Structural Classification of Proteins
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Superfamily: SMAD/FHA domain

has a few short helices inserted in loops
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: SMAD/FHA domain [49878]
    sandwich; 11 strands in 2 sheets; greek-key
  4. Superfamily: SMAD/FHA domain [49879]
    has a few short helices inserted in loops
    link to SUPERFAMILY database - Superfamily

Families:

  1. SMAD domain [49880] (4)
    1. Smad4 tumor suppressor C-terminal domain [49881]
      1. Human (Homo sapiens) [TaxId: 9606] [49882] (6)
        SQ Q13485 314-546
        1. 1ygs picpic
          1. chain a [23907] picpiclink
        2. 1dd1 picpic
          1. chain a [23908] picpiclink
          2. chain b [23909] picpiclink
          3. chain c [23910] picpiclink
        3. 1g88 picpic
          mutant
          1. chain a [23911] picpiclink
          2. chain b [23912] picpiclink
          3. chain c [23913] picpiclink
        4. 1u7f picpicxref
          1. chain b [107721] picpiclink
        5. 1u7v picpicxref
          1. chain b [107730] picpiclink
        6. 1mr1 picpicxref
          complex with Ski
          complexed with zn
          1. chain a [79418] picpiclink
          2. chain b [79419] picpiclink
    2. Smad3 MH2 domain [82030]
      1. Human (Homo sapiens) [TaxId: 9606] [82031] (4)
        SQ P84022 228-425
        1. 1mjs picpic
          1. chain a [79211] picpiclink
        2. 1u7f picpicxref
          1. chain a [107720] picpiclink
          2. chain c [107722] picpiclink
        3. 1u7v picpicxref
          1. chain a [107729] picpiclink
          2. chain c [107731] picpiclink
        4. 1mk2 picpicxref
          complexed with acy
          1. chain a [79217] picpiclink
    3. Smad2 MH2 domain [49883]
      1. Human (Homo sapiens) [TaxId: 9606] [49884] (2)
        1. 1khx picpic
          1. chain a [68631] picpiclink
        2. 1dev picpicxref
          1. chain a [23914] picpiclink
          2. chain c [23915] picpiclink
    4. Smad1 [69233]
      1. Human (Homo sapiens) [TaxId: 9606] [69234] (1)
        1. 1khu picpic
          1. chain a [68623] picpiclink
          2. chain b [68624] picpiclink
          3. chain c [68625] picpiclink
          4. chain d [68626] picpiclink
  2. FHA domain [49885] (12)
    1. Phosphotyrosine binding domain of Rad53 [49886]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [49887] (18)
        1. 1g6g picpic
          complexed with a phosphothreonine peptide
          1. chain a [23916] picpiclink
          2. chain b [23917] picpiclink
        2. 1k3q picpic
          complex with a rad9-derived phosphothreonine peptide
          1. chain a [68119] picpiclink
        3. 1k3j picpic
          1. chain a [68116] picpiclink
        4. 2a0t picpic
          automatically matched to d1g3ga_
          1. region a:14-164 [125964] picpiclink
        5. 1k2m picpic
          complexed with a phosphotyrosyl peptide
          1. chain a [68059] picpiclink
        6. 1k2n picpic
          complexed with a phosphothreonine peptide
          1. chain a [68060] picpiclink
        7. 1dmz picpic
          1. chain a [23921] picpiclink
        8. 1j4o picpic
          1. chain a [66386] picpiclink
        9. 1g3g picpic
          mutant
          1. chain a [23918] picpiclink
        10. 2jqi picpic
          automatically matched to d1g3ga_
          1. region a:14-164 [148178] picpiclink
        11. 1k3n picpic
          complex with a rad9-derived phosphothreonine peptide
          1. chain a [68118] picpiclink
        12. 1fhq picpic
          1. chain a [23919] picpiclink
        13. 1j4q picpic
          complex with a rad9-derived phosphothreonine peptide
          1. chain a [66388] picpiclink
        14. 1fhr picpic
          complexed with a phosphotyrosyl peptide
          1. chain a [23920] picpiclink
        15. 1j4l picpic
          complexed with a phosphothreonine peptide
          1. chain a [66384] picpiclink
        16. 1j4k picpic
          complexed with a phosphotyrosyl peptide
          1. chain a [66383] picpiclink
        17. 1j4p picpic
          complex with a rad9-derived phosphothreonine peptide
          1. chain a [66387] picpiclink
        18. 1qu5 picpic
          1. chain a [23922] picpiclink
    2. Cell cycle checkpoint protein Chfr [74899]
      1. Human (Homo sapiens) [TaxId: 9606] [74900] (2)
        1. 1lgp picpic
          complexed with wo4
          1. chain a [73890] picpiclink
        2. 1lgq picpic
          1. chain a [73891] picpiclink
          2. chain b [73892] picpiclink
    3. Chk2 kinase [74901]
      1. Human (Homo sapiens) [TaxId: 9606] [74902] (1)
        1. 1gxc picpic
          complexed with a synthetic phosphopeptide
          complexed with tpo
          1. chain a [70687] picpiclink
          2. chain d [70688] picpiclink
          3. chain g [70689] picpiclink
          4. chain j [70690] picpiclink
    4. Kinase associated protein phosphatase [101622]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [101623] (1)
        1. 1mzk picpic
          1. chain a [91499] picpiclink
    5. FHA domain containing protein At4G14490 [101624]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [101625] (1)
        1. 1uht picpic
          structural genomics
          1. chain a [99401] picpiclink
    6. Antigen ki-67 [101626]
      1. Human (Homo sapiens) [TaxId: 9606] [101627] (2)
        1. 2aff picpic
          automatically matched to d1r21a_
          1. region a:3-100 [126678] picpiclink
        2. 1r21 picpic
          mutant
          1. chain a [96846] picpiclink
    7. Polynucleotide kinase 3'-phosphatase [101628]
      1. Mouse (Mus musculus) [TaxId: 10090] [101629] (5)
        1. 1yjm picpic
          complexed with ace
          1. region a:4-110 [123427] picpiclink
        2. 1yjm picpic
          automatically matched to 1YJM A:4-110
          complexed with ace
          1. region b:6-110 [123428] picpiclink
        3. 1yjm picpic
          automatically matched to 1YJM A:4-110
          complexed with ace
          1. region c:7-107 [123429] picpiclink
        4. 1yj5 picpicxrefxrefxrefxref
          complexed with so4
          1. region c:6-110 [123384] picpiclink
        5. 1ujx picpic
          1. chain a [99473] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [141134] (1)
        SQ Q96T60 8-108
        1. 2brf picpic
          complexed with so4
          1. region a:8-108 [128996] picpiclink
    8. Afadin [141135]
      1. Mouse (Mus musculus) [TaxId: 10090] [141136] (1)
        SQ Q9QZQ1 382-487
        1. 1wln picpic
          1. region a:8-114 [121009] picpiclink
    9. Kinesin-like protein kif1c [141137]
      1. Human (Homo sapiens) [TaxId: 9606] [141138] (1)
        SQ O43896 498-599
        1. 2g1l picpic
          complexed with cl, ni, unx
          1. region a:498-599 [134520] picpiclink
    10. Probable regulatory protein EmbR, C-terminal domain [141139]
      1. Mycobacterium tuberculosis [TaxId: 1773] [141140] (3)
        SQ P66799 284-382
        1. 2ff4 picpicxrefxrefxrefxref
          automatically matched to 2FEZ A:284-382
          1. region a:284-382 [133369] picpiclink
        2. 2ff4 picpicxrefxrefxrefxref
          automatically matched to 2FEZ A:284-382
          1. region b:284-380 [133372] picpiclink
        3. 2fez picpicxrefxref
          1. region a:284-382 [133359] picpiclink
    11. Ubiquitin ligase protein RNF8 [141141]
      1. Human (Homo sapiens) [TaxId: 9606] [141142] (2)
        SQ O76064 8-139
        1. 2pie picpic
          automatically matched to d2cswa1
          1. region a:13-139 [149508] picpiclink
        2. 2csw picpic
          1. region a:8-139 [130787] picpiclink
  3. Interferon regulatory factor 3 (IRF3), transactivation domain [101630] (1)
    weak sequence similarity to SMAD domain
    1. Interferon regulatory factor 3 (IRF3), transactivation domain [101631]
      1. Human (Homo sapiens) [TaxId: 9606] [101632] (2)
        1. 1qwt picpic
          complexed with po4
          1. chain a [96501] picpiclink
          2. chain b [96502] picpiclink
        2. 1j2f picpic
          1. chain a [90785] picpiclink
          2. chain b [90786] picpiclink
  4. EssC N-terminal domain-like [141143] (1)
    PfamB 051221 covers two consecutive domains; the first one is of canonical topology, whereas the second domain has a cirular permutation, beginnig at strand 2 and ending at strand 1 of the canonical fold
    1. Protein EssC [141144]
      SAV0287; similar to DNA segregation ATPase and related proteins
      1. Staphylococcus aureus [TaxId: 1280] [141145] (2)
        SQ Q8NYF3 1-78! SQ Q8NYF3 79-186
        1. 1wv3 picpic
          1st domain, canonical topology
          complexed with cl
          1. region a:1-78 [121318] picpiclink
        2. 1wv3 picpic
          2nd domain, circularly permuted topology
          complexed with cl
          1. region a:79-186 [121319] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk