Structural Classification of Proteins
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Superfamily: p53-like transcription factors

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379]
    sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
  4. Superfamily: p53-like transcription factors [49417]
    link to SUPERFAMILY database - Superfamily

Families:

  1. p53 DNA-binding domain-like [81314] (3)
    1. p53 tumor suppressor, DNA-binding domain [49419]
      1. Human (Homo sapiens) [TaxId: 9606] [49420] (37)
        1. 2ac0 picpic
          automatically matched to d1uola_
          complexed with zn
          1. region a:96-289 [126539] picpiclink
        2. 2ac0 picpic
          automatically matched to d1uola_
          complexed with zn
          1. region b:96-289 [126540] picpiclink
        3. 2ac0 picpic
          automatically matched to d1uola_
          complexed with zn
          1. region c:96-289 [126541] picpiclink
        4. 2ac0 picpic
          automatically matched to d1uola_
          complexed with zn
          1. region d:96-289 [126542] picpiclink
        5. 1uol picpic
          complexed with zn; mutant
          1. chain a [99695] picpiclink
          2. chain b [99696] picpiclink
        6. 2ahi picpic
          automatically matched to d1uola_
          complexed with zn
          1. region a:96-289 [126756] picpiclink
        7. 2ahi picpic
          automatically matched to d1uola_
          complexed with zn
          1. region b:96-289 [126757] picpiclink
        8. 2ahi picpic
          automatically matched to d1uola_
          complexed with zn
          1. region c:96-288 [126758] picpiclink
        9. 2ahi picpic
          automatically matched to d1uola_
          complexed with zn
          1. region d:96-289 [126759] picpiclink
        10. 2ocj picpic
          automatically matched to d1uola_
          complexed with zn
          1. region a:96-289 [139008] picpiclink
        11. 2ocj picpic
          automatically matched to d1uola_
          complexed with zn
          1. region b:96-289 [139009] picpiclink
        12. 2ocj picpic
          automatically matched to d1uola_
          complexed with zn
          1. region c:96-289 [139010] picpiclink
        13. 2ocj picpic
          automatically matched to d1uola_
          complexed with zn
          1. region d:96-289 [139011] picpiclink
        14. 2ata picpic
          automatically matched to d1uola_
          complexed with zn
          1. region a:96-289 [127285] picpiclink
        15. 2ata picpic
          automatically matched to d1uola_
          complexed with zn
          1. region b:96-289 [127286] picpiclink
        16. 2ata picpic
          automatically matched to d1uola_
          complexed with zn
          1. region c:96-289 [127287] picpiclink
        17. 2ata picpic
          automatically matched to d1uola_
          complexed with zn
          1. region d:96-289 [127288] picpiclink
        18. 1ycs picpicxrefxref
          complexed with zn
          1. chain a [22433] picpiclink
        19. 1kzy picpicxref
          complexed with zn
          1. chain a [73381] picpiclink
          2. chain b [73382] picpiclink
        20. 2ady picpic
          automatically matched to d1uola_
          complexed with zn
          1. region a:96-289 [126597] picpiclink
        21. 2ady picpic
          automatically matched to d1uola_
          complexed with zn
          1. region b:96-289 [126598] picpiclink
        22. 1tup picpic
          protein/DNA complex; complexed with zn
          1. chain a [22434] picpiclink
          2. chain b [22435] picpiclink
          3. chain c [22436] picpiclink
        23. 1tsr picpic
          protein/DNA complex; complexed with zn
          1. chain a [22437] picpiclink
          2. chain b [22438] picpiclink
          3. chain c [22439] picpiclink
        24. 1gzh picpicxref
          complexed with so4, zn
          1. chain a [70807] picpiclink
          2. chain c [70810] picpiclink
        25. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region m:96-289 [135959] picpiclink
        26. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region n:96-289 [135960] picpiclink
        27. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region o:96-289 [135961] picpiclink
        28. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region p:96-289 [135962] picpiclink
        29. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region q:96-289 [135963] picpiclink
        30. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region r:96-289 [135964] picpiclink
        31. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region s:96-289 [135965] picpiclink
        32. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region t:96-289 [135966] picpiclink
        33. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region u:96-289 [135967] picpiclink
        34. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region v:96-289 [135968] picpiclink
        35. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region w:96-289 [135969] picpiclink
        36. 2h1l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1uola_
          complexed with zn
          1. region x:96-289 [135970] picpiclink
        37. 2fej picpic
          automatically matched to d1uola_
          complexed with zn
          1. region a:96-290 [133349] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [63683] (1)
        1. 1hu8 picpic
          complexed with zn; mutant
          1. chain a [61269] picpiclink
          2. chain b [61270] picpiclink
          3. chain c [61271] picpiclink
    2. Transcription factor CEP-1 [110078]
      1. Caenorhabditis elegans [TaxId: 6239] [110079] (1)
        SQ Q20646 223-418
        1. 1t4w picpic
          complexed with zn
          1. chain a [106427] picpiclink
  2. Rel/Dorsal transcription factors, DNA-binding domain [81315] (9)
    1. T-cell transcription factor NFAT1 (NFATC), DNA-binding domain [49421]
      1. Human (Homo sapiens) [TaxId: 9606] [49422] (12)
        1. 1p7h picpicxref
          1. region l:393-575 [94272] picpiclink
          2. region m:393-575 [94274] picpiclink
          3. region n:393-575 [94276] picpiclink
          4. region o:393-575 [94278] picpiclink
        2. 2as5 picpicxrefxrefxrefxref
          automatically matched to d1p7hl2
          complexed with mg; mutant
          1. region m:396-575 [127238] picpiclink
        3. 2as5 picpicxrefxrefxrefxref
          automatically matched to d1p7hl2
          complexed with mg; mutant
          1. region n:396-575 [127240] picpiclink
        4. 2o93 picpicxrefxrefxref
          automatically matched to d1p7hl2
          1. region l:393-575 [138944] picpiclink
        5. 2o93 picpicxrefxrefxref
          automatically matched to d1p7hl2
          1. region m:395-575 [138946] picpiclink
        6. 2o93 picpicxrefxrefxref
          automatically matched to d1p7hl2
          1. region o:393-575 [138948] picpiclink
        7. 1owr picpicxref
          1. region m:395-575 [93658] picpiclink
          2. region n:395-575 [93660] picpiclink
          3. region p:395-575 [93662] picpiclink
          4. region q:395-575 [93664] picpiclink
        8. 1a02 picpicxrefxrefxref
          mutant
          1. region n:399-576 [22440] picpiclink
        9. 1s9k picpicxrefxrefxref
          automatically matched to d1p7hl2
          1. region c:399-575 [118922] picpiclink
        10. 1pzu picpicxref
          1. region b:399-571 [95472] picpiclink
          2. region d:399-571 [95474] picpiclink
          3. region h:399-571 [95476] picpiclink
          4. region i:399-571 [95478] picpiclink
          5. region l:399-571 [95480] picpiclink
          6. region m:399-571 [95482] picpiclink
        11. 1a66 picpic
          protein/DNA complex; mutant
          1. chain a [22441] picpiclink
        12. 1nfa picpic
          1. chain a [22442] picpiclink
    2. T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain [69185]
      1. Human (Homo sapiens) [TaxId: 9606] [69186] (1)
        1. 1imh picpicxref
          1. region c:188-367 [66215] picpiclink
          2. region d:188-367 [66217] picpiclink
    3. p50 subunit of NF-kappa B (NFKB), N-terminal domain [49423]
      1. Human (Homo sapiens) [TaxId: 9606] [49424] (2)
        1. 1svc picpicxref
          protein/DNA complex; mutant
          1. region p:43-250 [22443] picpiclink
        2. 2o61 picpicxref
          automatically matched to d1svcp2
          1. region b:40-246 [148621] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [49425] (8)
        1. 1ooa picpicxref
          1. region a:38-250 [87193] picpiclink
          2. region b:38-250 [87195] picpiclink
        2. 1nfk picpicxref
          protein/DNA complex
          1. region a:39-250 [22444] picpiclink
          2. region b:39-250 [22445] picpiclink
        3. 2i9t picpicxrefxrefxref
          automatically matched to d1le5b2
          1. region b:339-547 [137132] picpiclink
        4. 1lei picpicxrefxrefxref
          complexed with 5it
          1. region b:39-250 [84602] picpiclink
        5. 1le5 picpicxrefxrefxref
          1. region b:38-250 [84586] picpiclink
          2. region f:38-250 [84590] picpiclink
        6. 1vkx picpicxrefxrefxref
          protein/DNA complex
          1. region b:339-546 [22446] picpiclink
        7. 2v2t picpicxref
          automatically matched to d1le5b2
          1. region b:39-247 [152426] picpiclink
        8. 1le9 picpicxrefxrefxref
          1. region b:39-250 [84594] picpiclink
          2. region f:39-250 [84598] picpiclink
    4. p52 subunit of NF-kappa B (NFKB), N-terminal domain [49426]
      1. Human (Homo sapiens) [TaxId: 9606] [49427] (1)
        1. 1a3q picpicxref
          protein/DNA complex; mutant
          1. region a:37-226 [22447] picpiclink
          2. region b:37-226 [22448] picpiclink
    5. p65 subunit of NF-kappa B (NFKB), N-terminal domain [49428]
      1. Mouse (Mus musculus) [TaxId: 10090] [49429] (8)
        1. 2ram picpicxref
          protein/DNA complex; complexed with 5iu, dtt
          1. region a:19-191 [22450] picpiclink
          2. region b:19-191 [22451] picpiclink
        2. 1ikn picpicxrefxrefxref
          1. region a:19-191 [22449] picpiclink
        3. 2i9t picpicxrefxrefxref
          automatically matched to d1le5a2
          1. region a:20-190 [137130] picpiclink
        4. 1lei picpicxrefxrefxref
          complexed with 5it
          1. region a:19-191 [84600] picpiclink
        5. 1ram picpicxref
          protein/DNA complex; complexed with dtt
          1. region a:19-191 [22452] picpiclink
          2. region b:19-191 [22453] picpiclink
        6. 1le5 picpicxrefxrefxref
          1. region a:18-191 [84584] picpiclink
          2. region e:18-191 [84588] picpiclink
        7. 1vkx picpicxrefxrefxref
          protein/DNA complex
          1. region a:19-191 [22454] picpiclink
        8. 1le9 picpicxrefxrefxref
          1. region a:19-191 [84592] picpiclink
          2. region e:19-191 [84596] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [49430] (1)
        1. 1nfi picpicxrefxrefxref
          1. region a:20-189 [22455] picpiclink
          2. region c:20-189 [22456] picpiclink
      3. Chicken (Gallus gallus), C-rel [TaxId: 9031] [74867] (1)
        1. 1gji picpicxref
          1. region a:7-181 [70188] picpiclink
          2. region b:7-181 [70190] picpiclink
    6. Dorsal homologue Gambif1 [49431]
      1. African malaria mosquito (Anopheles gambiae) [TaxId: 7165] [49432] (1)
        1. 1bvo picpic
          protein/DNA complex
          1. chain a [22457] picpiclink
  3. T-box [81316] (2)
    1. T domain from Brachyury transcription factor [49433]
      1. African clawed frog (Xenopus laevis) [TaxId: 8355] [49434] (1)
        1. 1xbr picpic
          protein/DNA complex
          1. chain a [22458] picpiclink
          2. chain b [22459] picpiclink
    2. T-box protein 3, tbx3 [74868]
      1. Human (Homo sapiens) [TaxId: 9606] [74869] (1)
        1. 1h6f picpic
          complexed with mo6
          1. chain a [70901] picpiclink
          2. chain b [70902] picpiclink
  4. STAT DNA-binding domain [81317] (3)
    1. STAT-1, DNA-binding domain [49435]
      1. Human (Homo sapiens) [TaxId: 9606] [49436] (1)
        1. 1bf5 picpicxrefxref
          includes most of the linker with SH2 domain
          protein/DNA complex
          1. region a:317-568 [22460] picpiclink
    2. STAT3b [49437]
      1. Mouse (Mus musculus) [TaxId: 10090] [49438] (1)
        1. 1bg1 picpicxrefxref
          protein/DNA complex
          1. region a:322-575 [22461] picpiclink
    3. STAT homologue [101554]
      1. Dictyostelium discoideum [TaxId: 44689] [101555] (2)
        1. 1uur picpicxrefxref
          1. region a:360-576 [100017] picpiclink
        2. 1uus picpicxrefxref
          1. region a:360-576 [100020] picpiclink
  5. RUNT domain [81318] (2)
    1. Acute myeloid leukemia 1 protein (AML1), RUNT domain [49439]
      synonym: core binding factor alpha, cbfa
      1. Human (Homo sapiens) [TaxId: 9606] [49440] (5)
        1. 1ljm picpic
          complexed with cl
          1. chain a [78051] picpiclink
          2. chain b [78052] picpiclink
        2. 1e50 picpicxref
          1. chain a [59244] picpiclink
          2. chain c [59246] picpiclink
          3. chain e [59248] picpiclink
          4. chain g [59250] picpiclink
          5. chain q [59252] picpiclink
          6. chain r [59253] picpiclink
        3. 1h9d picpicxref
          1. chain a [60821] picpiclink
          2. chain c [60823] picpiclink
        4. 1cmo picpic
          1. chain a [22462] picpiclink
        5. 1co1 picpic
          1. chain a [22463] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [63684] (6)
        almost identical sequence to the human protein
        1. 1eaq picpic
          complexed with cl, mse; mutant
          1. chain a [76144] picpiclink
          2. chain b [76145] picpiclink
        2. 1eao picpic
          complexed with br; mutant
          1. chain a [76142] picpiclink
          2. chain b [76143] picpiclink
        3. 1ean picpic
          complexed with cl; mutant
          1. chain a [76141] picpiclink
        4. 1hjc picpic
          1. chain a [61079] picpiclink
          2. chain d [61080] picpiclink
        5. 1hjb picpicxref
          1. chain c [61075] picpiclink
          2. chain f [61078] picpiclink
        6. 1io4 picpicxrefxref
          complexed with au
          1. chain c [62616] picpiclink
  6. DNA-binding domain from NDT80 [81992] (1)
    1. DNA-binding domain from NDT80 [81993]
      common fold is decorated with many additional structures
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [81994] (14)
        1. 1mnn picpic
          complex with DNA
          1. chain a [79324] picpiclink
        2. 2evg picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132429] picpiclink
        3. 2evf picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132428] picpiclink
        4. 2euz picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132412] picpiclink
        5. 2eux picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132411] picpiclink
        6. 2euw picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132410] picpiclink
        7. 2etw picpic
          automatically matched to d1mnna_
          1. region a:33-335 [132374] picpiclink
        8. 2evi picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132431] picpiclink
        9. 2evj picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132432] picpiclink
        10. 2evh picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132430] picpiclink
        11. 2euv picpic
          automatically matched to d1mnna_
          mutant
          1. region a:33-335 [132409] picpiclink
        12. 1mn4 picpic
          1. chain a [79313] picpiclink
        13. 1m6u picpic
          complexed with so4
          1. chain a [78706] picpiclink
          2. chain b [78707] picpiclink
        14. 1m7u picpic
          1. chain a [78746] picpiclink
          2. chain b [78747] picpiclink
  7. DNA-binding protein LAG-1 (CSL) [110080] (1)
    1. DNA-binding protein LAG-1 (CSL) [110081]
      1. Caenorhabditis elegans [TaxId: 6239] [110082] (4)
        SQ Q9TYY1 195-660
        1. 3brd picpicxrefxref
          automatically matched to d1ttua2
          complexed with edo
          1. region a:197-380 [155506] picpiclink
        2. 3brf picpicxrefxref
          automatically matched to d1ttua2
          complexed with sor
          1. region a:197-380 [155509] picpiclink
        3. 1ttu picpicxrefxref
          complexed with egl
          1. region a:196-380 [107306] picpiclink
        4. 2fo1 picpicxrefxrefxrefxref
          automatically matched to d1ttua2
          1. region a:196-380 [133866] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk