Structural Classification of Proteins

Fold: SMAD/FHA domain

: sandwich; 11 strands in 2 sheets; greek-key

Lineage:

Root: scop
Class: All beta proteins [48724]
Fold: SMAD/FHA domain [49878]
sandwich; 11 strands in 2 sheets; greek-key

Superfamilies:

SMAD/FHA domain [49879] (4)
has a few short helices inserted in loops
uperfamily
1. SMAD domain [49880] (4)
  1. Smad4 tumor suppressor C-terminal domain [49881]
    1. Human (Homo sapiens) [TaxId: 9606] [49882] (6)
      SQ Q13485 314-546
  2. Smad3 MH2 domain [82030]
    1. Human (Homo sapiens) [TaxId: 9606] [82031] (4)
      SQ P84022 228-425
  3. Smad2 MH2 domain [49883]
    1. Human (Homo sapiens) [TaxId: 9606] [49884] (2)
  4. Smad1 [69233]
    1. Human (Homo sapiens) [TaxId: 9606] [69234] (1)
2. FHA domain [49885] (12)
  1. Phosphotyrosine binding domain of Rad53 [49886]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [49887] (18)
  2. Cell cycle checkpoint protein Chfr [74899]
    1. Human (Homo sapiens) [TaxId: 9606] [74900] (2)
  3. Chk2 kinase [74901]
    1. Human (Homo sapiens) [TaxId: 9606] [74902] (1)
  4. Kinase associated protein phosphatase [101622]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [101623] (1)
  5. FHA domain containing protein At4G14490 [101624]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [101625] (1)
  6. Antigen ki-67 [101626]
    1. Human (Homo sapiens) [TaxId: 9606] [101627] (2)
  7. Polynucleotide kinase 3'-phosphatase [101628]
    1. Mouse (Mus musculus) [TaxId: 10090] [101629] (5)
    2. Human (Homo sapiens) [TaxId: 9606] [141134] (1)
      SQ Q96T60 8-108
  8. Afadin [141135]
    1. Mouse (Mus musculus) [TaxId: 10090] [141136] (1)
      SQ Q9QZQ1 382-487
  9. Kinesin-like protein kif1c [141137]
    1. Human (Homo sapiens) [TaxId: 9606] [141138] (1)
      SQ O43896 498-599
  10. Probable regulatory protein EmbR, C-terminal domain [141139]
    1. Mycobacterium tuberculosis [TaxId: 1773] [141140] (3)
      SQ P66799 284-382
  11. Ubiquitin ligase protein RNF8 [141141]
    1. Human (Homo sapiens) [TaxId: 9606] [141142] (2)
      SQ O76064 8-139
3. Interferon regulatory factor 3 (IRF3), transactivation domain [101630] (1)
  weak sequence similarity to SMAD domain
  1. Interferon regulatory factor 3 (IRF3), transactivation domain [101631]
    1. Human (Homo sapiens) [TaxId: 9606] [101632] (2)
4. EssC N-terminal domain-like [141143] (1)
  PfamB 051221 covers two consecutive domains; the first one is of canonical topology, whereas the second domain has a cirular permutation, beginnig at strand 2 and ending at strand 1 of the canonical fold
  1. Protein EssC [141144]
    SAV0287; similar to DNA segregation ATPase and related proteins
    1. Staphylococcus aureus [TaxId: 1280] [141145] (2)
      SQ Q8NYF3 1-78! SQ Q8NYF3 79-186