Structural Classification of Proteins
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Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)

two constituent families are related by circular permutation
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: C2 domain-like [49561]
    sandwich; 8 strands in 2 sheets; greek-key
  4. Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB) [49562]
    two constituent families are related by circular permutation
    link to SUPERFAMILY database - Superfamily

Families:

  1. PLC-like (P variant) [49563] (12)
    1. PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain [49564]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49565] (10) picpic
    2. Domain from cytosolic phospholipase A2 [49566]
      1. Human (Homo sapiens) [TaxId: 9606] [49567] (3) picpic
    3. Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain [49568]
      1. Human (Homo sapiens) [TaxId: 9606] [49569] (1) picpic
    4. Phoshoinositide 3-kinase (PI3K) [49570]
      1. Pig (Sus scrofa) [TaxId: 9823] [49571] (5) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [49572] (3) picpic
    5. Domain from protein kinase C delta [49573]
      rudiment form lacking calcium-binding site
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49574] (1) picpic
    6. Domain from protein kinase C epsilon [69196]
      Calcium-independent
      1. Rat (Rattus rattus) [TaxId: 10117] [69197] (1) picpic
    7. E3 ubiquitin-protein ligase Itchy [141103]
      1. Human (Homo sapiens) [TaxId: 9606] [141104] (1) picpic
        SQ Q96J02 13-145
    8. Unc-13 homolog A [141105]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [141106] (6) picpic
        SQ Q62768 1-128! SQ Q62768 2-150
    9. Multiple C2 and transmembrane domain-containing protein 2, MCTP2 [158940]
      1. Human (Homo sapiens) [TaxId: 9606] [158941] (1) picpic
        SQ Q6DN12 504-629
    10. Fantom [158942]
      RPGR-interacting protein 1-like protein
      1. Human (Homo sapiens) [TaxId: 9606] [158943] (1) picpic
        SQ Q68CZ1 596-737
    11. Phospholipase C-beta-2 [158944]
      1. Human (Homo sapiens) [TaxId: 9606] [158945] (2) picpic
        SQ Q00722 678-799
  2. Synaptotagmin-like (S variant) [49575] (12)
    topologically similar to the C-terminal domain of PapD
    1. Synaptogamin I [49576]
      duplication: contains tandem repeat of two similar domains
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49577] (7) picpic
        SQ P21707 271-419 ! SQ P21707 271-419
      2. Homo sapiens [TaxId: 9606] [158946] (2) picpic
    2. Synaptotagmin III [109606]
      duplication: contains 2 C2 domains
      1. Rat (Rattus norvegicus) [TaxId: 10116] [109607] (1) picpic
        SQ P40748 293-588
    3. Synaptotagmin IV [101562]
      duplication: contains 2 C2 domains
      1. Human (Homo sapiens) [TaxId: 9606] [101563] (1) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [110115] (2) picpic
        SQ P50232 288-425
    4. Regulating synaptic membrane exocytosis protein, rim2 [101564]
      1. Human (Homo sapiens) [TaxId: 9606] [101565] (2) picpic
    5. Piccolo [101566]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [101567] (1) picpic
    6. C2 domain from protein kinase c (alpha) [49578]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49579] (1) picpic
    7. C2 domain from protein kinase c (beta) [49580]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49581] (1) picpic
    8. C2b-domain of rabphilin [49582]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49583] (4) picpic
    9. C2 domain protein At1g63220 [117082]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117083] (1) picpic
        SQ Q9C8S6 2-125
    10. Synaptotagmin XIII [117084]
      1. Human (Homo sapiens) [TaxId: 9606] [117085] (1) picpic
        SQ Q7L8C5 155-280
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk