Structural Classification of Proteins
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Superfamily: Tudor/PWWP/MBT

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: SH3-like barrel [50036]
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
  4. Superfamily: Tudor/PWWP/MBT [63748]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Tudor domain [63749] (7)
    Pfam 00567
    1. Survival motor neuron protein 1, smn [63750]
      1. Human (Homo sapiens) [TaxId: 9606] [63751] (2)
        1. 1mhn picpic
          1. chain a [84964] picpiclink
        2. 1g5v picpic
          1. chain a [60292] picpiclink
    2. p53-binding protein 1, 53BP1 [110163]
      duplication; contains two Tudor domains in tandem
      1. Human (Homo sapiens) [TaxId: 9606] [110164] (6)
        SQ Q12888 1485-1602 ! SQ Q12888 1484-1606
        1. 2g3r picpic
          automatically matched to d1ssfa1
          complexed with so4
          1. region a:1485-1537 [134570] picpiclink
        2. 2g3r picpic
          automatically matched to d1ssfa2
          complexed with so4
          1. region a:1538-1603 [134571] picpiclink
        3. 2ig0 picpic
          automatically matched to d1ssfa1
          complexed with mly, so4
          1. region a:1485-1537 [137350] picpiclink
        4. 2ig0 picpic
          automatically matched to d1ssfa2
          complexed with mly, so4
          1. region a:1538-1603 [137351] picpiclink
        5. 1xni picpic
          1. region a:1485-1537 [115582] picpiclink
          2. region a:1538-1602 [115583] picpiclink
          3. region b:1485-1537 [115584] picpiclink
          4. region b:1538-1602 [115585] picpiclink
          5. region c:1485-1537 [115586] picpiclink
          6. region c:1538-1602 [115587] picpiclink
          7. region d:1485-1537 [115588] picpiclink
          8. region d:1538-1602 [115589] picpiclink
          9. region e:1485-1537 [115590] picpiclink
          10. region e:1538-1602 [115591] picpiclink
          11. region f:1485-1537 [115592] picpiclink
          12. region f:1538-1602 [115593] picpiclink
          13. region g:1485-1537 [115594] picpiclink
          14. region g:1538-1602 [115595] picpiclink
          15. region h:1485-1537 [115596] picpiclink
          16. region h:1538-1602 [115597] picpiclink
          17. region i:1485-1537 [115598] picpiclink
          18. region i:1538-1602 [115599] picpiclink
          19. region j:1485-1537 [115600] picpiclink
          20. region j:1538-1602 [115601] picpiclink
        6. 1ssf picpic
          1. region a:7-60 [105982] picpiclink
          2. region a:61-129 [105983] picpiclink
    3. Tudor domain-containing protein 3, TDRD3 [141201]
      1. Mouse (Mus musculus) [TaxId: 10090] [141202] (1)
        SQ Q91W18 553-612
        1. 2d9t picpic
          1. region a:8-67 [131351] picpiclink
    4. Jumonji domain-containing protein 2A [141203]
      contains tandem repeat of two segment-swapped Tudor domains
      1. Human (Homo sapiens) [TaxId: 9606] [141204] (20)
        SQ O75164 897-955! SQ O75164 956-1011
        1. 2qqr picpic
          automatically matched to d2gf7a2
          complexed with so4
          1. region a:897-955 [151226] picpiclink
        2. 2qqr picpic
          automatically matched to d2gf7a1
          complexed with so4
          1. region a:956-1011 [151227] picpiclink
        3. 2qqr picpic
          automatically matched to d2gf7a2
          complexed with so4
          1. region b:897-955 [151228] picpiclink
        4. 2qqr picpic
          automatically matched to d2gf7a1
          complexed with so4
          1. region b:956-1011 [151229] picpiclink
        5. 2gfa picpic
          automatically matched to 2GF7 A:956-1011
          complexed with m3l
          1. region a:956-1008 [135089] picpiclink
        6. 2gfa picpic
          automatically matched to 2GF7 A:897-955
          complexed with m3l
          1. region a:897-955 [135090] picpiclink
        7. 2gfa picpic
          automatically matched to 2GF7 A:956-1011
          complexed with m3l
          1. region b:956-1011 [135091] picpiclink
        8. 2gfa picpic
          automatically matched to 2GF7 A:897-955
          complexed with m3l
          1. region b:897-955 [135092] picpiclink
        9. 2gf7 picpic
          complexed with so4
          1. region a:956-1011 [135081] picpiclink
        10. 2gf7 picpic
          complexed with so4
          1. region a:897-955 [135082] picpiclink
        11. 2gf7 picpic
          automatically matched to 2GF7 A:956-1011
          complexed with so4
          1. region b:956-1011 [135083] picpiclink
        12. 2gf7 picpic
          automatically matched to 2GF7 A:897-955
          complexed with so4
          1. region b:897-955 [135084] picpiclink
        13. 2gf7 picpic
          automatically matched to 2GF7 A:956-1011
          complexed with so4
          1. region c:956-1011 [135085] picpiclink
        14. 2gf7 picpic
          automatically matched to 2GF7 A:897-955
          complexed with so4
          1. region c:897-955 [135086] picpiclink
        15. 2gf7 picpic
          automatically matched to 2GF7 A:956-1011
          complexed with so4
          1. region d:956-1011 [135087] picpiclink
        16. 2gf7 picpic
          automatically matched to 2GF7 A:897-955
          complexed with so4
          1. region d:897-955 [135088] picpiclink
        17. 2qqs picpic
          automatically matched to d2gf7a2
          complexed with m3l
          1. region a:897-955 [151230] picpiclink
        18. 2qqs picpic
          automatically matched to d2gf7a1
          complexed with m3l
          1. region a:956-1005 [151231] picpiclink
        19. 2qqs picpic
          automatically matched to d2gf7a2
          complexed with m3l
          1. region b:899-955 [151232] picpiclink
        20. 2qqs picpic
          automatically matched to d2gf7a1
          complexed with m3l
          1. region b:956-1006 [151233] picpiclink
    5. Tudor and KH domain-containing protein TDRKH [141205]
      1. Human (Homo sapiens) [TaxId: 9606] [141206] (1)
        SQ Q9Y2W6 329-425
        1. 2diq picpic
          1. region a:8-104 [131531] picpiclink
    6. P100 co-activator, SND1 [141207]
      1. Human (Homo sapiens) [TaxId: 9606] [141208] (2)
        SQ Q7KZF4 705-794
        1. 2hqx picpic
          1. region a:8-97 [136675] picpiclink
        2. 2hqx picpic
          automatically matched to 2HQX A:8-97
          1. region b:8-97 [136676] picpiclink
    7. Lamin-b receptor [141209]
      1. Human (Homo sapiens) [TaxId: 9606] [141210] (1)
        SQ Q14739 1-55
        1. 2dig picpic
          1. region a:8-62 [131529] picpiclink
  2. PWWP domain [69250] (6)
    includes the C-terminal all-alpha subdomain
    1. DNA methyltransferase DNMT3B [69251]
      1. Mouse (Mus musculus) [TaxId: 10090] [69252] (1)
        1. 1khc picpic
          1. chain a [68608] picpiclink
    2. Hypothetical protein SPBC215.07c [89297]
      1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [89298] (1)
        1. 1h3z picpic
          1. chain a [83471] picpiclink
    3. Hepatoma-derived growth factor, related protein 3 [101684]
      1. Mouse (Mus musculus) [TaxId: 10090] [101685] (1)
        1. 1n27 picpic
          1. chain a [91549] picpiclink
    4. Hepatoma-derived growth factor, HDGF [117151]
      1. Human (Homo sapiens) [TaxId: 9606] [117152] (3)
        SQ P51858 1-100
        1. 2nlu picpic
          automatically matched to d2b8aa1
          1. region a:1-100 [148284] picpiclink
        2. 2nlu picpic
          automatically matched to d2b8aa1
          1. region b:101-200 [148285] picpiclink
        3. 1ri0 picpic
          1. chain a [111806] picpiclink
      2. Rat (Rattus norvegicus) [TaxId: 10116] [141211] (1)
        SQ Q8VHK7 1-110
        1. 2b8a picpic
          1. region a:1-110 [128067] picpiclink
    5. Histone-lysine N-methyltransferase NSD3 [141212]
      WHSC1L1
      1. Human (Homo sapiens) [TaxId: 9606] [141213] (1)
        SQ Q9BZ95 957-1053
        1. 2daq picpic
          1. region a:8-104 [131354] picpiclink
  3. MBT repeat [89299] (4)
    Pfam 02820
    contains extended 'arm', N-terminal to the common fold core
    1. Scml2 protein [89300]
      duplication: contains tandem repeat of two MBT repeats
      1. Human (Homo sapiens) [TaxId: 9606] [89301] (7)
        1. 1oi1 picpic
          complexed with peg; mutant
          1. region a:33-135 [87037] picpiclink
          2. region a:140-243 [87038] picpiclink
        2. 2biv picpic
          automatically matched to d1oi1a1
          complexed with iod, na
          1. region a:33-135 [128592] picpiclink
        3. 2biv picpic
          automatically matched to d1oi1a2
          complexed with iod, na
          1. region a:140-243 [128593] picpiclink
        4. 2biv picpic
          automatically matched to d1oi1a1
          complexed with iod, na
          1. region b:33-133 [128594] picpiclink
        5. 2biv picpic
          automatically matched to d1oi1a2
          complexed with iod, na
          1. region b:140-243 [128595] picpiclink
        6. 2vyt picpic
          automatically matched to d1oi1a1
          complexed with mlz, pge; mutant
          1. region a:33-135 [153713] picpiclink
        7. 2vyt picpic
          automatically matched to d1oi1a2
          complexed with mlz, pge; mutant
          1. region a:140-243 [153714] picpiclink
    2. Lethal(3)malignant brain tumor-like protein [101686]
      1. Human (Homo sapiens) [TaxId: 9606] [101687] (3)
        1. 1oz2 picpic
          complexed with mes, so4
          1. region a:204-313 [93781] picpiclink
          2. region a:314-421 [93782] picpiclink
          3. region a:422-527 [93783] picpiclink
        2. 1oyx picpic
          complexed with mes, so4
          1. region a:206-313 [93763] picpiclink
          2. region a:314-421 [93764] picpiclink
          3. region a:422-518 [93765] picpiclink
          4. region b:206-313 [93766] picpiclink
          5. region b:314-421 [93767] picpiclink
          6. region b:422-518 [93768] picpiclink
          7. region c:206-313 [93769] picpiclink
          8. region c:314-421 [93770] picpiclink
          9. region c:422-518 [93771] picpiclink
        3. 1oz3 picpic
          complexed with mes, so4
          1. region a:206-313 [93784] picpiclink
          2. region a:314-421 [93785] picpiclink
          3. region a:422-518 [93786] picpiclink
          4. region b:206-313 [93787] picpiclink
          5. region b:314-421 [93788] picpiclink
          6. region b:422-518 [93789] picpiclink
          7. region c:206-313 [93790] picpiclink
          8. region c:314-421 [93791] picpiclink
          9. region c:422-518 [93792] picpiclink
    3. Lethal(3)malignant brain tumor-like 3 protein, L3MBTL3 (KIAA1798) [117153]
      1. Human (Homo sapiens) [TaxId: 9606] [117154] (2)
        SQ Q96JM7 259-372, 469-562
        1. 1wjs picpic
          Structural genomics target; 1st MBT repeat
          1. chain a [114710] picpiclink
        2. 1wjq picpic
          Structural genomics target; 3rd MBT repeat
          1. chain a [114708] picpiclink
    4. Scm-like with four MBT domains protein 2, SFMBT2 (KIAA1617) [117155]
      1. Human (Homo sapiens) [TaxId: 9606] [117156] (1)
        SQ Q5VUG0 181-285
        1. 1wjr picpic
          Structural genomics target; 2nd MBT repeat
          1. chain a [114709] picpiclink
  4. CPH domain [159021] (1)
    1. Cullin-7 [159022]
      1. Human (Homo sapiens) [TaxId: 9606] [159023] (1)
        SQ Q14999 360-435
        1. 2jng picpic
          1. region a:5-80 [148150] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk