain d [25605]
      6. Serine protease inhibitor DrTI [110213]
         1. Royal poinciana (Delonix regia) [TaxId: 72433] [110214] (1)
            SQ P83667
            1. 1r8n
               1. chain a [104851]
      7. Two-chain trypsin inhibitor [110215]
         1. Balsam copaiba (Copaifera langsdorffii) [TaxId: 280048] [110216] (1)
            SQ P84144,P84145 # two chains probably resulted from a single chain precursor
            1. 1r8o
               1. chain a,b [104852]
   2. Clostridium neurotoxins, C-terminal domain [50399] (3)
      overall fold is very similar to that of the STI family
      1. Tetanus neurotoxin [50400]
         1. Clostridium tetani [TaxId: 1513] [50401] (10)
            1. 1a8d
               complexed with au; mutant
               1. region a:248-452 [25607]
            2. 1dll
               complexed with gol, lat
               1. region a:1111-1315 [25608]
            3. 1diw
               complexed with gal
               1. region a:1111-1315 [25609]
            4. 1d0h
               complexed with nga, so4; mutant
               1. region a:1111-1315 [25610]
            5. 1yxw
               automatically matched to d1a8d_2
               complexed with glu, trp, tyr
               1. region a:1111-1315 [124202]
            6. 1yyn
               automatically matched to d1a8d_2
               complexed with gla, glc, sia
               1. region a:1111-1315 [124243]
            7. 1af9
               mutant
               1. region a:1111-1315 [25611]
            8. 1fv2
               complexed with ceq, gal, glc, nan, nga, po4, slb
               1. region a:1111-1315 [60037]
            9. 1fv3
               complexed with ceq, gal, glc, nan, nga, po4, slb
               1. region a:1111-1315 [60039]
               2. region b:1111-1315 [60041]
            10. 1dfq
                complexed with sia
                1. region a:1111-1315 [25612]
      2. Botulinum neurotoxin [50402]
         1. Clostridium botulinum, serotype A [TaxId: 1491] [50403] (1)
            1. 3bta
               complexed with zn
               1. region a:1079-1295 [25613]
         2. Clostridium botulinum, serotype B [TaxId: 1491] [50404] (17)
            1. 1epw
               complexed with so4, zn
               1. region a:1080-1290 [25614]
            2. 1s0e
               complexed with ca, zn
               1. region a:1080-1290 [98278]
            3. 1s0b
               complexed with ca
               1. region a:1080-1290 [98266]
            4. 1g9b
               complexed with bab, zn
               1. region a:1080-1290 [76205]
            5. 1g9a
               complexed with bab, zn
               1. region a:1080-1290 [76201]
            6. 2nm1
               automatically matched to d1epwa2
               1. region a:1081-1291 [138370]
            7. 1s0c
               complexed with ca, zn
               1. region a:1080-1290 [98270]
            8. 1z0h
               automatically matched to d1epwa2
               1. region a:1080-1290 [124315]
            9. 1z0h
               automatically matched to d1epwa2
               1. region b:1080-1290 [124317]
            10. 1s0d
                complexed with ca, zn
                1. region a:1080-1290 [98274]
            11. 1g9c
                complexed with bab, zn
                1. region a:1080-1290 [76209]
            12. 1i1e
                complexed with dm2, so4, zn
                1. region a:1080-1290 [65979]
            13. 1s0f
                complexed with ca, zn
                1. region a:1080-1290 [98282]
            14. 1s0g
                1. region a:1080-1290 [98286]
            15. 2np0
                automatically matched to d1epwa2
                complexed with ca, cl, zn
                1. region a:1080-1290 [138417]
            16. 1g9d
                complexed with bab, zn
                1. region a:1080-1290 [76213]
            17. 1f31
                complexed with gal, glc, sia, so4, zn
                1. region a:1080-1290 [25615]
6. Actin-crosslinking proteins [50405] (2)
   uperfamily
   1. Fascin [50406] (1)
      1. Fascin [50407]
         duplication: tandem repeat of four domains
         1. Human (Homo sapiens) [TaxId: 9606] [50408] (1)
            1. 1dfc
               1. region a:1008-1140 [25616]
               2. region a:1141-1259 [25617]
               3. region a:1260-1382 [25618]
               4. region a:1383-1493 [25619]
               5. region b:2008-2140 [25620]
               6. region b:2141-2259 [25621]
               7. region b:2260-2382 [25622]
               8. region b:2383-2493 [25623]
   2. Histidine-rich actin-binding protein (hisactophilin) [50409] (1)
      1. Histidine-rich actin-binding protein (hisactophilin) [50410]
         1. Dictyostelium discoideum [TaxId: 44689] [50411] (2)
            1. 1hcd
               1. chain a [25624]
            2. 1hce
               1. chain a [25625]
7. DNA-binding protein LAG-1 (CSL) [110217] (1)
   contains rudiment hairpin triplet lacking one hairpin
   uperfamily
   1. DNA-binding protein LAG-1 (CSL) [110218] (1)
      1. DNA-binding protein LAG-1 (CSL) [110219]
         1. Caenorhabditis elegans [TaxId: 6239] [110220] (4)
            SQ Q9TYY1 195-660
            1. 3brd
               automatically matched to d1ttua3
               complexed with edo
               1. region a:381-541 [155507]
            2. 3brf
               automatically matched to d1ttua3
               complexed with sor
               1. region a:381-541 [155510]
            3. 1ttu
               complexed with egl
               1. region a:381-541 [107307]
            4. 2fo1
               automatically matched to d1ttua3
               1. region a:381-541 [133867]
8. AbfB domain [110221] (1)
   uperfamily
   1. AbfB domain [110222] (1)
      Pfam 05270
      1. Alpha-L-arabinofuranosidase B (AbfB), C-terminal domain [110223]
         1. Aspergillus kawachii [TaxId: 40384] [110224] (4)
            SQ Q8NK89 19-499
            1. 1wd3
               complexed with nag
               1. region a:338-499 [109234]
            2. 1wd4
               complexed with ahr, nag
               1. region a:338-499 [109236]
            3. 2d44
               automatically matched to d1wd3a2
               complexed with ahr, nag, xys; mutant
               1. region a:338-499 [131241]
            4. 2d43
               automatically matched to d1wd3a2
               complexed with ahr, nag; mutant
               1. region a:338-499 [131239]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk