Structural Classification of Proteins
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Superfamily: p53-like transcription factors

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379]
    sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
  4. Superfamily: p53-like transcription factors [49417]
    link to SUPERFAMILY database - Superfamily

Families:

  1. p53 DNA-binding domain-like [81314] (3)
    1. p53 tumor suppressor, DNA-binding domain [49419]
      1. Human (Homo sapiens) [TaxId: 9606] [49420] (37) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [63683] (1) picpic
    2. Transcription factor CEP-1 [110078]
      1. Caenorhabditis elegans [TaxId: 6239] [110079] (1) picpic
        SQ Q20646 223-418
  2. Rel/Dorsal transcription factors, DNA-binding domain [81315] (9)
    1. T-cell transcription factor NFAT1 (NFATC), DNA-binding domain [49421]
      1. Human (Homo sapiens) [TaxId: 9606] [49422] (12) picpic
    2. T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain [69185]
      1. Human (Homo sapiens) [TaxId: 9606] [69186] (1) picpic
    3. p50 subunit of NF-kappa B (NFKB), N-terminal domain [49423]
      1. Human (Homo sapiens) [TaxId: 9606] [49424] (2) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [49425] (8) picpic
    4. p52 subunit of NF-kappa B (NFKB), N-terminal domain [49426]
      1. Human (Homo sapiens) [TaxId: 9606] [49427] (1) picpic
    5. p65 subunit of NF-kappa B (NFKB), N-terminal domain [49428]
      1. Mouse (Mus musculus) [TaxId: 10090] [49429] (8) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [49430] (1) picpic
      3. Chicken (Gallus gallus), C-rel [TaxId: 9031] [74867] (1) picpic
    6. Dorsal homologue Gambif1 [49431]
      1. African malaria mosquito (Anopheles gambiae) [TaxId: 7165] [49432] (1) picpic
  3. T-box [81316] (2)
    1. T domain from Brachyury transcription factor [49433]
      1. African clawed frog (Xenopus laevis) [TaxId: 8355] [49434] (1) picpic
    2. T-box protein 3, tbx3 [74868]
      1. Human (Homo sapiens) [TaxId: 9606] [74869] (1) picpic
  4. STAT DNA-binding domain [81317] (3)
    1. STAT-1, DNA-binding domain [49435]
      1. Human (Homo sapiens) [TaxId: 9606] [49436] (1) picpic
    2. STAT3b [49437]
      1. Mouse (Mus musculus) [TaxId: 10090] [49438] (1) picpic
    3. STAT homologue [101554]
      1. Dictyostelium discoideum [TaxId: 44689] [101555] (2) picpic
  5. RUNT domain [81318] (2)
    1. Acute myeloid leukemia 1 protein (AML1), RUNT domain [49439]
      synonym: core binding factor alpha, cbfa
      1. Human (Homo sapiens) [TaxId: 9606] [49440] (5) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [63684] (6) picpic
        almost identical sequence to the human protein
  6. DNA-binding domain from NDT80 [81992] (1)
    1. DNA-binding domain from NDT80 [81993]
      common fold is decorated with many additional structures
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [81994] (14) picpic
  7. DNA-binding protein LAG-1 (CSL) [110080] (1)
    1. DNA-binding protein LAG-1 (CSL) [110081]
      1. Caenorhabditis elegans [TaxId: 6239] [110082] (4) picpic
        SQ Q9TYY1 195-660
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk