Structural Classification of Proteins
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Superfamily: E set domains

"Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: E set domains [81296]
    "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
    link to SUPERFAMILY database - Superfamily

Families:

  1. NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [81279] (10)
    subgroup of the larger IPT/TIG domain family
    1. T-cell transcription factor NFAT1 (NFATC2) [49246]
      1. Human (Homo sapiens) [TaxId: 9606] [49247] (10) picpic
    2. T-cell transcription factor NFAT5 (TONEBP) [69170]
      1. Human (Homo sapiens) [TaxId: 9606] [69171] (1) picpic
    3. p50 subunit of NF-kappa B transcription factor [49248]
      1. Human (Homo sapiens) [TaxId: 9606] [49249] (9) picpic
        SQ P25799 245-350
      2. Mouse (Mus musculus) [TaxId: 10090] [49250] (10) picpic
    4. p52 subunit of NF-kappa B (NFKB) [49251]
      1. Human (Homo sapiens) [TaxId: 9606] [49252] (1) picpic
    5. p65 subunit of NF-kappa B (NFKB), dimerization domain [49253]
      1. Mouse (Mus musculus) [TaxId: 10090] [49254] (10) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [49255] (4) picpic
      3. Chicken (Gallus gallus), C-rel [TaxId: 9031] [74848] (1) picpic
    6. DNA-binding protein LAG-1 (CSL) [110052]
      1. Caenorhabditis elegans [TaxId: 6239] [110053] (4) picpic
        SQ Q9TYY1 195-660
    7. Calmodulin binding transcription activator 1 [141017]
      this domain is in the middle of long protein chain
      1. Human (Homo sapiens) [TaxId: 9606] [141018] (5) picpic
        SQ Q9Y6Y1 872-953
  2. E-set domains of sugar-utilizing enzymes [81282] (30)
    domains of unknown function associated with different type of catalytic domains in a different sequential location
    subgroup of the larger IPT/TIG domain family
    1. Galactose oxidase, C-terminal domain [49209]
      follows the catalytic seven-bladed beta-propeller domain
      1. Dactylium dendroides [TaxId: 5132] [49210] (8) picpic
        SQ Q01745 42-680
      2. Fungi (Fusarium sp.) [TaxId: 29916] [69164] (1) picpic
        sequence identical to that of Dactylium dendroides
      3. Fusarium graminearum (Gibberella zeae) [TaxId: 5518] [158881] (3) picpic
    2. Sialidase, "linker" domain [49237]
      follows the catalytic six-bladed beta-propeller domain
      1. Micromonospora viridifaciens [TaxId: 1881] [49238] (8) picpic
        SQ Q02834 47-647
    3. CelD cellulase, N-terminal domain [49231]
      precedes the catalytic alpha6/alpha6 domain
      1. Clostridium thermocellum [TaxId: 1515] [49232] (1) picpic
    4. Cellulose 1,4-beta-cellobiosidase CbhA, precatalytic domain [101521]
      1. Clostridium thermocellum [TaxId: 1515] [101522] (2) picpic
    5. Hyaluronate lyase precatalytic domain [69167]
      precedes the catalytic incomplete alpha5/alpha5 barrel
      a rudiment form of Ig-like domain
      1. Streptococcus agalactiae [TaxId: 1311] [69168] (3) picpic
    6. Bacterial chitobiase (N-acetyl-beta-glucoseaminidase), C-terminal domain [49211]
      rudiment form of Ig-like domain; follows the catalytic (beta/alpha)8-barrel domain; family 20 glycosyl hydrolases
      1. Serratia marcescens [TaxId: 615] [49212] (4) picpic
    7. Cyclomaltodextrin glycanotransferase, domain D [49215]
      follows the starch-binding domain C; the catalytic domain A has (beta/alpha)8-barrel fold; family 13 glycosyl hydrolases
      1. Bacillus circulans, different strains [TaxId: 1397] [49216] (36) picpic
      2. Bacillus stearothermophilus [TaxId: 1422] [49217] (1) picpic
      3. Bacillus sp., strain 1011 [TaxId: 1409] [49219] (8) picpic
        SQ P05618
      4. Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId: 33950] [49220] (2) picpic
      5. Thermoanaerobacterium [TaxId: 28895] [158882] (2) picpic
    8. Five domain "maltogenic" alpha-amylase (glucan 1,4-alpha-maltohydrolase), domain D [81280]
      domain architecture similar to cyclomaltodextrin glycosylhydrolases
      1. Bacillus stearothermophilus [TaxId: 1422] [81281] (2) picpic
    9. Maltogenic amylase, N-terminal domain N [49221]
      precedes the catalytic (beta/alpha)8-barrel domain
      1. Thermus sp. [TaxId: 275] [49222] (2) picpic
      2. Bacillus sp., cyclomaltodextrinase [TaxId: 1409] [74842] (1) picpic
      3. Thermoactinomyces vulgaris, TVAI [TaxId: 2026] [74843] (9) picpic
      4. Thermoactinomyces vulgaris, TVAII [TaxId: 2026] [49223] (25) picpic
    10. Neopullulanase, N-terminal domain [81960]
      homologous to maltogenic amylase
      1. Bacillus stearothermophilus [TaxId: 1422] [81961] (4) picpic
    11. Cyclomaltodextrinase, N-terminal domain [101523]
      protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
      1. Flavobacterium sp. 92 [TaxId: 197856] [101524] (1) picpic
    12. Isoamylase, N-terminal domain N [49226]
      elaborated with a few large insertions in the common fold
      precedes the catalytic (beta/alpha)8-barrel domain, the domain architecture similar to maltogenic amylases
      1. Pseudomonas amyloderamosa [TaxId: 32043] [49227] (1) picpic
    13. Glycosyltrehalose trehalohydrolase, N-terminal domain N [49224]
      domain architecture similar to isoamylase
      1. Archaeon Sulfolobus solfataricus, km1 [TaxId: 2287] [49225] (2) picpic
      2. Deinococcus radiodurans [TaxId: 1299] [141019] (9) picpic
        SQ Q9RX51 14-110
    14. 1,4-alpha-glucan branching enzyme, N-terminal domain N [81962]
      domain architecture similar to isoamylase
      1. Escherichia coli [TaxId: 562] [81963] (1) picpic
    15. Chitinase A, N-terminal domain N [49233]
      precedes the catalytic (beta/alpha)8-barrel domain
      1. Serratia marcescens [TaxId: 615] [49234] (11) picpic
        SQ P07254 24-563
    16. Glucodextranase, domain B [101525]
      1. Arthrobacter globiformis [TaxId: 1665] [101526] (2) picpic
    17. Glucans biosynthesis protein G (MdoG, OpgG), C-terminal domain [110054]
      1. Escherichia coli [TaxId: 562] [110055] (1) picpic
        SQ P33136 23-511
    18. Chitin-binding protein CBP21 [117045]
      member of Pfam 03067; elaborated fold with a large insertion between strands A and A'
      1. Serratia marcescens [TaxId: 615] [117046] (2) picpic
        SQ O83009 28-197
    19. Beta-1,4-mannanase domain 2 (postcatalytic) [141020]
      1. Cellulomonas fimi [TaxId: 1708] [141021] (3) picpic
        SQ Q9XCV5 421-514
    20. Pullulanase PulA [158883]
      contains two E-set domains in tandem
      1. Klebsiella pneumoniae [TaxId: 573] [158884] (6) picpic
        SQ P07206 170-294! SQ P07206 295-409
  3. Other IPT/TIG domains [89191] (1)
    apart from the domains of transcription factors and sugar-utilizing enzymes
    1. Exocyst complex component Sec5, Ral-binding domain [89192]
      1. Mouse (Mus musculus) [TaxId: 10090] [89193] (2) picpic
  4. Arthropod hemocyanin, C-terminal domain [81283] (2)
    1. Arthropod hemocyanin, C-terminal domain [49228]
      elaborated with many loop insertions in the common fold
      1. Horseshoe crab (Limulus polyphemus) [TaxId: 6850] [49229] (4) picpic
      2. Spiny lobster (Panulirus interruptus) [TaxId: 6735] [49230] (7) picpic
  5. Class II viral fusion proteins C-terminal domain [81284] (6)
    1. Envelope glycoprotein [49213]
      1. Tick-borne encephalitis virus [TaxId: 11084] [49214] (2) picpic
      2. Dengue virus type 2 [TaxId: 11060] [89194] (12) picpic
        SQ P12823 281-675 # 99% sequence identity
      3. Japanese encephalitis virus [TaxId: 11072] [101527] (1) picpic
      4. West Nile virus [TaxId: 11082] [110056] (5) picpic
        SQ Q8JU42 586-696
      5. Langat virus [TaxId: 11085] [141022] (2) picpic
        SQ P29838 583-765
    2. Fusion glycoprotein E1 [74840]
      1. Semliki forest virus [TaxId: 11033] [74841] (5) picpic
  6. Cytomegalovirus protein US2 [81285] (1)
    1. Cytomegalovirus protein US2 [63668]
      similar to both C1 and C2 set
      1. Human cytomegalovirus [TaxId: 10359] [63669] (1) picpic
  7. Molybdenum-containing oxidoreductases-like dimerisation domain [81286] (2)
    1. Sulfite oxidase, C-terminal domain [49259]
      1. Chicken (Gallus gallus) [TaxId: 9031] [49260] (5) picpic
      2. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [101528] (1) picpic
  8. ML domain [81287] (3)
    implicated in lipid recognition, particularly in the recognition of pathogen related products
    1. Epididymal secretory protein E1 (Niemann-Pick C2 protein) [81964]
      a cholesterol binding protein
      1. Cow (Bos taurus) [TaxId: 9913] [81965] (4) picpic
    2. Major mite allergen [49256]
      contains additional N-terminal strand
      1. House-dust mite (Dermatophagoides farinae), Der f 2 [TaxId: 6954] [49257] (8) picpic
        SQ Q00855 18-146
      2. House-dust mite (Dermatophagoides pteronyssinus), Der p 2 [TaxId: 6956] [49258] (2) picpic
  9. RhoGDI-like [81288] (3)
    1. Rho GDP-dissociation inhibitor 1, RhoGDI [49241]
      1. Human (Homo sapiens) [TaxId: 9606] [49242] (17) picpic
      2. Cow (Bos taurus) [TaxId: 9913] [49243] (4) picpic
    2. GMP-PDE delta [74846]
      1. Human (Homo sapiens) [TaxId: 9606] [74847] (3) picpic
  10. Cytoplasmic domain of inward rectifier potassium channel [81966] (3)
    1. G protein-gated inward rectifier Girk1 [81967]
      forms tetrameric cytoplasmic pore; contains a C-terminal extension
      1. Mouse (Mus musculus) [TaxId: 10090] [81968] (1) picpic
    2. Inward rectifier potassium channel Kirbac1.1 [89195]
      1. Burkholderia pseudomallei [TaxId: 28450] [89196] (1) picpic
    3. Inward rectifier potassium channel kirbac3.1 [117047]
      1. Magnetospirillum magnetotacticum [TaxId: 188] [117048] (2) picpic
        SQ Q8YY97 # 46% sequence identity; Anabaena sp. PCC 7120 TaxID: 103690
  11. Transglutaminase N-terminal domain [81289] (4)
    1. Transglutaminase N-terminal domain [49235]
      elaborated with many loop insertions in the common fold
      1. Human (Homo sapiens), blood isozyme [TaxId: 9606] [49236] (8) picpic
        Coagulation factor XIII
      2. Human (Homo sapiens), tissue isozyme [TaxId: 9606] [74844] (2) picpic
        GDP-binding protein
      3. Human (Homo sapiens), TGase E3 [TaxId: 9606] [74845] (8) picpic
      4. Red sea bream (Chrysophrys major) [TaxId: 143350] [63667] (1) picpic
  12. Filamin repeat (rod domain) [81290] (4)
    Pfam 00630
    1. F-actin cross-linking gelation factor (ABP-120) repeats [49239]
      1. Dictyostelium discoideum [TaxId: 44689] [49240] (3) picpic
        SQ P13466 547-857
    2. Filamin C [117049]
      1. Human (Homo sapiens) [TaxId: 9606] [117050] (7) picpic
        SQ Q14315 2633-2725
    3. Filamin a [141023]
      1. Human (Homo sapiens) [TaxId: 9606] [141024] (8) picpic
        SQ P21333 1863-1953! SQ P21333 1863-1955! SQ P21333 2236-2328
    4. Filamin b [141025]
      1. Human (Homo sapiens) [TaxId: 9606] [141026] (14) picpic
        SQ O75369 1017-1134! SQ O75369 1130-1229! SQ O75369 1215-1329! SQ O75369 1325-1442! SQ O75369 1418-1518! SQ O75369 1611-1721! SQ O75369 1899-2001! SQ O75369 1999-2096! SQ O75369 2104-2192
  13. Arrestin/Vps26-like [81291] (2)
    1. Arrestin [49244]
      duplication: contains tandem repeat of two elaborated Ig-like domains contacting each other head-to-head
      1. Cow (Bos taurus), visual arrestin [TaxId: 9913] [49245] (2) picpic
      2. Cow (Bos taurus), beta-arrestin 1 [TaxId: 9913] [69169] (5) picpic
  14. Gingipain R (RgpB), C-terminal domain [81292] (1)
    1. Gingipain R (RgpB), C-terminal domain [49261]
      Arginine-specific cysteine proteinase
      follows the catalytic alpha/beta domains
      1. Porphyromonas gingivalis [TaxId: 837] [49262] (1) picpic
  15. Copper resistance protein C (CopC, PcoC) [81969] (2)
    1. Copper resistance protein C (CopC, PcoC) [81970]
      1. Pseudomonas syringae [TaxId: 317] [81971] (7) picpic
      2. Escherichia coli [TaxId: 562] [81972] (2) picpic
  16. Cellulosomal scaffoldin protein CipC, module x2.1 [81293] (1)
    1. Cellulosomal scaffoldin protein CipC, module x2.1 [49263]
      1. Clostridium cellulolyticum [TaxId: 1521] [49264] (1) picpic
  17. Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [81294] (2)
    1. Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [69176]
      duplication: tandem repeat of two Ig-like domains
      1. Paracoccus denitrificans [TaxId: 266] [69177] (2) picpic
      2. Pseudomonas putida [TaxId: 303] [69178] (2) picpic
  18. Internalin Ig-like domain [81295] (3)
    truncated fold fused to an LRR domain
    1. Internalin A [81973]
      1. Listeria monocytogenes [TaxId: 1639] [81974] (7) picpic
    2. Internalin B [69172]
      1. Listeria monocytogenes [TaxId: 1639] [69173] (5) picpic
    3. Internalin H [69174]
      1. Listeria monocytogenes [TaxId: 1639] [69175] (1) picpic
  19. SoxZ-like [141027] (1)
    1. Sulfur oxidation protein SoxZ [141028]
      1. Thermus thermophilus [TaxId: 274] [141029] (2) picpic
        SQ Q5SME6 2-107
        TTHA1420
  20. Enterochelin esterase N-terminal domain-like [141030] (2)
    PfamB 013071
    1. Enterochelin esterase [141031]
      1. Shigella flexneri [TaxId: 623] [141032] (1) picpic
        SQ Q83SB9 3-150
      2. Shigella flexneri 2a str. 2457T [TaxId: 198215] [158885] (10) picpic
  21. AMPK-beta glycogen binding domain-like [158886] (3)
    lacks the N-terminal strand (A) and contains a beta-hairpin insertion in the C-terminal strand (G)
    1. 5'-AMP-activated protein kinase subunit beta-2 [158887]
      1. Human (Homo sapiens) [TaxId: 9606] [158888] (1) picpic
        SQ O43741 75-163
    2. SIP2 [158889]
      1. Saccharomyces cerevisiae [TaxId: 4932] [158890] (2) picpic
        SQ P34164 161-247
    3. 5'-AMP-activated protein kinase subunit beta-1 [158891]
      1. Rattus norvegicus [TaxId: 10116] [158892] (6) picpic
        SQ P80386 76-162
  22. Sec63 C-terminal domain-like [158893] (1)
    C-terminal part of Pfam 02889
    1. Protein pro2281 [158894]
      1. Human (Homo sapiens) [TaxId: 9606] [158895] (1) picpic
        SQ Q9P172 209-322
  23. SVA-like [158896] (1)
    Pfam 05326
    1. Prolactin-inducible protein, PIP [158897]
      1. Human (Homo sapiens) [TaxId: 9606] [158898] (1) picpic
        SQ P12273 29-146
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk